Exact Mass: 1447.5886578
Exact Mass Matches: 1447.5886578
Found 2 metabolites which its exact mass value is equals to given mass value 1447.5886578,
within given mass tolerance error 3.2E-7 dalton. Try search metabolite list with more accurate mass tolerance error
6.4E-8 dalton.
Sucralfate
Sucralfate is only found in individuals that have used or taken this drug. It is a basic aluminum complex of sulfated sucrose. [PubChem]Although sucralfates mechanism is not entirely understood, there are several factors that most likely contribute to its action. Sucralfate, with its strong negative charge, binds to exposed positively-charged proteins at the base of ulcers. In this way, it coats the ulcer and forms a physical barrier that protects the ulcer surface from further injury by acid and pepsin. It directly inhibits pepsin (an enzyme that breaks apart proteins) in the presence of stomach acid and binds bile salts coming from the liver via the bile thus protecting the stomach lining from injury caused by the bile acids. Sucralfate may increase prostaglandin production. Prostaglandins are known to protect the lining of the stomach and may also bind epithelial growth factor and fibroblast growth factor, both of which enhance the growth and repair mechanism of the stomach lining.
