NCBI Taxonomy: 462559

Senecio selloi (ncbi_taxid: 462559)

found 63 associated metabolites at species taxonomy rank level.

Ancestor: Senecio

Child Taxonomies: none taxonomy data.

Senecionine

(1,6)Dioxacyclododecino(2,3,4-gh)pyrrolizine-2,7-dione, 3-ethylidene-3,4,5,6,9,11,13,14,14a,14b-decahydro-6-hydroxy-5,6-dimethyl-, (3Z,5R,6R,14aR,14bR)-

C18H25NO5 (335.173264)


Senecionine is a pyrrolizidine alkaloid isolated from the plant species of the genus Senecio. It has a role as a plant metabolite. It is a lactone, a pyrrolizidine alkaloid and a tertiary alcohol. It is functionally related to a senecionan. It is a conjugate base of a senecionine(1+). Senecionine is a natural product found in Dorobaea pimpinellifolia, Crotalaria micans, and other organisms with data available. Senecionine is an organic compound with the chemical formula C18H25NO5. It is classified as a pyrrolizidine alkaloid. See also: Petasites hybridus root (part of); Tussilago farfara flower (part of); Tussilago farfara leaf (part of). A pyrrolizidine alkaloid isolated from the plant species of the genus Senecio. D000970 - Antineoplastic Agents Annotation level-1 CONFIDENCE Reference Standard (Level 1); INTERNAL_ID 2251 CONFIDENCE Reference Standard (Level 1); INTERNAL_ID 122 CONFIDENCE Reference Standard (Level 1); INTERNAL_ID 102 CONFIDENCE Reference Standard (Level 1); INTERNAL_ID 142 CONFIDENCE Reference Standard (Level 1); INTERNAL_ID 152 CONFIDENCE Reference Standard (Level 1); INTERNAL_ID 162 CONFIDENCE Reference Standard (Level 1); INTERNAL_ID 172 CONFIDENCE Reference Standard (Level 1); INTERNAL_ID 132 CONFIDENCE Reference Standard (Level 1); INTERNAL_ID 112 [Raw Data] CB082a_Senecionine_pos_40eV_CB000034.txt [Raw Data] CB082a_Senecionine_pos_10eV_CB000034.txt [Raw Data] CB082a_Senecionine_pos_30eV_CB000034.txt [Raw Data] CB082a_Senecionine_pos_20eV_CB000034.txt [Raw Data] CB082a_Senecionine_pos_50eV_CB000034.txt Senecionine (Senecionan-11,16-dione, 12-hydroxy-) is a pyrrolizidine alkaloid could be isolated from Senecio vulgaris. Senecionine decreases the activities of glutathione S-transferase, aminopyrine demethylase and arylhydrocarbon hydroxylase (AHH)[1][2][3]. Senecionine (Senecionan-11,16-dione, 12-hydroxy-) is a pyrrolizidine alkaloid could be isolated from Senecio vulgaris. Senecionine decreases the activities of glutathione S-transferase, aminopyrine demethylase and arylhydrocarbon hydroxylase (AHH)[1][2][3].

   

Isatidine

retrorsine

C18H25NO6 (351.168179)


Origin: Plant; SubCategory_DNP: Alkaloids derived from ornithine, Pyrrolizidine alkaloids relative retention time with respect to 9-anthracene Carboxylic Acid is 0.363 relative retention time with respect to 9-anthracene Carboxylic Acid is 0.358 relative retention time with respect to 9-anthracene Carboxylic Acid is 0.361 CONFIDENCE Reference Standard (Level 1); INTERNAL_ID 2325 CONFIDENCE Reference Standard (Level 1); INTERNAL_ID 177 CONFIDENCE Reference Standard (Level 1); INTERNAL_ID 117 INTERNAL_ID 147; CONFIDENCE Reference Standard (Level 1) CONFIDENCE Reference Standard (Level 1); INTERNAL_ID 147 CONFIDENCE Reference Standard (Level 1); INTERNAL_ID 137 CONFIDENCE Reference Standard (Level 1); INTERNAL_ID 157 CONFIDENCE Reference Standard (Level 1); INTERNAL_ID 167 CONFIDENCE Reference Standard (Level 1); INTERNAL_ID 127 CONFIDENCE Reference Standard (Level 1); INTERNAL_ID 107 D000970 - Antineoplastic Agents Retrorsine is a naturally occurring toxic pyrrolizidine alkaloid. Retrorsine can bind with DNA and inhibits the proliferative capacity of hepatocytes. Retrorsine can be used for the research of hepatocellular injury[1][2]. Retrorsine is a naturally occurring toxic pyrrolizidine alkaloid. Retrorsine can bind with DNA and inhibits the proliferative capacity of hepatocytes. Retrorsine can be used for the research of hepatocellular injury[1][2].

