Tert-Butylbicyclophosphorothionate (BioDeep_00001869011)

Main id: BioDeep_00000013134

 


代谢物信息卡片


Tert-Butylbicyclophosphorothionate

化学式: C8H15O3PS (222.047949)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(C)(C)C12COP(=S)(OC1)OC2
InChI: InChI=1S/C8H15O3PS/c1-7(2,3)8-4-9-12(13,10-5-8)11-6-8/h4-6H2,1-3H3

描述信息

D002491 - Central Nervous System Agents > D000697 - Central Nervous System Stimulants > D003292 - Convulsants

同义名列表

2 个代谢物同义名

Tert-Butylbicyclophosphorothionate; tert-Butylbicyclophosphorothionate



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Dan Shi, William L Padgett, John W Daly. Caffeine analogs: effects on ryanodine-sensitive calcium-release channels and GABAA receptors. Cellular and molecular neurobiology. 2003 Jun; 23(3):331-47. doi: 10.1023/a:1023688604792. [PMID: 12825831]
  • Ramin Darbandi-Tonkabon, William R Hastings, Chun-Min Zeng, Gustav Akk, Brad D Manion, John R Bracamontes, Joseph H Steinbach, Steven J Mennerick, Douglas F Covey, Alex S Evers. Photoaffinity labeling with a neuroactive steroid analogue. 6-azi-pregnanolone labels voltage-dependent anion channel-1 in rat brain. The Journal of biological chemistry. 2003 Apr; 278(15):13196-206. doi: 10.1074/jbc.m213168200. [PMID: 12560326]
  • Jan-Jurjen Koksma, Ronald E van Kesteren, Thomas W Rosahl, Ruud Zwart, August B Smit, Hartmut Lüddens, Arjen B Brussaard. Oxytocin regulates neurosteroid modulation of GABA(A) receptors in supraoptic nucleus around parturition. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2003 Feb; 23(3):788-97. doi: 10.1523/jneurosci.23-03-00788.2003. [PMID: 12574407]
  • A R Green, A H Hainsworth, A Misra, T A Debens, D M Jackson, T K Murray, R M Nelson, A J Cross. The interaction of AR-A008055 and its enantiomers with the GABA(A) receptor complex and their sedative, muscle relaxant and anticonvulsant activity. Neuropharmacology. 2001 Aug; 41(2):167-74. doi: 10.1016/s0028-3908(01)00053-3. [PMID: 11489453]
  • P Ghezzi, E D Santo, S Sacco, C Foddi, M L Barbaccia, T Mennini. Neurosteroid levels are increased in vivo after LPS treatment and negatively regulate LPS-induced TNF production. European cytokine network. 2000 Sep; 11(3):464-9. doi: NULL. [PMID: 11022133]
  • A Concas, P Follesa, M L Barbaccia, R H Purdy, G Biggio. Physiological modulation of GABA(A) receptor plasticity by progesterone metabolites. European journal of pharmacology. 1999 Jun; 375(1-3):225-35. doi: 10.1016/s0014-2999(99)00232-0. [PMID: 10443579]
  • M Serra, A Concas, M C Mostallino, M F Chessa, M Stomati, F Petraglia, A R Genazzani, G Biggio. Antagonism by pivagabine of stress-induced changes in GABAA receptor function and corticotropin-releasing factor concentrations in rat brain. Psychoneuroendocrinology. 1999 Apr; 24(3):269-84. doi: 10.1016/s0306-4530(98)00049-3. [PMID: 10101733]
  • H K Im, W B Im, J F Pregenzer, N C Stratman, P F VonVoigtlander, E J Jacobsen. Two imidazoquinoxaline ligands for the benzodiazepine site sharing a second low affinity site on rat GABA(A) receptors but with the opposite functionality. British journal of pharmacology. 1998 Apr; 123(8):1490-4. doi: 10.1038/sj.bjp.0701763. [PMID: 9605552]
