Classification Term: 842

Pyridinylpiperazines (ontology term: CHEMONTID:0001976)

Compounds containing a pyridinylpiperazine skeleton, which consists of a pyridine linked (not fused) to a piperazine by a bond by a single bond that is not part of a ring." []

found 21 associated metabolites at category metabolite taxonomy ontology rank level.

Ancestor: Piperazines

Child Taxonomies: 5-piperazinylimidazo[1,2-a]pyridines , 6-piperazinylimidazo[1,2-a]pyridines , 7-piperazinylimidazo[1,2-a]pyridines , 8-piperazinylimidazo[1,2-a]pyridines

N-desalkyl delavirdine

N-{2-[4-(3-aminopyridin-2-yl)piperazine-1-carbonyl]-1H-indol-5-yl}methanesulfonamide

C19H22N6O3S (414.1474)

N-desalkyl delavirdine is a metabolite of delavirdine. Delavirdine (DLV) (brand name Rescriptor) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) marketed by ViiV Healthcare. It is used as part of highly active antiretroviral therapy (HAART) for the treatment of human immunodeficiency virus (HIV) type 1. It is presented as the mesylate. The recommended dosage is 400 mg, three times a day. Although delavirdine was approved by the U.S. (Wikipedia)

(R)-6-(3-Methylpiperazin-1-yl)nicotinonitrile

6-(3-methylpiperazin-1-yl)pyridine-3-carbonitrile

C11H14N4 (202.1218)

4-[[2-Methyl-2-[4-[5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]propanoyl]amino]adamantane-1-carboxamide

N-(5-(Aminocarbonyl)tricyclo(3.3.1.13,7)dec-2-yl)-alpha,alpha-dimethyl-4-(5-(trifluoromethyl)-2-pyridinyl)-1-piperazineacetamide

C25H34F3N5O2 (493.2664)

Atevirdine

N-ethyl-2-[4-(5-methoxy-1H-indole-2-carbonyl)piperazin-1-yl]pyridin-3-amine

C21H25N5O2 (379.2008)

Bctc

N-(4-Tert-butylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine-1(2H)-carboxamide

C20H25ClN4O (372.1717)

Bitopertin

1-[3-fluoro-5-(trifluoromethyl)pyridin-2-yl]-4-{5-methanesulfonyl-2-[(1,1,1-trifluoropropan-2-yl)oxy]benzoyl}piperazine

C21H20F7N3O4S (543.1063)

Blonanserin

2-(4-Ethyl-1-piperazinyl)-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta(b)pyridine

C23H30FN3 (367.2424)

C78272 - Agent Affecting Nervous System > C66885 - Serotonin Antagonist Blonanserin (AD-5423) is a potent?and orally active 5-HT2A?(Ki=0.812 nM) and?dopamine D2?receptor?(Ki =0.142?nM)?antagonist. Blonanserin is usually acts as an atypical antipsychotic?agent and can be used for the research of extrapyramidal symptoms, excessive?sedation, or?hypotension[1].

Blonanserin C

1-[4-(4-fluorophenyl)-5H,6H,7H,8H,9H,10H-cycloocta[b]pyridin-2-yl]piperazine

C21H26FN3 (339.2111)

Kaspar

8-{4-[4-(quinolin-2-yl)piperazin-1-yl]butyl}-8-azaspiro[4.5]decane-7,9-dione

C26H34N4O2 (434.2682)

(S)-1-(Sec-Butyl)-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-methyl-6-(6-(piperazin-1-yl)pyridin-3-yl)-1H-indole-4-carboxamide

1-(butan-2-yl)-N-[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-3-methyl-6-[6-(piperazin-1-yl)pyridin-3-yl]-1H-indole-4-carboxamide

C31H38N6O2 (526.3056)

1-Isopropyl-N-((6-methyl-2-oxo-4-propyl-1,2-dihydropyridin-3-yl)methyl)-6-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-1H-indazole-4-carboxamide

N-[(6-methyl-2-oxo-4-propyl-1,2-dihydropyridin-3-yl)methyl]-6-[2-(4-methylpiperazin-1-yl)pyridin-4-yl]-1-(propan-2-yl)-1H-indazole-4-carboxamide

