NCBI Taxonomy: 35754

Dactylosporangium aurantiacum (ncbi_taxid: 35754)

found 42 associated metabolites at species taxonomy rank level.

Ancestor: Dactylosporangium

Child Taxonomies: Dactylosporangium aurantiacum subsp. hamdenensis

Fidaxomicin

6-{[12-({3,4-dihydroxy-6,6-dimethyl-5-[(2-methylpropanoyl)oxy]oxan-2-yl}oxy)-11-ethyl-8-hydroxy-18-(1-hydroxyethyl)-9,13,15-trimethyl-2-oxo-1-oxacyclooctadeca-3,5,9,13,15-pentaen-3-yl]methoxy}-4-hydroxy-5-methoxy-2-methyloxan-3-yl 3,5-dichloro-2-ethyl-4,6-dihydroxybenzoic acid

C52H74Cl2O18 (1056.4251964)


   

Fidaxomicin

Fidaxomicin

C52H74Cl2O18 (1056.4251964)


An 18-membered macrolide that is a fermentation product obtained from the Actinomycete Dactylosporangium aurantiacum. A narrow spectrum antibiotic used for treatment of Clostridium difficile-related infections.

   

Lipiarmycin

Lipiarmycin

C52H74Cl2O18 (1056.4251964)


A - Alimentary tract and metabolism > A07 - Antidiarrheals, intestinal antiinflammatory/antiinfective agents > A07A - Intestinal antiinfectives > A07AA - Antibiotics D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents C784 - Protein Synthesis Inhibitor > C261 - Macrolide Antibiotic C254 - Anti-Infective Agent > C258 - Antibiotic Fidaxomicin (OPT-80), a macrocyclic antibiotic, is an orally active and potent RNA polymerase inhibitor. Fidaxomicin has a narrow spectrum of antibacterial activity and a good anti-Clostridium difficile activity (MIC90=0.12?μg/mL). Fidaxomicin can be used for Clostridium difficile infection (CDI) research[1][2][3].

   

(2s,3r,4r,5r,6s)-6-{[(3z,5z,9z,13z,15z)-12-{[(2r,3s,4s,5s)-4,5-dihydroxy-6,6-dimethyl-3-[(2-methylpropanoyl)oxy]oxan-2-yl]oxy}-11-ethyl-8-hydroxy-18-(1-hydroxyethyl)-9,13,15-trimethyl-2-oxo-1-oxacyclooctadeca-3,5,9,13,15-pentaen-3-yl]methoxy}-4-hydroxy-5-methoxy-2-methyloxan-3-yl 3-bromo-6-ethyl-2,4-dihydroxybenzoate

(2s,3r,4r,5r,6s)-6-{[(3z,5z,9z,13z,15z)-12-{[(2r,3s,4s,5s)-4,5-dihydroxy-6,6-dimethyl-3-[(2-methylpropanoyl)oxy]oxan-2-yl]oxy}-11-ethyl-8-hydroxy-18-(1-hydroxyethyl)-9,13,15-trimethyl-2-oxo-1-oxacyclooctadeca-3,5,9,13,15-pentaen-3-yl]methoxy}-4-hydroxy-5-methoxy-2-methyloxan-3-yl 3-bromo-6-ethyl-2,4-dihydroxybenzoate

C52H75BrO18 (1066.413651)


   

(2s,3r,4r,5r,6s)-6-{[(3z,5z,9z,13z,15z)-12-{[(2r,3s,4r,5s)-3,4-dihydroxy-6,6-dimethyl-5-[(2-methylpropanoyl)oxy]oxan-2-yl]oxy}-11-ethyl-8-hydroxy-18-(1-hydroxyethyl)-9,13,15-trimethyl-2-oxo-1-oxacyclooctadeca-3,5,9,13,15-pentaen-3-yl]methoxy}-4-hydroxy-5-methoxy-2-methyloxan-3-yl 3-bromo-5-chloro-2-ethyl-4,6-dihydroxybenzoate

(2s,3r,4r,5r,6s)-6-{[(3z,5z,9z,13z,15z)-12-{[(2r,3s,4r,5s)-3,4-dihydroxy-6,6-dimethyl-5-[(2-methylpropanoyl)oxy]oxan-2-yl]oxy}-11-ethyl-8-hydroxy-18-(1-hydroxyethyl)-9,13,15-trimethyl-2-oxo-1-oxacyclooctadeca-3,5,9,13,15-pentaen-3-yl]methoxy}-4-hydroxy-5-methoxy-2-methyloxan-3-yl 3-bromo-5-chloro-2-ethyl-4,6-dihydroxybenzoate

