Exact Mass: 359.0228286

Exact Mass Matches: 359.0228286

Found 1 metabolites which its exact mass value is equals to given mass value 359.0228286, within given mass tolerance error 4.0E-5 dalton. Try search metabolite list with more accurate mass tolerance error 8.0E-6 dalton.

VU0422288

VU0422288

C17H11Cl2N3O2 (359.0228286)


VU0422288 (ML396) is a positive allosteric modulator of group III mGluRs. VU0422288 inhibits mGluRs with EC50s of 125 nM, 146 nM, and 108 nM for mGluR4, mGluR7, and mGluR8, respectively in calcium mobilization assays. VU0422288 reverses deficits in contextual fear memory, social recognition, and apneas in Rett syndrome (RTT) model mice[1][2].