   

Senecivernine

21-Norsenecionan-11,16-dione, 12-hydroxy-14-methyl-, (12zeta,13zeta)-

C18H25NO5 (335.173264)


CONFIDENCE Reference Standard (Level 1); INTERNAL_ID 2276

   

Usaramine

(15E)-12,18-Dihydroxysenecionan-11,16-dione

C18H25NO6 (351.168179)


Usaramine is a pyrrolizidine alkaloid isolated from seeds of Crolatalaria pallida. Usaramine demonstrates a highlighted antibiofilm activity against Staphylococcus epidermidis by reducing more than 50\\% of biofilm formation without killing the bacteria[1]. Usaramine is a pyrrolizidine alkaloid isolated from seeds of Crolatalaria pallida. Usaramine demonstrates a highlighted antibiofilm activity against Staphylococcus epidermidis by reducing more than 50\% of biofilm formation without killing the bacteria[1].

   

(1R,4E,6S,7S,17R)-4-Ethylidene-7-hydroxy-7-(hydroxymethyl)-6-methyl-2,9-dioxa-14-azatricyclo[9.5.1.014,17]heptadec-11-ene-3,8-dione

(1R,4E,6S,7S,17R)-4-Ethylidene-7-hydroxy-7-(hydroxymethyl)-6-methyl-2,9-dioxa-14-azatricyclo[9.5.1.014,17]heptadec-11-ene-3,8-dione

C18H25NO6 (351.168179)


   

Integerrimine

4-ethylidene-7-hydroxy-6,7-dimethyl-2,9-dioxa-14-azatricyclo[9.5.1.0¹⁴,¹⁷]heptadec-11-ene-3,8-dione

C18H25NO5 (335.173264)


   

1ST40320

(1,6)Dioxacyclododecino(2,3,4-gh)pyrrolizine-2,7-dione, 3-ethylidene-3,4,5,6,9,11,13,14,14a,14b-decahydro-6-hydroxy-6-(hydroxymethyl)-5-methyl-, (3Z,5R,6S,14aR,14bR)-

C18H25NO6 (351.168179)


Retrorsine is a macrolide. Retrorsine is a natural product found in Crotalaria spartioides, Senecio malacitanus, and other organisms with data available. D000970 - Antineoplastic Agents Retrorsine is a naturally occurring toxic pyrrolizidine alkaloid. Retrorsine can bind with DNA and inhibits the proliferative capacity of hepatocytes. Retrorsine can be used for the research of hepatocellular injury[1][2]. Retrorsine is a naturally occurring toxic pyrrolizidine alkaloid. Retrorsine can bind with DNA and inhibits the proliferative capacity of hepatocytes. Retrorsine can be used for the research of hepatocellular injury[1][2].

   

retrorsine

retrorsine

C18H25NO6 (351.168179)


Annotation level-1

   

5-methyl-7-(6-methylhept-5-en-2-yl)-2,3-dioxabicyclo[2.2.2]oct-5-ene

5-methyl-7-(6-methylhept-5-en-2-yl)-2,3-dioxabicyclo[2.2.2]oct-5-ene

C15H24O2 (236.1776204)


   

(4e)-4-ethylidene-7-hydroxy-6,7-dimethyl-2,9-dioxa-14-azatricyclo[9.5.1.0¹⁴,¹⁷]heptadec-11-ene-3,8-dione

(4e)-4-ethylidene-7-hydroxy-6,7-dimethyl-2,9-dioxa-14-azatricyclo[9.5.1.0¹⁴,¹⁷]heptadec-11-ene-3,8-dione

C18H25NO5 (335.173264)


   

(1r,4s,7s)-5-methyl-7-[(2r)-6-methylhept-5-en-2-yl]-2,3-dioxabicyclo[2.2.2]oct-5-ene

(1r,4s,7s)-5-methyl-7-[(2r)-6-methylhept-5-en-2-yl]-2,3-dioxabicyclo[2.2.2]oct-5-ene

C15H24O2 (236.1776204)


   

4-(1-chloroethyl)-4,7-dihydroxy-7-(hydroxymethyl)-6-methyl-2,9-dioxa-14-azatricyclo[9.5.1.0¹⁴,¹⁷]heptadec-11-ene-3,8-dione

4-(1-chloroethyl)-4,7-dihydroxy-7-(hydroxymethyl)-6-methyl-2,9-dioxa-14-azatricyclo[9.5.1.0¹⁴,¹⁷]heptadec-11-ene-3,8-dione

C18H26ClNO7 (403.1397716)


