Classification Term: 757

Benzoxadiazoles (ontology term: CHEMONTID:0001930)

Organic compounds containing a benzene fused to an oxadiazole ring (a five-membered ring with two carbon atoms, one nitrogen atom, and one oxygen atom)." []

found 13 associated metabolites at class metabolite taxonomy ontology rank level.

Ancestor: Organoheterocyclic compounds

Child Taxonomies: There is no child term of current ontology term.

Isradipine

3-methyl 5-propan-2-yl 4-(2,1,3-benzoxadiazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

C19H21N3O5 (371.1481)

Isradipine belongs to the dihydropyridine (DHP) class of calcium channel blockers (CCBs), the most widely used class of CCBs. It is structurally related to felodipine, nifedipine, and nimodipine and is the most potent calcium-channel blocking agent of the DHP class. Isradipine binds to calcium channels with high affinity and specificity and inhibits calcium flux into cardiac and arterial smooth muscle cells. It exhibits greater selectivity towards arterial smooth muscle cells owing to alternative splicing of the alpha-1 subunit of the channel and increased prevalence of inactive channels in smooth muscle cells. Isradipine may be used to treat mild to moderate essential hypertension. C - Cardiovascular system > C08 - Calcium channel blockers > C08C - Selective calcium channel blockers with mainly vascular effects > C08CA - Dihydropyridine derivatives C78274 - Agent Affecting Cardiovascular System > C270 - Antihypertensive Agent > C333 - Calcium Channel Blocker D002317 - Cardiovascular Agents > D002121 - Calcium Channel Blockers D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents D000077264 - Calcium-Regulating Hormones and Agents D049990 - Membrane Transport Modulators C93038 - Cation Channel Blocker

2-(N-(7-Nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose

6-(Hydroxymethyl)-3-[(4-nitro-2,1,3-benzoxadiazol-7-yl)amino]oxane-2,4,5-triol

C12H14N4O8 (342.0812)

D-Glucose, 6-deoxy-6-((7-nitro-4-benzofurazanyl)amino)-

2,3,4,5-tetrahydroxy-6-[(7-nitro-2,1,3-benzoxadiazol-4-yl)amino]hexanal

C12H14N4O8 (342.0812)

4-(N,N-Dimethylsulfamoyl)-7-hydrazino-benzofurazan

4-(N,N-Dimethylaminosulfonyl)-7-hydrazino-2,1,3-benzoxadiazole

C8H11N5O3S (257.0583)

(2R,3R,4S,5R)-3,4,5,6-Tetrahydroxy-2-((7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)amino)hexanal

3,4,5,6-tetrahydroxy-2-[(7-nitro-2,1,3-benzoxadiazol-4-yl)amino]hexanal

C12H14N4O8 (342.0812)

2,1,3-Benzoxadiazole-4-sulfonic acid, 7-fluoro-

Ammonium-7-fluorobenzo-2-oxa-1,3-diazole-4-sulfonate

C6H3FN2O4S (217.9798)

4-Chloro-7-nitrobenzofurazan

7-Chloro-4-nitrobenzo-2-oxa-1,3-diazole

C6H2ClN3O3 (198.9785)

4-Fluoro-7-nitrobenzofurazan

7-Fluoro-4-nitrobenzo-2-oxa-1,3-diazole

C6H2FN3O3 (183.008)

D019995 - Laboratory Chemicals > D007202 - Indicators and Reagents > D049408 - Luminescent Agents D004396 - Coloring Agents > D005456 - Fluorescent Dyes

4-(Aminosulfonyl)-7-fluoro-2,1,3-benzoxadiazole

4-(Aminosulphonyl)-7-fluoro-2,1,3-benzoxadiazole

C6H4FN3O3S (216.9957)

D019995 - Laboratory Chemicals > D007202 - Indicators and Reagents > D049408 - Luminescent Agents D004396 - Coloring Agents > D005456 - Fluorescent Dyes

4-(N,N-Dimethylaminosulfonyl)-7-fluoro-2,1,3-benzoxadiazole

4-(N,N-Dimethylaminosulphonyl)-7-fluoro-2,1,3-benzoxadiazole

C8H8FN3O3S (245.027)

7-(3-Isothiocyanatopyrrolidin-1-yl)-N,N-dimethyl-2,1,3-benzoxadiazole-4-sulfonamide

4-(3-Isothiocyanatopyrrolidin-1-yl)-7-(N,N-dimethylaminosulfonyl)-2,1,3-benzoxadiazole

C13H15N5O3S2 (353.0616)

Benzofurazan

2,1,3-benzoxadiazole

C6H4N2O (120.0324)

Darodipine

3,5-Diethyl 4-(2,1,3-benzoxadiazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid

C19H21N3O5 (371.1481)

C78274 - Agent Affecting Cardiovascular System > C270 - Antihypertensive Agent > C333 - Calcium Channel Blocker D002317 - Cardiovascular Agents > D002121 - Calcium Channel Blockers D000077264 - Calcium-Regulating Hormones and Agents D049990 - Membrane Transport Modulators C93038 - Cation Channel Blocker