HMR-3647 (BioDeep_00001871381)

Main id: BioDeep_00000009034

 

Volatile Flavor Compounds


代谢物信息卡片


Telithromycin

化学式: C43H65N5O10 (811.473119)
中文名称: 泰利霉素
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCC1C2(C(C(C(=O)C(CC(C(C(C(=O)C(C(=O)O1)C)C)OC3C(C(CC(O3)C)N(C)C)O)(C)OC)C)C)N(C(=O)O2)CCCCN4C=C(N=C4)C5=CN=CC=C5)C
InChI: InChI=1S/C43H65N5O10/c1-12-33-43(8)37(48(41(53)58-43)19-14-13-18-47-23-31(45-24-47)30-16-15-17-44-22-30)27(4)34(49)25(2)21-42(7,54-11)38(28(5)35(50)29(6)39(52)56-33)57-40-36(51)32(46(9)10)20-26(3)55-40/h15-17,22-29,32-33,36-38,40,51H,12-14,18-21H2,1-11H3/t25-,26-,27+,28+,29-,32+,33-,36-,37-,38-,40+,42-,43-/m1/s1

描述信息

J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use > J01F - Macrolides, lincosamides and streptogramins > J01FA - Macrolides
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents
C784 - Protein Synthesis Inhibitor > C261 - Macrolide Antibiotic
C254 - Anti-Infective Agent > C258 - Antibiotic
Same as: D01078

同义名列表

6 个代谢物同义名

Telithromycin; HMR-3647; RU-66647; HMR3647; RU66647; Telithromycin



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Xue-Meng Li, Wei Lv, Si-Yang Guo, Ya-Xin Li, Bing-Zhi Fan, Mark Cushman, Fan-Sheng Kong, Jun Zhang, Jian-Hua Liang. Synthesis and structure-bactericidal activity relationships of non-ketolides: 9-Oxime clarithromycin 11,12-cyclic carbonate featured with three-to eight-atom-length spacers at 3-OH. European journal of medicinal chemistry. 2019 Jun; 171(?):235-254. doi: 10.1016/j.ejmech.2019.03.037. [PMID: 30925339]
  • Robert Elsby, Victoria Hare, Hannah Neal, Samuel Outteridge, Catherine Pearson, Katie Plant, Rachel Upcott Gill, Philip Butler, Robert J Riley. Mechanistic In Vitro Studies Indicate that the Clinical Drug-Drug Interaction between Telithromycin and Simvastatin Acid Is Driven by Time-Dependent Inhibition of CYP3A4 with Minimal Effect on OATP1B1. Drug metabolism and disposition: the biological fate of chemicals. 2019 01; 47(1):1-8. doi: 10.1124/dmd.118.083832. [PMID: 30348903]
  • Kohei Togami, Yoshiaki Hayashi, Sumio Chono, Kazuhiro Morimoto. Involvement of intestinal permeability in the oral absorption of clarithromycin and telithromycin. Biopharmaceutics & drug disposition. 2014 Sep; 35(6):321-9. doi: 10.1002/bdd.1900. [PMID: 24801141]
  • K Ikawa, E Kikuchi, J Kikuchi, M Nishimura, H Derendorf, N Morikawa. Pharmacokinetic modelling of serum and bronchial concentrations for clarithromycin and telithromycin, and site-specific pharmacodynamic simulation for their dosages. Journal of clinical pharmacy and therapeutics. 2014 Aug; 39(4):411-7. doi: 10.1111/jcpt.12157. [PMID: 24661290]
  • K Togami, S Chono, K Morimoto. Transport characteristics of clarithromycin, azithromycin and telithromycin, antibiotics applied for treatment of respiratory infections, in Calu-3 cell monolayers as model lung epithelial cells. Die Pharmazie. 2012 May; 67(5):389-93. doi: . [PMID: 22764569]
