Chemical Formula: C45H68F3N13O12

Chemical Formula C45H68F3N13O12

Found 1 metabolite its formula value is C45H68F3N13O12

TRV-120027 (TFA)

TRV-120027 (TFA)

C45H68F3N13O12 (1039.5062244)


TRV120027 TFA, a β-arrestin-1-biased agonist of the angiotensin II receptor type 1 (AT1R), engages ?-arrestins while blocking G-protein signaling[1]. TRV120027?TFA induces?acute?catecholamine?secretion?through cation channel subfamily C3 (TRPC3) coupling, promotes the formation of a macromolecular complex composed of AT1R–β-arrestin-1–TRPC3–PLCγ at the plasma membrane. TRV120027 TFA inhibits angiotensin II–mediated vasoconstriction and increases cardiomyocyte contractility. TRV120027 TFA has the potential for the?acute decompensated heart failure (ADHF) treatment[2].