Exact Mass: 292.0211188

Carboxyphosphamide

3-({amino[bis(2-chloroethyl)amino]phosphoryl}oxy)propanoic acid

In contrast to previous adult studies on urinary metabolites, plasma carboxyphosphamide concentrations did not support the existence of polymorphic metabolism. Plasma concentrations of dechlorethylcyclophosphamide and carboxyphosphamide were correlated in individual patients, suggesting that the activity of both aldehyde dehydrogenase and cytochrome P450 enzyme(s) determine carboxyphosphamide production in vivo. (PMID: 7850793) Detoxification of cyclophosphamide is effected, in part, by hepatic class 1 aldehyde dehydrogenase (ALDH-1)-catalyzed oxidation of aldophosphamide, a pivotal aldehyde intermediate, to the nontoxic metabolite, carboxyphosphamide. (PMID: 9394035) A key finding was the detection of a metabolite, most likely carboxyphosphamide, that is formed only by cytosols from cells expressing either class 3 or class 1 ALDH. (PMID: 8662659) D000970 - Antineoplastic Agents > D018906 - Antineoplastic Agents, Alkylating > D009588 - Nitrogen Mustard Compounds D000970 - Antineoplastic Agents > D018906 - Antineoplastic Agents, Alkylating > D010752 - Phosphoramide Mustards

Carboxyifosfamide

3-({Bis[(2-chloroethyl)amino]phosphoryl}oxy)propanoic acid

Carboxyifosfamide is a metabolite of ifosfamide. Ifosfamide (also marketed as Mitoxana and Ifex) is a nitrogen mustard alkylating agent used in the treatment of cancer. It is sometimes abbreviated IFO. (Wikipedia) D000970 - Antineoplastic Agents > D018906 - Antineoplastic Agents, Alkylating > D009588 - Nitrogen Mustard Compounds D000970 - Antineoplastic Agents > D018906 - Antineoplastic Agents, Alkylating > D010752 - Phosphoramide Mustards

Bis(4-isothiocyanatobutyl) disulfide

1-Isothiocyanato-4-[(4-isothiocyanatobutyl)disulphanyl]butane

C10H16N2S4 (292.0196296)

Bis(4-isothiocyanatobutyl) disulfide is found in brassicas. Bis(4-isothiocyanatobutyl) disulfide is a constituent of salad rocket (Eruca sativa) Constituent of salad rocket (Eruca sativa). Bis(4-isothiocyanatobutyl) disulfide is found in brassicas.

Citreovirone

5,5-dichloro-4-Hydroxy-1-(3-hydroxy-5-methoxyphenyl)-2-pentanone, 9ci

Citreovirone is a mycotoxin produced by the rice storage mould Penicillium citreo-viride. Mycotoxin production by the rice storage mould Penicillium citreo-viride.

2-Hydroxychlorpropamide

N-(4-Chloro-2-hydroxybenzenesulphonyl)propane-1-carbamimidic acid

2-Hydroxychlorpropamide is a metabolite of Chlorpropamide. 2-hydroxychlorpropamide belongs to the family of Benzenesulfonamides. These are organic compounds containing a sulfonamide group that is S-linked to a benzene ring.

3-Hydroxychlorpropamide

N-(4-Chloro-3-hydroxybenzenesulphonyl)propane-1-carbamimidic acid

3-Hydroxychlorpropamide is only found in individuals that have used or taken Chlorpropamide. 3-Hydroxychlorpropamide is a metabolite of Chlorpropamide. 3-hydroxychlorpropamide belongs to the family of Benzenesulfonamides. These are organic compounds containing a sulfonamide group that is S-linked to a benzene ring.

