Exact Mass: 152.0222

Mercaptopurine

C5H4N4S (152.0157)

Mercaptopurine is only found in individuals that have used or taken this drug. It is an antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia. [PubChem]Mercaptopurine competes with hypoxanthine and guanine for the enzyme hypoxanthine-guanine phosphoribosyltransferase (HGPRTase) and is itself converted to thioinosinic acid (TIMP). This intracellular nucleotide inhibits several reactions involving inosinic acid (IMP), including the conversion of IMP to xanthylic acid (XMP) and the conversion of IMP to adenylic acid (AMP) via adenylosuccinate (SAMP). In addition, 6-methylthioinosinate (MTIMP) is formed by the methylation of TIMP. Both TIMP and MTIMP have been reported to inhibit glutamine-5-phosphoribosylpyrophosphate amidotransferase, the first enzyme unique to the de novo pathway for purine ribonucleotide synthesis. Experiments indicate that radiolabeled mercaptopurine may be recovered from the DNA in the form of deoxythioguanosine. Some mercaptopurine is converted to nucleotide derivatives of 6-thioguanine (6-TG) by the sequential actions of inosinate (IMP) dehydrogenase and xanthylate (XMP) aminase, converting TIMP to thioguanylic acid (TGMP). L - Antineoplastic and immunomodulating agents > L01 - Antineoplastic agents > L01B - Antimetabolites > L01BB - Purine analogues C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C272 - Antimetabolite D004791 - Enzyme Inhibitors > D019384 - Nucleic Acid Synthesis Inhibitors D007155 - Immunologic Factors > D007166 - Immunosuppressive Agents C308 - Immunotherapeutic Agent > C574 - Immunosuppressant D009676 - Noxae > D000963 - Antimetabolites D000970 - Antineoplastic Agents

S-Methyl benzenecarbothioate

C8H8OS (152.0296)

S-Methyl benzenecarbothioate is a flavouring agent for food Flavouring agent for foods

S-Phenyl thioacetate

C8H8OS (152.0296)

9-Sulfanylpurine

C5H4N4S (152.0157)

Phenyl vinyl sulfoxide

C8H8OS (152.0296)

(4-chloro-phenyl)-carbamonitrile|(4-chlorophenyl)cyanamide|4-chlorophenyl cyanamide|4-chlorophenylcyanamide|4-Cl-pcyd-H|4-ClpcydH|N-(4-chlorophenyl)cyanamide

C7H5ClN2 (152.0141)

4-methoxybenzenecarbothialdehyde

C8H8OS (152.0296)

mercaptopurine

C5H4N4S (152.0157)

L - Antineoplastic and immunomodulating agents > L01 - Antineoplastic agents > L01B - Antimetabolites > L01BB - Purine analogues C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C272 - Antimetabolite D004791 - Enzyme Inhibitors > D019384 - Nucleic Acid Synthesis Inhibitors D007155 - Immunologic Factors > D007166 - Immunosuppressive Agents C308 - Immunotherapeutic Agent > C574 - Immunosuppressant D009676 - Noxae > D000963 - Antimetabolites D000970 - Antineoplastic Agents CONFIDENCE standard compound; INTERNAL_ID 2786 KEIO_ID M054

6-Mercaptopurine

C5H4N4S (152.0157)

2-Mercaptopurine

C5H4N4S (152.0157)

Methyl thiobenzoate

C8H8OS (152.0296)

Furo[3,2-d]pyrimidine-2,4-diol

C6H4N2O3 (152.0222)

Cyclopropyl 2-thienyl ketone

C8H8OS (152.0296)

3-(Trifluoromethyl)-5-pyrazolone

C4H3F3N2O (152.0197)

Tisopurine

C5H4N4S (152.0157)

M - Musculo-skeletal system > M04 - Antigout preparations > M04A - Antigout preparations > M04AA - Preparations inhibiting uric acid production D018501 - Antirheumatic Agents > D006074 - Gout Suppressants C471 - Enzyme Inhibitor > C1637 - Xanthine Oxidase Inhibitor C26170 - Protective Agent > C921 - Uricosuric Agent

1,4-dichlorocyclohexane

C6H10Cl2 (152.016)

