Classification Term: 170010
嘧啶单羧酸 (ontology term: e0d733300fb933fd3b6c8c787ddb188e)
found 1 associated metabolites at no_class-level_20 metabolite taxonomy ontology rank level.
Ancestor: 嘧啶
Child Taxonomies: There is no child term of current ontology term.
Orotidine
Orotidine is a nucleoside formed by attaching orotic acid to a ribose ring via a beta-N1-glycosidic bond. It is a water-soluble solid. Orotidine is found in bacteria, fungi, plants, and animals. In humans, orotidine occurs as its 5-phosphate (orotidylic acid), which is an intermediate in the biosynthesis of pyrimidine nucleosides (cytidine and uridine) that are found in nucleic acids (as the nucleotides containing the bases cytosine and uracil). Orotidine itself is not a component of nucleic acid. Orotidine monophosphate (OMP) is converted to uridine monophosphate by OMP decarboxylase, which is inhibited by mononucleotide precursors. Large amounts of orotidine are excreted in the urine of cancer patients treated with 6-azauridine, which is one such inhibitor, indicating that the subject has increased DNA synthesis due to cancer. Orotidine was first isolated from a mutant strain of the fungus Neurospora by A. Michael Michelson, William Drell, and Herschel K. Mitchell (PMID: 14853953). Isolated from Phaseolus vulgaris (kidney bean) Orotidine. CAS Common Chemistry. CAS, a division of the American Chemical Society, n.d. https://commonchemistry.cas.org/detail?cas_rn=314-50-1 (retrieved 2024-07-16) (CAS RN: 314-50-1). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).