Cyclic ADP-ribose (BioDeep_00001028438)
代谢物信息卡片
Cyclic ADP-ribose
化学式: C15H21N5O13P2 (541.0611076)
中文名称: 环状ADP核糖
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1C2C(C(C(O2)N3C=NC4=C3N=CN(C4=N)C5C(C(C(O5)COP(=O)(OP(=O)(O1)O)O)O)O)O)O
InChI: InChI=1S/C15H21N5O13P2/c16-12-7-13-18-4-19(12)14-10(23)8(21)5(31-14)1-29-34(25,26)33-35(27,28)30-2-6-9(22)11(24)15(32-6)20(13)3-17-7/h3-6,8-11,14-16,21-24H,1-2H2,(H,25,26)(H,27,28)/t5-,6-,8-,9-,10-,11-,14-,15-/m1/s1
数据库引用编号
5 个数据库交叉引用编号
- ChEBI: CHEBI:31445
- PubChem: 123847
- MeSH: Cyclic ADP-Ribose
- CAS: 119340-53-3
- RefMet: Cyclic ADP-ribose
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
1 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(1)
- NAD+ Signalling Pathway (Cancer):
Niacinamide + Phosphoribosyl pyrophosphate ⟶ Nicotinic acid mononucleotide + Phosphate
PharmGKB(0)
3 个相关的物种来源信息
- 7461 - Apis cerana: 10.1371/JOURNAL.PONE.0175573
- 13345 - Ardisia crenata: 10.3389/FMOLB.2021.683671
- 180039 - Psychotria punctata: 10.3389/FMOLB.2021.683671
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Adam M Bayless, Sisi Chen, Sam C Ogden, Xiaoyan Xu, John D Sidda, Mohammad K Manik, Sulin Li, Bostjan Kobe, Thomas Ve, Lijiang Song, Murray Grant, Li Wan, Marc T Nishimura. Plant and prokaryotic TIR domains generate distinct cyclic ADPR NADase products.
Science advances.
2023 03; 9(11):eade8487. doi:
10.1126/sciadv.ade8487. [PMID: 36930706] - Michelle T Hulin, Lionel Hill, Jonathan D G Jones, Wenbo Ma. Pangenomic analysis reveals plant NAD+ manipulation as an important virulence activity of bacterial pathogen effectors.
Proceedings of the National Academy of Sciences of the United States of America.
2023 Feb; 120(7):e2217114120. doi:
10.1073/pnas.2217114120. [PMID: 36753463] - Mohammad K Manik, Yun Shi, Sulin Li, Mark A Zaydman, Neha Damaraju, Samuel Eastman, Thomas G Smith, Weixi Gu, Veronika Masic, Tamim Mosaiab, James S Weagley, Steven J Hancock, Eduardo Vasquez, Lauren Hartley-Tassell, Nestoras Kargios, Natsumi Maruta, Bryan Y J Lim, Hayden Burdett, Michael J Landsberg, Mark A Schembri, Ivan Prokes, Lijiang Song, Murray Grant, Aaron DiAntonio, Jeffrey D Nanson, Ming Guo, Jeffrey Milbrandt, Thomas Ve, Bostjan Kobe. Cyclic ADP ribose isomers: Production, chemical structures, and immune signaling.
Science (New York, N.Y.).
2022 09; 377(6614):eadc8969. doi:
10.1126/science.adc8969. [PMID: 36048923] - Gal Ofir, Ehud Herbst, Maya Baroz, Daniel Cohen, Adi Millman, Shany Doron, Nitzan Tal, Daniel B A Malheiro, Sergey Malitsky, Gil Amitai, Rotem Sorek. Antiviral activity of bacterial TIR domains via immune signalling molecules.
Nature.
2021 12; 600(7887):116-120. doi:
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Carbohydrate polymers.
