NCBI Taxonomy: 2755564
Mollisiaceae (ncbi_taxid: 2755564)
found 167 associated metabolites at family taxonomy rank level.
Ancestor: Helotiales
Child Taxonomies: Niptera, Mollisia, Barrenia, Acephala, Loramyces, Haglundia, Pulvinata, Nipterella, Belonopsis, Neomollisia, Cheirospora, Variocladium, Cystodendron, Phialocephala, Obtectodiscus, Phaeomollisia, Trichobelonium, Neopyrenopeziza, environmental samples, unclassified Mollisiaceae
Podofilox
Podophyllotoxin is an organic heterotetracyclic compound that has a furonaphthodioxole skeleton bearing a 3,4,5-trimethoxyphenyl substituent. It is found in the roots and rhizomes of Podophyllum species and is used for the topical treatment of genital warts. It has a role as an antineoplastic agent, a keratolytic drug, a tubulin modulator, a microtubule-destabilising agent, an antimitotic and a plant metabolite. It is a furonaphthodioxole, a lignan and an organic heterotetracyclic compound. ["Podofilox is a prescription medicine approved by the U.S. Food and Drug Administration (FDA) for the treatment of external genital warts and perianal warts. Podofilox gel and solution are for topicalcutaneous use only.","External genital and perianal warts are caused by the human papillomavirus (HPV). HPV can be an opportunistic infection (OI) of HIV."] A lignan found in podophyllin resin from the roots of podophyllum plants. It is a potent spindle poison, toxic if taken internally, and has been used as a cathartic. It is very irritating to skin and mucous membranes, has keratolytic actions, has been used to treat warts and keratoses, and may have antineoplastic properties, as do some of its congeners and derivatives. The physiologic effect of podofilox is by means of Decreased Mitosis. Podofilox is a natural product found in Juniperus, Hernandia ovigera, and other organisms with data available. Podofilox is a pure, stabilized form of podophyllin, in which only the biologically active portion of the compound is present. Podophyllotoxin is a toxic, polycyclic antimitotic agent isolated primarily from the rhizome of the plant Podophyllum peltatum. This agent is formulated for topical applications. (NCI04) A lignan (lignans) found in podophyllin resin from the roots of podophyllum plants. It is a potent spindle poison, toxic if taken internally, and has been used as a cathartic. It is very irritating to skin and mucous membranes, has keratolytic actions, has been used to treat warts and keratoses, and may have antineoplastic properties, as do some of its congeners and derivatives. A lignan (LIGNANS) found in PODOPHYLLIN resin from the roots of PODOPHYLLUM plants. It is a potent spindle poison, toxic if taken internally, and has been used as a cathartic. It is very irritating to skin and mucous membranes, has keratolytic actions, has been used to treat warts and keratoses, and may have antineoplastic properties, as do some of its congeners and derivatives. A lignan (lignans) found in podophyllin resin from the roots of podophyllum plants. It is a potent spindle poison, toxic if taken internally, and has been used as a cathartic. It is very irritating to skin and mucous membranes, has keratolytic actions, has been used to treat warts and keratoses, and may have antineoplastic properties, as do some of its congeners and derivatives. [PubChem] An organic heterotetracyclic compound that has a furonaphthodioxole skeleton bearing a 3,4,5-trimethoxyphenyl substituent. It is found in the roots and rhizomes of Podophyllum species and is used for the topical treatment of genital warts. D - Dermatologicals > D06 - Antibiotics and chemotherapeutics for dermatological use > D06B - Chemotherapeutics for topical use > D06BB - Antivirals C274 - Antineoplastic Agent > C2189 - Signal Transduction Inhibitor > C129824 - Antineoplastic Protein Inhibitor C274 - Antineoplastic Agent > C1931 - Antineoplastic Plant Product > C1331 - Epipodophyllotoxin Compound C471 - Enzyme Inhibitor > C129825 - Antineoplastic Enzyme Inhibitor > C1748 - Topoisomerase Inhibitor C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C273 - Antimitotic Agent D050258 - Mitosis Modulators > D050256 - Antimitotic Agents > D050257 - Tubulin Modulators D000970 - Antineoplastic Agents > D050256 - Antimitotic Agents D003879 - Dermatologic Agents > D007641 - Keratolytic Agents C1907 - Drug, Natural Product Same as: D05529 Picropodophyllin (AXL1717) is a selective insulin-like growth factor-1 receptor (IGF-1R) inhibitor with an IC50 of 1 nM. Picropodophyllin (AXL1717) is a selective insulin-like growth factor-1 receptor (IGF-1R) inhibitor with an IC50 of 1 nM. Podofilox (Podophyllotoxin) is a potent inhibitor of microtubule assembly and DNA topoisomerase II. Podofilox (Podophyllotoxin) is a potent inhibitor of microtubule assembly and DNA topoisomerase II.
