DTX 1 (BioDeep_00001883369)
Main id: BioDeep_00000011452
Toxin Marine Natural Products
代谢物信息卡片
化学式: C45H70O13 (818.4816)
中文名称: 鳍藻毒素
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1CCC2(C(CCCO2)C)OC1C(C)CC(C3C(=C)C(C4C(O3)CCC5(O4)CCC(O5)C=CC(C)C6CC(=CC7(O6)C(CCC(O7)CC(C)(C(=O)O)O)O)C)O)O
InChI: InChI=1S/C45H70O13/c1-25-21-35(56-45(23-25)36(47)13-12-32(55-45)24-42(7,51)41(49)50)26(2)10-11-31-15-17-43(54-31)18-16-34-40(57-43)37(48)30(6)39(53-34)33(46)22-28(4)38-27(3)14-19-44(58-38)29(5)9-8-20-52-44/h10-11,23,26-29,31-40,46-48,51H,6,8-9,12-22,24H2,1-5,7H3,(H,49,50)/b11-10+/t26-,27-,28+,29-,31+,32+,33+,34-,35+,36-,37-,38+,39+,40-,42-,43-,44-,45-/m1/s1
描述信息
A ketal that is a marine toxin structurally related to okadaic acid. Produced by dinoflagellates it is known to accumulate in shellfish and cause diarrhoeic shellfish poisoning. It is an inhibitor of serine/threonine protein phosphatases 1 (PP1) and PP2A and has been shown to promote cancer cell growth in tumour cell lines and animal models.
D009676 - Noxae > D011042 - Poisons > D008387 - Marine Toxins
同义名列表
3 个代谢物同义名
数据库引用编号
9 个数据库交叉引用编号
- ChEBI: CHEBI:144400
- KEGG: C16870
- PubChem: 20055920
- ChEMBL: CHEMBL443145
- KNApSAcK: C00044717
- CAS: 81720-10-7
- MetaboLights: MTBLC144400
- PubChem: 135626064
- PDB-CCD: XT1
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Xu Wen, Dian Li, Peng Chen, Ming Tan, Hui Zhang, Yuting Liu, Jihua Ren, Shengtao Cheng. Gambogic acid inhibits HBx-mediated hepatitis B virus replication by targeting the DTX1-Notch signaling pathway.
Virus research.
2024 Jan; 339(?):199273. doi:
10.1016/j.virusres.2023.199273. [PMID: 38029800] - Jiangbing Qiu, Ying Ji, Yuan Fang, Mingyue Zhao, Shuqin Wang, Qinghui Ai, Aifeng Li. Response of fatty acids and lipid metabolism enzymes during accumulation, depuration and esterification of diarrhetic shellfish toxins in mussels (Mytilus galloprovincialis).
Ecotoxicology and environmental safety.
2020 Dec; 206(?):111223. doi:
10.1016/j.ecoenv.2020.111223. [PMID: 32891913] - Paula Abal, M Carmen Louzao, Toshiyuki Suzuki, Ryuichi Watanabe, Natalia Vilariño, Cristina Carrera, Ana M Botana, Mercedes R Vieytes, Luis M Botana. Toxic Action Reevaluation of Okadaic Acid, Dinophysistoxin-1 and Dinophysistoxin-2: Toxicity Equivalency Factors Based on the Oral Toxicity Study.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2018; 49(2):743-757. doi:
10.1159/000493039. [PMID: 30176657] - Polina A Kameneva, Ekaterina A Krasheninina, Valentina V Slobodskova, Sergey P Kukla, Tatiana Yu Orlova. Accumulation and Tissue Distribution of Dinophysitoxin-1 and Dinophysitoxin-3 in the Mussel Crenomytilus grayanus Feeding on the Benthic Dinoflagellate Prorocentrum foraminosum.
Marine drugs.