4-amino-2-mercaptopyrimidine-5-carbonitrile

C5H4N4S (152.0157)

4H-1-OXA-3,4-DIAZA-PENTALENE-5-CARBOXYLIC ACID

C6H4N2O3 (152.0222)

3-(Methylsulfanyl)benzaldehyde

C8H8OS (152.0296)

2-(METHYLTHIO)BENZALDEHYDE

C8H8OS (152.0296)

S-Phenyl thioacetate

C8H8OS (152.0296)

3-(Methylsulfonyl)propanoic acid

C4H8O4S (152.0143)

2-Amino-6-chlorobenzonitrile

C7H5ClN2 (152.0141)

7-Chloro-1H-pyrrolo[3,2-c]pyridine

C7H5ClN2 (152.0141)

7-Chloroimidazo[1,2-a]pyridine

C7H5ClN2 (152.0141)

Benzeneacetaldehyde,4-fluoro-a-oxo-

C8H5FO2 (152.0274)

1-chlorobenzimidazole

C7H5ClN2 (152.0141)

3-(Trifluoromethyl)isoxazol-5-amine

C4H3F3N2O (152.0197)

5-Chloroimidazo[1,2-a]Pyridine

C7H5ClN2 (152.0141)

4-Chloro-1H-pyrrolo[2,3-b]pyridine

C7H5ClN2 (152.0141)

2-(Chloromethoxy)ethyl acetate

C5H9ClO3 (152.024)

6-Chloro-7-azaindole

C7H5ClN2 (152.0141)

cis-1,2-dichlorocyclohexane

C6H10Cl2 (152.016)

5-(3-THIENYL)-2H-1,2,3,4-TETRAZOLE

C5H4N4S (152.0157)

(6-Chloro-3-pyridinyl)acetonitrile

C7H5ClN2 (152.0141)

2-Chloro-pyrazolo[1,5-a]pyridine

C7H5ClN2 (152.0141)

5-Chloro-4-azaindole

C7H5ClN2 (152.0141)

8-Mercaptopurine

C5H4N4S (152.0157)

3-Chloro-1H-indazole

C7H5ClN2 (152.0141)

5-Chloro-1H-benzimidazole

C7H5ClN2 (152.0141)

3-Chloro-1H-pyrrolo[3,2-c]pyridine

C7H5ClN2 (152.0141)

2-(5-chloropyridin-2-yl)acetonitrile

C7H5ClN2 (152.0141)

6,7-Dihydro-1-benzothiophen-4(5H)-one

C8H8OS (152.0296)

6-Chloroimidazo[1,2-a]pyridine

C7H5ClN2 (152.0141)

2-ethylsulfonylacetic acid

C4H8O4S (152.0143)

Methyl 4-chloro-3-hydroxybutanoate

C5H9ClO3 (152.024)

4-(2-Thienyl)but-3-en-2-one

C8H8OS (152.0296)

4-(Trifluoromethyl)-1,3-oxazol-2-amine

C4H3F3N2O (152.0197)

6-Chloro-1H-indazole

C7H5ClN2 (152.0141)

4-Amino-2-chlorobenzonitrile

C7H5ClN2 (152.0141)

Methyl (2-chloroethoxy)acetate

C5H9ClO3 (152.024)

2-ethoxyethyl carbonochloridate

C5H9ClO3 (152.024)

6-FLUOROISOBENZOFURAN-1(3H)-ONE

C8H5FO2 (152.0274)

4-Chloro-1H-pyrrolo[3,2-c]pyridine

C7H5ClN2 (152.0141)

7-Fluorobenzofuran-3(2H)-one

C8H5FO2 (152.0274)

(methylthio)benzaldehyde

C8H8OS (152.0296)

THIOETHANOLAMINE

C5H9ClO3 (152.024)

Chloromethyl isopropyl carbonate

C5H9ClO3 (152.024)

5-Chloro-7-azaindole

C7H5ClN2 (152.0141)

3-chloro-1H-pyrrolo[3,2-b]pyridine

C7H5ClN2 (152.0141)

3-Methylphosphinicopropionic Acid

C4H9O4P (152.0238)