   

6-[4-(5,5-dimethyl-1,2,4-trioxolan-3-yl)butan-2-yl]-2,5,9,14,14-pentamethyl-18-oxapentacyclo[13.2.1.0¹,¹³.0²,¹⁰.0⁵,⁹]octadecane

6-[4-(5,5-dimethyl-1,2,4-trioxolan-3-yl)butan-2-yl]-2,5,9,14,14-pentamethyl-18-oxapentacyclo[13.2.1.0¹,¹³.0²,¹⁰.0⁵,⁹]octadecane

C30H50O4 (474.37089000000003)


   

(1s,4r,7s)-5-methyl-7-[(2r)-6-methylhept-5-en-2-yl]-2,3-dioxabicyclo[2.2.2]oct-5-ene

(1s,4r,7s)-5-methyl-7-[(2r)-6-methylhept-5-en-2-yl]-2,3-dioxabicyclo[2.2.2]oct-5-ene

C15H24O2 (236.1776204)


   

(1s,2s,5r,6r,9s,10s,13r,15r)-2,5,9,14,14-pentamethyl-6-[(2r)-6-methylhept-5-en-2-yl]-18-oxapentacyclo[13.2.1.0¹,¹³.0²,¹⁰.0⁵,⁹]octadecane

(1s,2s,5r,6r,9s,10s,13r,15r)-2,5,9,14,14-pentamethyl-6-[(2r)-6-methylhept-5-en-2-yl]-18-oxapentacyclo[13.2.1.0¹,¹³.0²,¹⁰.0⁵,⁹]octadecane

C30H50O (426.386145)


   

(1s,2s,5r,6r,9s,10s,13r,15r)-6-[(2s)-4-[(3r)-5,5-dimethyl-1,2,4-trioxolan-3-yl]butan-2-yl]-2,5,9,14,14-pentamethyl-18-oxapentacyclo[13.2.1.0¹,¹³.0²,¹⁰.0⁵,⁹]octadecane

(1s,2s,5r,6r,9s,10s,13r,15r)-6-[(2s)-4-[(3r)-5,5-dimethyl-1,2,4-trioxolan-3-yl]butan-2-yl]-2,5,9,14,14-pentamethyl-18-oxapentacyclo[13.2.1.0¹,¹³.0²,¹⁰.0⁵,⁹]octadecane

C30H50O4 (474.37089000000003)


   

2,5,9,14,14-pentamethyl-6-(6-methylhept-5-en-2-yl)-18-oxapentacyclo[13.2.1.0¹,¹³.0²,¹⁰.0⁵,⁹]octadecane

2,5,9,14,14-pentamethyl-6-(6-methylhept-5-en-2-yl)-18-oxapentacyclo[13.2.1.0¹,¹³.0²,¹⁰.0⁵,⁹]octadecane

C30H50O (426.386145)


   

(1r,6r,7s,17s)-4-ethylidene-7-hydroxy-7-(hydroxymethyl)-6-methyl-2,9-dioxa-14-azatricyclo[9.5.1.0¹⁴,¹⁷]heptadec-11-ene-3,8-dione

(1r,6r,7s,17s)-4-ethylidene-7-hydroxy-7-(hydroxymethyl)-6-methyl-2,9-dioxa-14-azatricyclo[9.5.1.0¹⁴,¹⁷]heptadec-11-ene-3,8-dione

C18H25NO6 (351.168179)


   

(1r,4r,6r,7s,17r)-4-[(1s)-1-chloroethyl]-4,7-dihydroxy-7-(hydroxymethyl)-6-methyl-2,9-dioxa-14-azatricyclo[9.5.1.0¹⁴,¹⁷]heptadec-11-ene-3,8-dione

(1r,4r,6r,7s,17r)-4-[(1s)-1-chloroethyl]-4,7-dihydroxy-7-(hydroxymethyl)-6-methyl-2,9-dioxa-14-azatricyclo[9.5.1.0¹⁴,¹⁷]heptadec-11-ene-3,8-dione

C18H26ClNO7 (403.1397716)


   

(1s,2s,5r,6r,9s,10s,13r,15r)-2,5,9,14,14-pentamethyl-6-[(2s)-6-methylhept-5-en-2-yl]-18-oxapentacyclo[13.2.1.0¹,¹³.0²,¹⁰.0⁵,⁹]octadecane

(1s,2s,5r,6r,9s,10s,13r,15r)-2,5,9,14,14-pentamethyl-6-[(2s)-6-methylhept-5-en-2-yl]-18-oxapentacyclo[13.2.1.0¹,¹³.0²,¹⁰.0⁵,⁹]octadecane

C30H50O (426.386145)