Exact Mass: 374.1102
Exact Mass Matches: 374.1102
Found 80 metabolites which its exact mass value is equals to given mass value 374.1102,
within given mass tolerance error 0.01 dalton. Try search metabolite list with more accurate mass tolerance error
0.001 dalton.
Portulacaxanthin II
Portulacaxanthin II is involved in betaxanthin biosynthesis (via dopaxanthin) pathway. This pathway demonstrates the formation of betaxanthins such as portulacaxanthin II and dopaxanthin by means of non-enzymatic condensation from the amino acids L-tyrosine and L-DOPA, respectively. Tyrosinases have been described as capable to use those betaxanthins [ GandiaHerr05a ] as substrates for further metabolization. [HMDB]. Portulacaxanthin II is found in many foods, some of which are pineappple sage, peppermint, japanese pumpkin, and medlar. Portulacaxanthin II is involved in betaxanthin biosynthesis (via dopaxanthin) pathway. This pathway demonstrates the formation of betaxanthins such as portulacaxanthin II and dopaxanthin by means of non-enzymatic condensation from the amino acids L-tyrosine and L-DOPA, respectively. Tyrosinases have been described as capable to use those betaxanthins [ GandiaHerr05a ] as substrates for further metabolization.
Succinylaminoimidazole carboxamide riboside
Succinylaminoimidazole carboxamide riboside, also known as SAICAr, is the riboside form of the better known compound SAICAR (the ribotide). Ribosides chemically resemble ribotides except they do not contain a phosphate group. The appearance of succinylaminoimidazolecarboxamide riboside (SAICAriboside) and succinyladenosine (S-Ado) in cerebrospinal fluid, in urine, and, to a lesser extent, in plasma is characteristic of a heritable deficiency known as adenylosuccinate lyase deficiency (ADSL). Adenylosuccinate lyase deficiency is responsible for a range of symptoms that involve psychomotor retardation, often accompanied by epileptic seizures, and autistic features. In adenylosuccinate lyase deficiency it is believed that the buildup of SAICAr causes neurotoxic effects. In the severely affected individuals, the concentration levels of SAICAr and S-Ado are comparable, whereas in people with milder forms of the disease, the concentration of S-Ado is more than double that of those more severely affected, while SAICAr concentration levels remain comparable. Therefore, when present in sufficiently high levels, SAICAr can act as a metabotoxin and an acidogen. An acidogen is an acidic compound that induces acidosis, which has multiple adverse effects on many organ systems. A metabotoxin is an endogenously produced metabolite that causes adverse health effects at chronically high levels. Acidosis typically occurs when arterial pH falls below 7.35. In infants with acidosis the initial symptoms include poor feeding, vomiting, loss of appetite, weak muscle tone (hypotonia), and lack of energy (lethargy). These can progress to heart, liver, and kidney abnormalities, seizures, coma, and possibly death. These are also the characteristic symptoms of untreated adenylosuccinate lyase deficiency. Many affected children with organic acidemias experience intellectual disability or delayed development.
Harmol glucuronide
4alpha,10alpha-dihydroxy-1alpha,2alpha-epoxy-5alpha,7alphaH-guaia-11(13)-en-12,6alpha-olide
3,8-epoxy-5-hydroxyvalechlorin-1-yl isovalerate|jatamanin O|rel-(2R,4S,4aS,5S,7S,7aS)-7-(acetyloxy)-7a-(chloromethyl)hexahydro-8-methylene-2,5-methanocyclopenta-1,3-dioxin-4-yl 3-methylbutanoate
Me glycoside,4,6-O-benzylidene,2-mesyl-3-O-Methylgalactose
6-(1,2-dihydroxy-ethyl)-8-D-ribitol-1-yl-1H,8H-pteridine-2,4,7-trione|Photolumazin A
4-Methylphenyl 4,6-O-benzylidene-1-thio-b-D-glucopyranoside
4-METHYLPHENYL4,6-O-[(R)-PHENYLMETHYLENE]-1-THIO-BETA-D-GLUCOPYRANOSIDE
4-Methylphenyl 4,6-O-benzylidene-1-thio-b-D-galactopyranoside
(11ar)-(+)-10,11,12,13-tetrahydrodiindeno[7,1-de:1,7-fg][1,3,2]dioxaphosphocin-5-phenoxy
ethyl (2S)-3-(4-aminophenyl)-2-(1,3-dioxoisoindol-2-yl)propanoate,hydrochloride
3-O-(4-TOLUENESULFONYL)-2-O-ACETYL-L-METHYLFUCOSIDE
3-(4-(2-chlorophenoxy)piperidine-1-carboxamido)benzoic acid
1-(2,6-Dichlorobenzyl)-3-(1-Pyrrolidinylmethyl)-1H-Indazol-6-Amine
1-[2-[(4-CHLORO-2-NITROPHENYL)AMINO]BENZOYL]-4-METHYL-PIPERAZINE
4-Amino-5-cyano-6-ethoxy-N-[4-(methylsulfonyl)benzyl]-2-pyridinec arboxamide
((2R,3R,4R,5R)-3-(benzoyloxy)-4-fluoro-5-hydroxy-4-methyltetrahydrofuran-2-yl)methyl benzoate
6-deoxy-1,2-O-isopropylidene-6-(4-methylbenzene)sulfonyloxy-D-glucofuranose
6-(difluoro(6-phenyl-[1,2,4]triazolo[4,3-b][1,2,4]triazin-3-yl)Methyl)quinoline
17-Beta-Estradiol-3-O-Sulfate Sodium
17β-Estradiol sulfate (sodium), also known as β-Estradiol 3-sulfate sodium salt, is a neuroactive steroid[1][2].
