Exact Mass: 426.0879012
Exact Mass Matches: 426.0879012
Found 18 metabolites which its exact mass value is equals to given mass value 426.0879012,
within given mass tolerance error 8.0E-6 dalton. Try search metabolite list with more accurate mass tolerance error
1.6E-6 dalton.
Cysteineglutathione disulfide
Cysteineglutathione disulfide is a molecule that is formed upon oxidative stress of glutathione, that will form mixed disulfides with protein thiol groups, causing reversible S-glutathionylation. S-glutathionylation is an important post-translational modification responsible for transducing oxidant signals. S-glutathionylation of thiols confers protection against their irreversible oxidation, like for instance the formation of sulphonic acid moieties. If the targeted cysteine is a functionally critical amino acid, S-glutathionylation will however also modify protein function. (PMID 16515838). S-sulfonation and S-thiolation of transthyretin Phe33Cys has been detected in a patient with familial transthyretin amyloidosis. (PMID 12876326). In Cystinotic human skin fibroblasts in tissue culture there is an accumulation of cystine. Stored cystine in cystinotic tissues may derive in part from glutathione-cysteine mixed disulfide via transpeptidation. (PMID 6130452). Cystinosis is an autosomal recessive disorder caused by an impaired transport of cystine out of lysosomes. (PMID 15042893). Cysteineglutathione disulfide is a molecule that is formed upon oxidative stress of glutathione, that will form mixed disulfides with protein thiol groups, causing reversible S-glutathionylation. [HMDB]
Cysteine-glutathione disulfide
Cys Cys Asp Ser
Cys Cys Ser Asp
Cys Asp Cys Ser
Cys Asp Ser Cys
Cys Ser Cys Asp
Cys Ser Asp Cys
Asp Cys Cys Ser
Asp Cys Ser Cys
Asp Ser Cys Cys
Ser Cys Cys Asp
Ser Cys Asp Cys
Ser Asp Cys Cys
L-cysteine glutathione disulfide
An organic disulfide that is the L-cysteinyl derivative of glutathione.