C52H74BrClO18 (1100.3746793999999)


   

6-{[(3z,5e,9e,13e,15e)-12-({4,5-dihydroxy-6,6-dimethyl-3-[(2-methylpropanoyl)oxy]oxan-2-yl}oxy)-11-ethyl-8-hydroxy-18-(1-hydroxyethyl)-9,13,15-trimethyl-2-oxo-1-oxacyclooctadeca-3,5,9,13,15-pentaen-3-yl]methoxy}-4-hydroxy-5-methoxy-2-methyloxan-3-yl 3,5-dichloro-2-ethyl-4,6-dihydroxybenzoate

6-{[(3z,5e,9e,13e,15e)-12-({4,5-dihydroxy-6,6-dimethyl-3-[(2-methylpropanoyl)oxy]oxan-2-yl}oxy)-11-ethyl-8-hydroxy-18-(1-hydroxyethyl)-9,13,15-trimethyl-2-oxo-1-oxacyclooctadeca-3,5,9,13,15-pentaen-3-yl]methoxy}-4-hydroxy-5-methoxy-2-methyloxan-3-yl 3,5-dichloro-2-ethyl-4,6-dihydroxybenzoate

C52H74Cl2O18 (1056.4251964)


   

(2s,3r,4r,5r,6s)-6-{[(3z,5z,9z,13z,15z)-18-acetyl-12-{[(2r,3s,4r,5s)-3,4-dihydroxy-6,6-dimethyl-5-[(2-methylpropanoyl)oxy]oxan-2-yl]oxy}-11-ethyl-8-hydroxy-9,13,15-trimethyl-2-oxo-1-oxacyclooctadeca-3,5,9,13,15-pentaen-3-yl]methoxy}-4-hydroxy-5-methoxy-2-methyloxan-3-yl 3-bromo-5-chloro-2-ethyl-4,6-dihydroxybenzoate

(2s,3r,4r,5r,6s)-6-{[(3z,5z,9z,13z,15z)-18-acetyl-12-{[(2r,3s,4r,5s)-3,4-dihydroxy-6,6-dimethyl-5-[(2-methylpropanoyl)oxy]oxan-2-yl]oxy}-11-ethyl-8-hydroxy-9,13,15-trimethyl-2-oxo-1-oxacyclooctadeca-3,5,9,13,15-pentaen-3-yl]methoxy}-4-hydroxy-5-methoxy-2-methyloxan-3-yl 3-bromo-5-chloro-2-ethyl-4,6-dihydroxybenzoate

C52H72BrClO18 (1098.3590302)


   

2-{[12-({4,5-dihydroxy-6,6-dimethyl-3-[(2-methylpropanoyl)oxy]oxan-2-yl}oxy)-11-ethyl-8-hydroxy-18-(1-hydroxyethyl)-9,13,15-trimethyl-2-oxo-1-oxacyclooctadeca-3,5,9,13,15-pentaen-3-yl]methoxy}-5-hydroxy-3-methoxy-6-methyloxan-4-yl 3,5-dichloro-2-ethyl-4,6-dihydroxybenzoate

2-{[12-({4,5-dihydroxy-6,6-dimethyl-3-[(2-methylpropanoyl)oxy]oxan-2-yl}oxy)-11-ethyl-8-hydroxy-18-(1-hydroxyethyl)-9,13,15-trimethyl-2-oxo-1-oxacyclooctadeca-3,5,9,13,15-pentaen-3-yl]methoxy}-5-hydroxy-3-methoxy-6-methyloxan-4-yl 3,5-dichloro-2-ethyl-4,6-dihydroxybenzoate

C52H74Cl2O18 (1056.4251964)


   

2-{[4,5-dihydroxy-2-(hydroxymethyl)-6-{[4,5,6-trihydroxy-2-(hydroxymethyl)cyclohex-2-en-1-yl]oxy}oxan-3-yl]oxy}-6-(hydroxymethyl)oxane-3,4,5-triol

2-{[4,5-dihydroxy-2-(hydroxymethyl)-6-{[4,5,6-trihydroxy-2-(hydroxymethyl)cyclohex-2-en-1-yl]oxy}oxan-3-yl]oxy}-6-(hydroxymethyl)oxane-3,4,5-triol