  • Ping Zhao, Manuela de L T Vieira, Joseph A Grillo, Pengfei Song, Ta-Chen Wu, Jenny H Zheng, Vikram Arya, Eva Gil Berglund, Arthur J Atkinson, Yuichi Sugiyama, K Sandy Pang, Kellie S Reynolds, Darrell R Abernethy, Lei Zhang, Lawrence J Lesko, Shiew-Mei Huang. Evaluation of exposure change of nonrenally eliminated drugs in patients with chronic kidney disease using physiologically based pharmacokinetic modeling and simulation. Journal of clinical pharmacology. 2012 Jan; 52(1 Suppl):91S-108S. doi: 10.1177/0091270011415528. [PMID: 22232759]
  • L H Javsicas, S Giguère, Ariel Y Womble. Disposition of oral telithromycin in foals and in vitro activity of the drug against macrolide-susceptible and macrolide-resistant Rhodococcus equi isolates. Journal of veterinary pharmacology and therapeutics. 2010 Aug; 33(4):383-8. doi: 10.1111/j.1365-2885.2009.01151.x. [PMID: 20646201]
  • Kohei Togami, Sumio Chono, Toshinobu Seki, Kazuhiro Morimoto. Aerosol-based efficient delivery of telithromycin, a ketolide antimicrobial agent, to lung epithelial lining fluid and alveolar macrophages for treatment of respiratory infections. Drug development and industrial pharmacy. 2010 Jul; 36(7):861-6. doi: 10.3109/03639040903551319. [PMID: 20515406]
  • Mirva Lehtopolku, Ulla-Maija Nakari, Pirkko Kotilainen, Pentti Huovinen, Anja Siitonen, Antti J Hakanen. Antimicrobial susceptibilities of multidrug-resistant Campylobacter jejuni and C. coli strains: in vitro activities of 20 antimicrobial agents. Antimicrobial agents and chemotherapy. 2010 Mar; 54(3):1232-6. doi: 10.1128/aac.00898-09. [PMID: 20038624]
  • J H Lee, H E Kang, M G Lee. Pharmacokinetic interaction between telithromycin and metformin in diabetes mellitus rats. Xenobiotica; the fate of foreign compounds in biological systems. 2010 Mar; 40(3):217-24. doi: 10.3109/00498250903470248. [PMID: 20039777]
  • Hidetoshi Furuie, Yutaka Saisho, Takayoshi Yoshikawa, Jingoro Shimada. Intrapulmonary pharmacokinetics of S-013420, a novel bicyclolide antibacterial, in healthy Japanese subjects. Antimicrobial agents and chemotherapy. 2010 Feb; 54(2):866-70. doi: 10.1128/aac.00567-09. [PMID: 19933801]
  • Juha Grönlund, Teijo Saari, Nora Hagelberg, Ilkka K Martikainen, Pertti J Neuvonen, Klaus T Olkkola, Kari Laine. Effect of telithromycin on the pharmacokinetics and pharmacodynamics of oral oxycodone. Journal of clinical pharmacology. 2010 Jan; 50(1):101-8. doi: 10.1177/0091270009336444. [PMID: 19755414]
  • Manthena V S Varma, Bo Feng, R Scott Obach, Matthew D Troutman, Jonathan Chupka, Howard R Miller, Ayman El-Kattan. Physicochemical determinants of human renal clearance. Journal of medicinal chemistry. 2009 Aug; 52(15):4844-52. doi: 10.1021/jm900403j. [PMID: 19445515]
  • Ayman M Noreddin, Walid F El-Khatib, Jason Aolie, Ahmed H Salem, George G Zhanel. Pharmacodynamic target attainment potential of azithromycin, clarithromycin, and telithromycin in serum and epithelial lining fluid of community-acquired pneumonia patients with penicillin-susceptible, intermediate, and resistant Streptococcus pneumoniae. International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases. 2009 Jul; 13(4):483-7. doi: 10.1016/j.ijid.2008.08.016. [PMID: 19046911]
  • Friederike Traunmüller, Manfred Fille, Christiane Thallinger, Christian Joukhadar. Multiple-dose pharmacokinetics of telithromycin in peripheral soft tissues. International journal of antimicrobial agents. 2009 Jul; 34(1):72-5. doi: 10.1016/j.ijantimicag.2009.01.016. [PMID: 19380214]
