Exact Mass: 274.0158

Exact Mass Matches: 274.0158

Found 69 metabolites which its exact mass value is equals to given mass value 274.0158, within given mass tolerance error 0.01 dalton. Try search metabolite list with more accurate mass tolerance error 0.001 dalton.

D-Glucuronic acid 1-phosphate

1-phospho-alpha-D-galacturonic acid

C6H11O10P (274.009)

KEIO_ID G066

6-phospho-2-dehydro-D-gluconate

6-Phospho-2-dehydro-D-gluconate; 2-Dehydro-D-gluconate 6-phosphate

C6H11O10P (274.009)

A ketoaldonic acid phosphate that is the 6-phospho derivative of 2-dehydro-D-gluconic acid.

3-Dehydro-L-gulonate 6-phosphate

2,4,5-Trihydroxy-3-oxo-6-phosphonooxyhexanoic acid

C6H11O10P (274.009)

3-Dehydro-L-gulonate 6-phosphate is an intermediate in the metabolic pathways of glucose metabolism. Its chemical structure is characterized by a hexose sugar backbone with specific modifications. The "3-Dehydro" part of its name indicates the presence of a double bond at the third carbon atom due to the removal of two hydrogen atoms, which differentiates it from the corresponding sugar. The "L-gulonate" portion refers to its derivation from L-gulonic acid, a sugar acid. The "6-phosphate" indicates the presence of a phosphate group attached to the sixth carbon atom of the sugar. Biologically, 3-Dehydro-L-gulonate 6-phosphate plays a role in the metabolism of glucose. It is involved in the process of gluconeogenesis, which is the synthesis of glucose from non-carbohydrate sources, such as amino acids and glycerol. This pathway is particularly important during periods of fasting or low carbohydrate intake, where the body needs to maintain blood glucose levels for energy production. Additionally, 3-Dehydro-L-gulonate 6-phosphate may also be involved in other metabolic pathways, including the pentose phosphate pathway, which is important for the production of NADPH (an important reducing agent in the cell) and ribose-5-phosphate (a precursor for nucleotide synthesis). In summary, 3-Dehydro-L-gulonate 6-phosphate is a chemically modified sugar phosphate that serves as an intermediate in various metabolic pathways, particularly in the synthesis and breakdown of glucose. Its presence and regulation are crucial for maintaining energy balance and providing necessary building blocks for cellular processes in living organisms.

D-Glucuronic acid 1-phosphate

(2S,3S,4S,5R,6R)-3,4,5-trihydroxy-6-(phosphonooxy)oxane-2-carboxylic acid

C6H11O10P (274.009)