Zaragozic acid C
A polyketide isolated from fungi that is a potent inhibitor of fungal and mammalian squalene synthase. D004791 - Enzyme Inhibitors
Podofilox
D - Dermatologicals > D06 - Antibiotics and chemotherapeutics for dermatological use > D06B - Chemotherapeutics for topical use > D06BB - Antivirals C274 - Antineoplastic Agent > C2189 - Signal Transduction Inhibitor > C129824 - Antineoplastic Protein Inhibitor C274 - Antineoplastic Agent > C1931 - Antineoplastic Plant Product > C1331 - Epipodophyllotoxin Compound C471 - Enzyme Inhibitor > C129825 - Antineoplastic Enzyme Inhibitor > C1748 - Topoisomerase Inhibitor C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C273 - Antimitotic Agent D050258 - Mitosis Modulators > D050256 - Antimitotic Agents > D050257 - Tubulin Modulators D000970 - Antineoplastic Agents > D050256 - Antimitotic Agents D003879 - Dermatologic Agents > D007641 - Keratolytic Agents C1907 - Drug, Natural Product Podofilox (Podophyllotoxin) is a potent inhibitor of microtubule assembly and DNA topoisomerase II. Podofilox (Podophyllotoxin) is a potent inhibitor of microtubule assembly and DNA topoisomerase II.
(1r,3r,4s,5r,6s,7s)-1-[(7e)-4-(acetyloxy)-5-methyl-8-phenyloct-7-en-1-yl]-4,7-dihydroxy-3-(methoxycarbonyl)-6-[(9-phenylnonanoyl)oxy]-2,8-dioxabicyclo[3.2.1]octane-4,5-dicarboxylic acid
6-heptyl-4,5-dihydroxy-5-methyl-2-methylidene-4h,6h-furo[2,3-b]pyran-3-one
(1r,3s,4s,5z,7r,8r)-3-hydroxy-5-[(2e,4e)-1-hydroxyhexa-2,4-dien-1-ylidene]-1,3-dimethyl-7-[(1e)-prop-1-en-1-yl]-8-[(5r)-2,4,5-trihydroxy-3,5-dimethyl-6-oxocyclohexa-1,3-diene-1-carbonyl]bicyclo[2.2.2]octane-2,6-dione
2,4,4,6,6-pentachloro-7-(dichloromethylidene)-1-oxaspiro[2.4]heptan-5-ol
2-nonyl-tetrahydro-2h-cyclopenta[b]furan-3,3a,4,6a-tetrol
1,3,5-trimethyl-8-(2-oxohept-5-en-1-yl)-2-(2-oxohepta-3,5-dien-1-yl)-6-oxabicyclo[3.2.1]oct-2-ene-4,7-dione
(4r,5r,6r)-6-heptyl-4,5-dihydroxy-5-methyl-2-methylidene-4h,6h-furo[2,3-b]pyran-3-one
(1r,5s,8r)-1,3,5-trimethyl-8-[(5e)-2-oxohept-5-en-1-yl]-2-[(3e,5e)-2-oxohepta-3,5-dien-1-yl]-6-oxabicyclo[3.2.1]oct-2-ene-4,7-dione