  • P A Davies, E F Kirkness, T G Hales. Modulation by general anaesthetics of rat GABAA receptors comprised of alpha 1 beta 3 and beta 3 subunits expressed in human embryonic kidney 293 cells. British journal of pharmacology. 1997 Mar; 120(5):899-909. doi: 10.1038/sj.bjp.0700987. [PMID: 9138697]
  • Y Yildirim, L Niemi, G Wong, E R Korpi, P H Rosenberg. Propofol-induced ataxia and hypnosis in rat lines selected for differential alcohol sensitivity. Pharmacology & toxicology. 1997 Jan; 80(1):44-8. doi: 10.1111/j.1600-0773.1997.tb00282.x. [PMID: 9148282]
  • J E Hawkinson, J A Drewe, C L Kimbrough, J S Chen, D J Hogenkamp, N C Lan, K W Gee, K Z Shen, E R Whittemore, R M Woodward. 3 alpha-Hydroxy-3 beta-trifluoromethyl-5 alpha-pregnan-20-one (Co 2-1970): a partial agonist at the neuroactive steroid site of the gamma-aminobutyric acidA receptor. Molecular pharmacology. 1996 May; 49(5):897-906. doi: NULL. [PMID: 8622640]
  • J Zezula, A Slany, W Sieghart. Interaction of allosteric ligands with GABAA receptors containing one, two, or three different subunits. European journal of pharmacology. 1996 Apr; 301(1-3):207-14. doi: 10.1016/0014-2999(96)00066-0. [PMID: 8773466]
  • M L Barbaccia, G Roscetti, M Trabucchi, M C Mostallino, A Concas, R H Purdy, G Biggio. Time-dependent changes in rat brain neuroactive steroid concentrations and GABAA receptor function after acute stress. Neuroendocrinology. 1996 Feb; 63(2):166-72. doi: 10.1159/000126953. [PMID: 9053781]
  • H K Im, W B Im, J F Pregenzer, D B Carter, B J Hamilton. U-89843A is a novel allosteric modulator of gamma-aminobutyric acidA receptors. The Journal of pharmacology and experimental therapeutics. 1995 Dec; 275(3):1390-5. doi: NULL. [PMID: 8531107]
  • H Lüddens, E R Korpi. GABA antagonists differentiate between recombinant GABAA/benzodiazepine receptor subtypes. The Journal of neuroscience : the official journal of the Society for Neuroscience. 1995 Oct; 15(10):6957-62. doi: 10.1523/jneurosci.15-10-06957.1995. [PMID: 7472452]
  • A Slany, J Zezula, V Tretter, W Sieghart. Rat beta 3 subunits expressed in human embryonic kidney 293 cells form high affinity [35S]t-butylbicyclophosphorothionate binding sites modulated by several allosteric ligands of gamma-aminobutyric acid type A receptors. Molecular pharmacology. 1995 Sep; 48(3):385-91. doi: NULL. [PMID: 7565617]
  • E R Korpi, A Herb, H Lüddens. Effects of ethanol on recombinant rat GABAA receptors: [35S]t-butylbicyclophosphorothionate ([35S]TBPS) binding study. Pharmacology & toxicology. 1995 Aug; 77(2):87-90. doi: 10.1111/j.1600-0773.1995.tb00994.x. [PMID: 8584509]
  • G H Dillon, W B Im, D B Carter, D D McKinley. Enhancement by GABA of the association rate of picrotoxin and tert-butylbicyclophosphorothionate to the rat cloned alpha 1 beta 2 gamma 2 GABAA receptor subtype. British journal of pharmacology. 1995 Jun; 115(3):539-45. doi: 10.1111/j.1476-5381.1995.tb16368.x. [PMID: 7582470]
  • H K Im, W B Im, J F Pregenzer, D B Carter, E J Jacobsen, B J Hamilton. Characterization of U-97775 as a GABAA receptor ligand of dual functionality in cloned rat GABAA receptor subtypes. British journal of pharmacology. 1995 May; 115(1):19-24. doi: 10.1111/j.1476-5381.1995.tb16314.x. [PMID: 7647975]
