Exact Mass: 426.9976

Exact Mass Matches: 426.9976

Found 1 metabolites which its exact mass value is equals to given mass value 426.9976, within given mass tolerance error 0.001 dalton. Try search metabolite list with more accurate mass tolerance error 0.0002 dalton.

PK11007

PK11007

C15H11ClFN5O3S2 (426.9976)


PK11007 is a mild thiol alkylator with anticancer activity. PK11007 stabilizes p53 via selective alkylation of two surface-exposed cysteines without compromising its DNA binding activity. PK11007 induces mutant p53 cancer cell death by increasing reactive oxygen species (ROS) levels[1][2].