Exact Mass: 429.22770180000003
Exact Mass Matches: 429.22770180000003
Found 6 metabolites which its exact mass value is equals to given mass value 429.22770180000003,
within given mass tolerance error 0.0002 dalton. Try search metabolite list with more accurate mass tolerance error
4.0E-5 dalton.
ON-123300
Narazaciclib (ON123300), a strong and brain-penetrant[1] multi-kinase inhibitor, inhibits CDK4 (IC50=3.9 nM), Ark5 (IC50=5 nM), PDGFRβ (IC50=26 nM), FGFR1 (IC50=26 nM), RET (IC50=9.2 nM), and FYN (IC50=11 nM). Single agent Narazaciclib causes a dose-dependent suppression of phosphorylation of Akt as well as activation of Erk in brain tumors[2]. Narazaciclib inhibits CDK6 with an IC50 of 9.82 nM[3].
3-[4-(2-Benzyl-5-tert-butylpyrazole-3-carbonyl)piperazin-1-yl]pyrazine-2-carbonitrile
asnovolin I(1-)
A monocarboxylic acid anion that is the conjugate base of asnovolin I resulting from the deprotonation of the carboxy group. Major microspecies at pH 7.3.