3,4-Dimethoxyphenylethylamine

2-(3,4-Dimethoxyphenyl)ethanamine (acd/name 4.0)

C10H15NO2 (181.110273)


3,4-Dimethoxyphenylethylamine, also known as 3,4-DMPEA or DMPEA is an endogenous metabolite found in urine that belongs to both the phenethylamine and catecholamine families. DMPEA is an analogue of dopamine (3,4-dihydroxyphenethylamine), with a substitution of the hydroxy groups with methoxy groups. DMPEA is also structurally similar to mescaline (3,4,5-trimethoxyphenylethylamine) and occurs naturally alongside it in various species of cacti such as the San Pedro and Peruvian Torch (PMID: 5511715, 925910, 600028). DMPEA received wide attention after it was proposed as a biomarker in schizophrenic patients urine, however later studies revealed that DMPEA is also excreted by non-schizophrenics (PMID: 709888). DMPEA has little known bioactivity, but it has some action as a monoamine oxidase inhibitor (PMID: 886445). DMPEA has also been shown to have neurotoxic effects, especially in the nigrostriatal system and among dopaminergic neurons (PMID: 9409711, 9134983). DMPEA appears to be an inhibitor of mitochondrial complex I (PMID: 9409711).

   

N-Methylhomoveratrylamine

N-Methyl-3,4-dimethoxyphenethylamine

C11H17NO2 (195.12592220000002)


   

3,4-Dimethoxyphenethylamine

3,4-Dimethoxyphenethylamine

C10H15NO2 (181.110273)


   

Dimethoxyphenylethylamine

2-(3,4-Dimethoxyphenyl)ethanamine

C10H15NO2 (181.110273)