Exact Mass: 378.0399
Exact Mass Matches: 378.0399
Found 3 metabolites which its exact mass value is equals to given mass value 378.0399,
within given mass tolerance error 4.0E-5 dalton. Try search metabolite list with more accurate mass tolerance error
8.0E-6 dalton.
6-Methylthiopurine 5'-monophosphate ribonucleotide
6-Methylthiopurine 5-monophosphate ribonucleotide, also known as methylthioinosine-5-monophosphate or meTIMP, is a metabolite of mercaptopurine. Mercaptopurine (also called 6-mercaptopurine, 6-MP, or its brand name Purinethol) is an immunosuppressive drug. Mercaptopurine is in the thiopurine and antimetabolite family of medications (Wikipedia). MeTIMP produced from 6-thioinosine monophosphate (6-TIMP) by thiopurine methyltransferase (TPMT) is an active metabolite that can inhibit de novo purine biosynthesis. High concentration of meTIMP has been related to hepatotoxicity and myelotoxicity (PMID: 21311411).