(10R)-10-methyl-3-(6-methylpyridin-3-yl)-9,10,11,12-tetrahydro-8H-[1,4]diazepino[5,6:4,5]thieno[3,2-f]quinolin-8-one
Ethyl 3-(benzylthio)-6,6-dimethyl-4-oxo-4,5,6,7-tetrahydrobenzo[c]thiophene-1-carboxylate
2-{4-(2-furylmethyl)-5-[(3-phenyl-2-propen-1-yl)thio]-4H-1,2,4-triazol-3-yl}pyridine
1-(1-Benzotriazolyl)-3-(10-phenothiazinyl)-2-propanol
4-(1,3-Benzodioxol-5-Yloxy)-2-[4-(1h-Imidazol-1-Yl)phenoxy]pyrimidine
(4E)-4-[2-[1-carboxy-2-(4-hydroxyphenyl)ethyl]iminoethylidene]-2,3-dihydro-1H-pyridine-2,6-dicarboxylic acid
2-[[5-(2-Furanyl)-4-(2-furanylmethyl)-1,2,4-triazol-3-yl]thio]-1-(4-morpholinyl)ethanone
N-[2-(trifluoromethyl)-1,3-benzodioxol-2-yl]-1,4-dioxa-8-azaspiro[4.5]decane-8-carboxamide
4-{4-(2-furylmethyl)-5-[(3-phenyl-2-propen-1-yl)thio]-4H-1,2,4-triazol-3-yl}pyridine
N-[3-chloro-2-(4-morpholinyl)phenyl]-2,3-dihydro-1,4-benzodioxin-6-carboxamide
4-[2-[(4-Fluorophenyl)methylamino]-2-oxoethyl]-2-methyl-5-thieno[3,2-b]pyrrolecarboxylic acid ethyl ester
4-[(E)-{2-[2-(2-fluorophenyl)quinazolin-4-yl]hydrazinylidene}methyl]benzene-1,3-diol
(2R,3R,4S)-1-ethylsulfonyl-3-[4-(3-fluorophenyl)phenyl]-4-(hydroxymethyl)azetidine-2-carbonitrile
(2R,3S,4S)-1-ethylsulfonyl-3-[4-(3-fluorophenyl)phenyl]-4-(hydroxymethyl)-2-azetidinecarbonitrile
(2S,3R,4R)-1-ethylsulfonyl-3-[4-(3-fluorophenyl)phenyl]-4-(hydroxymethyl)azetidine-2-carbonitrile
(2S,3S,4R)-1-ethylsulfonyl-3-[4-(3-fluorophenyl)phenyl]-4-(hydroxymethyl)-2-azetidinecarbonitrile
6-CEPN
6-CEPN is a RAS inhibitor. 6-CEPN can inhibit RAS activation by binding to Icmt binding sites. 6-CEPN has anticancer activity. 6-CEPN can block cancer cells in the G1 phase. 6-CEPN can induce autophagy and necrosis of Cancer cells (Icmt: isovalerylcysteine carboxymethyltransferase)[1].
RK-9123016
RK-9123016 is a potent inhibitor of SIRT2. RK-9123016 inhibits the enzymatic activity of SIRT2 with an IC50?value of 0.18?μM but not other human sirtuin members including SIRT1 and SIRT3 at 100?μM. RK-9123016 increases the acetylation level of eukaryotic translation initiation factor 5A (eIF5A), a physiological substrate of SIRT2, and reduces cell viability of human breast cancer cells accompanied with a decrease in c-Myc expression[1].
