Exact Mass: 227.1521
Exact Mass Matches: 227.1521
Found 55 metabolites which its exact mass value is equals to given mass value 227.1521,
within given mass tolerance error 0.001 dalton. Try search metabolite list with more accurate mass tolerance error
0.0002 dalton.
N-Octanoyl-L-homoserine lactone
N-(2-oxooxolan-3-yl)octanimidic acid belongs to the class of organic compounds known as n-acyl-alpha amino acids and derivatives. N-acyl-alpha amino acids and derivatives are compounds containing an alpha amino acid (or a derivative thereof) which bears an acyl group at its terminal nitrogen atom. Based on a literature review very few articles have been published on N-(2-oxooxolan-3-yl)octanimidic acid. This compound has been identified in human blood as reported by (PMID: 31557052 ). Octanoyl-l-homoserine lactone is not a naturally occurring metabolite and is only found in those individuals exposed to this compound or its derivatives. Technically Octanoyl-L-homoserine lactone is part of the human exposome. The exposome can be defined as the collection of all the exposures of an individual in a lifetime and how those exposures relate to health. An individual's exposure begins before birth and includes insults from environmental and occupational sources. N-Octanoyl-L-homoserine lactone (OHL) is an important signaling molecule used by many bacteria in a process known as quorum sensing (QS). This process allows bacteria to communicate with each other and coordinate their behavior based on population density. Here are some of the key biological functions of OHL: 1. **Quorum Sensing Signaling**: As a quorum sensing autoinducer, OHL plays a critical role in regulating gene expression in response to changes in cell population density. When the concentration of OHL reaches a certain threshold, it binds to specific receptors, triggering a cascade of cellular responses. 2. **Regulation of Virulence Factors**: In many pathogenic bacteria, OHL is involved in the regulation of virulence factors, which are molecules or proteins that enhance the bacterium's ability to cause disease. By controlling the expression of these factors, OHL can significantly influence the pathogenicity of the bacteria. 3. **Biofilm Formation and Regulation**: Biofilms are structured communities of bacteria that are often encased in a self-produced matrix. OHL can play a role in the initiation, development, and maintenance of biofilms. Biofilms are associated with increased resistance to antibiotics and immune system evasion, making them a significant concern in medical and industrial settings. 4. **Cell Motility and Swarm Behavior**: In some bacteria, OHL is involved in regulating cell motility, which includes the ability to move towards or away from certain stimuli. This can affect the bacteria's ability to colonize new areas or to form biofilms. 5. **Symbiotic Interactions**: OHL is not only important in pathogenic bacteria but also in beneficial interactions, such as those found in nitrogen-fixing bacteria or in symbiotic relationships with plants and animals. Understanding the role of OHL and other quorum sensing molecules is crucial for developing new strategies to control bacterial infections, manage biofilm-related issues, and potentially exploit these systems for beneficial purposes.
C8-homoserine lactone
CONFIDENCE standard compound; INTERNAL_ID 203
