NCBI Taxonomy: 284475
Ecteinascidia (ncbi_taxid: 284475)
found 85 associated metabolites at genus taxonomy rank level.
Ancestor: Perophoridae
Child Taxonomies: Ecteinascidia venui, environmental samples, Ecteinascidia conklini, Ecteinascidia turbinata, Ecteinascidia thurstoni, Ecteinascidia herdmanni, Ecteinascidia diaphanis, Ecteinascidia styeloides, unclassified Ecteinascidia, Ecteinascidia cf. conklini SLL-2021
Trabectedin
(1R,2R,3R,11S,12S,14R,26R)-5,6,12-trihydroxy-6,7-dimethoxy-7,21,30-trimethyl-27-oxo-3,4-dihydro-2H-17,19,28-trioxa-24-thia-13,30-diazaspiro[heptacyclo[12.9.6.1³,¹¹.0²,¹³.0⁴,⁹.0¹⁵,²³.0¹⁶,²⁰]triacontane-26,1-isoquinoline]-4,6,8,15,20,22-hexaen-22-yl acetate
Trabectedin, also referred as ET-743 during its development, is a marine derived antitumoral agent discovered in the Carribean tunicate _Ecteinascidia turbinata_ and now produced synthetically. Trabectedin has a unique mechanism of action. It binds to the minor groove of DNA interfering with cell division and genetic transcription processes and DNA repair machinery. It is approved for use in Europe, Russia and South Korea for the treatment of advanced soft tissue sarcoma refractory to or unsuitable to receive anthracycline or ifosfamide chemotherapy. L - Antineoplastic and immunomodulating agents > L01 - Antineoplastic agents > L01C - Plant alkaloids and other natural products C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C2842 - DNA Binding Agent D009676 - Noxae > D000477 - Alkylating Agents D000970 - Antineoplastic Agents
Trabectedin
Trabectedin
A tetrahydroisoquinoline alkaloid obtained from a Caribbean tunicate Ecteinascidia turbinata. Used for the treatment of soft tissue sarcoma and relapsed ovarian cancer. L - Antineoplastic and immunomodulating agents > L01 - Antineoplastic agents > L01C - Plant alkaloids and other natural products C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C2842 - DNA Binding Agent D009676 - Noxae > D000477 - Alkylating Agents D000970 - Antineoplastic Agents
(1r,2r,3r,11s,12r,14r,26r)-12-cyano-5,6'-dihydroxy-6,7'-dimethoxy-7,21,30-trimethyl-27-oxo-3',4'-dihydro-2'h-17,19,28-trioxa-24-thia-13,30-diazaspiro[heptacyclo[12.9.6.1³,¹¹.0²,¹³.0⁴,⁹.0¹⁵,²³.0¹⁶,²⁰]triacontane-26,1'-isoquinoline]-4,6,8,15,20,22-hexaen-22-yl acetate
