Piperacillin Sodium (BioDeep_00001868426)
Main id: BioDeep_00000015162
代谢物信息卡片
Piperacillin Sodium
化学式: C23H26N5NaO7S (539.1450566000001)
中文名称: 哌拉西林钠
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCN1CCN(C(=O)C1=O)C(=O)NC(C2=CC=CC=C2)C(=O)NC3C4N(C3=O)C(C(S4)(C)C)C(=O)[O-].[Na+]
InChI: /q
描述信息
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D047090 - beta-Lactams
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D010406 - Penicillins
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D007769 - Lactams
C254 - Anti-Infective Agent > C258 - Antibiotic > C260 - Beta-Lactam Antibiotic
同义名列表
1 个代谢物同义名
数据库引用编号
9 个数据库交叉引用编号
- ChEBI: CHEBI:8233
- KEGG: C07361
- KEGGdrug: D00466
- PubChem: 23666879
- ChEMBL: CHEMBL1200820
- MeSH: Piperacillin
- CAS: 59703-84-3
- PubChem: 9565
- NIKKAJI: J18.443H
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Zhang Ruijuan, Xiao Li, Wang Yingjie, Wang Rui, Lu Chunqing. Effects of Catheter Tracking Management on Urinary Tract Function and Infection Rates in Patients With Spinal Cord Injury.
Alternative therapies in health and medicine.
2023 Jan; ?(?):. doi:
. [PMID: 36634314] - Wei Zhang, Chun-Yu Yan, Shu-Rui Li, Ting-Ting Fan, Shan-Shan Cao, Bin Cui, Meng-Ying Li, Bo-Yuan Fan, Bo Ji, Li Wang, Fei Cui, Jia Cui, Lei Wang, Yue Guan, Jing-Wen Wang. Efficacy and safety of piperacillin-tazobactam compared with meropenem in treating complicated urinary tract infections including acute pyelonephritis due to extended-spectrum β-lactamase-producing Enterobacteriaceae.
Frontiers in cellular and infection microbiology.
2023; 13(?):1093842. doi:
10.3389/fcimb.2023.1093842. [PMID: 37207190] - Shungo Imai, Shota Kadomura, Takayuki Miyai, Hitoshi Kashiwagi, Yuki Sato, Mitsuru Sugawara, Yoh Takekuma. Using Japanese big data to investigate novel factors and their high-risk combinations that affect vancomycin-induced nephrotoxicity.
British journal of clinical pharmacology.
2022 07; 88(7):3241-3255. doi:
10.1111/bcp.15252. [PMID: 35106797] - Robert Strengen Bigseth, Håkon Sandholdt, Andreas Petersen, Christian Østergaard, Thomas Benfield, Louise Thorlacius-Ussing. Comparable Effectiveness of Cefuroxime and Piperacillin-Tazobactam as Empirical Therapy for Methicillin-Susceptible Staphylococcus aureus Bacteremia.
Microbiology spectrum.
2022 06; 10(3):e0153021. doi:
10.1128/spectrum.01530-21. [PMID: 35438533] - Hiie Soeorg, Aveli Noortoots, Maarja Karu, Kadri Saks, Jana Lass, Irja Lutsar, Lenne-Triin Kõrgvee. Estimation of cefepime, piperacillin, and tazobactam clearance with iohexol-based glomerular filtration rate in paediatric patients.
European journal of clinical pharmacology.
2022 Jun; 78(6):989-1001. doi:
10.1007/s00228-022-03307-0. [PMID: 35275224] - Eveline Wallenburg, Rob Ter Heine, Jeroen A Schouten, Jelmer Raaijmakers, Jaap Ten Oever, Eva Kolwijck, David M Burger, Peter Pickkers, Tim Frenzel, Roger J M Brüggemann. An Integral Pharmacokinetic Analysis of Piperacillin and Tazobactam in Plasma and Urine in Critically Ill Patients.
Clinical pharmacokinetics.