  • Li-Juan Jiang, Michelle Wang, Yat Sun Or. Pharmacokinetics of EDP-420 after ascending single oral doses in healthy adult volunteers. Antimicrobial agents and chemotherapy. 2009 May; 53(5):1786-92. doi: 10.1128/aac.01270-08. [PMID: 19223626]
  • Kohei Togami, Sumio Chono, Toshinobu Seki, Kazuhiro Morimoto. Distribution characteristics of telithromycin, a novel ketolide antimicrobial agent applied for treatment of respiratory infection, in lung epithelial lining fluid and alveolar macrophages. Drug metabolism and pharmacokinetics. 2009; 24(5):411-7. doi: 10.2133/dmpk.24.411. [PMID: 19881252]
  • R Scott Obach, Franco Lombardo, Nigel J Waters. Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals. 2008 Jul; 36(7):1385-405. doi: 10.1124/dmd.108.020479. [PMID: 18426954]
  • Joo H Lee, Yu K Cho, Young S Jung, Young C Kim, Myung G Lee. Effects of Escherichia coli lipopolysaccharide on telithromycin pharmacokinetics in rats: inhibition of metabolism via CYP3A. Antimicrobial agents and chemotherapy. 2008 Mar; 52(3):1046-51. doi: 10.1128/aac.01210-07. [PMID: 18160519]
  • Scott Bolesta, Brian P Roslund. Elevated hepatic transaminases associated with telithromycin therapy: a case report and literature review. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists. 2008 Jan; 65(1):37-41. doi: 10.2146/ajhp070164. [PMID: 18159037]
  • Joo H Lee, Myung G Lee. Effects of acute renal failure on the pharmacokinetics of telithromycin in rats: negligible effects of increase in CYP3A1 on the metabolism of telithromycin. Biopharmaceutics & drug disposition. 2007 May; 28(4):157-66. doi: 10.1002/bdd.542. [PMID: 17377958]
  • Junko Kikuchi, Koichi Yamazaki, Eiki Kikuchi, Akitoshi Ishizaka, Masaharu Nishimura. Pharmacokinetics of telithromycin using bronchoscopic microsampling after single and multiple oral doses. Pulmonary pharmacology & therapeutics. 2007; 20(5):549-55. doi: 10.1016/j.pupt.2006.05.006. [PMID: 17127087]
  • Joo Hyun Lee, Myung Gull Lee. Dose-dependent pharmacokinetics of telithromycin after intravenous and oral administration to rats: contribution of intestinal first-pass effect to low bioavailability. Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques. 2007; 10(1):37-50. doi: NULL. [PMID: 17498392]
  • Sonja Eberl, Bertold Renner, Antje Neubert, Mareike Reisig, Iouri Bachmakov, Jörg König, Frank Dörje, Thomas E Mürdter, Andreas Ackermann, Harald Dormann, Karl G Gassmann, Eckhart G Hahn, Stefanie Zierhut, Kay Brune, Martin F Fromm. Role of p-glycoprotein inhibition for drug interactions: evidence from in vitro and pharmacoepidemiological studies. Clinical pharmacokinetics. 2007; 46(12):1039-49. doi: 10.2165/00003088-200746120-00004. [PMID: 18027988]
  • Gary E Stein, Sharon Schooley, Kerin L Tyrrell, Diane M Citron, Ellie J C Goldstein. Human serum activity of telithromycin, azithromycin and amoxicillin/clavulanate against common aerobic and anaerobic respiratory pathogens. International journal of antimicrobial agents. 2007 Jan; 29(1):39-43. doi: 10.1016/j.ijantimicag.2006.08.041. [PMID: 17189093]