(1r,2r,3r,11s,12r,14r,26r)-12-cyano-5,6'-dihydroxy-6,7'-dimethoxy-7,21,30-trimethyl-27-oxo-3',4'-dihydro-2'h-17,19,28-trioxa-24-thia-13,30-diazaspiro[heptacyclo[12.9.6.1³,¹¹.0²,¹³.0⁴,⁹.0¹⁵,²³.0¹⁶,²⁰]triacontane-26,1'-isoquinoline]-4,6,8,15,20,22-hexaen-22-yl acetate
C40H42N4O10S (770.2621512000001)
(1s,2r,3r,11s,12s,14s,26r)-5,6',12-trihydroxy-6,7'-dimethoxy-7,21,30-trimethyl-27-oxo-3',4'-dihydro-2'h-17,19,28-trioxa-24-thia-13,30-diazaspiro[heptacyclo[12.9.6.1³,¹¹.0²,¹³.0⁴,⁹.0¹⁵,²³.0¹⁶,²⁰]triacontane-26,1'-isoquinoline]-4,6,8,15,20,22-hexaen-22-yl acetate
(1s,2r,3r,11s,12s,14s,26r)-5,6',12-trihydroxy-6,7'-dimethoxy-7,21,30-trimethyl-27-oxo-3',4'-dihydro-2'h-17,19,28-trioxa-24-thia-13,30-diazaspiro[heptacyclo[12.9.6.1³,¹¹.0²,¹³.0⁴,⁹.0¹⁵,²³.0¹⁶,²⁰]triacontane-26,1'-isoquinoline]-4,6,8,15,20,22-hexaen-22-yl acetate
5,6',12-trihydroxy-6,7'-dimethoxy-7,21,30-trimethyl-27-oxo-3',4'-dihydro-2'h-17,19,28-trioxa-24-thia-13,30-diazaspiro[heptacyclo[12.9.6.1³,¹¹.0²,¹³.0⁴,⁹.0¹⁵,²³.0¹⁶,²⁰]triacontane-26,1'-isoquinoline]-4,6,8,15,20,22-hexaen-22-yl acetate
5,6',12-trihydroxy-6,7'-dimethoxy-7,21,30-trimethyl-27-oxo-3',4'-dihydro-2'h-17,19,28-trioxa-24-thia-13,30-diazaspiro[heptacyclo[12.9.6.1³,¹¹.0²,¹³.0⁴,⁹.0¹⁵,²³.0¹⁶,²⁰]triacontane-26,1'-isoquinoline]-4,6,8,15,20,22-hexaen-22-yl acetate
(1s,12s,26s)-5,6',12-trihydroxy-6,7'-dimethoxy-7,21,30-trimethyl-27-oxo-3',4'-dihydro-2'h-17,19,28-trioxa-24-thia-13,30-diazaspiro[heptacyclo[12.9.6.1³,¹¹.0²,¹³.0⁴,⁹.0¹⁵,²³.0¹⁶,²⁰]triacontane-26,1'-isoquinoline]-4(9),5,7,15,20,22-hexaen-22-yl acetate
(1s,12s,26s)-5,6',12-trihydroxy-6,7'-dimethoxy-7,21,30-trimethyl-27-oxo-3',4'-dihydro-2'h-17,19,28-trioxa-24-thia-13,30-diazaspiro[heptacyclo[12.9.6.1³,¹¹.0²,¹³.0⁴,⁹.0¹⁵,²³.0¹⁶,²⁰]triacontane-26,1'-isoquinoline]-4(9),5,7,15,20,22-hexaen-22-yl acetate
(1r,2r,3r,11s,12r,14r,24r,26r)-22-(acetyloxy)-12-cyano-5,6'-dihydroxy-6,7'-dimethoxy-7,21,30-trimethyl-27-oxo-3',4'-dihydro-2'h-17,19,28-trioxa-24-thia-13,30-diazaspiro[heptacyclo[12.9.6.1³,¹¹.0²,¹³.0⁴,⁹.0¹⁵,²³.0¹⁶,²⁰]triacontane-26,1'-isoquinoline]-4,6,8,15,20,22-hexaen-24-ium-24-olate