(2r,3r,3as,4s,6ar)-2-(9-hydroxynonyl)-tetrahydro-2h-cyclopenta[b]furan-3,3a,4,6a-tetrol
(4s,10bs)-2,8,10-trihydroxy-7,9-dimethyl-6-oxo-10b-(pent-3-en-1-yl)-3h,4h-pyrimido[2,1-a]isoindole-4-carboxylic acid
6,7,12-trihydroxy-13-{1-hydroxy-3-[5-hydroxy-8-(1-hydroxyhexa-2,4-dien-1-ylidene)-1,3,5-trimethyl-6,7-dioxobicyclo[2.2.2]octan-2-yl]prop-2-en-1-ylidene}-4-(1-hydroxyhexa-2,4-dien-1-ylidene)-2,6,9,11-tetramethyl-8-oxatricyclo[7.4.0.0²,⁷]tridec-11-ene-3,5,10-trione
(3s,4s,6r,7r)-1-[(7e)-4-(acetyloxy)-5-methyl-8-phenyloct-7-en-1-yl]-4,7-dihydroxy-6-{[(8e)-9-phenylnon-8-enoyl]oxy}-2,8-dioxabicyclo[3.2.1]octane-3,4,5-tricarboxylic acid
(1r,3r,4r,7r,8s,10s,11r,14r)-3,10-dihydroxy-6-[(2e)-1-hydroxy-3-[(1r,2s,3s,4s,5s)-5-hydroxy-8-[(2e,4e)-1-hydroxyhexa-2,4-dien-1-ylidene]-1,3,5-trimethyl-6,7-dioxobicyclo[2.2.2]octan-2-yl]prop-2-en-1-ylidene]-13-[(2e,4e)-1-hydroxyhexa-2,4-dien-1-ylidene]-1,4,8,11-tetramethyl-2,9-dioxapentacyclo[8.4.0.0³,⁸.0⁴,¹⁴.0⁷,¹¹]tetradecane-5,12-dione
1-[(7e)-4-(acetyloxy)-5-methyl-8-phenyloct-7-en-1-yl]-4,7-dihydroxy-3-(methoxycarbonyl)-6-{[(8e)-9-phenylnon-8-enoyl]oxy}-2,8-dioxabicyclo[3.2.1]octane-4,5-dicarboxylic acid
(1r,3r,4s,5r,6s,7s)-1-[(7e)-4-(acetyloxy)-5-methyl-8-phenyloct-7-en-1-yl]-4,7-dihydroxy-3-(methoxycarbonyl)-6-{[(8e)-9-phenylnon-8-enoyl]oxy}-2,8-dioxabicyclo[3.2.1]octane-4,5-dicarboxylic acid
4,7-dihydroxy-1-[(7e)-4-hydroxy-3,5-dimethyl-8-phenyloct-7-en-1-yl]-6-[(6e,12e)-tetradeca-6,12-dienoyloxy]-2,8-dioxabicyclo[3.2.1]octane-3,4,5-tricarboxylic acid
5-(hex-4-enoyl)-3,6-dihydroxy-1,3-dimethyl-7-(prop-1-en-1-yl)-8-(2,4,5-trihydroxy-3,5-dimethyl-6-oxocyclohexa-1,3-diene-1-carbonyl)bicyclo[2.2.2]oct-5-en-2-one
(1s,3r,4r,5r,6r,7s)-1-[(4r,5r,7e)-4-(acetyloxy)-5-methyl-8-phenyloct-7-en-1-yl]-4,7-dihydroxy-3-(methoxycarbonyl)-6-[(9-phenylnonanoyl)oxy]-2,8-dioxabicyclo[3.2.1]octane-4,5-dicarboxylic acid
1-[4-(acetyloxy)-5-methyl-8-phenyloct-7-en-1-yl]-4,7-dihydroxy-3-(methoxycarbonyl)-6-[(9-phenylnonanoyl)oxy]-2,8-dioxabicyclo[3.2.1]octane-4,5-dicarboxylic acid
