Classification Term: 168245
Diacylglycerophosphoserines [GP0301] (ontology term: bcb494fbba2ada66ccaeeb181e9a8894)
Diacylglycerophosphoserines [GP0301]
found 138 associated metabolites at sub_class metabolite taxonomy ontology rank level.
Ancestor: Glycerophosphoserines [GP03]
Child Taxonomies: There is no child term of current ontology term.
PS(16:0/18:1(9Z))
C40H76NO10P (761.5206565999999)
PS(16:0/18:1(9Z)) is a phosphatidylserine (PS or GPSer). It is a glycerophospholipid in which a phosphorylserine moiety occupies a glycerol substitution site. As is the case with diacylglycerols, glycerophosphoserines can have many different combinations of fatty acids of varying lengths and saturation attached at the C-1 and C-2 positions. Fatty acids containing 16, 18 and 20 carbons are the most common. PS(16:0/18:1(9Z)), in particular, consists of one chain of palmitic acid at the C-1 position and one chain of oleic acid at the C-2 position. The palmitic acid moiety is derived from fish oils, milk fats, vegetable oils and animal fats, while the oleic acid moiety is derived from vegetable oils, especially olive and canola oil. Phosphatidylserine or 1,2-diacyl-sn-glycero-3-phospho-L-serine is distributed widely among animals, plants and microorganisms. It is usually less than 10\\% of the total phospholipids, the greatest concentration being in myelin from brain tissue. However, it may comprise 10 to 20 mol\\% of the total phospholipid in the plasma membrane and endoplasmic reticulum of the cell. Phosphatidylserine is an acidic (anionic) phospholipid with three ionizable groups, i.e. the phosphate moiety, the amino group and the carboxyl function. As with other acidic lipids, it exists in nature in salt form, but it has a high propensity to chelate to calcium via the charged oxygen atoms of both the carboxyl and phosphate moieties, modifying the conformation of the polar head group. This interaction may be of considerable relevance to the biological function of phosphatidylserine, especially during bone formation for example. As phosphatidylserine is located entirely on the inner monolayer surface of the plasma membrane (and of other cellular membranes) and it is the most abundant anionic phospholipids. Therefore phosphatidylseriine may make the largest contribution to interfacial effects in membranes involving non-specific electrostatic interactions. This normal distribution is disturbed during platelet activation and cellular apoptosis. In human plasma, 1-stearoyl-2-oleoyl and 1-stearoyl-2-arachidonoyl species predominate, but in brain (especially grey matter), retina and many other tissues 1-stearoyl-2-docosahexaenoyl species are very abundant. Indeed, the ratio of n-3 to n-6 fatty acids in brain phosphatidylserine is very much higher than in most other lipids. While most phospholipids have a saturated fatty acid on C-1 and an unsaturated fatty acid on C-2 of the glycerol backbone, the fatty acid distribution at the C-1 and C-2 positions of glycerol within phospholipids is continually in flux, owing to phospholipid degradation and the continuous phospholipid remodeling that occurs while these molecules are in membranes. Phosphatidylserines typically carry a net charge of -1 at physiological pH. They mostly have palmitic or stearic acid on carbon 1 and a long chain unsaturated fatty acid (e.g. 18:2, 20:4 and 22:6) on carbon 2. PS biosynthesis involves an exchange reaction of serine for ethanolamine in PE. PS(16:0/18:1(9Z)) is a phosphatidylserine. It is a glycerophospholipid in which a phosphorylserine moiety occupies a glycerol substitution site. As is the case with diacylglycerols, phosphatidylserines can have many different combinations of fatty acids of varying lengths and saturation attached to the C-1 and C-2 atoms. PS(16:0/18:1(9Z)), in particular, consists of one hexadecanoyl chain to the C-1 atom, and one 9Z-octadecenoyl to the C-2 atom. Phosphatidylserine or 1,2-diacyl-sn-glycero-3-phospho-L-serine is distributed widely among animals, plants and microorganisms. Phosphatidylserine is an acidic (anionic) phospholipid with three ionizable groups, i.e. the phosphate moiety, the amino group and the carboxyl function. As with other acidic lipids, it exists in nature in salt form, but it has a high propensity to chelate to calcium via the charged oxygen atoms of both the carboxyl and phosphate moieties, modifying the conformation of the polar head group. This interaction may be of considerable relevance to the biological function of phosphatidylserine. While most phospholipids have a saturated fatty acid on C-1 and an unsaturated fatty acid on C-2 of the glycerol backbone, the fatty acid distribution at the C-1 and C-2 positions of glycerol within phospholipids is continually in flux, owing to phospholipid degradation and the continuous phospholipid remodeling that occurs while these molecules are in membranes. Phosphatidylserines typically carry a net charge of -1 at physiological pH. They mostly have palmitic or stearic acid on carbon 1 and a long chain unsaturated fatty acid (e.g. 18:2, 20:4 and 22:6) on carbon 2. PS biosynthesis involves an exchange reaction of serine for ethanolamine in PE.