2022 06; 61(6):907-918. doi:
10.1007/s40262-022-01113-6. [PMID: 35377133] - Wei-Chun Huang, Mei-Tzu Wang, Tai-Shuan Lai, Kuo-Hua Lee, Shih-Chieh Shao, Chien-Hao Chen, Chien-Hao Su, Yih-Ting Chen, Junne-Ming Sung, Yung-Chang Chen. Nephrotoxins and acute kidney injury - The consensus of the Taiwan acute kidney injury Task Force.
Journal of the Formosan Medical Association = Taiwan yi zhi.
2022 May; 121(5):886-895. doi:
10.1016/j.jfma.2021.12.007. [PMID: 34998658] - Yong Kyun Kim, Hyoung Soo Kim, Sunghoon Park, Hwan-Il Kim, Sun Hee Lee, Dong-Hwan Lee. Population pharmacokinetics of piperacillin/tazobactam in critically ill Korean patients and the effects of extracorporeal membrane oxygenation.
The Journal of antimicrobial chemotherapy.
2022 04; 77(5):1353-1364. doi:
10.1093/jac/dkac059. [PMID: 35224630] - Dhakrit Rungkitwattanakul, Amy L Ives, Nicole G Harriott, Sarah Pan-Chen, Lan Duong. Comparative incidence of acute kidney injury in patients on vancomycin therapy in combination with cefepime, piperacillin-tazobactam or meropenem.
Journal of chemotherapy (Florence, Italy).
2022 Apr; 34(2):103-109. doi:
10.1080/1120009x.2021.1965334. [PMID: 34424136] - Ping Li, Zengsheng Chen, Rong Wang, Changfeng Shao, Yan Liu, Qiang Ju, Peng Zong, Haiyan Wang. Pancytopenia in a newborn due to maternal piperacillin and human leukocyte antigen antibodies.
Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis.
2022 Apr; 61(2):103324. doi:
10.1016/j.transci.2021.103324. [PMID: 34865972] - Stefan Hagel, Friedhelm Bach, Thorsten Brenner, Hendrik Bracht, Alexander Brinkmann, Thorsten Annecke, Andreas Hohn, Markus Weigand, Guido Michels, Stefan Kluge, Axel Nierhaus, Dominik Jarczak, Christina König, Dirk Weismann, Otto Frey, Dominic Witzke, Carsten Müller, Michael Bauer, Michael Kiehntopf, Sophie Neugebauer, Thomas Lehmann, Jason A Roberts, Mathias W Pletz. Effect of therapeutic drug monitoring-based dose optimization of piperacillin/tazobactam on sepsis-related organ dysfunction in patients with sepsis: a randomized controlled trial.
Intensive care medicine.
2022 Mar; 48(3):311-321. doi:
10.1007/s00134-021-06609-6. [PMID: 35106617] - Hadrien Winiszewski, Cyrielle Despres, Marc Puyraveau, Jennifer Lagoutte-Renosi, Damien Montange, Guillaume Besch, Sebastien Pili Floury, Claire Chaignat, Guylaine Labro, Lucie Vettoretti, Anne-Laure Clairet, Gilles Capellier, Berengère Vivet, Gael Piton. β-lactam dosing at the early phase of sepsis: Performance of a pragmatic protocol for target concentration achievement in a prospective cohort study.
Journal of critical care.
2022 02; 67(?):141-146. doi:
10.1016/j.jcrc.2021.10.023. [PMID: 34768176] - Mitchell S Buckley, Ivan A Komerdelj, Paul A D'Alessio, Pooja Rangan, Sumit K Agarwal, Nicole C Tinta, Brandon K Martinez, Delia S Ziadat, Melanie J Yerondopoulos, Emir Kobic, Sandra L Kane-Gill. Vancomycin with concomitant piperacillin/tazobactam vs. cefepime or meropenem associated acute kidney injury in the critically ill: A multicenter propensity score-matched study.
Journal of critical care.
2022 02; 67(?):134-140. doi:
10.1016/j.jcrc.2021.10.018. [PMID: 34768175] - Robert Włodarski, Karolina Żuchowska, Wojciech Filipiak. Quantitative Determination of Unbound Piperacillin and Imipenem in Biological Material from Critically Ill Using Thin-Film Microextraction-Liquid Chromatography-Mass Spectrometry.
Molecules (Basel, Switzerland).
