Exact Mass: 503.13785220000005

Exact Mass Matches: 503.13785220000005

Found 1 metabolites which its exact mass value is equals to given mass value 503.13785220000005, within given mass tolerance error 1.6E-6 dalton. Try search metabolite list with more accurate mass tolerance error 3.2E-7 dalton.

YH239-EE

YH239-EE

C25H27Cl2N3O4 (503.13785220000005)


YH239-EE, ethyl ester of the free carboxylic acid compound YH239, is a potent p53-MDM2 antagonizing and apoptosis-inducing agent. IC50 value: Target: MDM2/p53 YH239-EE inhibits the growth of OCI-AML-3 cells with wild type p53 by inhibiting the p53-MDM2 interaction. YH239-EE induces cell cycle arrest and causes potent cell apoptosis via activation of p53 and downstream targets in four AML cells (OCI-AML-3 and MOLM-13 with wt p53, NB4 with p53 mutation, and HL60 with p53 deletion).