5-(trifluoromethyl)-1,3-oxazol-2-amine

C4H3F3N2O (152.0197)

Methyl Methanesulfonylacetate

C4H8O4S (152.0143)

5-FLUOROISOPHTHALALDEHYDE

C8H5FO2 (152.0274)

5-Chloroindazole

C7H5ClN2 (152.0141)

3-Chloro-7-azaindole

C7H5ClN2 (152.0141)

tetramethylene phosphate

C4H9O4P (152.0238)

2-Chloro-6-methylnicotinonitrile

C7H5ClN2 (152.0141)

6-(Chloromethyl)nicotinonitrile

C7H5ClN2 (152.0141)

2-(2-chloropyridin-4-yl)acetonitrile

C7H5ClN2 (152.0141)

5-NITRONICOTINALDEHYDE

C6H4N2O3 (152.0222)

6-Fluoro-1-benzofuran-3(2H)-one

C8H5FO2 (152.0274)

4-fluorophthalaldehyde

C8H5FO2 (152.0274)

5-FLUORO-7-HYDROXYBENZOFURAN

C8H5FO2 (152.0274)

2H-Tetrazole,5-(2-thienyl)-

C5H4N4S (152.0157)

7-Chloro-4-azaindole

C7H5ClN2 (152.0141)

5,6-dihydro-1-benzothiophen-7(4H)-one

C8H8OS (152.0296)

(Vinylsulfinyl)benzene

C8H8OS (152.0296)

2-Chloro-5-methylnicotinonitrile

C7H5ClN2 (152.0141)

Acetic acid, 2-chloro-,2-methoxyethyl ester

C5H9ClO3 (152.024)

4-chloro-1H-pyrrolo[2,3-c]pyridine

C7H5ClN2 (152.0141)

(2-Chloro-3-pyridinyl)acetonitrile

C7H5ClN2 (152.0141)

6-CHLORO-4-METHYLNICOTINONITRILE

C7H5ClN2 (152.0141)

3-Amino-4-chlorobenzonitrile

C7H5ClN2 (152.0141)

3-(chloromethyl)pyridine-2-carbonitrile

C7H5ClN2 (152.0141)

5-(Trifluoromethyl)-1,2-oxazol-3-amine

C4H3F3N2O (152.0197)

4-(chloromethyl)pyridine-2-carbonitrile

C7H5ClN2 (152.0141)

3-Amino-5-chlorobenzonitrile

C7H5ClN2 (152.0141)

Thiazolo[4,5-d]pyrimidine,2-amino- (5CI)

C5H4N4S (152.0157)

3-CHLOROIMIDAZO[1,2-A]PYRIDINE

C7H5ClN2 (152.0141)

trans-1,2-Dichlorocyclohexane

C6H10Cl2 (152.016)

6-Chloro-1H-pyrrolo[3,2-b]pyridine

C7H5ClN2 (152.0141)

[1,3]Thiazolo[5,4-d]pyrimidin-2-amine

C5H4N4S (152.0157)

2-Chloro-5-cyano-3-picoline

C7H5ClN2 (152.0141)

3-nitropyridine-2-carbaldehyde

C6H4N2O3 (152.0222)

dl-tartaric-2,3-d2 acid

C4H4D2O6 (152.029)

6-chloro-2-methylnicotinonitrile

C7H5ClN2 (152.0141)

Isothiazolo[4,5-b]pyrazin-3-amine

C5H4N4S (152.0157)

7-Chloro-1H-pyrrolo[2,3-c]pyridine

C7H5ClN2 (152.0141)

2-Chloro-4-methylpyridine-3-carbonitrile

C7H5ClN2 (152.0141)

1-Chloropyrrolo[1,2-a]pyrazine

C7H5ClN2 (152.0141)

4-(chloromethyl)pyridine-3-carbonitrile

C7H5ClN2 (152.0141)

7-chloro-1H-indazole

C7H5ClN2 (152.0141)

2-Chlorobenzimidazole

C7H5ClN2 (152.0141)

5-Chloro-3-ethynylpyridin-2-amine

C7H5ClN2 (152.0141)

3-(Trifluoromethyl)-1H-1,2,4-triazol-5-amine

C3H3F3N4 (152.031)