  • M Samochocki, J Strosznajder. Age-related changes of GABA-activated chloride channel properties in brain cortex synaptic plasma membrane: evidence for phospholipase involvement. Journal of neurochemistry. 1994 Oct; 63(4):1522-8. doi: 10.1046/j.1471-4159.1994.63041522.x. [PMID: 7931306]
  • E R Korpi, P H Seeburg. Natural mutation of GABAA receptor alpha 6 subunit alters benzodiazepine affinity but not allosteric GABA effects. European journal of pharmacology. 1993 Sep; 247(1):23-7. doi: 10.1016/0922-4106(93)90133-t. [PMID: 8258357]
  • M Samochocki, J Strosznajder. Modulatory action of arachidonic acid on GABAA/chloride channel receptor function in adult and aged brain cortex membranes. Neurochemistry international. 1993 Sep; 23(3):261-7. doi: 10.1016/0197-0186(93)90117-n. [PMID: 8220171]
  • T Kimura, T Miyaoka, P A Saunders, M L Baker, A S Hume, I Yamamoto, I K Ho. Induction of tolerance to and physical dependence on pentobarbital continuous intracerebroventricular administration. The Journal of pharmacology and experimental therapeutics. 1993 Sep; 266(3):1300-5. doi: NULL. [PMID: 8371137]
  • E R Korpi, H Lüddens. Regional gamma-aminobutyric acid sensitivity of t-butylbicyclophosphoro[35S]thionate binding depends on gamma-aminobutyric acidA receptor alpha subunit. Molecular pharmacology. 1993 Jul; 44(1):87-92. doi: NULL. [PMID: 8393526]
  • E J Moody, B D Harris, P Skolnick. Stereospecific actions of the inhalation anesthetic isoflurane at the GABAA receptor complex. Brain research. 1993 Jun; 615(1):101-6. doi: 10.1016/0006-8993(93)91119-d. [PMID: 8395953]
  • Y T Tseng, T Miyaoka, I K Ho. Region-specific changes of GABAA receptors by tolerance to and dependence upon pentobarbital. European journal of pharmacology. 1993 May; 236(1):23-30. doi: 10.1016/0014-2999(93)90222-4. [PMID: 8391453]
  • J D Petke, H K Im, W B Im, D P Blakeman, J F Pregenzer, E J Jacobsen, B J Hamilton, D B Carter. Characterization of functional interactions of imidazoquinoxaline derivatives with benzodiazepine-gamma-aminobutyric acidA receptors. Molecular pharmacology. 1992 Aug; 42(2):294-301. doi: NULL. [PMID: 1355261]
  • J A Koenig, I L Martin. Effect of free fatty acids on GABAA receptor ligand binding. Biochemical pharmacology. 1992 Jul; 44(1):11-5. doi: 10.1016/0006-2952(92)90031-d. [PMID: 1321625]
  • D M Rutherford, M P Nielsen, S K Hansen, M R Witt, O Bergendorff, O Sterner. Isolation and identification from Salvia officinalis of two diterpenes which inhibit t-butylbicyclophosphoro[35S]thionate binding to chloride channel of rat cerebrocortical membranes in vitro. Neuroscience letters. 1992 Feb; 135(2):224-6. doi: 10.1016/0304-3940(92)90441-9. [PMID: 1378214]
  • B R de Costa, A H Lewin, K C Rice, P Skolnick, J A Schoenheimer. Novel site-directed affinity ligands for GABA-gated chloride channels: synthesis, characterization, and molecular modeling of 1-(isothiocyanatophenyl)-4-tert-butyl-2,6,7-trioxabicyclo[2.2.2]octanes . Journal of medicinal chemistry. 1991 May; 34(5):1531-8. doi: 10.1021/jm00109a002. [PMID: 2033577]
