Exact Mass: 495.0446412
Exact Mass Matches: 495.0446412
Found 34 metabolites which its exact mass value is equals to given mass value 495.0446412,
within given mass tolerance error 0.05 dalton. Try search metabolite list with more accurate mass tolerance error
0.01 dalton.
Dihydroneopterin triphosphate
The biosynthesis of tetrahydrobiopterin (BH4) from dihydroneopterin triphosphate (NH2P3) was studied in human liver extract. The phosphate-eliminating enzyme (PEE) was purified approximately 750-fold. The conversion of NH2P3 to BH4 was catalyzed by this enzyme in the presence of partially purified sepiapterin reductase, Mg2+, and NADPH. The PEE is heat stable when heated at 80°C for 5 min. It has a molecular weight of 63 000 daltons. One possible intermediate 6-(1-hydroxy-2-oxopropyl)5,6,7,8-tetrahydropterin(2-oxo-tetrahydropte rin) was formed upon incubation of BH4 in the presence of sepiapterin reductase and NADP+ at pH 9.0. The reduction of this compound with NaBD4 yielded monodeutero-, threo-, and erythro-BH4; the deuterium was incorporated at the 2 position. This and the UV spectra were consistent with a 2-oxo-tetrahydropterin structure. Dihydrofolate reductase (DHFR) catalyzed the reduction of BH2 into BH4 and was found to be specific for the pro-R-NADPH side. The sepiapterin reductase catalyzed the transfer of the pro-S hydrogen of NADPH during the reduction of sepiapterin into BH2. In the presence of crude liver extracts, the conversion of NH2P3 into BH4 requires NADPH. Two deuterium atoms were incorporated from (4S-2H)NADHP in the 1 and 2 position of the BH4 side chain. The incorporation of one hydrogen from the solvent was found at position C(6). These results are consistent with the occurrence of an intramolecular redox exchange between the pteridine nucleus and the side chain and formation of 6-pyruvoyl-5,6,7,8-tetrahydropterin(tetrahydro-1-2-dioxopterin) as an intermediate (PMID: 3930838). COVID info from COVID-19 Disease Map Corona-virus Coronavirus SARS-CoV-2 COVID-19 SARS-CoV COVID19 SARS2 SARS
Isopentenyl-ADP
C15H23N5O10P2 (495.09201179999997)
A purine ribonucleoside 5-diphosphate that is ADP substituted at position N-6 by a dimethylallyl (isopentenyl) group.
4-Chloro-N-[5-methyl-2-[7H-pyrrolo[2,3-d]pyrimidine-4-carbonyl]-3-pyridyl]-3-(trifluoromethyl)benzenesulfonamide
C20H13ClF3N5O3S (495.03796940000007)
C308 - Immunotherapeutic Agent > C63817 - Chemokine Receptor Antagonist
High Temperature Requirement A2 Inhibitor I
C27H17N3O5S (495.08888720000004)
Dihydroneopterin triphosphate
COVID info from COVID-19 Disease Map Corona-virus Coronavirus SARS-CoV-2 COVID-19 SARS-CoV COVID19 SARS2 SARS
4-((4-(DIETHYLAMINO)-2-HYDROXYPHENYL)DIAZENYL)-5-HYDROXYNAPHTHALENE-2,7-DISULFONIC ACID
2-Anthracenesulfonicacid, 1-amino-9,10-dihydro-4-[[(4-methylphenyl)sulfonyl]amino]-9,10-dioxo-,sodium salt (1:1)
4-[(2,5-dichlorophenyl)azo]-N-(2,5-dimethoxyphenyl)-3-hydroxynaphthalene-2-carboxamide
C25H19Cl2N3O4 (495.07525540000006)
(Z)-3-(((4-((dimethylamino)methyl)phenyl)amino)(phenyl)methylene)-6-iodoindolin-2-one
SODIUM [(S)-1,2-DIAMINOPROPANE-N,N,N,N-TETRAACETATO]SAMARATE(III) HYDRATE
(N-methyl-n-phenylamino)triphenylphosphonium iodide
High Temperature Requirement A2 Inhibitor I
C27H17N3O5S (495.08888720000004)
N-(3-methoxyphenyl)-2-{(2Z)-4-oxo-3-phenyl-2-[(phenylsulfonyl)imino]-1,3-thiazolidin-5-yl}acetamide
C24H21N3O5S2 (495.09225760000004)
(2S)-2-[(2,4-Dichloro-benzoyl)-(3-trifluoromethyl-benzyl)-amino]-3-phenyl-propionic acid
C24H18Cl2F3NO3 (495.06157740000003)
N(6)-(Dimethylallyl)adenosine 5-diphosphate
C15H23N5O10P2 (495.09201179999997)
[(5E)-5-sulfooxyimino-5-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]sulfanylpentyl] benzoate
C18H25NO11S2 (495.08689799999996)
2-[[3-(3,4-dichlorophenyl)-4-oxo-2-quinazolinyl]thio]-N-(2,3-dihydro-1H-inden-5-yl)acetamide
C25H19Cl2N3O2S (495.05749740000005)
ethyl 4-cyano-5-[[2-[[5-(2,4-dichlorophenyl)-1H-1,2,4-triazol-3-yl]sulfanyl]acetyl]amino]-3-methylthiophene-2-carboxylate
C19H15Cl2N5O3S2 (494.99933400000003)
N-(4-ethoxyphenyl)sulfonyl-N-(2-oxo-5-benzo[g][1,3]benzoxathiolyl)-2-furancarboxamide
(6R,7R)-7-[3-(difluoromethylsulfanyl)-2-oxopropyl]-3-[[1-(2-hydroxyethyl)tetrazol-5-yl]sulfanylmethyl]-7-methoxy-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
N(6)-(Dimethylallyl)adenosine 5'-diphosphate
C15H23N5O10P2 (495.09201179999997)
2,5-dimethyl 3,4-bis(5-chloro-1h-indol-3-yl)-1-methylpyrrole-2,5-dicarboxylate
C25H19Cl2N3O4 (495.07525540000006)
{[1-(benzoyloxy)butan-2-yl]imino}({[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]sulfanyl})methoxysulfonic acid
C18H25NO11S2 (495.08689799999996)
(z)-{[(2r)-1-[(z)-benzoyloxy]butan-2-yl]imino}({[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]sulfanyl})methoxysulfonic acid
C18H25NO11S2 (495.08689799999996)
12',14'-dimethyl (3r)-4',5-dichloro-1-methyl-2h-8',13'-diazaspiro[indole-3,10'-tetracyclo[7.6.0.0²,⁷.0¹¹,¹⁵]pentadecane]-1'(9'),2',4',6',11',14'-hexaene-12',14'-dicarboxylate
C25H19Cl2N3O4 (495.07525540000006)