Ro 61-8048 (BioDeep_00001869167)

Main id: BioDeep_00000009710

 


代谢物信息卡片


3,4-Dimethoxy-N-(4-(3-nitrophenyl)thiazol-2-yl)benzenesulfonamide

化学式: C17H15N3O6S2 (421.0402)
中文名称: Ro 61-8048
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: COC1=C(C=C(C=C1)S(=O)(=O)NC2=NC(=CS2)C3=CC(=CC=C3)[N+](=O)[O-])OC
InChI: InChI=1S/C17H15N3O6S2/c1-25-15-7-6-13(9-16(15)26-2)28(23,24)19-17-18-14(10-27-17)11-4-3-5-12(8-11)20(21)22/h3-10H,1-2H3,(H,18,19)

描述信息

同义名列表

3 个代谢物同义名

3,4-Dimethoxy-N-(4-(3-nitrophenyl)thiazol-2-yl)benzenesulfonamide; Ro 61-8048; Ro 61-8048



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 12 ATF4, CA1, CASP3, DCX, DISC1, ELANE, GRIN2B, HTT, KYNU, NOS3, QPRT, RBFOX3
Endosome membrane 1 HTT
Endoplasmic reticulum membrane 2 GRIN2A, GRIN2B
Nucleus 8 ATF4, CASP3, GRM1, HTT, MECP2, NOS3, PCNA, RBFOX3
autophagosome 1 HTT
cytosol 13 ATF4, CA1, CASP3, DCX, DISC1, ELANE, HTT, KMO, KYNU, MECP2, NOS3, QPRT, VAMP1
dendrite 2 GRM1, HTT
nuclear body 1 PCNA
phagocytic vesicle 1 ELANE
centrosome 4 ATF4, DISC1, MECP2, PCNA
nucleoplasm 7 ATF4, CASP3, HTT, KYNU, MECP2, NOS3, PCNA
RNA polymerase II transcription regulator complex 1 ATF4
Cell membrane 6 ATF4, GRIN2A, GRIN2B, GRM1, HTT, SLC6A12
Multi-pass membrane protein 6 GRIN2A, GRIN2B, GRM1, HTT, KMO, SLC6A12
Synapse 2 GRIN2A, HTT
cell surface 3 ELANE, GRIN2A, GRIN2B
glutamatergic synapse 6 CASP3, DCX, DISC1, GRIN2A, GRM1, MECP2
Golgi apparatus 2 HTT, NOS3
Golgi membrane 1 NOS3
neuronal cell body 1 CASP3
postsynapse 1 MECP2
presynaptic membrane 2 GRIN2A, HTT
synaptic vesicle 2 DISC1, GRIN2A
Cytoplasm, cytosol 1 KYNU
Lysosome 1 GRIN2B
Presynapse 2 DISC1, SLC6A12
plasma membrane 8 GRIN2A, GRIN2B, GRM1, HTT, IFNLR1, NOS3, SLC6A12, VAMP1
synaptic vesicle membrane 1 VAMP1
Membrane 5 GRIN2A, GRIN2B, IFNLR1, KMO, SLC6A12
axon 1 HTT
basolateral plasma membrane 1 SLC6A12
caveola 1 NOS3
extracellular exosome 4 CA1, ELANE, PCNA, QPRT
endoplasmic reticulum 2 GRIN2A, HTT
extracellular space 3 ELANE, KMO, MECP2
perinuclear region of cytoplasm 3 DISC1, HTT, NOS3
Schaffer collateral - CA1 synapse 1 GRM1
mitochondrion 3 DISC1, KMO, KYNU
protein-containing complex 3 ATF4, HTT, MECP2
postsynaptic density 4 CASP3, DISC1, GRIN2A, GRIN2B
Single-pass type I membrane protein 1 IFNLR1
extracellular region 1 ELANE
Mitochondrion outer membrane 1 KMO
mitochondrial outer membrane 2 KMO, VAMP1
central region of growth cone 1 DISC1
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 2 ATF4, DISC1
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 VAMP1
dendritic spine 1 GRIN2A
perikaryon 1 RBFOX3
Cytoplasm, P-body 1 NOS3