2022 Jan; 27(3):. doi:
10.3390/molecules27030926. [PMID: 35164191] - Brian Pacca Elliott, Michael M Tang, Joshua Alexander Madden, Ronald James Markert, Steven Dale Burdette, Craig Matthew Pleiman, Emily Claire Speelmon. A retrospective cohort study assessing acute kidney injury and renal recovery among septic patients empirically treated with vancomycin piperacillin-tazobactam versus vancomycin cefepime.
Internal and emergency medicine.
2022 Jan; 17(1):91-99. doi:
10.1007/s11739-021-02772-2. [PMID: 34089468] - Chi-Hao Shao, Chih-Hsun Tai, Fang-Ju Lin, Chien-Chih Wu, Jann-Tay Wang, Chi-Chuan Wang. Comparison of risk of acute kidney injury between patients receiving the combination of teicoplanin and piperacillin/tazobactam versus vancomycin and piperacillin/tazobactam.
Journal of the Formosan Medical Association = Taiwan yi zhi.
2022 Jan; 121(1 Pt 1):117-125. doi:
10.1016/j.jfma.2021.02.004. [PMID: 33637370] - Y Al-Jebawi, K Karalic, P Shekhawat, M J Mhanna. The concomitant use of vancomycin and piperacillin-tazobactam is associated with acute kidney injury (AKI) in extremely low birth weight infants (ELBW).
Journal of neonatal-perinatal medicine.
2022; 15(2):303-309. doi:
10.3233/npm-210866. [PMID: 34864693] - Jongsung Hahn, Kyoung Lok Min, Soyoung Kang, Seungwon Yang, Min Soo Park, Jin Wi, Min Jung Chang. Population Pharmacokinetics and Dosing Optimization of Piperacillin-Tazobactam in Critically Ill Patients on Extracorporeal Membrane Oxygenation and the Influence of Concomitant Renal Replacement Therapy.
Microbiology spectrum.
2021 12; 9(3):e0063321. doi:
10.1128/spectrum.00633-21. [PMID: 34937189] - Alfredo Traversa, Drayton A Hammond, Gary D Peksa, Joshua M DeMott. Short Versus Extended Duration Vancomycin and Piperacillin/Tazobactam and the Incidence of Acute Kidney Injury in Noncritically Ill Patients.
Journal of pharmacy practice.
2021 Dec; 34(6):882-887. doi:
10.1177/0897190020933488. [PMID: 32578474] - Sofie Colman, Sofie Dhaese, Veronique Stove, Jan J De Waele, Alain G Verstraete. Pilot study of oral fluid and plasma meropenem and piperacillin concentrations in the intensive care unit.
Clinica chimica acta; international journal of clinical chemistry.
2021 Dec; 523(?):72-76. doi:
10.1016/j.cca.2021.09.005. [PMID: 34508687] - Kohei Sazanami, Ryo Inose, Tatsuya Yagi, Satoshi Dote, Nozomu Horiuchi, Yuka Kobayashi, Yuichi Muraki. Incidence of acute kidney injury after teicoplanin- or vancomycin- and piperacillin/tazobactam combination therapy: A comparative study using propensity score matching analysis.
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy.
2021 Dec; 27(12):1723-1728. doi:
10.1016/j.jiac.2021.08.012. [PMID: 34446352] - Naoto Okada, Yuki Izumi, Aki Nakamoto, Masayuki Chuma, Mitsuhiro Goda, Kenta Yagi, Fuka Aizawa, Hirofumi Hamano, Yoshito Zamami, Momoyo Azuma, Keisuke Ishizawa. Impact of Area Under the Concentration-Time Curve on the Prevalence of Vancomycin-Induced Nephrotoxicity in Combination With Tazobactam/Piperacillin or Cefepime: A Single-Institution Retrospective Study.
Clinical therapeutics.
2021 11; 43(11):1910-1920.e3. doi:
10.1016/j.clinthera.2021.09.007. [PMID: 34642081] - Yuma Yamashita, Hiroshi Kawaguchi, Tsubasa Yano, Norihiro Sakurai, Wataru Shibata, Kazuhiro Oshima, Takumi Imai, Koichi Yamada, Yasutaka Nakamura, Katsuya Nagayama, Hiroshi Kakeya. Risk factors for acute kidney injury in vancomycin and piperacillin/tazobactam combination therapy: A retrospective study.
