Classification Term: 2874
Imidazole ribonucleosides and ribonucleotides (ontology term: CHEMONTID:0001997)
Organic compounds in which the C-1 of a ribosyl moiety is N-linked to an imidazole ring. Nucleotides have a phosphate group linked to the C5 carbon of the ribose (or deoxyribose) moiety. This class does not contain benzimidazole nucleosides and nucleotides." []
found 2 associated metabolites at class metabolite taxonomy ontology rank level.
Ancestor: Nucleosides, nucleotides, and analogues
Child Taxonomies: 1-phosphoribosyl-imidazoles, 1-ribosyl-imidazolecarboxamides
AICA-riboside
AICA-riboside, also known as acadesine or AICAR, is an AMP-activated protein kinase activator which is used for the treatment of acute lymphoblastic leukemia and may have applications in treating other disorders such as diabetes. AICA-riboside is an adenosine regulating agent developed by PeriCor Therapeutics and licensed to Schering-Plough in 2007 for phase III studies. The drug is a potential first-in-class agent for prevention of reperfusion injury in CABG surgery. Schering began patient enrollment in phase III studies in May, 2009. The trial was terminated in late 2010 based on an interim futility analysis (Wikipedia). AICA-riboside is a minor constituent found in human milk (PMID: 7702711). C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C272 - Antimetabolite C - Cardiovascular system > C01 - Cardiac therapy D007004 - Hypoglycemic Agents
Imidazoleacetic acid riboside
Imidazoleacetic acid riboside is a metabolite of imidazoleacetic acid (itself histamines oxidative metabolite). (PMID: 7616240). In kidney glomeruli, histamine is predominantly catabolized to acid metabolites of the diamine oxidase (histaminase) pathway, imidazoleacetic acid and Imidazoleacetic acid riboside. (PMID: 7616240). Imidazoleacetic acid riboside is a metabolite of imidazoleacetic acid (itself histamines oxidative metabolite). (PMID: 7616240)