2021 Jul; 263(?):117927. doi:
10.1016/j.carbpol.2021.117927. [PMID: 33858586] - Na Xie, Lu Zhang, Wei Gao, Canhua Huang, Peter Ernst Huber, Xiaobo Zhou, Changlong Li, Guobo Shen, Bingwen Zou. NAD+ metabolism: pathophysiologic mechanisms and therapeutic potential.
Signal transduction and targeted therapy.
2020 10; 5(1):227. doi:
10.1038/s41392-020-00311-7. [PMID: 33028824] - Yo Sasaki, Thomas M Engber, Robert O Hughes, Matthew D Figley, Tong Wu, Todd Bosanac, Rajesh Devraj, Jeffrey Milbrandt, Raul Krauss, Aaron DiAntonio. cADPR is a gene dosage-sensitive biomarker of SARM1 activity in healthy, compromised, and degenerating axons.
Experimental neurology.
2020 07; 329(?):113252. doi:
10.1016/j.expneurol.2020.113252. [PMID: 32087251] - Antony Galione, Kai-Ting Chuang. Pyridine Nucleotide Metabolites and Calcium Release from Intracellular Stores.
Advances in experimental medicine and biology.
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Science (New York, N.Y.).
2019 08; 365(6455):799-803. doi:
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Journal of cellular physiology.
2019 04; 234(4):4572-4581. doi:
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Chembiochem : a European journal of chemical biology.
2018 07; 19(13):1444-1451. doi:
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Human antibodies.
2017; 25(3-4):75-85. doi:
10.3233/hab-160305. [PMID: 28035914] - M A Hossain, W Ye, S Munemasa, Y Nakamura, I C Mori, Y Murata. Cyclic adenosine 5'-diphosphoribose (cADPR) cyclic guanosine 3',5'-monophosphate positively function in Ca(2+) elevation in methyl jasmonate-induced stomatal closure, cADPR is required for methyl jasmonate-induced ROS accumulation NO production in guard cells.
Plant biology (Stuttgart, Germany).
2014 Nov; 16(6):1140-4. doi:
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Veterinary anaesthesia and analgesia.
2013 Sep; 40(5):512-6. doi:
10.1111/vaa.12039. [PMID: 23565906] - Andreas H Guse. Measuring Ca2+ release evoked by cyclic adp-ribose.
Cold Spring Harbor protocols.
2013 Jun; 2013(6):574-8. doi:
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Circulation research.
2013 Feb; 112(4):721-41. doi:
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The Plant cell.
2013 Feb; 25(2):558-71. doi:
10.1105/tpc.112.105049. [PMID: 23396828] - Richard M Graeff, Hon Cheung Lee. Determination of ADP-ribosyl cyclase activity, cyclic ADP-ribose, and nicotinic acid adenine dinucleotide phosphate in tissue extracts.
Methods in molecular biology (Clifton, N.J.).
2013; 1016(?):39-56. doi:
10.1007/978-1-62703-441-8_4. [PMID: 23681571] - Jing Xiong, Min Xia, Fan Yi, Justine M Abais, Ningjun Li, Krishna M Boini, Pin-Lan Li. Regulation of renin release via cyclic ADP-ribose-mediated signaling: evidence from mice lacking CD38 gene.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2013; 31(1):44-55. doi:
10.1159/000343348. [PMID: 23343681] - Jeng-Shane Lin, Chih-Ching Lin, Hsin-Hung Lin, Yu-Chi Chen, Shih-Tong Jeng. MicroR828 regulates lignin and H2O2 accumulation in sweet potato on wounding.
The New phytologist.
2012 Oct; 196(2):427-440. doi:
10.1111/j.1469-8137.2012.04277.x. [PMID: 22931461] - Antony Galione, Kai-Ting Chuang. Pyridine nucleotide metabolites and calcium release from intracellular stores.
Advances in experimental medicine and biology.
