Exact Mass: 368.1336

Exact Mass Matches: 368.1336

Found 1 metabolites which its exact mass value is equals to given mass value 368.1336, within given mass tolerance error 0.0002 dalton. Try search metabolite list with more accurate mass tolerance error 4.0E-5 dalton.

LJI308

LJI308

C21H18F2N2O2 (368.1336)


LJI308 is a potent pan-ribosomal S6 kinase (RSK) inhibitor, with IC50s of 6 nM, 4 nM, and 13 nM for RSK1, RSK2, and RSK3, respectively. LJI308 inhibits the phosphorylation of RSK (T359/S363) and YB-1 (S102) after irradiation, treatment with EGF, and in cells expressing a KRAS mutation[1][2].