  • Matthew T Burger, Christy Hiebert, Mehran Seid, Daniel T Chu, Lynn Barker, Mike Langhorne, Ribhi Shawar, Jolene Kidney, Manoj C Desai, Jacob J Plattner. Synthesis and antibacterial activity of novel C12 ethyl ketolides. Bioorganic & medicinal chemistry. 2006 Aug; 14(16):5592-604. doi: 10.1016/j.bmc.2006.04.032. [PMID: 16697203]
  • Laura M Nenciu, Patrice Laberge, Daniel J G Thirion. Telithromycin-induced digoxin toxicity and electrocardiographic changes. Pharmacotherapy. 2006 Jun; 26(6):872-6. doi: 10.1592/phco.26.6.872. [PMID: 16716140]
  • Michael J Rybak. Pharmacodynamics: relation to antimicrobial resistance. The American journal of medicine. 2006 Jun; 119(6 Suppl 1):S37-44; discussion S62. doi: 10.1016/j.amjmed.2006.04.001. [PMID: 16735150]
  • Hiroyuki Nosaka, Masayuki Nadai, Miki Kato, Kazumasa Yasui, Hideo Yoshizumi, Mika Miyoshi, Ying Lan Zhao, Kenji Baba, Kenzo Takagi, Takaaki Hasegawa. Effect of a newly developed ketolide antibiotic, telithromycin, on metabolism of theophylline and expression of cytochrome P450 in rats. Life sciences. 2006 May; 79(1):50-6. doi: 10.1016/j.lfs.2005.12.022. [PMID: 16423372]
  • Matthew T Burger, Xiaodong Lin, Daniel T Chu, Christy Hiebert, Alice C Rico, Mehran Seid, Georgia L Carroll, Lynn Barker, Kay Huh, Mike Langhorne, Ribhi Shawar, Jolene Kidney, Kelly Young, Scott Anderson, Manoj C Desai, Jacob J Plattner. Synthesis and antibacterial activity of novel C12 vinyl ketolides. Journal of medicinal chemistry. 2006 Mar; 49(5):1730-43. doi: 10.1021/jm051157a. [PMID: 16509588]
  • Lauri I Kajosaari, Mikko Niemi, Janne T Backman, Pertti J Neuvonen. Telithromycin, but not montelukast, increases the plasma concentrations and effects of the cytochrome P450 3A4 and 2C8 substrate repaglinide. Clinical pharmacology and therapeutics. 2006 Mar; 79(3):231-42. doi: 10.1016/j.clpt.2005.11.002. [PMID: 16513447]
  • Shoji Yamaguchi, Ying Lan Zhao, Masayuki Nadai, Hideo Yoshizumi, Xiaobo Cen, Shoko Torita, Kenji Takagi, Kenzo Takagi, Takaaki Hasegawa. Involvement of the drug transporters p glycoprotein and multidrug resistance-associated protein Mrp2 in telithromycin transport. Antimicrobial agents and chemotherapy. 2006 Jan; 50(1):80-7. doi: 10.1128/aac.50.1.80-87.2006. [PMID: 16377671]
  • Carman A Ciervo, Jun Shi. Pharmacokinetics of telithromycin: application to dosing in the treatment of community-acquired respiratory tract infections. Current medical research and opinion. 2005 Oct; 21(10):1641-50. doi: 10.1185/030079905x65466. [PMID: 16238904]
  • C T Ong, P K Dandekar, C Sutherland, C H Nightingale, D P Nicolau. Intrapulmonary concentrations of telithromycin: clinical implications for respiratory tract infections due to Streptococcus pneumoniae. Chemotherapy. 2005 Oct; 51(6):339-46. doi: 10.1159/000088958. [PMID: 16224186]
  • Christina Lippert, Seth Gbenado, Chunfu Qiu, Bruce Lavin, Steven J Kovacs. The bioequivalence of telithromycin administered orally as crushed tablets versus tablets swallowed whole. Journal of clinical pharmacology. 2005 Sep; 45(9):1025-31. doi: 10.1177/0091270005279273. [PMID: 16100296]
