Classification Term: 3524

Benzazocines (ontology term: CHEMONTID:0004007)

Organic compounds containing the benzazocine ring system, which consists of a benzene ring bound to an azocine ring." []

found 5 associated metabolites at sub_class metabolite taxonomy ontology rank level.

Ancestor: Benzene and substituted derivatives

Child Taxonomies: There is no child term of current ontology term.

Trabectedin

(1R,2R,3R,11S,12S,14R,26R)-5,6,12-trihydroxy-6,7-dimethoxy-7,21,30-trimethyl-27-oxo-3,4-dihydro-2H-17,19,28-trioxa-24-thia-13,30-diazaspiro[heptacyclo[12.9.6.1³,¹¹.0²,¹³.0⁴,⁹.0¹⁵,²³.0¹⁶,²⁰]triacontane-26,1-isoquinoline]-4,6,8,15,20,22-hexaen-22-yl acetate

C39H43N3O11S (761.2618168)


Trabectedin, also referred as ET-743 during its development, is a marine derived antitumoral agent discovered in the Carribean tunicate _Ecteinascidia turbinata_ and now produced synthetically. Trabectedin has a unique mechanism of action. It binds to the minor groove of DNA interfering with cell division and genetic transcription processes and DNA repair machinery. It is approved for use in Europe, Russia and South Korea for the treatment of advanced soft tissue sarcoma refractory to or unsuitable to receive anthracycline or ifosfamide chemotherapy. L - Antineoplastic and immunomodulating agents > L01 - Antineoplastic agents > L01C - Plant alkaloids and other natural products C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C2842 - DNA Binding Agent D009676 - Noxae > D000477 - Alkylating Agents D000970 - Antineoplastic Agents

   

z-Clausenamide

5,6-dihydro-5-Hydroxy-3-methyl-6-phenyl-3-benzazocin-4(3H)-one, 9ci

C18H17NO2 (279.1259222)


z-Clausenamide is found in fruits. z-Clausenamide is an alkaloid from Clausena lansium (wampee). Alkaloid from Clausena lansium (wampee). z-Clausenamide is found in fruits.

   

Cenicriviroc

8-(4-(2-Butoxyethoxy)phenyl)-1,2,3,4-tetrahydro-1-(2-methylpropyl)-N-(4-((S)-((1-propyl-1H-imidazol-5-yl)methyl)sulfinyl)phenyl)-1-benzazocine-5-carboxamide

C41H52N4O4S (696.3709072)


   

Ecteinascidin 729

(5,6,12-trihydroxy-6,7-dimethoxy-7,21-dimethyl-27-oxospiro[17,19,28-trioxa-24-thia-13,30-diazaheptacyclo[12.9.6.13,11.02,13.04,9.015,23.016,20]triaconta-4(9),5,7,15,20,22-hexaene-26,1-3,4-dihydro-2H-isoquinoline]-22-yl) acetate

C38H41N3O11S (747.2461676)


   

ecteinascidin 743

5,6,12-trihydroxy-6,7-dimethoxy-7,21,30-trimethyl-27-oxo-3,4-dihydro-2H-17,19,28-trioxa-24-thia-13,30-diazaspiro[heptacyclo[12.9.6.1³,¹¹.0²,¹³.0⁴,⁹.0¹⁵,²³.0¹⁶,²⁰]triacontane-26,1-isoquinoline]-4,6,8,15,20,22-hexaen-22-yl acetate

C39H43N3O11S (761.2618168)