Exact Mass: 378.03990500000003

Exact Mass Matches: 378.03990500000003

Found 3 metabolites which its exact mass value is equals to given mass value 378.03990500000003, within given mass tolerance error 0.0002 dalton. Try search metabolite list with more accurate mass tolerance error 4.0E-5 dalton.

6-Methylthiopurine 5'-monophosphate ribonucleotide

{[(2R,3S,4R,5R)-3,4-dihydroxy-5-[6-(methylsulfanyl)-9H-purin-9-yl]oxolan-2-yl]methoxy}phosphonic acid

C11H15N4O7PS (378.03990500000003)

6-Methylthiopurine 5-monophosphate ribonucleotide, also known as methylthioinosine-5-monophosphate or meTIMP, is a metabolite of mercaptopurine. Mercaptopurine (also called 6-mercaptopurine, 6-MP, or its brand name Purinethol) is an immunosuppressive drug. Mercaptopurine is in the thiopurine and antimetabolite family of medications (Wikipedia). MeTIMP produced from 6-thioinosine monophosphate (6-TIMP) by thiopurine methyltransferase (TPMT) is an active metabolite that can inhibit de novo purine biosynthesis. High concentration of meTIMP has been related to hepatotoxicity and myelotoxicity (PMID: 21311411).

6-Methylthiopurine ribonucleoside

{[3,4-dihydroxy-5-(2-methyl-6-sulfanylidene-6,9-dihydro-3H-purin-9-yl)oxolan-2-yl]methoxy}phosphonic acid

C11H15N4O7PS (378.03990500000003)

6-Methylthioinosine-5-monophosphate

6-Methylthiopurine 5-monophosphate ribonucleotide

C11H15N4O7PS (378.03990500000003)