  • Friederike Traunmüller, Rainer Gattringer, Markus A Zeitlinger, Wolfgang Graninger, Markus Müller, Christian Joukhadar. Determination of telithromycin in human plasma and microdialysates by high-performance liquid chromatography. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2005 Aug; 822(1-2):133-6. doi: 10.1016/j.jchromb.2005.05.030. [PMID: 15990374]
  • Megan Nguyen, Eunice P Chung. Telithromycin: the first ketolide antimicrobial. Clinical therapeutics. 2005 Aug; 27(8):1144-63. doi: 10.1016/j.clinthera.2005.08.009. [PMID: 16199242]
  • Jean-Louis Démolis, Soraya Strabach, Françoise Vacheron, Christian Funck-Brentano. Assessment of the effect of a single oral dose of telithromycin on sotalol-induced qt interval prolongation in healthy women. British journal of clinical pharmacology. 2005 Aug; 60(2):120-7. doi: 10.1111/j.1365-2125.2005.02395.x. [PMID: 16042664]
  • Tetsuro Muratani, Tetsuro Matsumoto, Susumu Arai. [In vitro antibacterial activities of telithromycin against clinical isolates of Neisseria gonorrhoeae]. The Japanese journal of antibiotics. 2005 Jun; 58(3):317-25. doi: . [PMID: 16161757]
  • George G Zhanel, Christel Johanson, Nancy Laing, Tamiko Hisanaga, Aleksandra Wierzbowski, Daryl J Hoban. Pharmacodynamic activity of telithromycin at simulated clinically achievable free-drug concentrations in serum and epithelial lining fluid against efflux (mefE)-producing macrolide-resistant Streptococcus pneumoniae for which telithromycin MICs vary. Antimicrobial agents and chemotherapy. 2005 May; 49(5):1943-8. doi: 10.1128/aac.49.5.1943-1948.2005. [PMID: 15855517]
  • T S Kuehnel, C Schurr, K Lotter, F Kees. Penetration of telithromycin into the nasal mucosa and ethmoid bone of patients undergoing rhinosurgery for chronic sinusitis. The Journal of antimicrobial chemotherapy. 2005 Apr; 55(4):591-4. doi: 10.1093/jac/dki034. [PMID: 15761076]
  • J Shi, S Chapel, G Montay, P Hardy, J S Barrett, D Sica, S K Swan, R Noveck, B Leroy, V O Bhargava. Effect of ketoconazole on the pharmacokinetics and safety of telithromycin and clarithromycin in older subjects with renal impairment. International journal of clinical pharmacology and therapeutics. 2005 Mar; 43(3):123-33. doi: 10.5414/cpp43123. [PMID: 15792396]
  • Xiaodong Xu, Todd Henninger, Darren Abbanat, Karen Bush, Barbara Foleno, Jamese Hilliard, Mark Macielag. Synthesis and antibacterial activity of C2-fluoro, C6-carbamate ketolides, and their C9-oximes. Bioorganic & medicinal chemistry letters. 2005 Feb; 15(4):883-7. doi: 10.1016/j.bmcl.2004.12.067. [PMID: 15686880]
  • Jun Shi, Marc Pfister, Stephen G Jenkins, Sunny Chapel, Jeffrey S Barrett, Ruedi E Port, Dan Howard. Pharmacodynamic analysis of the microbiological efficacy of telithromycin in patients with community-acquired pneumonia. Clinical pharmacokinetics. 2005; 44(3):317-29. doi: 10.2165/00003088-200544030-00007. [PMID: 15762772]
  • Jun Shi, Guy Montay, Bruno Leroy, Vijay O Bhargava. Effects of itraconazole or grapefruit juice on the pharmacokinetics of telithromycin. Pharmacotherapy. 2005 Jan; 25(1):42-51. doi: 10.1592/phco.25.1.42.55621. [PMID: 15767219]
  • Jun Shi, Guy Montay, Vijay O Bhargava. Clinical pharmacokinetics of telithromycin, the first ketolide antibacterial. Clinical pharmacokinetics. 2005; 44(9):915-34. doi: 10.2165/00003088-200544090-00003. [PMID: 16122280]