C19H32O15 (500.17411219999997)


   

6-{[(3z,5z,9z,13z,15z)-12-({3,5-dihydroxy-6,6-dimethyl-4-[(2-methylpropanoyl)oxy]oxan-2-yl}oxy)-11-ethyl-8-hydroxy-18-(1-hydroxyethyl)-9,13,15-trimethyl-2-oxo-1-oxacyclooctadeca-3,5,9,13,15-pentaen-3-yl]methoxy}-4-hydroxy-5-methoxy-2-methyloxan-3-yl 3,5-dichloro-2-ethyl-4,6-dihydroxybenzoate

6-{[(3z,5z,9z,13z,15z)-12-({3,5-dihydroxy-6,6-dimethyl-4-[(2-methylpropanoyl)oxy]oxan-2-yl}oxy)-11-ethyl-8-hydroxy-18-(1-hydroxyethyl)-9,13,15-trimethyl-2-oxo-1-oxacyclooctadeca-3,5,9,13,15-pentaen-3-yl]methoxy}-4-hydroxy-5-methoxy-2-methyloxan-3-yl 3,5-dichloro-2-ethyl-4,6-dihydroxybenzoate

C52H74Cl2O18 (1056.4251964)


   

(3r,4r,5s,6r)-6-{[(4e,6e,10e,14z,16e)-2,9-diethyl-12-hydroxy-5,7,11,17-tetramethyl-18-oxo-1-oxacyclooctadeca-4,6,10,14,16-pentaen-8-yl]oxy}-4,5-dihydroxy-2,2-dimethyloxan-3-yl acetate

(3r,4r,5s,6r)-6-{[(4e,6e,10e,14z,16e)-2,9-diethyl-12-hydroxy-5,7,11,17-tetramethyl-18-oxo-1-oxacyclooctadeca-4,6,10,14,16-pentaen-8-yl]oxy}-4,5-dihydroxy-2,2-dimethyloxan-3-yl acetate

C34H52O9 (604.3611142)


   

6-{[(3z,5e,9e,13e,15e)-12-({3,5-dihydroxy-6,6-dimethyl-4-[(2-methylpropanoyl)oxy]oxan-2-yl}oxy)-11-ethyl-8-hydroxy-18-(1-hydroxyethyl)-9,13,15-trimethyl-2-oxo-1-oxacyclooctadeca-3,5,9,13,15-pentaen-3-yl]methoxy}-4-hydroxy-5-methoxy-2-methyloxan-3-yl 3,5-dichloro-2-ethyl-4,6-dihydroxybenzoate

6-{[(3z,5e,9e,13e,15e)-12-({3,5-dihydroxy-6,6-dimethyl-4-[(2-methylpropanoyl)oxy]oxan-2-yl}oxy)-11-ethyl-8-hydroxy-18-(1-hydroxyethyl)-9,13,15-trimethyl-2-oxo-1-oxacyclooctadeca-3,5,9,13,15-pentaen-3-yl]methoxy}-4-hydroxy-5-methoxy-2-methyloxan-3-yl 3,5-dichloro-2-ethyl-4,6-dihydroxybenzoate

C52H74Cl2O18 (1056.4251964)


   

6-[(12-{[4,5-dihydroxy-6,6-dimethyl-3-(propanoyloxy)oxan-2-yl]oxy}-11-ethyl-8-hydroxy-18-(1-hydroxyethyl)-9,13,15-trimethyl-2-oxo-1-oxacyclooctadeca-3,5,9,13,15-pentaen-3-yl)methoxy]-4-hydroxy-5-methoxy-2-methyloxan-3-yl 3,5-dichloro-2-ethyl-4,6-dihydroxybenzoate

6-[(12-{[4,5-dihydroxy-6,6-dimethyl-3-(propanoyloxy)oxan-2-yl]oxy}-11-ethyl-8-hydroxy-18-(1-hydroxyethyl)-9,13,15-trimethyl-2-oxo-1-oxacyclooctadeca-3,5,9,13,15-pentaen-3-yl)methoxy]-4-hydroxy-5-methoxy-2-methyloxan-3-yl 3,5-dichloro-2-ethyl-4,6-dihydroxybenzoate

C51H72Cl2O18 (1042.4095472000001)