2012; 740(?):305-23. doi:
10.1007/978-94-007-2888-2_13. [PMID: 22453948] - Chengju Tian, Chun Hong Shao, Caronda J Moore, Shelby Kutty, Timothy Walseth, Cyrus DeSouza, Keshore R Bidasee. Gain of function of cardiac ryanodine receptor in a rat model of type 1 diabetes.
Cardiovascular research.
2011 Jul; 91(2):300-9. doi:
10.1093/cvr/cvr076. [PMID: 21421556] - Kay-Pong Yip, James S K Sham. Mechanisms of vasopressin-induced intracellular Ca2+ oscillations in rat inner medullary collecting duct.
American journal of physiology. Renal physiology.
2011 Feb; 300(2):F540-8. doi:
10.1152/ajprenal.00544.2009. [PMID: 21147839] - N Lycke, M Bemark. Mucosal adjuvants and long-term memory development with special focus on CTA1-DD and other ADP-ribosylating toxins.
Mucosal immunology.
2010 Nov; 3(6):556-66. doi:
10.1038/mi.2010.54. [PMID: 20844480] - Latha Ramakrishnan, Hélène Muller-Steffner, Christophe Bosc, Victor D Vacquier, Francis Schuber, Marie-Jo Moutin, Leslie Dale, Sandip Patel. A single residue in a novel ADP-ribosyl cyclase controls production of the calcium-mobilizing messengers cyclic ADP-ribose and nicotinic acid adenine dinucleotide phosphate.
The Journal of biological chemistry.
2010 Jun; 285(26):19900-9. doi:
10.1074/jbc.m110.105312. [PMID: 20385553] - Fushun Hao, Shiling Zhao, Huan Dong, Huan Zhang, Lirong Sun, Chen Miao. Nia1 and Nia2 are involved in exogenous salicylic acid-induced nitric oxide generation and stomatal closure in Arabidopsis.
Journal of integrative plant biology.
2010 Mar; 52(3):298-307. doi:
10.1111/j.1744-7909.2010.00920.x. [PMID: 20377690] - Sonia Scarfì, Chiara Fresia, Chiara Ferraris, Santina Bruzzone, Floriana Fruscione, Cesare Usai, Federica Benvenuto, Mirko Magnone, Marina Podestà, Laura Sturla, Lucrezia Guida, Ennio Albanesi, Gianluca Damonte, Annalisa Salis, Antonio De Flora, Elena Zocchi. The plant hormone abscisic acid stimulates the proliferation of human hemopoietic progenitors through the second messenger cyclic ADP-ribose.
Stem cells (Dayton, Ohio).
2009 Oct; 27(10):2469-77. doi:
10.1002/stem.173. [PMID: 19593794] - Tanja Kirchberger, Christelle Moreau, Gerd K Wagner, Ralf Fliegert, Cornelia C Siebrands, Merle Nebel, Frederike Schmid, Angelika Harneit, Francesca Odoardi, Alexander Flügel, Barry V L Potter, Andreas H Guse. 8-Bromo-cyclic inosine diphosphoribose: towards a selective cyclic ADP-ribose agonist.
The Biochemical journal.
2009 Jul; 422(1):139-49. doi:
10.1042/bj20082308. [PMID: 19492987] - Rukhsana Gul, Jae-Hyeong Park, Seon-Young Kim, Kyu Yoon Jang, Jei-Keon Chae, Jae-Ki Ko, Uh-Hyun Kim. Inhibition of ADP-ribosyl cyclase attenuates angiotensin II-induced cardiac hypertrophy.
Cardiovascular research.
2009 Feb; 81(3):582-91. doi:
10.1093/cvr/cvn232. [PMID: 18719074] - Dev Churamani, Michael J Boulware, Latha Ramakrishnan, Timothy J Geach, Andrew C R Martin, Victor D Vacquier, Jonathan S Marchant, Leslie Dale, Sandip Patel. Molecular characterization of a novel cell surface ADP-ribosyl cyclase from the sea urchin.
Cellular signalling.