4-Hydroperoxycyclophosphamide

2-(Bis(2-chloroethyl)amino)tetrahydro-2-oxideo-2H-1,3,2-oxazaphosphorin-4-yl hydroperoxide

Brevifolincarboxylic acid

7,8,9-trihydroxy-3,5-dioxo-1H,2H,3H,5H-cyclopenta[c]isochromene-1-carboxylic acid

C13H8O8 (292.0219168)

Brevifolincarboxylic acid belongs to isocoumarins and derivatives class of compounds. Those are polycyclic compounds containing an isochromane which bears a ketone at the carbon C1. Brevifolincarboxylic acid is slightly soluble (in water) and a moderately acidic compound (based on its pKa). Brevifolincarboxylic acid can be found in pomegranate, which makes brevifolincarboxylic acid a potential biomarker for the consumption of this food product. Brevifolincarboxylic acid is extracted from Polygonum capitatum[1], has inhibitory effect on the aryl hydrocarbon receptor (AhR)[2]. Brevifolincarboxylic acid is an α-glucosidase inhibitor with an IC50 of 323.46 μM[3]. Brevifolincarboxylic acid is extracted from Polygonum capitatum[1], has inhibitory effect on the aryl hydrocarbon receptor (AhR)[2]. Brevifolincarboxylic acid is an α-glucosidase inhibitor with an IC50 of 323.46 μM[3].

Brevifolincarboxylic acid

InChI=1/C13H8O8/c14-5-2-4-7(10(17)9(5)16)8-3(12(18)19)1-6(15)11(8)21-13(4)20/h2-3,14,16-17H,1H2,(H,18,19)

C13H8O8 (292.0219168)

Brevifolincarboxylic acid is a natural product found in Melaleuca leucadendra, Euphorbia maculata, and other organisms with data available. Brevifolincarboxylic acid is extracted from Polygonum capitatum[1], has inhibitory effect on the aryl hydrocarbon receptor (AhR)[2]. Brevifolincarboxylic acid is an α-glucosidase inhibitor with an IC50 of 323.46 μM[3]. Brevifolincarboxylic acid is extracted from Polygonum capitatum[1], has inhibitory effect on the aryl hydrocarbon receptor (AhR)[2]. Brevifolincarboxylic acid is an α-glucosidase inhibitor with an IC50 of 323.46 μM[3].

Brevifolincarboxylic

InChI=1/C13H8O8/c14-5-2-4-7(10(17)9(5)16)8-3(12(18)19)1-6(15)11(8)21-13(4)20/h2-3,14,16-17H,1H2,(H,18,19)

C13H8O8 (292.0219168)

2-acetoxy-4-[2,2]bithiophenyl-5-yl-but-3-yn-1-ol|5-(3-acetoxy-4-hydroxy-1-butynyl)-2,2-bithiophene|5-(4-Hydroxy-3-acetoxybutin-1-yl)-bithienyl-2,2

7-Chlornorlichexanthone

2-Chloronorlichexanthone

7-Chloronorlichexanthone

4-Chloro-N-[(2-hydroxypropyl)carbamoyl]benzenesulfonamide

2-Hydroxychlorpropamide

NSC 652287

5,5-(2,5-furandiyl)bis-2-thiophenemethanol

RITA is an inhibitor of p53-HDM-2 interaction, binds to p53dN, with a Kd of 1.5 nM, and also induces DNA-DNA cross-links.

3-Hydroxychlorpropamide

4-chloro-3-hydroxy-N-(propylcarbamoyl)benzenesulfonamide

Citreovirone

5,5-dichloro-4-Hydroxy-1-(3-hydroxy-5-methoxyphenyl)-2-pentanone, 9ci

bis(4-isothiocyanatobutyl) disulfide

1-isothiocyanato-4-[(4-isothiocyanatobutyl)disulfanyl]butane

C10H16N2S4 (292.0196296)

2-ETHOXY-5-(3-METHYL-UREIDO)-BENZENESULFONYL CHLORIDE

C11H8ClF3N2O2 (292.02263739999995)

ethyl 8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carboxylate

2-chloro-N,N-diethyl-5-nitrobenzenesulfonamide

Ethyl perfluoropentanoate

C7H5F9O2 (292.0145818)

1-(4-BROMOPHENYL)-4-1H-IMIDAZOL-1-YL-BUTANONE

C13H13BrN2O (292.0211188)

6-BROMO-N-(4-METHOXYBENZYL)PYRIDIN-2-AMINE

C13H13BrN2O (292.0211188)

ETHYL [2-METHYL-3-(CHLOROSULFONYL)PHENOXY]ACETATE

C11H13ClO5S (292.0172198)

(7-CHLOROTHIAZOLO[5,4-D]PYRIMIDIN-2-YL)-(4-METHOXYPHENYL)AMINE

C12H9ClN4OS (292.0185574)

