Exact Mass: 410.147
Exact Mass Matches: 410.147
Found 31 metabolites which its exact mass value is equals to given mass value 410.147,
within given mass tolerance error 0.001 dalton. Try search metabolite list with more accurate mass tolerance error
0.0002 dalton.
Cys Ser Thr Thr
Cys Thr Ser Thr
Cys Thr Thr Ser
Met Ser Ser Ser
Ser Cys Thr Thr
Ser Met Ser Ser
Ser Ser Met Ser
Ser Ser Ser Met
Ser Thr Cys Thr
Ser Thr Thr Cys
Thr Cys Ser Thr
Thr Cys Thr Ser
Thr Ser Cys Thr
Thr Ser Thr Cys
Thr Thr Cys Ser
Thr Thr Ser Cys
Darusentan
C78274 - Agent Affecting Cardiovascular System > C270 - Antihypertensive Agent D065128 - Endothelin Receptor Antagonists C28313 - Endothelin Receptor Antagonist Darusentan (Lu-135252) is a selective endothelin receptor A (ET-A) receptor antagonist, which binds with a Ki of 1.4 nM to the ET-A receptor and a Ki of 184 nM to ET-B receptor, respectively with a 100-fold selectivity for ETA rather than ETB receptors[1]. Darusentan competes for radiolabeled endothelin binding in rat aortic vascular smooth muscle cells (RAVSMs) membranes with single-site kinetics, exhibiting a Ki of 13 nM[2].
3-(4-fluorophenyl)-4,4,6,8-tetramethyl-5,6-dihydro-4H,4H-spiro[pyrrolo[3,2,1-ij]quinoline-1,2-[1,3]thiazolidine]-2,4-dione
(2S)-2-[12-ethyl-2-hydroxy-8-(hydroxymethyl)-9-oxo-11H-indolizino[1,2-b]quinolin-7-yl]-2-hydroxybutanoic acid
SN-38 carboxylic acid
A 2-hydroxy monocarboxylic acid resulting from the hydrolysis of the delta-lactone ring of SN-38. It is a metabolite of SN-38.
MMV009085
MMV009085 is a potent PfHT1 (Plasmodium?falciparum?hexose transporter)-specific inhibitor and a potential anti-malarial agent . MMV009085 is also a human glucose transporter inhibitor, it has high potency in inhibiting both glucose uptake (IC50: 2.6 μM in glucose uptake assay) and growth of the parasites (EC50: 1.23±0.04 μM against 3D7)[1].