(1r,2r,3r,11s,12r,14r,24r,26r)-22-(acetyloxy)-12-cyano-5,6'-dihydroxy-6,7'-dimethoxy-7,21,30-trimethyl-27-oxo-3',4'-dihydro-2'h-17,19,28-trioxa-24-thia-13,30-diazaspiro[heptacyclo[12.9.6.1³,¹¹.0²,¹³.0⁴,⁹.0¹⁵,²³.0¹⁶,²⁰]triacontane-26,1'-isoquinoline]-4,6,8,15,20,22-hexaen-24-ium-24-olate
12-cyano-5,6'-dihydroxy-6,7'-dimethoxy-7,21,30-trimethyl-27-oxo-3',4'-dihydro-2'h-17,19,28-trioxa-24-thia-13,30-diazaspiro[heptacyclo[12.9.6.1³,¹¹.0²,¹³.0⁴,⁹.0¹⁵,²³.0¹⁶,²⁰]triacontane-26,1'-isoquinoline]-4,6,8,15,20,22-hexaen-22-yl acetate
12-cyano-5,6'-dihydroxy-6,7'-dimethoxy-7,21,30-trimethyl-27-oxo-3',4'-dihydro-2'h-17,19,28-trioxa-24-thia-13,30-diazaspiro[heptacyclo[12.9.6.1³,¹¹.0²,¹³.0⁴,⁹.0¹⁵,²³.0¹⁶,²⁰]triacontane-26,1'-isoquinoline]-4,6,8,15,20,22-hexaen-22-yl acetate
C40H42N4O10S (770.2621512000001)
(1r,2s,3r,11s,14r,26r)-5,6'-dihydroxy-6,7'-dimethoxy-7,21,30-trimethyl-27-oxo-3',4'-dihydro-2'h-17,19,28-trioxa-24-thia-13,30-diazaspiro[heptacyclo[12.9.6.1³,¹¹.0²,¹³.0⁴,⁹.0¹⁵,²³.0¹⁶,²⁰]triacontane-26,1'-isoquinoline]-4,6,8,15,20,22-hexaen-22-yl acetate
(1r,2s,3r,11s,14r,26r)-5,6'-dihydroxy-6,7'-dimethoxy-7,21,30-trimethyl-27-oxo-3',4'-dihydro-2'h-17,19,28-trioxa-24-thia-13,30-diazaspiro[heptacyclo[12.9.6.1³,¹¹.0²,¹³.0⁴,⁹.0¹⁵,²³.0¹⁶,²⁰]triacontane-26,1'-isoquinoline]-4,6,8,15,20,22-hexaen-22-yl acetate
(1s,2s,3r,11s,12r,14s,24s,26r)-22-(acetyloxy)-12-cyano-5,6'-dihydroxy-6,7'-dimethoxy-7,21,30-trimethyl-27-oxo-3',4'-dihydro-2'h-17,19,28-trioxa-24-thia-13,30-diazaspiro[heptacyclo[12.9.6.1³,¹¹.0²,¹³.0⁴,⁹.0¹⁵,²³.0¹⁶,²⁰]triacontane-26,1'-isoquinoline]-4(9),5,7,15,20,22-hexaen-24-ium-24-olate
(1s,2s,3r,11s,12r,14s,24s,26r)-22-(acetyloxy)-12-cyano-5,6'-dihydroxy-6,7'-dimethoxy-7,21,30-trimethyl-27-oxo-3',4'-dihydro-2'h-17,19,28-trioxa-24-thia-13,30-diazaspiro[heptacyclo[12.9.6.1³,¹¹.0²,¹³.0⁴,⁹.0¹⁵,²³.0¹⁶,²⁰]triacontane-26,1'-isoquinoline]-4(9),5,7,15,20,22-hexaen-24-ium-24-olate
(1r,2r,3r,11s,12s,14r,24r,26r)-22-(acetyloxy)-5,6'-dihydroxy-6,7'-dimethoxy-7,12,21,30-tetramethyl-27-oxo-3',4'-dihydro-2'h-17,19,28-trioxa-24-thia-13,30-diazaspiro[heptacyclo[12.9.6.1³,¹¹.0²,¹³.0⁴,⁹.0¹⁵,²³.0¹⁶,²⁰]triacontane-26,1'-isoquinoline]-4,6,8,15,20,22-hexaen-24-ium-24-olate