  • T McIntyre, P Skolnick. t-[35S]butylbicyclophosphorothionate binding under equilibrium and nonequilibrium conditions: differential effects of barbiturates and gamma-aminobutyric acid in the long-sleep and short-sleep selected mouse lines. Journal of neurochemistry. 1991 Jan; 56(1):287-93. doi: 10.1111/j.1471-4159.1991.tb02594.x. [PMID: 1846173]
  • G Evoniuk, E J Moody, P Skolnick. Ultraviolet irradiation selectively disrupts the gamma-aminobutyric acid/benzodiazepine receptor-linked chloride ionophore. Molecular pharmacology. 1989 May; 35(5):695-700. doi: NULL. [PMID: 2542759]
  • L G Miller, D J Greenblatt, R B Roy, A Gaver, F Lopez, R I Shader. Chronic benzodiazepine administration. III. Upregulation of gamma-aminobutyric acidA receptor binding and function associated with chronic benzodiazepine antagonist administration. The Journal of pharmacology and experimental therapeutics. 1989 Mar; 248(3):1096-101. doi: NULL. [PMID: 2539456]
  • A H Lewin, B R de Costa, K C Rice, P Skolnick. meta- and para-isothiocyanato-t-butylbicycloorthobenzoate: irreversible ligands of the gamma-aminobutyric acid-regulated chloride ionophore. Molecular pharmacology. 1989 Feb; 35(2):189-94. doi: NULL. [PMID: 2537456]
  • G Evoniuk, P Skolnick. Picrate and niflumate block anion modulation of radioligand binding to the gamma-aminobutyric acid/benzodiazepine receptor complex. Molecular pharmacology. 1988 Dec; 34(6):837-42. doi: NULL. [PMID: 2849050]
  • T D McIntyre, R Trullas, P Skolnick. Differences in the biophysical properties of the benzodiazepine/gamma-aminobutyric acid receptor chloride channel complex in the long-sleep and short-sleep mouse lines. Journal of neurochemistry. 1988 Aug; 51(2):642-7. doi: 10.1111/j.1471-4159.1988.tb01086.x. [PMID: 2455777]
  • T D McIntyre, R Trullas, P Skolnick. Asymmetrical activation of GABA-gated chloride channels in cerebral cortex. Pharmacology, biochemistry, and behavior. 1988 Aug; 30(4):911-6. doi: 10.1016/0091-3057(88)90119-0. [PMID: 2465553]
  • K G Lloyd, G Danielou, F Thuret. Differentiation of activities within the GABAA-chloride ionophore complex by means of 35-S-TBPS binding. Advances in biochemical psychopharmacology. 1988; 45(?):199-207. doi: NULL. [PMID: 2459920]
  • D N Stephens, H H Schneider, W Kehr, L H Jensen, E Petersen, T Honore. Modulation of anxiety by beta-carbolines and other benzodiazepine receptor ligands: relationship of pharmacological to biochemical measures of efficacy. Brain research bulletin. 1987 Sep; 19(3):309-18. doi: 10.1016/0361-9230(87)90099-2. [PMID: 2824003]
  • A Pitkänen, V Saano, L Tuomisto, P J Riekkinen. Effect of anticonvulsant drugs on (35S)t-butylbicyclophosphorothionate binding in vitro and ex vivo. Pharmacology & toxicology. 1987 Aug; 61(2):103-6. doi: 10.1111/j.1600-0773.1987.tb01784.x. [PMID: 3671324]
  • H Havoundjian, R M Cohen, S M Paul, P Skolnick. Differential sensitivity of 'central' and 'peripheral' type benzodiazepine receptors to phospholipase A2. Journal of neurochemistry. 1986 Mar; 46(3):804-11. doi: 10.1111/j.1471-4159.1986.tb13043.x. [PMID: 3005493]