2-((4-CHLORO-2-NITROPHENYL)AMINO)BENZOIC ACID

C13H9ClN2O4 (292.0250824)

3,5-Bis(Trifluoromethyl)Benzamidine Hydrochloride

C9H7ClF6N2 (292.0201924)

4-Hydroperoxycyclophosphamide

4-Hydroperoxy cyclophosphamide

A phosphorodiamide that is the active metabolite of the nitrogen mustard cyclophosphamide. It has potent antineoplastic and immunosuppressive properties. D000970 - Antineoplastic Agents > D018906 - Antineoplastic Agents, Alkylating > D009588 - Nitrogen Mustard Compounds D000970 - Antineoplastic Agents > D018906 - Antineoplastic Agents, Alkylating > D010752 - Phosphoramide Mustards

4-nitro-5-piperazin-1-ylthiophene-2-sulfonamide

C8H12N4O4S2 (292.0299952)

2H-1,3,2-Oxazaphosphorin-2-amine,N,3-bis(2-chloroethyl)tetrahydro-4-hydroperoxy-, 2-oxide

ETHYL 5-CHLORO-2-METHYL-4-SULFAMOYLPHENYLCARBAMATE

(2,3,4,5,6-pentafluorophenyl) 2-methylpyrazole-3-carboxylate

C11H5F5N2O2 (292.027117)

4-PROPYL-4-BROMO-3-FLUOROBIPHENYL

C15H14BrF (292.0262836)

2-(4-AMINO-3-CHLORO-PHENYL)-4-CHLORO-3H-BENZOIMIDAZOL-5-YLAMINE

C13H10Cl2N4 (292.028248)

dimethyl 3-(4-chlorophenoxy)-2-oxopropylphosphonate

C11H14ClO5P (292.0267354)

Toluidine bule

C10H11AsN5O (292.0179516)

2-Chloro-N-(4-hydroxyphenyl)-5-nitrobenzamide

C13H9ClN2O4 (292.0250824)

4-chloro-n,n-diethyl-3-nitrobenzenesulfonamide

C11H8ClF3N2O2 (292.02263739999995)

Dimethyl [3-(3-chlorophenoxy)-2-oxopropyl]phosphonate

C11H14ClO5P (292.0267354)

2-DIAZO-1-NAPHTHOL-5-SULFONIC ACID SOD&

C10H9N2NaO5S (292.0129864)

ethyl 6-chloro-2-(trifluoroMethyl)-1H-pyrrolo[2,3-b]pyridine-3-carboxylate

(3,5-Dichloro-2,4,6-trihydroxyphenyl)hexan-1-one

An aromatic ketone that is phloroglucinol in which two of the hydrogens attached to the benzene ring have been replaced by chlorines while the third has been replaced by a hexanoyl group. It is the immediate biosynthetic precursor for differentiation-inducing factor 1 (DIF-1). DIF-1 is released by developing Dictyostelium amoebae, inducing them to differentiate into stalk cells.

2-Chloro-3,6,8-trihydroxy-1-methyl-9H-xanthen-9-one

1-(3,5-Dichloro-2,6-dihydroxy-4-methoxyphenyl)pentan-1-one

A differentiation-inducing factor that is pentaphenone bearing two chloro substituents at positions 3 and 5, two hydroxy substituents at positions 2 and 6 as well as a single methoxy substituent at position 4. A secreted, chlorinated molecule that controls cell fate during development of Dictyostelium cells.

2-chloro-N-(pyrimidin-2-ylcarbamothioyl)benzamide

C12H9ClN4OS (292.0185574)

2-{5-[2-(Phenylthio)acetyl]-2-thienyl}acetic acid

Perfosfamide

D000970 - Antineoplastic Agents > D018906 - Antineoplastic Agents, Alkylating > D009588 - Nitrogen Mustard Compounds D000970 - Antineoplastic Agents > D018906 - Antineoplastic Agents, Alkylating > D010752 - Phosphoramide Mustards C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C2842 - DNA Binding Agent

Pergamid (TN)

RITA (NSC 652287)

[5-[5-[5-(Hydroxymethyl)thiophen-2-yl]furan-2-yl]thiophen-2-yl]methanol