  • George G Zhanel, Christel Johanson, Tamiko Hisanaga, Chris Mendoza, Nancy Laing, Ayman Noreddin, Aleksandra Wierzbowski, Daryl J Hoban. Pharmacodynamic activity of telithromycin against macrolide-susceptible and macrolide-resistant Streptococcus pneumoniae simulating clinically achievable free serum and epithelial lining fluid concentrations. The Journal of antimicrobial chemotherapy. 2004 Dec; 54(6):1072-7. doi: 10.1093/jac/dkh475. [PMID: 15531596]
  • Rainer Gattringer, Eleonora Urbauer, Friederike Traunmüller, Markus Zeitlinger, Pejman Dehghanyar, Petra Zeleny, Wolfgang Graninger, Markus Müller, Christian Joukhadar. Pharmacokinetics of telithromycin in plasma and soft tissues after single-dose administration to healthy volunteers. Antimicrobial agents and chemotherapy. 2004 Dec; 48(12):4650-3. doi: 10.1128/aac.48.12.4650-4653.2004. [PMID: 15561839]
  • Liisa Törmäkangas, Hannu Alakärppä, Denise Bem David, Maija Leinonen, Pekka Saikku. Telithromycin treatment of chronic Chlamydia pneumoniae infection in C57BL/6J mice. Antimicrobial agents and chemotherapy. 2004 Oct; 48(10):3655-61. doi: 10.1128/aac.48.10.3655-3661.2004. [PMID: 15388416]
  • Michel Tintillier, Lotti Kirch, Carole Almpanis, Jean-Pierre Cosyns, Jean-Michel Pochet, Charles Cuvelier. Telithromycin-induced acute interstitial nephritis: a first case report. American journal of kidney diseases : the official journal of the National Kidney Foundation. 2004 Aug; 44(2):e25-27. doi: 10.1053/j.ajkd.2004.04.045. [PMID: 15264209]
  • L Törmäkangas, E Saario, D Bem David, A Bryskier, M Leinonen, P Saikku. Treatment of acute Chlamydia pneumoniae infection with telithromycin in C57BL/6J mice. The Journal of antimicrobial chemotherapy. 2004 Jun; 53(6):1101-4. doi: 10.1093/jac/dkh213. [PMID: 15117927]
  • S J Harnett, A P Fraise, J M Andrews, G Jevons, N P Brenwald, R Wise. Comparative study of the in vitro activity of a new fluoroquinolone, ABT-492. The Journal of antimicrobial chemotherapy. 2004 May; 53(5):783-92. doi: 10.1093/jac/dkh180. [PMID: 15056651]
  • H Thadepalli, S K Chuah, A Vidad, S Gollapudi. Efficacy of telithromycin in the treatment of experimental Bacteroides fragilis intraabdominal abscess in the senescent mice. Le infezioni in medicina. 2004 Mar; 12(1):44-50. doi: . [PMID: 15329528]
  • Jun Shi, Guy Montay, Sunny Chapel, Pierre Hardy, Jeffrey S Barrett, Marshall Sack, Thomas Marbury, Suzanne K Swan, Ramon Vargas, Violette Leclerc, Bruno Leroy, Vijay O Bhargava. Pharmacokinetics and safety of the ketolide telithromycin in patients with renal impairment. Journal of clinical pharmacology. 2004 Mar; 44(3):234-44. doi: 10.1177/0091270003262952. [PMID: 14973302]
  • David P Nicolau. Optimizing outcomes with antimicrobial therapy through pharmacodynamic profiling. Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy. 2003 Dec; 9(4):292-6. doi: 10.1007/s10156-003-0279-x. [PMID: 14691648]
  • C Cantalloube, V Bhargava, E Sultan, F Vacheron, I Batista, G Montay. Pharmacokinetics of the ketolide telithromycin after single and repeated doses in patients with hepatic impairment. International journal of antimicrobial agents. 2003 Aug; 22(2):112-21. doi: 10.1016/s0924-8579(03)00128-6. [PMID: 12927950]