(1r,2r,3r,11s,12s,14r,24r,26r)-22-(acetyloxy)-5,6'-dihydroxy-6,7'-dimethoxy-7,12,21,30-tetramethyl-27-oxo-3',4'-dihydro-2'h-17,19,28-trioxa-24-thia-13,30-diazaspiro[heptacyclo[12.9.6.1³,¹¹.0²,¹³.0⁴,⁹.0¹⁵,²³.0¹⁶,²⁰]triacontane-26,1'-isoquinoline]-4,6,8,15,20,22-hexaen-24-ium-24-olate
C40H45N3O11S (775.2774660000001)
(1r,2s,3r,11s,12r,14r,26r)-5,12-dihydroxy-6-methoxy-7,21,30-trimethyl-27-oxo-2',3',4',9'-tetrahydro-17,19,28-trioxa-24-thia-13,30-diazaspiro[heptacyclo[12.9.6.1³,¹¹.0²,¹³.0⁴,⁹.0¹⁵,²³.0¹⁶,²⁰]triacontane-26,1'-pyrido[3,4-b]indole]-4,6,8,15,20,22-hexaen-22-yl acetate
(1r,2s,3r,11s,12r,14r,26r)-5,12-dihydroxy-6-methoxy-7,21,30-trimethyl-27-oxo-2',3',4',9'-tetrahydro-17,19,28-trioxa-24-thia-13,30-diazaspiro[heptacyclo[12.9.6.1³,¹¹.0²,¹³.0⁴,⁹.0¹⁵,²³.0¹⁶,²⁰]triacontane-26,1'-pyrido[3,4-b]indole]-4,6,8,15,20,22-hexaen-22-yl acetate
C40H42N4O9S (754.2672362000001)
22-(acetyloxy)-12-cyano-5,6'-dihydroxy-6,7'-dimethoxy-7,21,30-trimethyl-27-oxo-3',4'-dihydro-2'h-17,19,28-trioxa-24-thia-13,30-diazaspiro[heptacyclo[12.9.6.1³,¹¹.0²,¹³.0⁴,⁹.0¹⁵,²³.0¹⁶,²⁰]triacontane-26,1'-isoquinoline]-4,6,8,15,20,22-hexaen-24-ium-24-olate
22-(acetyloxy)-12-cyano-5,6'-dihydroxy-6,7'-dimethoxy-7,21,30-trimethyl-27-oxo-3',4'-dihydro-2'h-17,19,28-trioxa-24-thia-13,30-diazaspiro[heptacyclo[12.9.6.1³,¹¹.0²,¹³.0⁴,⁹.0¹⁵,²³.0¹⁶,²⁰]triacontane-26,1'-isoquinoline]-4,6,8,15,20,22-hexaen-24-ium-24-olate
(1r,17s,18r,19r,31s)-7,19,21,25-tetrahydroxy-9,19,31-trimethyl-2,30-dioxaoctacyclo[16.11.2.0¹,¹⁷.0³,¹⁶.0⁴,¹³.0⁶,¹¹.0¹⁷,²².0²⁴,²⁹]hentriaconta-3,6,8,10,13,15,21,24,26,28-decaene-5,12,23-trione
(1r,17s,18r,19r,31s)-7,19,21,25-tetrahydroxy-9,19,31-trimethyl-2,30-dioxaoctacyclo[16.11.2.0¹,¹⁷.0³,¹⁶.0⁴,¹³.0⁶,¹¹.0¹⁷,²².0²⁴,²⁹]hentriaconta-3,6,8,10,13,15,21,24,26,28-decaene-5,12,23-trione
(1s,12s,26s)-5,6',12-trihydroxy-6,7'-dimethoxy-7,21-dimethyl-27-oxo-3',4'-dihydro-2'h-17,19,28-trioxa-24-thia-13,30-diazaspiro[heptacyclo[12.9.6.1³,¹¹.0²,¹³.0⁴,⁹.0¹⁵,²³.0¹⁶,²⁰]triacontane-26,1'-isoquinoline]-4,6,8,15,20,22-hexaen-22-yl acetate
(1s,12s,26s)-5,6',12-trihydroxy-6,7'-dimethoxy-7,21-dimethyl-27-oxo-3',4'-dihydro-2'h-17,19,28-trioxa-24-thia-13,30-diazaspiro[heptacyclo[12.9.6.1³,¹¹.0²,¹³.0⁴,⁹.0¹⁵,²³.0¹⁶,²⁰]triacontane-26,1'-isoquinoline]-4,6,8,15,20,22-hexaen-22-yl acetate
7,19,21,25-tetrahydroxy-9,19,31-trimethyl-2,30-dioxaoctacyclo[16.11.2.0¹,¹⁷.0³,¹⁶.0⁴,¹³.0⁶,¹¹.0¹⁷,²².0²⁴,²⁹]hentriaconta-3,6,8,10,13,15,21,24,26,28-decaene-5,12,23-trione
