Exact Mass: 501.2185
Exact Mass Matches: 501.2185
Found 15 metabolites which its exact mass value is equals to given mass value 501.2185
,
within given mass tolerance error 0.001 dalton. Try search metabolite list with more accurate mass tolerance error
0.0002 dalton.
Asp Asp Pro Arg
Asp Asp Arg Pro
Asp Pro Asp Arg
Asp Pro Arg Asp
Asp Arg Asp Pro
Asp Arg Pro Asp
Pro Asp Asp Arg
Pro Asp Arg Asp
Pro Arg Asp Asp
Arg Asp Asp Pro
Arg Asp Pro Asp
Arg Pro Asp Asp
(S,R)-GSK321
(S,R)-GSK321 is a potent, selective mutant IDH1 inhibitor with IC50 values of 2.9, 3.8, 4.6 and 46 nM for R132G, R132C, R132H and WT IDH1, respectively, and >100-fold selectivity over IDH2. (S,R)-GSK321 induces decrease in intracellular 2-HG, abrogation of the myeloid differentiation block and induction of granulocytic differentiation at the level of leukemic blasts and more immature stem-like cells. (S,R)-GSK321can be used for research of acute myeloid leukemia (AML) and other cancers[1].
GSK321
GSK321 is a potent inhibitor of mutant isocitrate dehydrogenase 1 (IDH1) enzymes. GSK321 has high inhibitory and selectivity for mutant IDH1 enzymes. GSK321 can be used for the research of acute myeloid leukemia[1][2].