C31H39N7O2 (541.3165)

Palbociclib

6-acetyl-8-cyclopentyl-5-methyl-2-{[5-(piperazin-1-yl)pyridin-2-yl]amino}-7H,8H-pyrido[2,3-d]pyrimidin-7-one

C24H29N7O2 (447.2383)

L - Antineoplastic and immunomodulating agents > L01 - Antineoplastic agents > L01E - Protein kinase inhibitors > L01EF - Cyclin-dependent kinase (cdk) inhibitors C274 - Antineoplastic Agent > C2189 - Signal Transduction Inhibitor > C129824 - Antineoplastic Protein Inhibitor C471 - Enzyme Inhibitor > C1404 - Protein Kinase Inhibitor > C2185 - Cyclin-Dependent Kinase Inhibitor COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials C471 - Enzyme Inhibitor > C129825 - Antineoplastic Enzyme Inhibitor D004791 - Enzyme Inhibitors > D047428 - Protein Kinase Inhibitors C274 - Antineoplastic Agent > C163758 - Targeted Therapy Agent D000970 - Antineoplastic Agents Corona-virus Coronavirus SARS-CoV-2 COVID-19 SARS-CoV COVID19 SARS2 SARS

8-(5-Chloro-2-(4-methylpiperazin-1-yl)isonicotinamido)-1-(4-fluorophenyl)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide

5-Chloro-N-[1-(4-fluorophenyl)-3-(C-hydroxycarbonimidoyl)-1H,4H,5H-benzo[g]indazol-8-yl]-2-(4-methylpiperazin-1-yl)pyridine-4-carboximidate

C29H27ClFN7O2 (559.1899)

piperaquine

7-chloro-4-(4-{3-[4-(7-chloroquinolin-4-yl)piperazin-1-yl]propyl}piperazin-1-yl)quinoline

C29H32Cl2N6 (534.2065)

quipazine

2-(piperazin-1-yl)quinoline

C13H15N3 (213.1266)

Ribociclib

7-cyclopentyl-N,N-dimethyl-2-{[5-(piperazin-1-yl)pyridin-2-yl]amino}-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide

C23H30N8O (434.2542)

Trelanserin

2-{7-fluoro-2-oxo-4-[2-(4-{thieno[3,2-c]pyridin-4-yl}piperazin-1-yl)ethyl]-1,2-dihydroquinolin-1-yl}ethanimidic acid

C24H24FN5O2S (465.1635)

Risdiplam

7-{4,7-diazaspiro[2.5]octan-7-yl}-2-{2,8-dimethylimidazo[1,2-b]pyridazin-6-yl}-4H-pyrido[1,2-a]pyrimidin-4-one

C22H23N7O (401.1964)

D018373 - Peripheral Nervous System Agents > D009465 - Neuromuscular Agents C78272 - Agent Affecting Nervous System M - Musculo-skeletal system

Selpercatinib

6-(2-Hydroxy-2-methylpropoxy)-4-(6-(6-((6-methoxypyridin-3-yl)methyl)-3,6-diazabicyclo(3.1.1)heptan-3-yl)pyridin-3-yl)pyrazolo(1,5-a)pyridine-3-carbonitrile

C29H31N7O3 (525.2488)

Fosnetupitant

4-(5-{2-[3,5-bis(trifluoromethyl)phenyl]-N,2-dimethylpropanamido}-4-(2-methylphenyl)pyridin-2-yl)-1-[(hydrogen phosphonooxy)methyl]-1-methylpiperazin-1-ium

C31H35F6N4O5P (688.2249)

C78272 - Agent Affecting Nervous System > C267 - Antiemetic Agent

Trilaciclib

12-{[5-(4-methylpiperazin-1-yl)pyridin-2-yl]amino}-2,5,11,13-tetraazaspiro[cyclohexane-1,3-tricyclo[7.4.0.0^{2,7}]tridecane]-1(9),7,10,12-tetraen-6-one

C24H30N8O (446.2542)