7,19,21,25-tetrahydroxy-9,19,31-trimethyl-2,30-dioxaoctacyclo[16.11.2.0¹,¹⁷.0³,¹⁶.0⁴,¹³.0⁶,¹¹.0¹⁷,²².0²⁴,²⁹]hentriaconta-3,6,8,10,13,15,21,24,26,28-decaene-5,12,23-trione
7,21,25-trihydroxy-9,19,31-trimethyl-2,30-dioxaoctacyclo[16.11.2.0¹,¹⁷.0³,¹⁶.0⁴,¹³.0⁶,¹¹.0¹⁷,²².0²⁴,²⁹]hentriaconta-3(16),4(13),6,8,10,14,19,21,24,26,28-undecaene-5,12,23-trione
7,21,25-trihydroxy-9,19,31-trimethyl-2,30-dioxaoctacyclo[16.11.2.0¹,¹⁷.0³,¹⁶.0⁴,¹³.0⁶,¹¹.0¹⁷,²².0²⁴,²⁹]hentriaconta-3(16),4(13),6,8,10,14,19,21,24,26,28-undecaene-5,12,23-trione
(1r,2s,3r,11s,12r,14r,26r)-5,12-dihydroxy-6-methoxy-7,21-dimethyl-27-oxo-2',3',4',9'-tetrahydro-17,19,28-trioxa-24-thia-13,30-diazaspiro[heptacyclo[12.9.6.1³,¹¹.0²,¹³.0⁴,⁹.0¹⁵,²³.0¹⁶,²⁰]triacontane-26,1'-pyrido[3,4-b]indole]-4,6,8,15,20,22-hexaen-22-yl acetate
(1r,2s,3r,11s,12r,14r,26r)-5,12-dihydroxy-6-methoxy-7,21-dimethyl-27-oxo-2',3',4',9'-tetrahydro-17,19,28-trioxa-24-thia-13,30-diazaspiro[heptacyclo[12.9.6.1³,¹¹.0²,¹³.0⁴,⁹.0¹⁵,²³.0¹⁶,²⁰]triacontane-26,1'-pyrido[3,4-b]indole]-4,6,8,15,20,22-hexaen-22-yl acetate
C39H40N4O9S (740.2515870000001)
(1r,2r,3r,11s,12s,14r,26r)-5,6'-dihydroxy-6,7'-dimethoxy-7,12,21,30-tetramethyl-27-oxo-3',4'-dihydro-2'h-17,19,28-trioxa-24-thia-13,30-diazaspiro[heptacyclo[12.9.6.1³,¹¹.0²,¹³.0⁴,⁹.0¹⁵,²³.0¹⁶,²⁰]triacontane-26,1'-isoquinoline]-4,6,8,15,20,22-hexaen-22-yl acetate
(1r,2r,3r,11s,12s,14r,26r)-5,6'-dihydroxy-6,7'-dimethoxy-7,12,21,30-tetramethyl-27-oxo-3',4'-dihydro-2'h-17,19,28-trioxa-24-thia-13,30-diazaspiro[heptacyclo[12.9.6.1³,¹¹.0²,¹³.0⁴,⁹.0¹⁵,²³.0¹⁶,²⁰]triacontane-26,1'-isoquinoline]-4,6,8,15,20,22-hexaen-22-yl acetate
C40H45N3O10S (759.2825510000001)
(1r,2r,3s,11s,12r,14r,26r)-22-(acetyloxy)-12-cyano-5,6'-dihydroxy-6,7'-dimethoxy-7,21,30-trimethyl-27-oxo-3',4'-dihydro-2'h-17,19,28-trioxa-24-thia-13,30-diazaspiro[heptacyclo[12.9.6.1³,¹¹.0²,¹³.0⁴,⁹.0¹⁵,²³.0¹⁶,²⁰]triacontane-26,1'-isoquinoline]-4,6,8,15,20,22-hexaen-24-ium-24-olate
(1r,2r,3s,11s,12r,14r,26r)-22-(acetyloxy)-12-cyano-5,6'-dihydroxy-6,7'-dimethoxy-7,21,30-trimethyl-27-oxo-3',4'-dihydro-2'h-17,19,28-trioxa-24-thia-13,30-diazaspiro[heptacyclo[12.9.6.1³,¹¹.0²,¹³.0⁴,⁹.0¹⁵,²³.0¹⁶,²⁰]triacontane-26,1'-isoquinoline]-4,6,8,15,20,22-hexaen-24-ium-24-olate
