NCBI Taxonomy: 69379

Funtumia elastica (ncbi_taxid: 69379)

found 30 associated metabolites at species taxonomy rank level.

Ancestor: Funtumia

Child Taxonomies: none taxonomy data.

Conessine

((2S,5S,12S,16S,1R,9R,13R)-6,7,13-trimethyl-7-azapentacyclo[10.8.0.0<2,9>.0<5, 9>.0<13,18>]icos-18-en-16-yl)dimethylamine

C24H40N2 (356.319132)


Conessine is a steroid alkaloid that is con-5-enine substituted by a N,N-dimethylamino group at position 3. It has been isolated from the plant species of the family Apocynaceae. It has a role as an antibacterial agent, an antimalarial, a H3-receptor antagonist and a plant metabolite. It is a steroid alkaloid and a tertiary amino compound. It is functionally related to a conanine. Conessine is a natural product found in Holarrhena floribunda, Funtumia elastica, and Holarrhena pubescens with data available. A steroid alkaloid that is con-5-enine substituted by a N,N-dimethylamino group at position 3. It has been isolated from the plant species of the family Apocynaceae. Annotation level-1 CONFIDENCE Reference Standard (Level 1); INTERNAL_ID 12 relative retention time with respect to 9-anthracene Carboxylic Acid is 0.501 relative retention time with respect to 9-anthracene Carboxylic Acid is 0.499 Conessine, a steroidal alkaloid, is a potent and selective histamine H3 receptor antagonist with Kis of 5.4, 6.0, 5.7 and 25 nM for human, dog, guinea pig, and rat H H3 receptor, respectively. Anti-malarial activity[1]. Conessine, a steroidal alkaloid, is a potent and selective histamine H3 receptor antagonist with Kis of 5.4, 6.0, 5.7 and 25 nM for human, dog, guinea pig, and rat H H3 receptor, respectively. Anti-malarial activity[1]. Conessine, a steroidal alkaloid, is a potent and selective histamine H3 receptor antagonist with Kis of 5.4, 6.0, 5.7 and 25 nM for human, dog, guinea pig, and rat H H3 receptor, respectively. Anti-malarial activity[1].

   

Conessine

N,N,6,7,13-pentamethyl-7-azapentacyclo[10.8.0.0²,⁹.0⁵,⁹.0¹³,¹⁸]icos-18-en-16-amine

C24H40N2 (356.319132)


   

1-[1-(dimethylamino)ethyl]-n,n,9a,11a-tetramethyl-1h,2h,3h,3ah,3bh,4h,6h,7h,8h,9h,9bh,10h,11h-cyclopenta[a]phenanthren-7-amine

1-[1-(dimethylamino)ethyl]-n,n,9a,11a-tetramethyl-1h,2h,3h,3ah,3bh,4h,6h,7h,8h,9h,9bh,10h,11h-cyclopenta[a]phenanthren-7-amine

C25H44N2 (372.3504304)


   

n,6,7,13-tetramethyl-7-azapentacyclo[10.8.0.0²,⁹.0⁵,⁹.0¹³,¹⁸]icos-18-en-16-amine

n,6,7,13-tetramethyl-7-azapentacyclo[10.8.0.0²,⁹.0⁵,⁹.0¹³,¹⁸]icos-18-en-16-amine

C23H38N2 (342.3034828)


   

16-(dimethylamino)-6,7,13-trimethyl-7-azapentacyclo[10.8.0.0²,⁹.0⁵,⁹.0¹³,¹⁸]icos-18-en-10-yl 4-methylpent-3-enoate

16-(dimethylamino)-6,7,13-trimethyl-7-azapentacyclo[10.8.0.0²,⁹.0⁵,⁹.0¹³,¹⁸]icos-18-en-10-yl 4-methylpent-3-enoate

C30H48N2O2 (468.37155879999995)


   

6,7,13-trimethyl-16-(methylamino)-7-azapentacyclo[10.8.0.0²,⁹.0⁵,⁹.0¹³,¹⁸]icos-18-en-10-yl 4-methylpent-3-enoate