PS(18:0/18:0)
PS(18:0/18:0) is a phosphatidylserine (PS or GPSer). It is a glycerophospholipid in which a phosphorylserine moiety occupies a glycerol substitution site. As is the case with diacylglycerols, glycerophosphoserines can have many different combinations of fatty acids of varying lengths and saturation attached at the C-1 and C-2 positions. Fatty acids containing 16, 18 and 20 carbons are the most common. PS(18:0/18:0), in particular, consists of one chain of stearic acid at the C-1 position and one chain of stearic acid at the C-2 position. The stearic acid moiety is derived from animal fats, coco butter and sesame oil, while the stearic acid moiety is derived from animal fats, coco butter and sesame oil. Phosphatidylserine or 1,2-diacyl-sn-glycero-3-phospho-L-serine is distributed widely among animals, plants and microorganisms. It is usually less than 10\\\\% of the total phospholipids, the greatest concentration being in myelin from brain tissue. However, it may comprise 10 to 20 mol\\\\% of the total phospholipid in the plasma membrane and endoplasmic reticulum of the cell. Phosphatidylserine is an acidic (anionic) phospholipid with three ionizable groups, i.e. the phosphate moiety, the amino group and the carboxyl function. As with other acidic lipids, it exists in nature in salt form, but it has a high propensity to chelate to calcium via the charged oxygen atoms of both the carboxyl and phosphate moieties, modifying the conformation of the polar head group. This interaction may be of considerable relevance to the biological function of phosphatidylserine, especially during bone formation for example. As phosphatidylserine is located entirely on the inner monolayer surface of the plasma membrane (and of other cellular membranes) and it is the most abundant anionic phospholipids. Therefore phosphatidylseriine may make the largest contribution to interfacial effects in membranes involving non-specific electrostatic interactions. This normal distribution is disturbed during platelet activation and cellular apoptosis. In human plasma, 1-stearoyl-2-oleoyl and 1-stearoyl-2-arachidonoyl species predominate, but in brain (especially grey matter), retina and many other tissues 1-stearoyl-2-docosahexaenoyl species are very abundant. Indeed, the ratio of n-3 to n-6 fatty acids in brain phosphatidylserine is very much higher than in most other lipids. While most phospholipids have a saturated fatty acid on C-1 and an unsaturated fatty acid on C-2 of the glycerol backbone, the fatty acid distribution at the C-1 and C-2 positions of glycerol within phospholipids is continually in flux, owing to phospholipid degradation and the continuous phospholipid remodeling that occurs while these molecules are in membranes. Phosphatidylserines typically carry a net charge of -1 at physiological pH. They mostly have palmitic or stearic acid on carbon 1 and a long chain unsaturated fatty acid (e.g. 18:2, 20:4 and 22:6) on carbon 2. PS biosynthesis involves an exchange reaction of serine for ethanolamine in PE. PS(18:0/18:0) is a phosphatidylserine. It is a glycerophospholipid in which a phosphorylserine moiety occupies a glycerol substitution site. As is the case with diacylglycerols, phosphatidylserines can have many different combinations of fatty acids of varying lengths and saturation attached to the C-1 and C-2 positions. PS(18:0/18:0), in particular, consists of two octadecanoyl chains at positions C-1 and C-2. Phosphatidylserine or 1,2-diacyl-sn-glycero-3-phospho-L-serine is distributed widely among animals, plants and microorganisms. Phosphatidylserine is an acidic (anionic) phospholipid with three ionizable groups, i.e. the phosphate moiety, the amino group and the carboxyl function. As with other acidic lipids, it exists in nature in salt form, but it has a high propensity to chelate to calcium via the charged oxygen atoms of both the carboxyl and phosphate moieties, modifying the conformation of the polar head group. This interaction may be of considerable relevance to the biological function of phosphatidylserine. While most phospholipids have a saturated fatty acid on C-1 and an unsaturated fatty acid on C-2 of the glycerol backbone, the fatty acid distribution at the C-1 and C-2 positions of glycerol within phospholipids is continually in flux, owing to phospholipid degradation and the continuous phospholipid remodeling that occurs while these molecules are in membranes. Phosphatidylserines typically carry a net charge of -1 at physiological pH. They mostly have palmitic or stearic acid on carbon 1 and a long chain unsaturated fatty acid (e.g. 18:2, 20:4 and 22:6) on carbon 2. PS biosynthesis involves an exchange reaction of serine for ethanolamine in PE. 1,2-distearoyl-sn-glycero-3-phosphoserine is a 3-sn-phosphatidyl L-serine in which the phosphatidyl acyl group at both positions 1 and 2 is stearoyl. It has a role as a mouse metabolite. It is functionally related to an octadecanoic acid. PS(18:0/18:0) is a metabolite found in or produced by Escherichia coli (strain K12, MG1655). Phosphatidylserine is a phospholipid with a polar serine found in phosphoester linkage to diacylglycerol. Derivatives of PHOSPHATIDIC ACIDS in which the phosphoric acid is bound in ester linkage to a SERINE moiety. A 3-sn-phosphatidyl L-serine in which the phosphatidyl acyl group at both positions 1 and 2 is stearoyl. Distearoylphosphatidylserine (DSPS) acts as a monolayer. Phosphatidylserine is a phospholipid with a polar serine found in phosphoester linkage to diacylglycerol[1]. Distearoylphosphatidylserine (DSPS) acts as a monolayer. Phosphatidylserine is a phospholipid with a polar serine found in phosphoester linkage to diacylglycerol[1].