   

2-(hydroxymethyl)-6-{[4,5,6-trihydroxy-2-(hydroxymethyl)cyclohex-2-en-1-yl]oxy}oxane-3,4,5-triol

2-(hydroxymethyl)-6-{[4,5,6-trihydroxy-2-(hydroxymethyl)cyclohex-2-en-1-yl]oxy}oxane-3,4,5-triol

C13H22O10 (338.1212912)


   

(2s,3r,4r,5r,6s)-6-{[(3z,5z,9z,13z,15z)-12-{[(2r,3s,4r,5r)-3,4-dihydroxy-6,6-dimethyl-5-[(2-methylpropanoyl)oxy]oxan-2-yl]oxy}-11-ethyl-8-hydroxy-18-(1-hydroxyethyl)-9,13,15-trimethyl-2-oxo-1-oxacyclooctadeca-3,5,9,13,15-pentaen-3-yl]methoxy}-4-hydroxy-5-methoxy-2-methyloxan-3-yl 3,5-dichloro-2-ethyl-4,6-dihydroxybenzoate

(2s,3r,4r,5r,6s)-6-{[(3z,5z,9z,13z,15z)-12-{[(2r,3s,4r,5r)-3,4-dihydroxy-6,6-dimethyl-5-[(2-methylpropanoyl)oxy]oxan-2-yl]oxy}-11-ethyl-8-hydroxy-18-(1-hydroxyethyl)-9,13,15-trimethyl-2-oxo-1-oxacyclooctadeca-3,5,9,13,15-pentaen-3-yl]methoxy}-4-hydroxy-5-methoxy-2-methyloxan-3-yl 3,5-dichloro-2-ethyl-4,6-dihydroxybenzoate

C52H74Cl2O18 (1056.4251964)


   

(2r,3s,4s,5s,6r)-6-{[(3e,5e,8s,9e,11s,12r,13e,15e)-12-{[(2r,3s,4r,5s)-3,4-dihydroxy-6,6-dimethyl-5-[(2-methylpropanoyl)oxy]oxan-2-yl]oxy}-11-ethyl-8-hydroxy-18-[(1r)-1-hydroxyethyl]-9,13,15-trimethyl-2-oxo-1-oxacyclooctadeca-3,5,9,13,15-pentaen-3-yl]methoxy}-4-hydroxy-5-methoxy-2-methyloxan-3-yl 3,5-dichloro-2-ethyl-4,6-dihydroxybenzoate

(2r,3s,4s,5s,6r)-6-{[(3e,5e,8s,9e,11s,12r,13e,15e)-12-{[(2r,3s,4r,5s)-3,4-dihydroxy-6,6-dimethyl-5-[(2-methylpropanoyl)oxy]oxan-2-yl]oxy}-11-ethyl-8-hydroxy-18-[(1r)-1-hydroxyethyl]-9,13,15-trimethyl-2-oxo-1-oxacyclooctadeca-3,5,9,13,15-pentaen-3-yl]methoxy}-4-hydroxy-5-methoxy-2-methyloxan-3-yl 3,5-dichloro-2-ethyl-4,6-dihydroxybenzoate

C52H74Cl2O18 (1056.4251964)


   

6-{[(3z,5e,9e,13e,15e)-12-({3,4-dihydroxy-6,6-dimethyl-5-[(2-methylpropanoyl)oxy]oxan-2-yl}oxy)-11-ethyl-8-hydroxy-18-(1-hydroxyethyl)-9,13,15-trimethyl-2-oxo-1-oxacyclooctadeca-3,5,9,13,15-pentaen-3-yl]methoxy}-4-hydroxy-5-methoxy-2-methyloxan-3-yl 3,5-dichloro-2-ethyl-4,6-dihydroxybenzoate

6-{[(3z,5e,9e,13e,15e)-12-({3,4-dihydroxy-6,6-dimethyl-5-[(2-methylpropanoyl)oxy]oxan-2-yl}oxy)-11-ethyl-8-hydroxy-18-(1-hydroxyethyl)-9,13,15-trimethyl-2-oxo-1-oxacyclooctadeca-3,5,9,13,15-pentaen-3-yl]methoxy}-4-hydroxy-5-methoxy-2-methyloxan-3-yl 3,5-dichloro-2-ethyl-4,6-dihydroxybenzoate

C52H74Cl2O18 (1056.4251964)