2017 Oct; 15(10):. doi:
10.3390/md15100330. [PMID: 29064453] - A Reum Yang, Sangbum Lee, Young Du Yoo, Hyung Seop Kim, Eun Ju Jeong, Jung-Rae Rho. Limaol: A Polyketide from the Benthic Marine Dinoflagellate Prorocentrum lima.
Journal of natural products.
2017 05; 80(5):1688-1692. doi:
10.1021/acs.jnatprod.7b00127. [PMID: 28383915] - Ryoji Matsushima, Hajime Uchida, Satoshi Nagai, Ryuichi Watanabe, Michiya Kamio, Hiroshi Nagai, Masaki Kaneniwa, Toshiyuki Suzuki. Assimilation, Accumulation, and Metabolism of Dinophysistoxins (DTXs) and Pectenotoxins (PTXs) in the Several Tissues of Japanese Scallop Patinopecten yessoensis.
Toxins.
2015 Dec; 7(12):5141-54. doi:
10.3390/toxins7124870. [PMID: 26633503] - Zhihong Wang, Margaret H Broadwater, John S Ramsdell. Analysis of diarrhetic shellfish poisoning toxins and pectenotoxin-2 in the bottlenose dolphin (Tursiops truncatus) by liquid chromatography-tandem mass spectrometry.
Journal of chromatography. A.
2015 Oct; 1416(?):22-30. doi:
10.1016/j.chroma.2015.08.066. [PMID: 26381568] - Bing Zhang, Li Hou, Dianping Tang, Bingqian Liu, Jianrong Li, Guonan Chen. Simultaneous multiplexed stripping voltammetric monitoring of marine toxins in seafood based on distinguishable metal nanocluster-labeled molecular tags.
Journal of agricultural and food chemistry.
2012 Sep; 60(36):8974-82. doi:
10.1021/jf302051k. [PMID: 22906150] - Shi-Ying Lu, Yu Zhou, Yan-Song Li, Chao Lin, Xian-Mei Meng, Dong-Ming Yan, Zhao-Hui Li, Shi-Yu Yu, Zeng-Shan Liu, Hong-Lin Ren. Production of monoclonal antibody and application in indirect competitive ELISA for detecting okadaic acid and dinophytoxin-1 in seafood.
Environmental science and pollution research international.
2011 Aug; 19(7):2619-26. doi:
10.1007/s11356-012-0819-y. [PMID: 22828889] - Patroklos Vareltzis, Ingrid Undeland. Removal of lipids and diarrhetic shellfish poisoning toxins from blue mussels (Mytilus edulis) during acid and alkaline isolation of proteins.
Journal of agricultural and food chemistry.
2008 May; 56(10):3675-81. doi:
10.1021/jf800224n. [PMID: 18454548] - Carlos García, Dominique Truan, Marcelo Lagos, Juan Pablo Santelices, Juan Carlos Díaz, Néstor Lagos. Metabolic transformation of dinophysistoxin-3 into dinophysistoxin-1 causes human intoxication by consumption of O-acyl-derivatives dinophysistoxins contaminated shellfish.
The Journal of toxicological sciences.
2005 Dec; 30(4):287-96. doi:
10.2131/jts.30.287. [PMID: 16404137] - H Yuasa, K Yoshida, H Iwata, H Nakanishi, M Suganuma, M Tatematsu. Increase of labeling indices in gastrointestinal mucosae of mice and rats by compounds of the okadaic acid type.
Journal of cancer research and clinical oncology.
1994; 120(4):208-12. doi:
10.1007/bf01372558. [PMID: 8288675] - K Terao, E Ito, T Yanagi, T Yasumoto. Histopathological studies on experimental marine toxin poisoning. I. Ultrastructural changes in the small intestine and liver of suckling mice induced by dinophysistoxin-1 and pectenotoxin-1.
Toxicon : official journal of the International Society on Toxinology.
1986; 24(11-12):1141-51. doi:
10.1016/0041-0101(86)90140-6. [PMID: 3564062]