2008 Dec; 20(12):2347-55. doi:
10.1016/j.cellsig.2008.09.005. [PMID: 18824228] - Santina Bruzzone, Nicoletta Bodrato, Cesare Usai, Lucrezia Guida, Iliana Moreschi, Rita Nano, Barbara Antonioli, Floriana Fruscione, Mirko Magnone, Sonia Scarfì, Antonio De Flora, Elena Zocchi. Abscisic acid is an endogenous stimulator of insulin release from human pancreatic islets with cyclic ADP ribose as second messenger.
The Journal of biological chemistry.
2008 Nov; 283(47):32188-97. doi:
10.1074/jbc.m802603200. [PMID: 18784081] - Sonia Scarfì, Chiara Ferraris, Floriana Fruscione, Chiara Fresia, Lucrezia Guida, Santina Bruzzone, Cesare Usai, Alessia Parodi, Enrico Millo, Annalisa Salis, Giorgio Burastero, Antonio De Flora, Elena Zocchi. Cyclic ADP-ribose-mediated expansion and stimulation of human mesenchymal stem cells by the plant hormone abscisic acid.
Stem cells (Dayton, Ohio).
2008 Nov; 26(11):2855-64. doi:
10.1634/stemcells.2008-0488. [PMID: 18687991] - Su-Jie Jia, Si Jin, Fan Zhang, Fan Yi, William L Dewey, Pin-Lan Li. Formation and function of ceramide-enriched membrane platforms with CD38 during M1-receptor stimulation in bovine coronary arterial myocytes.
American journal of physiology. Heart and circulatory physiology.
2008 Oct; 295(4):H1743-52. doi:
10.1152/ajpheart.00617.2008. [PMID: 18723763] - Andreas H Guse. Back from the dormant stage: second messenger cyclic ADP-ribose essential for Toxoplasma gondii pathogenicity.
Science signaling.
2008 Apr; 1(17):pe18. doi:
10.1126/stke.117pe18. [PMID: 18445834] - Byung-Ju Kim, Kwang-Hyun Park, Chang-Yeol Yim, Shin Takasawa, Hiroshi Okamoto, Mie-Jae Im, Uh-Hyun Kim. Generation of nicotinic acid adenine dinucleotide phosphate and cyclic ADP-ribose by glucagon-like peptide-1 evokes Ca2+ signal that is essential for insulin secretion in mouse pancreatic islets.
Diabetes.
2008 Apr; 57(4):868-78. doi:
10.2337/db07-0443. [PMID: 18184929] - Kisaburo Nagamune, Leslie M Hicks, Blima Fux, Fabien Brossier, Eduardo N Chini, L David Sibley. Abscisic acid controls calcium-dependent egress and development in Toxoplasma gondii.
Nature.
2008 Jan; 451(7175):207-10. doi:
10.1038/nature06478. [PMID: 18185591] - Joseph A Jude, Mark E Wylam, Timothy F Walseth, Mathur S Kannan. Calcium signaling in airway smooth muscle.
Proceedings of the American Thoracic Society.
2008 Jan; 5(1):15-22. doi:
10.1513/pats.200704-047vs. [PMID: 18094080] - Antony N Dodd, Michael J Gardner, Carlos T Hotta, Katharine E Hubbard, Neil Dalchau, John Love, Jean-Maurice Assie, Fiona C Robertson, Mia Kyed Jakobsen, Jorge Gonçalves, Dale Sanders, Alex A R Webb. The Arabidopsis circadian clock incorporates a cADPR-based feedback loop.
Science (New York, N.Y.).
2007 Dec; 318(5857):1789-92. doi:
10.1126/science.1146757. [PMID: 18084825] - Takato Imaizumi, Steve A Kay, Julian I Schroeder. Circadian rhythms. Daily watch on metabolism.
Science (New York, N.Y.).
2007 Dec; 318(5857):1730-1. doi:
10.1126/science.1151360. [PMID: 18006706] - Sandy Vanderauwera, Marc De Block, Nancy Van de Steene, Brigitte van de Cotte, Michael Metzlaff, Frank Van Breusegem. Silencing of poly(ADP-ribose) polymerase in plants alters abiotic stress signal transduction.
