NCBI Taxonomy: 30344
Ranoidea caerulea (ncbi_taxid: 30344)
found 14 associated metabolites at species taxonomy rank level.
Ancestor: Ranoidea
Child Taxonomies: none taxonomy data.
Ceruletide
Ceruletide, also known as caerulein, is only found in individuals that have used or taken this drug. It is a specific decapeptide similar in action and composition to the natural gastrointestinal peptide hormone cholecystokinin. It stimulates gastric, biliary, and pancreatic secretion; and certain smooth muscle.Ceruletide acts according to its similarity to the natural gastrointestinal peptide hormone cholecystokinin. Cholecystokinin is a peptide hormone of the gastrointestinal system responsible for stimulating the digestion of fat and protein. Cholecystokinin is secreted by the duodenum, the first segment of the small intestine. There it binds to CCK receptors, activating them and causing downstream effects. Specifically, it results in the release of digestive enzymes and bile from the pancreas and gall bladder, respectively. It also acts as a hunger suppresant. Cholecystokinin is secreted by the duodenum when fat- or protein-rich chyme leaves the stomach and enters the duodenum. The hormone acts on the pancreas to stimulate the secretion of the enzymes lipase, amylase, trypsin, and chymotrypsin. Together these pancreatic enzymes catalyze the digestion of fat and protein. Cholecystokinin also stimulates both the contraction of the gall bladder, and the relaxtion of the Sphincter of Oddi (Glissons Sphinctor), which delivers, (not secretes) bile into the small intestine. Bile salts serve to emulsify fats, thereby increasing the effectiveness with which enzymes can digest them. V - Various > V04 - Diagnostic agents > V04C - Other diagnostic agents > V04CC - Tests for bile duct patency Ceruletide is a decapeptide and a potent cholecystokinin receptor agonist. Ceruletide is a safe and effective cholecystokinetic agent with a direct spasmogenic effect on the gallbladder muscle and bile ducts[1].
(3s)-3-{[(2s)-2-{[(2s)-2-[(2-amino-1-hydroxyethylidene)amino]-1-hydroxy-4-methylpentylidene]amino}-1-hydroxy-4-methylpentylidene]amino}-3-[({[(1s)-1-{[(1s)-1-[({[(1s,2r)-2-hydroxy-1-{[(1s)-1-[({[(1s)-1-(c-hydroxycarbonimidoyl)-3-methylbutyl]-c-hydroxycarbonimidoyl}methyl)-c-hydroxycarbonimidoyl]-3-methylbutyl]-c-hydroxycarbonimidoyl}propyl]-c-hydroxycarbonimidoyl}methyl)-c-hydroxycarbonimidoyl]-3-methylbutyl]-c-hydroxycarbonimidoyl}-3-methylbutyl]-c-hydroxycarbonimidoyl}methyl)-c-hydroxycarbonimidoyl]propanoic acid
C52H93N13O15 (1139.6913748000002)
3-{[1-({1-[({[1-({1-[(2-carboxy-1-{[1-(c-hydroxycarbonimidoyl)-2-phenylethyl]-c-hydroxycarbonimidoyl}ethyl)-c-hydroxycarbonimidoyl]-3-(methylsulfanyl)propyl}-c-hydroxycarbonimidoyl)-2-(1h-indol-3-yl)ethyl]-c-hydroxycarbonimidoyl}methyl)-c-hydroxycarbonimidoyl]-2-hydroxypropyl}-c-hydroxycarbonimidoyl)-2-[4-(sulfooxy)phenyl]ethyl]-c-hydroxycarbonimidoyl}-3-[(1-hydroxy-2-{[hydroxy(5-hydroxy-3,4-dihydro-2h-pyrrol-2-yl)methylidene]amino}-4-(c-hydroxycarbonimidoyl)butylidene)amino]propanoic acid
3-{[2-({2-[(2-amino-1-hydroxyethylidene)amino]-1-hydroxy-4-methylpentylidene}amino)-1-hydroxy-4-methylpentylidene]amino}-3-[({[1-({1-[({[2-hydroxy-1-({1-[({[1-(c-hydroxycarbonimidoyl)-3-methylbutyl]-c-hydroxycarbonimidoyl}methyl)-c-hydroxycarbonimidoyl]-3-methylbutyl}-c-hydroxycarbonimidoyl)propyl]-c-hydroxycarbonimidoyl}methyl)-c-hydroxycarbonimidoyl]-3-methylbutyl}-c-hydroxycarbonimidoyl)-3-methylbutyl]-c-hydroxycarbonimidoyl}methyl)-c-hydroxycarbonimidoyl]propanoic acid
C52H93N13O15 (1139.6913748000002)