Reaction Process: Reactome:R-RNO-1660661
Sphingolipid de novo biosynthesis related metabolites
find 2 related metabolites which is associated with chemical reaction(pathway) Sphingolipid de novo biosynthesis
3-ketosphinganine + H+ + TPNH ⟶ SPA + TPN
N-palmitoyl-sphinganine (d18:0/16:0)
Ceramides, also known as N-acylsphingosines, consist of a sphingoid base linked to a fatty acid chain via the amine group. Ceramides are one of the hydrolysis byproducts of sphingomyelin via the enzyme sphingomyelinase (sphingomyelin phosphorylcholine phosphohydrolase, E.C.3.1.4.12) which has been identified in the subcellular fractions of human epidermis and many other tissues (PMID: 25935). They can also be synthesized from serine and palmitate in a de novo pathway and are regarded as important cellular signals for inducing apoptosis (PMID: 14998372). Ceramides are key to the biosynthesis of glycosphingolipids and gangliosides. Cer(d18:0/16:0), in particular, consists of a saturated 18-carbon dihydroxylated sphingoid base linked to one chain of palmitic acid. Ceramides (N-acylsphingosine) are one of the hydrolysis byproducts of sphingomyelin by the enzyme sphingomyelinase (sphingomyelin phosphorylcholine phosphohydrolase E.C.3.1.4.12) which has been identified in the subcellular fractions of human epidermis (PMID 25935) and many other tissues. They can also be synthesized from serine and palmitate in a de novo pathway and are regarded as important cellular signals for inducing apoptosis (PMID 14998372). Is key in the biosynthesis of glycosphingolipids and gangliosides. [HMDB]
2-azaniumylethyl (2S,3R)-3-hydroxy-2-(palmitoylamino)octadecyl phosphate
C36H75N2O6P (662.5362459999999)