1-[4-(acetyloxy)-5-methyl-6-phenylhexyl]-4,7-dihydroxy-6-{[(4e)-6-methyl-9-phenylnon-4-enoyl]oxy}-2,8-dioxabicyclo[3.2.1]octane-3,4,5-tricarboxylic acid
(1s,3r,4s,5r,6r,7s)-1-[(4s,5s,7e)-4-(acetyloxy)-5-methyl-8-phenyloct-7-en-1-yl]-4,7-dihydroxy-3-(methoxycarbonyl)-6-{[(8e)-9-phenylnon-8-enoyl]oxy}-2,8-dioxabicyclo[3.2.1]octane-4,5-dicarboxylic acid
(1r,4s,7r,8r)-5-[(4e)-hex-4-enoyl]-3,6-dihydroxy-1,3-dimethyl-7-[(1e)-prop-1-en-1-yl]-8-[(5r)-2,4,5-trihydroxy-3,5-dimethyl-6-oxocyclohexa-1,3-diene-1-carbonyl]bicyclo[2.2.2]oct-5-en-2-one
(1s,2s,6r,7s,9r,13z)-3,6,7,12-tetrahydroxy-4-[(1r,2s,3s,4s,6r,7z)-6-hydroxy-7-[(2e,4e)-1-hydroxyhexa-2,4-dien-1-ylidene]-4,6-dimethyl-5,8-dioxo-3-[(1e)-prop-1-en-1-yl]bicyclo[2.2.2]octane-2-carbonyl]-13-[(2e,4e)-1-hydroxyhexa-2,4-dien-1-ylidene]-2,6,9,11-tetramethyl-8-oxatricyclo[7.4.0.0²,⁷]trideca-3,11-diene-5,10-dione
(1s,3s,4r,5r,6r,7s)-1-[(4r,5s,7e)-4-(acetyloxy)-5-methyl-8-phenyloct-7-en-1-yl]-4,7-dihydroxy-6-[(9-phenylnonanoyl)oxy]-2,8-dioxabicyclo[3.2.1]octane-3,4,5-tricarboxylic acid
8-(2,2-dichloroacetyl)-5-hydroxy-2,7-dimethylnaphthalene-1,4-dione
C14H10Cl2O4 (311.99561200000005)
3,6,7,12-tetrahydroxy-4-[6-hydroxy-7-(1-hydroxyhexa-2,4-dien-1-ylidene)-4,6-dimethyl-5,8-dioxo-3-(prop-1-en-1-yl)bicyclo[2.2.2]octane-2-carbonyl]-13-(1-hydroxyhexa-2,4-dien-1-ylidene)-2,6,9,11-tetramethyl-8-oxatricyclo[7.4.0.0²,⁷]trideca-3,11-diene-5,10-dione
2-(9-hydroxynonyl)-tetrahydro-2h-cyclopenta[b]furan-3,3a,4,6a-tetrol
9-{3,3a,4,6a-tetrahydroxy-tetrahydro-2h-cyclopenta[b]furan-2-yl}nonanoic acid
(4e)-1-(2,4-dihydroxy-3-methylphenyl)hex-4-en-1-one
(1s,3r,4r,5r,6r,7s)-1-[(4s,5s,7e)-4-(acetyloxy)-5-methyl-8-phenyloct-7-en-1-yl]-4,7-dihydroxy-6-{[(8e)-9-phenylnon-8-enoyl]oxy}-2,8-dioxabicyclo[3.2.1]octane-3,4,5-tricarboxylic acid
2,8,10-trihydroxy-7,9-dimethyl-6-oxo-10b-(pent-3-en-1-yl)-3h,4h-pyrimido[2,1-a]isoindole-4-carboxylic acid
1-[4-(acetyloxy)-5-methyl-8-phenyloct-7-en-1-yl]-4,7-dihydroxy-3-(methoxycarbonyl)-6-[(9-phenylnon-8-enoyl)oxy]-2,8-dioxabicyclo[3.2.1]octane-4,5-dicarboxylic acid