Proceedings of the National Academy of Sciences of the United States of America.
2007 Sep; 104(38):15150-5. doi:
10.1073/pnas.0706668104. [PMID: 17823244] - Kristy Welshhans, Vincent Rehder. Nitric oxide regulates growth cone filopodial dynamics via ryanodine receptor-mediated calcium release.
The European journal of neuroscience.
2007 Sep; 26(6):1537-47. doi:
10.1111/j.1460-9568.2007.05768.x. [PMID: 17714493] - Susan K Fellner, William J Arendshorst. Voltage-gated Ca2+ entry and ryanodine receptor Ca2+-induced Ca2+ release in preglomerular arterioles.
American journal of physiology. Renal physiology.
2007 May; 292(5):F1568-72. doi:
10.1152/ajprenal.00459.2006. [PMID: 17190906] - R Fliegert, A Gasser, A H Guse. Regulation of calcium signalling by adenine-based second messengers.
Biochemical Society transactions.
2007 Feb; 35(Pt 1):109-14. doi:
10.1042/bst0350109. [PMID: 17233614] - Tae-Sik Nam, Sung Hoon Choi, So-Young Rah, Seon-Young Kim, Won Jang, Mie-Jae Im, Ho Jeong Kwon, Uh-Hyun Kim. Discovery of a small-molecule inhibitor for kidney ADP-ribosyl cyclase: Implication for intracellular calcium signal mediated by cyclic ADP-ribose.
Experimental & molecular medicine.
2006 Dec; 38(6):718-26. doi:
10.1038/emm.2006.84. [PMID: 17202848] - John G McCarron, Susan Chalmers, Karen N Bradley, Debbi MacMillan, Thomas C Muir. Ca2+ microdomains in smooth muscle.
Cell calcium.
2006 Nov; 40(5-6):461-93. doi:
10.1016/j.ceca.2006.08.010. [PMID: 17069885] - Jianfeng Xu, Zhenjun Yang, Werner Dammermann, Liangren Zhang, Andreas H Guse, Li-He Zhang. Synthesis and agonist activity of cyclic ADP-ribose analogues with substitution of the northern ribose by ether or alkane chains.
Journal of medicinal chemistry.
2006 Sep; 49(18):5501-12. doi:
10.1021/jm060320e. [PMID: 16942023] - Genevieve S Young, Elena Choleris, Frances E Lund, James B Kirkland. Decreased cADPR and increased NAD+ in the Cd38-/- mouse.
Biochemical and biophysical research communications.
2006 Jul; 346(1):188-92. doi:
10.1016/j.bbrc.2006.05.100. [PMID: 16750163] - Katsuya Morita, Tomoya Kitayama, Shigeo Kitayama, Toshihiro Dohi. Cyclic ADP-ribose requires FK506-binding protein to regulate intracellular Ca2+ dynamics and catecholamine release in acetylcholine-stimulated bovine adrenal chromaffin cells.
Journal of pharmacological sciences.
2006 May; 101(1):40-51. doi:
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The Biochemical journal.
2006 Feb; 393(Pt 3):697-704. doi:
10.1042/bj20051302. [PMID: 16225456] - Martin Kolisek, Andreas Beck, Andrea Fleig, Reinhold Penner. Cyclic ADP-ribose and hydrogen peroxide synergize with ADP-ribose in the activation of TRPM2 channels.
Molecular cell.
2005 Apr; 18(1):61-9. doi:
10.1016/j.molcel.2005.02.033. [PMID: 15808509] - Susan K Fellner, William J Arendshorst. Angiotensin II Ca2+ signaling in rat afferent arterioles: stimulation of cyclic ADP ribose and IP3 pathways.
American journal of physiology. Renal physiology.
