Exact Mass: 454.2402344
Exact Mass Matches: 454.2402344
Found 2 metabolites which its exact mass value is equals to given mass value 454.2402344,
within given mass tolerance error 8.0E-6 dalton. Try search metabolite list with more accurate mass tolerance error
1.6E-6 dalton.
Tenovin-6
N-[[[4-[[5-(dimethylamino)-1-oxopentyl]amino]phenyl]amino]thioxomethyl]-4-(1,1-dimethylethyl)-benzamide
Tenovin-6, an analog of Tenovin-1 (HY-13423), is an activator of p53 transcriptional activity. Tenovin-6 inhibits the protein deacetylase activities of purified human SIRT1, SIRT2, and SIRT3 with IC50s of 21 μM, 10 μM, and 67 μM, respectively. Tenovin-6 also inhibits dihydroorotate dehydrogenase (DHODH)[1][2].