Exact Mass: 639.00812
Exact Mass Matches: 639.00812
Found 2 metabolites which its exact mass value is equals to given mass value 639.00812,
within given mass tolerance error 0.001 dalton. Try search metabolite list with more accurate mass tolerance error
0.0002 dalton.
Heparan sulfate
Heparan sulfate (HS) is a linear polysaccharide that belongs to the class of compounds known as glycosaminoglycans (PMID: 24146040). It is found in all animal tissues and consists of repeating subunits of N-acetylglucosamine and glucuronic acid, and closely related in structure to heparin. It occurs as a proteoglycan (HSPG) in which two or three HS chains are attached to either cell surface components or the extracellular matrix (ECM), where they serve to reinforce cell adhesion (PMID: 27241222). HS synthesis starts with the transfer of xylose from UDP-xylose by the enzyme known as xylosyltransferase (XT) to specific serine residues within the protein core. Attachment of two galactose (Gal) residues by galactosyltransferases I and II (GalTI and GalTII) and glucuronic acid (GlcA) by the enzyme glucuronosyltransferase I (GlcATI) completes the formation of a tetrasaccharide linker. After attachment of the first N-acetylglucosamine (GlcNAc) residue by the enzyme known as GalNAc Transferase I (GalNAcT-I), elongation of the tetrasaccharide linker is continued by the stepwise addition of GlcA and GlcNAc residues. These are transferred from their respective UDP-sugar nucleotides. HS functions through binding to a variety of protein ligands including interferon gamma, Wnt, antithrombin III, interleukin 8, fibroblast growth factor, endostatin and others. HS thereby regulates a wide range of developmental signaling pathways such as the Wnt, Hedgehog, transforming growth factor-β, and fibroblast growth factor pathways (PMID: 15563523). Heparan sulfate plays a role in a number of biological activities, including developmental processes, angiogenesis, blood coagulation, abolishing detachment activity by GrB (Granzyme B) and tumour metastasis. A heteropolysaccharide that is similar in structure to heparin. It accumulates in individuals with mucopolysaccharidosis.