PS 37:4
C43H76NO10P (797.5206565999999)
Found in mouse spleen; TwoDicalId=1419; MgfFile=160729_spleen_AA_18_Neg; MgfId=672
PS 39:6
C45H76NO10P (821.5206565999999)
Found in mouse spleen; TwoDicalId=817; MgfFile=160729_spleen_DHA_13_Neg; MgfId=641
PS 38:3
Found in mouse lung; TwoDicalId=249; MgfFile=160901_Lung_normal_Neg_02; MgfId=699
PS 40:4
Found in mouse brain; TwoDicalId=294; MgfFile=160720_brain_AA_18_Neg; MgfId=968
PS 32:0
Found in mouse spleen; TwoDicalId=657; MgfFile=160729_spleen_EPA_07_Neg; MgfId=763
PS 34:2
Found in mouse lung; TwoDicalId=676; MgfFile=160901_Lung_normal_Neg_02_never; MgfId=641
PS 36:4
Found in mouse kidney; TwoDicalId=238; MgfFile=160827_Kidney_normal_Neg_02_never; MgfId=822
PS 38:6
Found in mouse spleen; TwoDicalId=211; MgfFile=160729_spleen_DHA_15_Neg; MgfId=653
PS 36:1
Found in mouse brain; TwoDicalId=54; MgfFile=160720_brain_AA_18_Neg; MgfId=965
PS 38:1
Found in mouse brain; TwoDicalId=638; MgfFile=160720_brain_AA_19_Neg; MgfId=1219
PS 38:4
C44H78NO10P (811.5363057999999)
Found in mouse spleen; TwoDicalId=70; MgfFile=160729_spleen_AA_17_Neg_never; MgfId=860
PS 38:5
C44H76NO10P (809.5206565999999)
Found in mouse lung; TwoDicalId=599; MgfFile=160901_Lung_normal_Neg_01_sute; MgfId=394 Found in mouse kidney; TwoDicalId=208; MgfFile=160827_Kidney_AA_Neg_16; MgfId=917
PS 40:5
Found in mouse spleen; TwoDicalId=121; MgfFile=160729_spleen_EPA_07_Neg_never; MgfId=879
PS 40:6
C46H78NO10P (835.5363057999999)
Found in mouse brain; TwoDicalId=19; MgfFile=160720_brain_DHA_12_Neg; MgfId=742
PS 36:3
C42H76NO10P (785.5206565999999)
Found in mouse lung; TwoDicalId=1415; MgfFile=160901_Lung_EPA_Neg_10; MgfId=509
PS 40:2
Found in mouse lung; TwoDicalId=969; MgfFile=160901_Lung_AA_Neg_17_never; MgfId=1140
PS 40:7
C46H76NO10P (833.5206565999999)
Found in mouse brain; TwoDicalId=444; MgfFile=160720_brain_AA_18_Neg; MgfId=651
PS 42:10
Found in mouse spleen; TwoDicalId=479; MgfFile=160729_spleen_DHA_12_Neg_never; MgfId=714
PS 44:12
Found in mouse brain; TwoDicalId=193; MgfFile=160720_brain_AA_17_Neg; MgfId=555
PS 34:1
C40H76NO10P (761.5206565999999)
A 3-sn-phosphatidyl-L-serine compound with a palmitoyl group at the 1-position and an oleoyl group at the 2-position.
PS 16:0
C22H42NO10P (511.25462020000003)
PS 36:2
C42H78NO10P (787.5363057999999)
PS 36:0
PS 30:4
C36H62NO10P (699.4111121999999)
PS 32:5
C38H64NO10P (725.4267613999999)
PS 35:1
C41H78NO10P (775.5363057999999)
PS 35:2
C41H76NO10P (773.5206565999999)
PS 36:7
PS 37:3
C43H78NO10P (799.5363057999999)
PS 39:5
C45H78NO10P (823.5363057999999)
PS 39:8
PS 38:8
PS 40:9
PS 38:9
PS 40:8
PS 40:10
PS 41:7
C47H78NO10P (847.5363057999999)
PS 42:2
C48H90NO10P (871.6302009999999)
PS 42:8
C48H78NO10P (859.5363057999999)
PS 42:9
C48H76NO10P (857.5206565999999)
PS 43:2
C49H92NO10P (885.6458501999999)
PS 44:2
C50H94NO10P (899.6614993999999)
PS 44:4
C50H90NO10P (895.6302009999999)
PS 44:3
C50H92NO10P (897.6458501999999)
PS 42:11
PS 44:10
C50H78NO10P (883.5363057999999)