(1r,17s,18s,19r,31s)-7,18,19,21,25-pentahydroxy-9,19,31-trimethyl-2,30-dioxaoctacyclo[16.11.2.0¹,¹⁷.0³,¹⁶.0⁴,¹³.0⁶,¹¹.0¹⁷,²².0²⁴,²⁹]hentriaconta-3,6,8,10,13,15,21,24,26,28-decaene-5,12,23-trione
(1r,17s,18s,19r,31s)-7,18,19,21,25-pentahydroxy-9,19,31-trimethyl-2,30-dioxaoctacyclo[16.11.2.0¹,¹⁷.0³,¹⁶.0⁴,¹³.0⁶,¹¹.0¹⁷,²².0²⁴,²⁹]hentriaconta-3,6,8,10,13,15,21,24,26,28-decaene-5,12,23-trione
22-acetyl-5,6',7-trihydroxy-6,7'-dimethoxy-21,30-dimethyl-27-oxo-3',4'-dihydro-2'h-17,28-dioxa-24-thia-13,30-diazaspiro[heptacyclo[12.9.6.1³,¹¹.0²,¹³.0⁴,⁹.0¹⁵,²³.0¹⁶,²⁰]triacontane-26,1'-isoquinoline]-4,6,8,15,20,22-hexaene-12-carbonitrile
22-acetyl-5,6',7-trihydroxy-6,7'-dimethoxy-21,30-dimethyl-27-oxo-3',4'-dihydro-2'h-17,28-dioxa-24-thia-13,30-diazaspiro[heptacyclo[12.9.6.1³,¹¹.0²,¹³.0⁴,⁹.0¹⁵,²³.0¹⁶,²⁰]triacontane-26,1'-isoquinoline]-4,6,8,15,20,22-hexaene-12-carbonitrile
C40H42N4O9S (754.2672362000001)
7,18,19,21,25-pentahydroxy-9,19,31-trimethyl-2,30-dioxaoctacyclo[16.11.2.0¹,¹⁷.0³,¹⁶.0⁴,¹³.0⁶,¹¹.0¹⁷,²².0²⁴,²⁹]hentriaconta-3,6,8,10,13,15,21,24,26,28-decaene-5,12,23-trione
7,18,19,21,25-pentahydroxy-9,19,31-trimethyl-2,30-dioxaoctacyclo[16.11.2.0¹,¹⁷.0³,¹⁶.0⁴,¹³.0⁶,¹¹.0¹⁷,²².0²⁴,²⁹]hentriaconta-3,6,8,10,13,15,21,24,26,28-decaene-5,12,23-trione
(1r,17s,18r,31s)-7,21,25-trihydroxy-9,19,31-trimethyl-2,30-dioxaoctacyclo[16.11.2.0¹,¹⁷.0³,¹⁶.0⁴,¹³.0⁶,¹¹.0¹⁷,²².0²⁴,²⁹]hentriaconta-3(16),4(13),6,8,10,14,19,21,24,26,28-undecaene-5,12,23-trione
(1r,17s,18r,31s)-7,21,25-trihydroxy-9,19,31-trimethyl-2,30-dioxaoctacyclo[16.11.2.0¹,¹⁷.0³,¹⁶.0⁴,¹³.0⁶,¹¹.0¹⁷,²².0²⁴,²⁹]hentriaconta-3(16),4(13),6,8,10,14,19,21,24,26,28-undecaene-5,12,23-trione
(1r,2s,3r,11s,12r,14r,26r)-5,6',12-trihydroxy-6,7'-dimethoxy-7,21-dimethyl-27-oxo-3',4'-dihydro-2'h-17,19,28-trioxa-24-thia-13,30-diazaspiro[heptacyclo[12.9.6.1³,¹¹.0²,¹³.0⁴,⁹.0¹⁵,²³.0¹⁶,²⁰]triacontane-26,1'-isoquinoline]-4,6,8,15,20,22-hexaen-22-yl acetate
(1r,2s,3r,11s,12r,14r,26r)-5,6',12-trihydroxy-6,7'-dimethoxy-7,21-dimethyl-27-oxo-3',4'-dihydro-2'h-17,19,28-trioxa-24-thia-13,30-diazaspiro[heptacyclo[12.9.6.1³,¹¹.0²,¹³.0⁴,⁹.0¹⁵,²³.0¹⁶,²⁰]triacontane-26,1'-isoquinoline]-4,6,8,15,20,22-hexaen-22-yl acetate