2005 Apr; 288(4):F785-91. doi:
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Nephron. Physiology.
2005; 100(4):p51-60. doi:
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The Journal of biological chemistry.
2004 Sep; 279(38):39783-8. doi:
10.1074/jbc.m405348200. [PMID: 15252012] - Jian Yao, Qin Li, Jin Chen, Shmuel Muallem. Subpopulation of store-operated Ca2+ channels regulate Ca2+-induced Ca2+ release in non-excitable cells.
The Journal of biological chemistry.
2004 May; 279(20):21511-9. doi:
10.1074/jbc.m314028200. [PMID: 15016819] - Irene Schulz, Elmar Krause. Inositol 1,4,5-trisphosphate and its co-players in the concert of Ca2+ signalling--new faces in the line up.
Current molecular medicine.
2004 May; 4(3):313-22. doi:
10.2174/1566524043360717. [PMID: 15101688] - Andreas H Guse. Regulation of calcium signaling by the second messenger cyclic adenosine diphosphoribose (cADPR).
Current molecular medicine.
2004 May; 4(3):239-48. doi:
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Journal of cell science.
2004 Apr; 117(Pt 10):2141-9. doi:
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Journal of neurochemistry.
2004 Apr; 89(1):264-72. doi:
10.1111/j.1471-4159.2003.02326.x. [PMID: 15030411] - Weronika Zielinska, Hosana Barata, Eduardo N Chini. Metabolism of cyclic ADP-ribose: Zinc is an endogenous modulator of the cyclase/NAD glycohydrolase ratio of a CD38-like enzyme from human seminal fluid.
Life sciences.
2004 Feb; 74(14):1781-90. doi:
10.1016/j.lfs.2003.08.033. [PMID: 14741735] - P-L Li, H C Lee, M T Nelson, G A Meininger, C Van Breemen. Novel Ca2+ signalling mechanisms in vascular myocytes: symposium overview.
Acta physiologica Scandinavica.
2003 Dec; 179(4):339-52. doi:
10.1046/j.0001-6772.2003.01216.x. [PMID: 14656371] - Santina Bruzzone, Svenja Kunerth, Elena Zocchi, Antonio De Flora, Andreas H Guse. Spatio-temporal propagation of Ca2+ signals by cyclic ADP-ribose in 3T3 cells stimulated via purinergic P2Y receptors.
The Journal of cell biology.
2003 Nov; 163(4):837-45. doi:
10.1083/jcb.200307016. [PMID: 14623867] - Santina Bruzzone, Antonio De Flora, Cesare Usai, Richard Graeff, Hon Cheung Lee. Cyclic ADP-ribose is a second messenger in the lipopolysaccharide-stimulated proliferation of human peripheral blood mononuclear cells.
The Biochemical journal.
2003 Oct; 375(Pt 2):395-403. doi:
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Proceedings of the National Academy of Sciences of the United States of America.
2003 Sep; 100(19):11116-21. doi:
10.1073/pnas.1434381100. [PMID: 12949257] - Richard M Graeff, Hon Cheung Lee. High throughput fluorescence-based assays for cyclic ADP-ribose, NAADP, and their metabolic enzymes.
Combinatorial chemistry & high throughput screening.
2003 Jun; 6(4):367-79. doi:
10.2174/138620703106298464. [PMID: 12769681] - Kousuke Sekimoto, Makoto Kashiwayanagi. Inward currents and increases in cytosolic Ca2+ concentration induced by cyclic ADP-ribose in turtle olfactory receptor cells.
Chemical senses.
2003 Jun; 28(5):415-22. doi:
10.1093/chemse/28.5.415. [PMID: 12826537] - Yan Wu, Juan Pablo Sanchez, Luis Lopez-Molina, Axel Himmelbach, Erwin Grill, Nam-Hai Chua. The abi1-1 mutation blocks ABA signaling downstream of cADPR action.
The Plant journal : for cell and molecular biology.
2003 May; 34(3):307-15. doi:
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