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy.
2021 Nov; 27(11):1614-1620. doi:
10.1016/j.jiac.2021.07.017. [PMID: 34366231] - Vesa Cheng, Mohd H Abdul-Aziz, Fay Burrows, Hergen Buscher, Young-Jae Cho, Amanda Corley, Arne Diehl, Eileen Gilder, Stephan M Jakob, Hyung-Sook Kim, Bianca J Levkovich, Sung Yoon Lim, Shay McGuinness, Rachael Parke, Vincent Pellegrino, Yok-Ai Que, Claire Reynolds, Sam Rudham, Steven C Wallis, Susan A Welch, David Zacharias, John F Fraser, Kiran Shekar, Jason A Roberts. Population Pharmacokinetics of Piperacillin and Tazobactam in Critically Ill Patients Receiving Extracorporeal Membrane Oxygenation: an ASAP ECMO Study.
Antimicrobial agents and chemotherapy.
2021 10; 65(11):e0143821. doi:
10.1128/aac.01438-21. [PMID: 34460303] - Jazmin D Lee, Brett H Heintz, Hilary J Mosher, Daniel J Livorsi, Jason A Egge, Brian C Lund. Risk of Acute Kidney Injury and Clostridioides difficile Infection With Piperacillin/Tazobactam, Cefepime, and Meropenem With or Without Vancomycin.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
2021 10; 73(7):e1579-e1586. doi:
10.1093/cid/ciaa1902. [PMID: 33382398] - Kang Liu, Ying Zhang, Xueqiang Xu, Buyun Wu, Juan Ni, Ting Li, Changying Xing, Huijuan Mao. Comparative Prevalence of Acute Kidney Injury in Chinese Patients Receiving Vancomycin with Concurrent β-Lactam Antibiotics: A Retrospective Cohort Study.
Clinical therapeutics.
2021 10; 43(10):e319-e351. doi:
10.1016/j.clinthera.2021.08.008. [PMID: 34579971] - Martin Knudsen, Mats Bue, Louise L Pontoppidan, Magnus A Hvistendahl, Kjeld Søballe, Maiken Stilling, Pelle Hanberg. Evaluation of Benzylpenicillin as an Internal Standard for Measurement of Piperacillin Bone Concentrations Via Microdialysis.
Journal of pharmaceutical sciences.
2021 10; 110(10):3500-3506. doi:
10.1016/j.xphs.2021.06.008. [PMID: 34102200] - Sarah Van Vooren, Jan J De Waele, Jerina Boelens, Michael Polet, Veronique Stove, Lynn Vanhaecke, Alain G Verstraete. Development and validation of a liquid chromatography high-resolution mass spectrometry orbitrap method for the sensitive quantification of amoxicillin, piperacillin, tazobactam and meropenem in human faeces.
Analytica chimica acta.
2021 Sep; 1177(?):338760. doi:
10.1016/j.aca.2021.338760. [PMID: 34482897] - Matthew W Bjergum, Erin F Barreto, Marc H Scheetz, Andrew D Rule, Paul J Jannetto. Stability and Validation of a High-Throughput LC-MS/MS Method for the Quantification of Cefepime, Meropenem, and Piperacillin and Tazobactam in Serum.
The journal of applied laboratory medicine.
2021 09; 6(5):1202-1212. doi:
10.1093/jalm/jfab036. [PMID: 34086904] - Adrien Contejean, Caroline Charlier, Jean-Marc Treluyer, Solen Kernéis, Laurent Chouchana. A worldwide pharmacovigilance database analysis to assess the risk of acute kidney injury in patients receiving teicoplanin in association with piperacillin, cefepime or meropenem.
The Journal of antimicrobial chemotherapy.
2021 07; 76(8):2221-2223. doi:
10.1093/jac/dkab144. [PMID: 34008026] - Tatchanapong Chongcharoenyanon, Noppadol Wacharachaisurapol, Suvaporn Anugulruengkitt, