Exact Mass: 427.142
Exact Mass Matches: 427.142
Found 3 metabolites which its exact mass value is equals to given mass value 427.142,
within given mass tolerance error 4.0E-5 dalton. Try search metabolite list with more accurate mass tolerance error
8.0E-6 dalton.
CMC2.24
CMC2.24
CMC2.24 (TRB-N0224), an orally active tricarbonylmethane agent, is effective against pancreatic tumor in mice by inhibiting Ras activation and its downstream effector ERK1/2 pathway. CMC2.24 is also a potent inhibitor of zinc-dependent MMPs with IC50s ranging from 2.0-69 μM. CMC2.24 alleviates osteoarthritis progression by restoring cartilage homeostasis and inhibiting chondrocyte apoptosis via the NF-κB/HIF-2α axis[1][2][3].
1-(3,5-dihydroxy-2-{11-hydroxy-5,15-dimethyl-8-oxa-16-azatetracyclo[7.7.1.0²,⁷.0¹³,¹⁷]heptadeca-1(16),2(7),3,5,9(17),10,12,14-octaen-3-yl}phenyl)propan-2-one
1-(3,5-dihydroxy-2-{11-hydroxy-5,15-dimethyl-8-oxa-16-azatetracyclo[7.7.1.0²,⁷.0¹³,¹⁷]heptadeca-1(16),2(7),3,5,9(17),10,12,14-octaen-3-yl}phenyl)propan-2-one
