Exact Mass: 494.9951

Exact Mass Matches: 494.9951

Found 6 metabolites which its exact mass value is equals to given mass value 494.9951, within given mass tolerance error 0.001 dalton. Try search metabolite list with more accurate mass tolerance error 0.0002 dalton.

Dihydroneopterin triphosphate

{[({[(2R,3S)-3-(2-amino-4-oxo-1,4,7,8-tetrahydropteridin-6-yl)-2,3-dihydroxypropoxy](hydroxy)phosphoryl}oxy)(hydroxy)phosphoryl]oxy}phosphonic acid

C9H16N5O13P3 (494.9957)


The biosynthesis of tetrahydrobiopterin (BH4) from dihydroneopterin triphosphate (NH2P3) was studied in human liver extract. The phosphate-eliminating enzyme (PEE) was purified approximately 750-fold. The conversion of NH2P3 to BH4 was catalyzed by this enzyme in the presence of partially purified sepiapterin reductase, Mg2+, and NADPH. The PEE is heat stable when heated at 80°C for 5 min. It has a molecular weight of 63 000 daltons. One possible intermediate 6-(1-hydroxy-2-oxopropyl)5,6,7,8-tetrahydropterin(2-oxo-tetrahydropte rin) was formed upon incubation of BH4 in the presence of sepiapterin reductase and NADP+ at pH 9.0. The reduction of this compound with NaBD4 yielded monodeutero-, threo-, and erythro-BH4; the deuterium was incorporated at the 2 position. This and the UV spectra were consistent with a 2-oxo-tetrahydropterin structure. Dihydrofolate reductase (DHFR) catalyzed the reduction of BH2 into BH4 and was found to be specific for the pro-R-NADPH side. The sepiapterin reductase catalyzed the transfer of the pro-S hydrogen of NADPH during the reduction of sepiapterin into BH2. In the presence of crude liver extracts, the conversion of NH2P3 into BH4 requires NADPH. Two deuterium atoms were incorporated from (4S-2H)NADHP in the 1 and 2 position of the BH4 side chain. The incorporation of one hydrogen from the solvent was found at position C(6). These results are consistent with the occurrence of an intramolecular redox exchange between the pteridine nucleus and the side chain and formation of 6-pyruvoyl-5,6,7,8-tetrahydropterin(tetrahydro-1-2-dioxopterin) as an intermediate (PMID: 3930838). COVID info from COVID-19 Disease Map Corona-virus Coronavirus SARS-CoV-2 COVID-19 SARS-CoV COVID19 SARS2 SARS

   

7,8-Dihydromonapterin 3-triphosphate

7,8-Dihydromonapterin 3-triphosphate

C9H16N5O13P3 (494.9957)


   

Dihydroneopterin triphosphate

7,8-Dihydroneopterin 3-triphosphate

C9H16N5O13P3 (494.9957)


COVID info from COVID-19 Disease Map Corona-virus Coronavirus SARS-CoV-2 COVID-19 SARS-CoV COVID19 SARS2 SARS

   

SODIUM [(S)-1,2-DIAMINOPROPANE-N,N,N,N-TETRAACETATO]SAMARATE(III) HYDRATE

SODIUM [(S)-1,2-DIAMINOPROPANE-N,N,N,N-TETRAACETATO]SAMARATE(III) HYDRATE

C11H16N2NaO9Sm (494.9951)


   

Dihydromonapterin triphosphate

Dihydromonapterin triphosphate

C9H16N5O13P3 (494.9957)


   

Amino-hydroxy-hydroxypropyl-dihydropteridin

Amino-hydroxy-hydroxypropyl-dihydropteridin

C9H16N5O13P3-2 (494.9957)