Classification Term: 1653

Atisane diterpenoids (ontology term: CHEMONTID:0002738)

Diterpenoids with a structure based on the atisane skeleton, which is a tetracyclic compound containing the [2,2,2]bicyc1ic ring system with the C15-C16 bridge attached at C12." [ISBN:9780080526980, ISBN:9780124695597]

found 4 associated metabolites at family metabolite taxonomy ontology rank level.

Ancestor: Villanovane, atisane, trachylobane or helvifulvane diterpenoids

Child Taxonomies: Atisine-type diterpenoid alkaloids, Hetidine-type diterpenoid alkaloids, Hetisine-type diterpenoid alkaloids, Danudatine-type diterpenoid alkaloids, Isoatisine-type diterpenoid alkaloids

Yucalexin A19

6,16-dihydroxy-5,5,9,16-tetramethyltetracyclo[10.2.2.0¹,¹⁰.0⁴,⁹]hexadec-13-en-7-one

C20H30O3 (318.21948299999997)


Yucalexin A19 is found in root vegetables. Yucalexin A19 is a constituent of cassava roots (Manihot esculenta). Constituent of cassava roots (Manihot esculenta). Yucalexin A19 is found in root vegetables.

   

Yucalexin A16

16-hydroxy-5,5,9,16-tetramethyltetracyclo[10.2.2.0¹,¹⁰.0⁴,⁹]hexadec-13-en-6-one

C20H30O2 (302.224568)


Yucalexin A16 is found in root vegetables. Yucalexin A16 is a stress metabolite of cassava root (Manihot esculenta). Stress metabolite of cassava root (Manihot esculenta). Yucalexin A16 is found in root vegetables.

   

Guan-fu base A

3-(acetyloxy)-9,19-dihydroxy-5-methyl-12-methylidene-7-azaheptacyclo[9.6.2.0^{1,8}.0^{5,17}.0^{7,16}.0^{9,14}.0^{14,18}]nonadecan-10-yl acetate

C24H31NO6 (429.2151266)


Guanfu base A is an antiarrhythmic alkaloid isolated from Aconitum coreanum and is a potent noncompetitive CYP2D6 inhibitor, with a Ki of 1.20 μM in human liver microsomes (HLMs) and a Ki of 0.37 μM for the human recombinant form (rCYP2D6). Guanfu base A is also a potent competitive inhibitor of CYP2D in monkey (Ki of 0.38 μM) and dog (Ki of 2.4 μM) microsomes[1]. Guanfu base A also inhibits HERG channel current[2]. Guanfu base A is an antiarrhythmic alkaloid isolated from Aconitum coreanum and is a potent noncompetitive CYP2D6 inhibitor, with a Ki of 1.20 μM in human liver microsomes (HLMs) and a Ki of 0.37 μM for the human recombinant form (rCYP2D6). Guanfu base A is also a potent competitive inhibitor of CYP2D in monkey (Ki of 0.38 μM) and dog (Ki of 2.4 μM) microsomes[1]. Guanfu base A also inhibits HERG channel current[2].

   

serofendic acid

14-hydroxy-13-(methanesulfinylmethyl)-5,9-dimethyltetracyclo[10.2.2.0^{1,10}.0^{4,9}]hexadecane-5-carboxylic acid

C21H34O4S (382.21776840000007)