7alpha-Hydroxy-3-oxochol-4-en-24-oic Acid (BioDeep_00001872155)

Main id: BioDeep_00000638113

 

PANOMIX_OTCML-2023


代谢物信息卡片


(4R)-4-[(7R,8S,9S,10R,13R,14S,17R)-7-hydroxy-10,13-dimethyl-3-oxo-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-17-yl]pentanoic acid

  化学式: C24H36O4 (388.2613)
中文名称:
  谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(CCC(=O)O)C1CCC2C1(CCC3C2C(CC4=CC(=O)CCC34C)O)C
InChI: InChI=1S/C24H36O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h12,14,17-20,22,26H,4-11,13H2,1-3H3,(H,27,28)/t14-,17-,18+,19+,20-,22+,23+,24-/m1/s1


描述信息

A 3-oxo Delta(4)-steroid that is 3-oxochol-4-en-24-oic acid carrying an additional 7alpha-hydroxy substituent.
D005765 - Gastrointestinal Agents > D001647 - Bile Acids and Salts
D005765 - Gastrointestinal Agents > D002793 - Cholic Acids
3-Oxo-7-hydroxychol-4-enoic acid is an endogenous metabolite. 3-Oxo-7-hydroxychol-4-enoic acid may be an important indicator of a poor prognosis in hepatobiliary disease[1].

同义名列表

23 个代谢物同义名

7alpha-Hydroxy-3-oxochol-4-en-24-oic Acid; 3-Oxo-7-hydroxychol-4-enoic acid; "(R)-4-((7R,8S,9S,10R,13R,14S,17R)-7-hydroxy-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid"; (4R)-4-[(1R,3aS,3bS,4R,9aR,9bS,11aR)-4-hydroxy-9a,11a-dimethyl-7-oxo-1H,2H,3H,3aH,3bH,4H,5H,8H,9H,9bH,10H,11H-cyclopenta[a]phenanthren-1-yl]pentanoic acid; (4R)-4-[(7R,8S,9S,10R,13R,14S,17R)-7-hydroxy-10,13-dimethyl-3-oxo-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-17-yl]pentanoic acid; (7a)-7-Hydroxy-3-oxochol-4-en-24-Oate; (7a)-7-Hydroxy-3-oxochol-4-en-24-Oic acid; (7alpha)-7-Hydroxy-3-oxochol-4-en-24-Oate; (7alpha)-7-Hydroxy-3-oxochol-4-en-24-oic acid; 3-oxo-7 alpha-hydroxychol-4-enoic acid; 3-oxo-7-Hydroxychol-4-enoate; 3-oxo-7a-Hydroxychol-4-enoate; 3-oxo-7a-Hydroxychol-4-enoic acid; 3-oxo-7alpha-Hydroxychol-4-enoate; 3-Oxo-7alpha-hydroxychol-4-enoic acid; 7-HOC acid; 7-hydroxy-3-oxochol-4-en-24-oic acid; 7a-Hydroxy-3-oxo-chol-4-enic Acid; 3-Oxo-7a-hydroxychol-4-en-24-oic Acid; 3-Oxo-7a-hydroxychol-4-enoic Acid; 7a-Hydroxy-3-oxo-4-cholen-24-oic Acid; 7a-Hydroxy-3-oxochol-4-enoic Acid; 7a-Hydroxy-3-oxochol-4-en-24-Oate; 7a-Hydroxy-3-oxochol-4-en-24-Oic acid; 7alpha-hydroxy-3-oxo-4-cholenoic acid; 7alpha-Hydroxy-3-oxo-chol-4-en-24-oic Acid; Chol-4-en-24-oic acid, 7-hydroxy-3-oxo-, (7alpha)-



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Andrew D Patterson, Olivier Maurhofer, Diren Beyoglu, Christian Lanz, Kristopher W Krausz, Thomas Pabst, Frank J Gonzalez, Jean-François Dufour, Jeffrey R Idle. Aberrant lipid metabolism in hepatocellular carcinoma revealed by plasma metabolomics and lipid profiling. Cancer research. 2011 Nov; 71(21):6590-600. doi: 10.1158/0008-5472.can-11-0885. [PMID: 21900402]
  • Nariyasu Mano, Yoshiaki Sato, Masanori Nagata, Takaaki Goto, Junichi Goto. Bioconversion of 3beta-hydroxy-5-cholenoic acid into chenodeoxycholic acid by rat brain enzyme systems. Journal of lipid research. 2004 Sep; 45(9):1741-8. doi: 10.1194/jlr.m400157-jlr200. [PMID: 15175361]
  • H A Lemonde, E J Custard, J Bouquet, M Duran, H Overmars, P J Scambler, P T Clayton. Mutations in SRD5B1 (AKR1D1), the gene encoding delta(4)-3-oxosteroid 5beta-reductase, in hepatitis and liver failure in infancy. Gut. 2003 Oct; 52(10):1494-9. doi: 10.1136/gut.52.10.1494. [PMID: 12970144]
  • K Maeda, A Kimura, Y Yamato, T Matsuishi. Perinatal bile acid metabolism: analysis of urinary unsaturated ketonic bile acids in preterm and full-term infants. Acta paediatrica (Oslo, Norway : 1992). 2003; 92(2):216-20. doi: 10.1111/j.1651-2227.2003.tb00529.x. [PMID: 12710649]
  • T Yoshimura, T Taniguchi, D Kobayashi, T Komiya, T Murai, A Kimura, T Kurosawa, M Tohma. Enzyme immunoassay for conjugated 7alpha-hydroxy-3-oxo-4-cholenoic acid in human urine. Journal of immunoassay & immunochemistry. 2001; 22(1):1-13. doi: 10.1081/ias-100102894. [PMID: 11486816]
  • A Kimura, M Suzuki, T Murai, T Kurosawa, M Tohma, M Sata, T Inoue, A Hoshiyama, E Nakashima, Y Yamashita, T Fujisawa, H Kato. Urinary 7alpha-hydroxy-3-oxochol-4-en-24-oic and 3-oxochola-4,6-dien-24-oic acids in infants with cholestasis. Journal of hepatology. 1998 Feb; 28(2):270-9. doi: 10.1016/0168-8278(88)80014-x. [PMID: 9514540]