Classification Term: 3880
Benzoylcyclohexane-1,3-diones (ontology term: CHEMONTID:0004673)
Alkyl-phenylketones where the alkyl group is a cyclohexane 1,3-dione." []
found 3 associated metabolites at no_class-level_9 metabolite taxonomy ontology rank level.
Ancestor: Alkyl-phenylketones
Child Taxonomies: There is no child term of current ontology term.
Nitisinone
Nitisinone is only found in individuals that have used or taken this drug. It is a synthetic reversible inhibitor of 4-hydroxyphenylpyruvate dioxygenase. It is used in the treatment of hereditary tyrosinemia type 1. It is sold under the brand name Orfadin. [Wikipedia]Nitisinone is a competitive inhibitor of 4-hydroxyphenyl-pyruvate dioxygenase, an enzyme upstream of fumarylacetoacetate hydrolyase (FAH) in the tyrosine catabolic pathway. By inhibiting the normal catabolism of tyrosine in patients with hereditary tyrosinemia type 1 (HT-1), nitisinone prevents the accumulation of the catabolic intermediates maleylacetoacetate and fumarylacetoacetate. A - Alimentary tract and metabolism > A16 - Other alimentary tract and metabolism products > A16A - Other alimentary tract and metabolism products > A16AX - Various alimentary tract and metabolism products D004791 - Enzyme Inhibitors C471 - Enzyme Inhibitor