P-body 1 NOS3
Early endosome 1 HTT
postsynaptic membrane 3 GRIN2A, GRIN2B, HTT
heterochromatin 1 MECP2
Membrane raft 1 HTT
Cell junction, focal adhesion 1 HTT
Cytoplasm, cytoskeleton 2 DISC1, GRIN2B
focal adhesion 1 HTT
microtubule 2 DCX, DISC1
GABA-ergic synapse 1 DISC1
Cell projection, dendritic spine 1 GRIN2A
collagen-containing extracellular matrix 1 ELANE
secretory granule 1 ELANE
nuclear speck 1 ATF4
Postsynaptic cell membrane 3 GRIN2A, GRIN2B, GRM1
Late endosome 2 GRIN2B, HTT
Cell projection, neuron projection 2 DCX, HTT
neuron projection 6 ATF4, DCX, GRIN2A, GRIN2B, HTT, VAMP1
ciliary basal body 1 DISC1
ciliary base 1 DISC1
chromatin 2 ATF4, PCNA
microtubule associated complex 1 DCX
cell projection 1 SLC6A12
cytoskeleton 3 DCX, GRIN2B, NOS3
centriole 1 HTT
nuclear replication fork 1 PCNA
chromosome, telomeric region 1 PCNA
Basolateral cell membrane 1 SLC6A12
Endomembrane system 1 HTT
Cytoplasmic vesicle membrane 2 GRIN2A, HTT
Cell projection, dendrite 1 GRIN2B
specific granule membrane 1 VAMP1
tertiary granule membrane 1 VAMP1
Cytoplasm, Stress granule 1 NOS3
cytoplasmic stress granule 1 NOS3
Nucleus speckle 1 ATF4
cell body 1 DISC1
replication fork 1 PCNA
intermediate filament cytoskeleton 1 DISC1
kinesin complex 1 DISC1
SNARE complex 1 VAMP1
synaptic membrane 2 GRIN2A, GRIN2B
transcription repressor complex 1 ELANE
male germ cell nucleus 1 PCNA
specific granule lumen 1 ELANE
endocytic vesicle membrane 1 NOS3
azurophil granule lumen 1 ELANE
postsynaptic density membrane 3 GRIN2A, GRIN2B, GRM1
dynein complex 1 DISC1
Single-pass type IV membrane protein 1 VAMP1
nuclear lamina 1 PCNA
Synapse, synaptosome 1 VAMP1
NMDA selective glutamate receptor complex 2 GRIN2A, GRIN2B
death-inducing signaling complex 1 CASP3
dendrite membrane 1 ATF4
postsynaptic cytosol 1 HTT
Cytoplasmic vesicle, phagosome 1 ELANE
nuclear periphery 1 ATF4
presynaptic cytosol 1 HTT
cyclin-dependent protein kinase holoenzyme complex 1 PCNA
inclusion body 1 HTT
catalytic complex 1 QPRT
PCNA complex 1 PCNA
PCNA-p21 complex 1 PCNA
replisome 1 PCNA
ATF4-CREB1 transcription factor complex 1 ATF4
ATF1-ATF4 transcription factor complex 1 ATF4
CHOP-ATF4 complex 1 ATF4
Lewy body core 1 ATF4
[Isoform 1]: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 VAMP1
[Isoform 2]: Cytoplasmic vesicle membrane 1 VAMP1
serotonergic synapse 1 HTT
[Huntingtin]: Cytoplasm 1 HTT
[Huntingtin, myristoylated N-terminal fragment]: Cytoplasmic vesicle, autophagosome 1 HTT
interleukin-28 receptor complex 1 IFNLR1
G protein-coupled receptor dimeric complex 1 GRM1
G protein-coupled receptor homodimeric complex 1 GRM1