6,7,13-trimethyl-16-(methylamino)-7-azapentacyclo[10.8.0.0²,⁹.0⁵,⁹.0¹³,¹⁸]icos-18-en-10-yl 4-methylpent-3-enoate

C29H46N2O2 (454.35590959999996)


   

(1r,2s,5s,6s,9s,10r,12s,13r,16s)-6,7,13-trimethyl-16-(methylamino)-7-azapentacyclo[10.8.0.0²,⁹.0⁵,⁹.0¹³,¹⁸]icos-18-en-10-yl 4-methylpent-3-enoate

(1r,2s,5s,6s,9s,10r,12s,13r,16s)-6,7,13-trimethyl-16-(methylamino)-7-azapentacyclo[10.8.0.0²,⁹.0⁵,⁹.0¹³,¹⁸]icos-18-en-10-yl 4-methylpent-3-enoate

C29H46N2O2 (454.35590959999996)


   

[7-(dimethylamino)-1-[1-(dimethylamino)ethyl]-9a-methyl-1h,2h,3h,3ah,3bh,4h,6h,7h,8h,9h,9bh,10h,11h-cyclopenta[a]phenanthren-11a-yl]methanol

[7-(dimethylamino)-1-[1-(dimethylamino)ethyl]-9a-methyl-1h,2h,3h,3ah,3bh,4h,6h,7h,8h,9h,9bh,10h,11h-cyclopenta[a]phenanthren-11a-yl]methanol

C25H44N2O (388.3453454)


   

(1r,2s,5s,6s,9r,12s,13r,16s)-n,6,7,13-tetramethyl-7-azapentacyclo[10.8.0.0²,⁹.0⁵,⁹.0¹³,¹⁸]icos-18-en-16-amine

(1r,2s,5s,6s,9r,12s,13r,16s)-n,6,7,13-tetramethyl-7-azapentacyclo[10.8.0.0²,⁹.0⁵,⁹.0¹³,¹⁸]icos-18-en-16-amine

C23H38N2 (342.3034828)


   

(1s,3as,3bs,7s,9ar,9bs,11as)-1-[(1r)-1-(dimethylamino)ethyl]-n,n,9a,11a-tetramethyl-1h,2h,3h,3ah,3bh,4h,6h,7h,8h,9h,9bh,10h,11h-cyclopenta[a]phenanthren-7-amine

(1s,3as,3bs,7s,9ar,9bs,11as)-1-[(1r)-1-(dimethylamino)ethyl]-n,n,9a,11a-tetramethyl-1h,2h,3h,3ah,3bh,4h,6h,7h,8h,9h,9bh,10h,11h-cyclopenta[a]phenanthren-7-amine

C25H44N2 (372.3504304)


   

(1r,2s,5s,6s,9s,10r,12s,13r,16s)-16-(dimethylamino)-6,7,13-trimethyl-7-azapentacyclo[10.8.0.0²,⁹.0⁵,⁹.0¹³,¹⁸]icos-18-en-10-yl 4-methylpent-3-enoate

(1r,2s,5s,6s,9s,10r,12s,13r,16s)-16-(dimethylamino)-6,7,13-trimethyl-7-azapentacyclo[10.8.0.0²,⁹.0⁵,⁹.0¹³,¹⁸]icos-18-en-10-yl 4-methylpent-3-enoate

C30H48N2O2 (468.37155879999995)


   

[(1s,3ar,3bs,7s,9ar,9br,11ar)-7-(dimethylamino)-1-[(1s)-1-(dimethylamino)ethyl]-9a-methyl-1h,2h,3h,3ah,3bh,4h,6h,7h,8h,9h,9bh,10h,11h-cyclopenta[a]phenanthren-11a-yl]methanol

[(1s,3ar,3bs,7s,9ar,9br,11ar)-7-(dimethylamino)-1-[(1s)-1-(dimethylamino)ethyl]-9a-methyl-1h,2h,3h,3ah,3bh,4h,6h,7h,8h,9h,9bh,10h,11h-cyclopenta[a]phenanthren-11a-yl]methanol

C25H44N2O (388.3453454)