D-Glucuronic acid 1-phosphate is an end product of the UDP-glucuronic acid pathway. Formation of free glucuronic acid from UDP-glucuronic acid can be considered as the first step in the synthesis of vitamin C, a pathway that occurs in most vertebrates, although not in guinea pigs and primates, including humans. Free glucuronic acid can also be converted to pentose phosphate intermediates via the pentose pathway. The latter is interrupted in subjects with pentosuria, who have a deficiency in l-xylulose reductase (EC 1.1.1.10, an enzyme that belongs to the short-chain dehydrogenase/reductase family) and excrete abnormal amounts of l-xylulose. Some xenobiotics stimulate the formation of vitamin C in animals and enhance the excretion of l-xylulose in humans with pentosuria and have shown that aminopyrine, metyrapone and other xenobiotics cause an almost instantaneous increase in the conversion of UDP-glucuronic acid to glucuronic acid. It is usually stated that glucuronic acid formation from UDP-glucuronic acid is the result of two successive reactions comprising the hydrolysis of UDP-glucuronic acid to glucuronic acid 1-phosphate and UMP by nucleotide pyrophosphatase (E-NPP3, EC 3.6.1.9), followed by dephosphorylation of glucuronic acid 1-phosphate. Glucuronidation is responsible for conjugating potentially toxic lipophilic compounds with glucuronic acid, thereby producing molecules with greater aqueous solubility that is excreted more readily into urine and bile. The rate at which any compound may be glucuronidated depends on the concentration and activity of the UDP-glucuronosyltransferases as well as the concentration of the cofactor UDP-glucuronic acid. UDP-glucuronic acid is formed after oxidation of UDP-glucose by UDP-glucose dehydrogenase (UGDH, EC 1.1.1.22) with NAD as the electron acceptor. UDP-glucuronic acid may then be either used as the glucuronic acid donor for xenobiotic conjugation reactions by UDPglucuronosyltransferases (GlcAT-P, EC 2.4.1.17), or degraded to D-glucuronic acid 1-phosphate after the phosphodiester bond is cleaved by E-NPP3. E-NPP3 is the same enzyme that further reduces D-Glucuronic acid 1-phosphate to free D-glucuronic acid. Decreases in UDP-glucuronic acid concentration may be due to reduced availability of UDP-glucose or decreased UGDH activity or to increased activities of GlcAT-P or E-NPP3. Exposure to volatile anesthetics reduces hepatic UDP-glucuronic acid concentrations, and alters the rate of conjugation of compounds such as acetaminophen, bilirubin, diethylstilbestrol, iopanoic acid and valproic acid in a non-sex-dependent fashion in experimental mice. The depletion of UDP-glucuronic acid by anesthetics is caused by altered activity of microsomal E-NPP3. (PMID: 2167093, 16689937, 1276) [HMDB] D-Glucuronic acid 1-phosphate is an end product of the UDP-glucuronic acid pathway. Formation of free glucuronic acid from UDP-glucuronic acid can be considered as the first step in the synthesis of vitamin C, a pathway that occurs in most vertebrates, although not in guinea pigs and primates, including humans. Free glucuronic acid can also be converted to pentose phosphate intermediates via the pentose pathway. The latter is interrupted in subjects with pentosuria, who have a deficiency in l-xylulose reductase (EC 1.1.1.10, an enzyme that belongs to the short-chain dehydrogenase/reductase family) and excrete abnormal amounts of l-xylulose. Some xenobiotics stimulate the formation of vitamin C in animals and enhance the excretion of l-xylulose in humans with pentosuria and have shown that aminopyrine, metyrapone and other xenobiotics cause an almost instantaneous increase in the conversion of UDP-glucuronic acid to glucuronic acid. It is usually stated that glucuronic acid formation from UDP-glucuronic acid is the result of two successive reactions comprising the hydrolysis of UDP-glucuronic acid to glucuronic acid 1-phosphate and UMP by nucleotide pyrophosphatase (E-NPP3, EC 3.6.1.9), followed by dephosphorylation of glucuronic acid 1-phosphate. Glucuronidation is responsible for conjugating potentially toxic lipophilic compounds with glucuronic acid, thereby producing molecules with greater aqueous solubility that is excreted more readily into urine and bile. The rate at which any compound may be glucuronidated depends on the concentration and activity of the UDP-glucuronosyltransferases as well as the concentration of the cofactor UDP-glucuronic acid. UDP-glucuronic acid is formed after oxidation of UDP-glucose by UDP-glucose dehydrogenase (UGDH, EC 1.1.1.22) with NAD as the electron acceptor. UDP-glucuronic acid may then be either used as the glucuronic acid donor for xenobiotic conjugation reactions by UDPglucuronosyltransferases (GlcAT-P, EC 2.4.1.17), or degraded to D-glucuronic acid 1-phosphate after the phosphodiester bond is cleaved by E-NPP3. E-NPP3 is the same enzyme that further reduces D-Glucuronic acid 1-phosphate to free D-glucuronic acid. Decreases in UDP-glucuronic acid concentration may be due to reduced availability of UDP-glucose or decreased UGDH activity or to increased activities of GlcAT-P or E-NPP3. Exposure to volatile anesthetics reduces hepatic UDP-glucuronic acid concentrations, and alters the rate of conjugation of compounds such as acetaminophen, bilirubin, diethylstilbestrol, iopanoic acid and valproic acid in a non-sex-dependent fashion in experimental mice. The depletion of UDP-glucuronic acid by anesthetics is caused by altered activity of microsomal E-NPP3. (PMID: 2167093, 16689937, 1276).

Ferulic acid 4-sulfate

2-Propenoic acid, 3-[3-methoxy-4-(sulfooxy)phenyl]-, (2E)-

C10H10O7S (274.0147)

Ferulic acid 4-O-sulfate (CAS: 86321-29-1) is a phenolic acid metabolite. It is also a coffee metabolite found in blood or urine. Ferulic acid 4-O-sulfate was found to be elevated in rat urine after whole rye consumption which makes this compound a potential urinary biomarker of whole grain intake (PMID: 26862900). A polyphenol metabolite detected in biological fluids [PhenolExplorer]

Isoferulic acid 3-sulfate

(2E)-3-[4-Methoxy-3-(sulphooxy)phenyl]prop-2-enoic acid

C10H10O7S (274.0147)

Isoferulic acid 3-sulfate is a polyphenol metabolite detected in biological fluids (PMID: 20428313).

cis-Ferulic acid 4-sulfate

3-[3-Methoxy-4-(sulphooxy)phenyl]prop-2-enoic acid

C10H10O7S (274.0147)

MEGxm0_000399

C11H11ClO6 (274.0244)

dimethyl 5-sulphoisophthalate

1,3-dimethyl 5-sulfoisophthalate

C10H10O7S (274.0147)

CONFIDENCE standard compound; INTERNAL_ID 2311

(1R,6R,9S,10S)-9-Chloro-10-hydroxy-8-methoxycarbonyl-4-methylene-2,5-dioxabicyclo<4.4.0>dec-3-one-7-ene|(1R,6R,9S,10S)-9-Chloro-10-hydroxy-8-methoxycarbonyl-4-methylene-2,5-dioxabicyclo[4.4.0]dec-3-one-7-ene

(1R,6R,9S,10S)-9-Chloro-10-hydroxy-8-methoxycarbonyl-4-methylene-2,5-dioxabicyclo<4.4.0>dec-3-one-7-ene|(1R,6R,9S,10S)-9-Chloro-10-hydroxy-8-methoxycarbonyl-4-methylene-2,5-dioxabicyclo[4.4.0]dec-3-one-7-ene

C11H11ClO6 (274.0244)