文献列表

  • Leticia Gil de Biedma-Elduayen, Pablo Giménez-Gómez, Nuria Morales-Puerto, Rebeca Vidal, Carlos Núñez-de la Calle, María Dolores Gutiérrez-López, Esther O'Shea, María Isabel Colado. Influx of kynurenine into the brain is involved in the reduction of ethanol consumption induced by Ro 61-8048 after chronic intermittent ethanol in mice. British journal of pharmacology. 2022 07; 179(14):3711-3726. doi: 10.1111/bph.15825. [PMID: 35189673]
  • Mary Ew Collier, Shaowei Zhang, Nigel S Scrutton, Flaviano Giorgini. Inflammation control and improvement of cognitive function in COVID-19 infections: is there a role for kynurenine 3-monooxygenase inhibition?. Drug discovery today. 2021 06; 26(6):1473-1481. doi: 10.1016/j.drudis.2021.02.009. [PMID: 33609782]
  • Pablo Giménez-Gómez, Mercedes Pérez-Hernández, María Dolores Gutiérrez-López, Rebeca Vidal, Cristina Abuin-Martínez, Esther O'Shea, María Isabel Colado. Increasing kynurenine brain levels reduces ethanol consumption in mice by inhibiting dopamine release in nucleus accumbens. Neuropharmacology. 2018 06; 135(?):581-591. doi: 10.1016/j.neuropharm.2018.04.016. [PMID: 29705534]
  • Maria G Beconi, Dawn Yates, Kathryn Lyons, Kim Matthews, Steve Clifton, Tania Mead, Michael Prime, Dirk Winkler, Catherine O'Connell, Daryl Walter, Leticia Toledo-Sherman, Ignacio Munoz-Sanjuan, Celia Dominguez. Metabolism and pharmacokinetics of JM6 in mice: JM6 is not a prodrug for Ro-61-8048. Drug metabolism and disposition: the biological fate of chemicals. 2012 Dec; 40(12):2297-306. doi: 10.1124/dmd.112.046532. [PMID: 22942319]
  • Bazoumana Ouattara, Samah Belkhir, Marc Morissette, Mehdi Dridi, Pershia Samadi, Laurent Grégoire, Leonard T Meltzer, Thérèse Di Paolo. Implication of NMDA receptors in the antidyskinetic activity of cabergoline, CI-1041, and Ro 61-8048 in MPTP monkeys with levodopa-induced dyskinesias. Journal of molecular neuroscience : MN. 2009 Jun; 38(2):128-42. doi: 10.1007/s12031-008-9137-8. [PMID: 18704766]
  • Laurent Grégoire, Arash Rassoulpour, Paolo Guidetti, Pershia Samadi, Paul J Bédard, Emanuela Izzo, Robert Schwarcz, Thérèse Di Paolo. Prolonged kynurenine 3-hydroxylase inhibition reduces development of levodopa-induced dyskinesias in parkinsonian monkeys. Behavioural brain research. 2008 Jan; 186(2):161-7. doi: 10.1016/j.bbr.2007.08.007. [PMID: 17868931]
  • Pershia Samadi, Laurent Grégoire, Arash Rassoulpour, Paolo Guidetti, Emanuela Izzo, Robert Schwarcz, Paul J Bédard. Effect of kynurenine 3-hydroxylase inhibition on the dyskinetic and antiparkinsonian responses to levodopa in Parkinsonian monkeys. Movement disorders : official journal of the Movement Disorder Society. 2005 Jul; 20(7):792-802. doi: 10.1002/mds.20596. [PMID: 15954116]
  • W E Dale, Y Dang, N Amiridze, O R Brown. Evidence that kynurenine pathway metabolites mediate hyperbaric oxygen-induced convulsions. Toxicology letters. 2000 Sep; 117(1-2):37-43. doi: 10.1016/s0378-4274(00)00232-0. [PMID: 11033231]
  • S Röver, A M Cesura, P Huguenin, R Kettler, A Szente. Synthesis and biochemical evaluation of N-(4-phenylthiazol-2-yl)benzenesulfonamides as high-affinity inhibitors of kynurenine 3-hydroxylase. Journal of medicinal chemistry. 1997 Dec; 40(26):4378-85. doi: 10.1021/jm970467t. [PMID: 9435907]