  • J Lorenz. Telithromycin: the first ketolide antibacterial for the treatment of community-acquired respiratory tract infections. International journal of clinical practice. 2003 Jul; 57(6):519-29. doi: . [PMID: 12918892]
  • Anne-Claude Crémieux, Claudette Muller-Serieys, Xavière Panhard, Frédérique Delatour, Marina Tchimichkian, France Mentre, Antoine Andremont. Emergence of resistance in normal human aerobic commensal flora during telithromycin and amoxicillin-clavulanic acid treatments. Antimicrobial agents and chemotherapy. 2003 Jun; 47(6):2030-5. doi: 10.1128/aac.47.6.2030-2035.2003. [PMID: 12760893]
  • P Gehanno, E Sultan, V Passot, P Nabet, J Danon, P Romanet, P Attal. Telithromycin (HMR 3647) achieves high and sustained concentrations in tonsils of patients undergoing tonsillectomy. International journal of antimicrobial agents. 2003 May; 21(5):441-5. doi: 10.1016/s0924-8579(03)00050-5. [PMID: 12727077]
  • José Mensa, Elisa García-Vázquez, Jordi Vila. [Macrolides, ketolides and streptogramins]. Enfermedades infecciosas y microbiologia clinica. 2003 Apr; 21(4):200-7; quiz 208, 219. doi: NULL. [PMID: 12681133]
  • C Perret, B Lenfant, E Weinling, D H Wessels, H E Scholtz, G Montay, E Sultan. Pharmacokinetics and absolute oral bioavailability of an 800-mg oral dose of telithromycin in healthy young and elderly volunteers. Chemotherapy. 2002 Dec; 48(5):217-23. doi: 10.1159/000066766. [PMID: 12476037]
  • F Namour, E Sultan, M H Pascual, B Lenfant. Penetration of telithromycin (HMR 3647), a new ketolide antimicrobial, into inflammatory blister fluid following oral administration. The Journal of antimicrobial chemotherapy. 2002 Jun; 49(6):1035-8. doi: 10.1093/jac/dkf062. [PMID: 12039900]
  • Katharina Semrad, Rachel Green. Osmolytes stimulate the reconstitution of functional 50S ribosomes from in vitro transcripts of Escherichia coli 23S rRNA. RNA (New York, N.Y.). 2002 Apr; 8(4):401-11. doi: 10.1017/s1355838202029722. [PMID: 11991636]
  • Jun-Ichi Kadota, Yuji Ishimatsu, Tetsuji Iwashita, Yuichi Matsubara, Kazunori Tomono, Masao Tateno, Roza Ishihara, Claudette Muller-Serieys, Shigeru Kohno. Intrapulmonary pharmacokinetics of telithromycin, a new ketolide, in healthy Japanese volunteers. Antimicrobial agents and chemotherapy. 2002 Mar; 46(3):917-21. doi: 10.1128/aac.46.3.917-921.2002. [PMID: 11850288]
  • D P Nicolau. Pharmacodynamic rationale for short-duration antibacterial therapy. The Journal of infection. 2002 Feb; 44 Suppl A(?):17-23. doi: NULL. [PMID: 12150491]
  • Vijay Bhargava, Bernard Lenfant, Catherine Perret, Marie-Helene Pascual, Eric Sultan, Guy Montay. Lack of effect of food on the bioavailability of a new ketolide antibacterial, telithromycin. Scandinavian journal of infectious diseases. 2002; 34(11):823-6. doi: 10.1080/0036554021000026958. [PMID: 12578152]
  • D P Nicolau. Predicting antibacterial response from pharmacodynamic and pharmacokinetic profiles. Infection. 2001 Dec; 29 Suppl 2(?):11-5. doi: NULL. [PMID: 11785851]
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