(1s,3s)-2,2,4,4-tetrachloro-1-(dichloromethyl)-5-(dichloromethylidene)cyclopentane-1,3-diol
C7H4Cl8O2 (399.77195240000003)
3-hydroxy-5-(1-hydroxyhexa-2,4-dien-1-ylidene)-1,3-dimethyl-7-(prop-1-en-1-yl)-8-(2,4,5-trihydroxy-3,5-dimethyl-6-oxocyclohexa-1,3-diene-1-carbonyl)bicyclo[2.2.2]octane-2,6-dione
(7s,9r,10s,12e)-7,9,10-trihydroxyoctadec-12-enoic acid
1-[4-(acetyloxy)-5-methyl-8-phenyloct-7-en-1-yl]-4,7-dihydroxy-6-[(9-phenylnonanoyl)oxy]-2,8-dioxabicyclo[3.2.1]octane-3,4,5-tricarboxylic acid
9-[(2r,3r,3as,4s,6ar)-3,3a,4,6a-tetrahydroxy-tetrahydro-2h-cyclopenta[b]furan-2-yl]nonanoic acid
(4r)-3,3,5,5-tetrachloro-4-hydroxy-2-(trichloromethyl)cyclopent-1-ene-1-carbaldehyde
methyl (8r)-8-hydroxy-8-[(2s,3s)-3-[(2e)-oct-2-en-1-yl]oxiran-2-yl]octanoate
(2r,3s,5s)-2,4,4,6,6-pentachloro-7-(dichloromethylidene)-1-oxaspiro[2.4]heptan-5-ol
1-[4-(acetyloxy)-5-methyl-8-phenyloct-7-en-1-yl]-4,7-dihydroxy-6-[(9-phenylnon-8-enoyl)oxy]-2,8-dioxabicyclo[3.2.1]octane-3,4,5-tricarboxylic acid
(1r,2r,6s,7r,9s)-6,7,12-trihydroxy-13-[(2e)-1-hydroxy-3-[(1r,2r,3r,4s,5s)-5-hydroxy-8-[(2e,4e)-1-hydroxyhexa-2,4-dien-1-ylidene]-1,3,5-trimethyl-6,7-dioxobicyclo[2.2.2]octan-2-yl]prop-2-en-1-ylidene]-4-[(2e,4e)-1-hydroxyhexa-2,4-dien-1-ylidene]-2,6,9,11-tetramethyl-8-oxatricyclo[7.4.0.0²,⁷]tridec-11-ene-3,5,10-trione
3,10-dihydroxy-6-{1-hydroxy-3-[5-hydroxy-8-(1-hydroxyhexa-2,4-dien-1-ylidene)-1,3,5-trimethyl-6,7-dioxobicyclo[2.2.2]octan-2-yl]prop-2-en-1-ylidene}-13-(1-hydroxyhexa-2,4-dien-1-ylidene)-1,4,8,11-tetramethyl-2,9-dioxapentacyclo[8.4.0.0³,⁸.0⁴,¹⁴.0⁷,¹¹]tetradecane-5,12-dione
(1r,3r,4s,5r,6s,7s)-1-[(7e)-4-(acetyloxy)-5-methyl-8-phenyloct-7-en-1-yl]-4,7-dihydroxy-6-[(9-phenylnonanoyl)oxy]-2,8-dioxabicyclo[3.2.1]octane-3,4,5-tricarboxylic acid
methyl 8-hydroxy-8-[3-(oct-2-en-1-yl)oxiran-2-yl]octanoate
methyl 3-(4-hydroxy-5-methyl-6-oxopyran-2-yl)propanoate
(2r,3r,3as,4s,6ar)-2-nonyl-tetrahydro-2h-cyclopenta[b]furan-3,3a,4,6a-tetrol
2,2,4,4-tetrachloro-1-(dichloromethyl)-5-(dichloromethylidene)cyclopentane-1,3-diol
C7H4Cl8O2 (399.77195240000003)