6-Chloro-3-Methylpicolinonitrile

C7H5ClN2 (152.0141)

6-CHLORO-5-METHYLPICOLINONITRILE

C7H5ClN2 (152.0141)

1,2,4]TRIAZOLO[1,5-A]PYRIMIDINE-2-THIOL

C5H4N4S (152.0157)

3-CHLORO-6-METHYLPICOLINONITRILE

C7H5ClN2 (152.0141)

(3-Chloro-4-pyridinyl)acetonitrile

C7H5ClN2 (152.0141)

5-Fluorobenzofuran-3(2H)-one

C8H5FO2 (152.0274)

4-Amino-3-chlorobenzonitrile

C7H5ClN2 (152.0141)

2-Amino-5-chlorobenzonitrile

C7H5ClN2 (152.0141)

1-Phenyl-2-sulfanylethanone

C8H8OS (152.0296)

6-CHLORO-4-METHYLPICOLINONITRILE

C7H5ClN2 (152.0141)

8-Chloroimidazo[1,2-a]pyridine

C7H5ClN2 (152.0141)

3-Amino-2-chlorobenzonitrile

C7H5ClN2 (152.0141)

1-Chloroethyl ethyl carbonate

C5H9ClO3 (152.024)

6-(Chloromethyl)-2-cyanopyridine

C7H5ClN2 (152.0141)

5-Chloro-1H-pyrrolo[2,3-c]pyridine

C7H5ClN2 (152.0141)

6-Chloro-5-Azaindole

C7H5ClN2 (152.0141)

3-Nitroisonicotinaldehyde

C6H4N2O3 (152.0222)

Thiazolo[5,4-d]pyrimidin-7-amine

C5H4N4S (152.0157)

4-Chloro-1H-indazole

C7H5ClN2 (152.0141)

(R)-4-Chloro-3-hydroxybutyric acid methyl ester

C5H9ClO3 (152.024)

4-chloro-6-methylnicotinonitrile

C7H5ClN2 (152.0141)

trans-1,4-dichlorocyclohexane

C6H10Cl2 (152.016)

2-Amino-4-Chlorobenzonitrile

C7H5ClN2 (152.0141)

4-Chloro-2-cyano-6-methylpyrimidine

C7H5ClN2 (152.0141)

4-Nitropicolinaldehyde

C6H4N2O3 (152.0222)

5-(2-FURYL)-1,3,4-OXADIAZOL-2(3H)-ONE

C6H4N2O3 (152.0222)

2-(2-METHOXYETHOXY)ACETYL CHLORIDE

C5H9ClO3 (152.024)

2-(Chloromethyl)nicotinonitrile

C7H5ClN2 (152.0141)

5-Nitropicolinaldehyde

C6H4N2O3 (152.0222)

5-Amino-2-chlorobenzonitrile

C7H5ClN2 (152.0141)

5-Fluoro-2-benzofuran-1(3H)-one

C8H5FO2 (152.0274)

Benzeneacetaldehyde, 2-fluoro-alpha-oxo- (9CI)

C8H5FO2 (152.0274)

(6-Chloro-2-pyridinyl)acetonitrile

C7H5ClN2 (152.0141)

2-Amino-3-chlorobenzonitrile

C7H5ClN2 (152.0141)

4-(Methylthio)benzaldehyde

C8H8OS (152.0296)

S-Methyl 4-chloro-3-hydroxybutyrate

C5H9ClO3 (152.024)

3-(Trifluoromethyl)-1H-pyrazol-5(4H)-one

C4H3F3N2O (152.0197)

Methyl 4,4-difluoro-3-oxobutanoate

C5H6F2O3 (152.0285)

5-chloro-2-ethynylpyridin-3-amine

C7H5ClN2 (152.0141)

1-Butyl phosphate

C4H9O4P-2 (152.0238)

Dithiobis(diaminomethylium)

C2H8N4S2+2 (152.019)

S-Methyl benzenecarbothioate

C8H8OS (152.0296)

2-hydroxy-2-methyl-1,2λ⁶-oxathiolane-2,5-dione

C4H8O4S (152.0143)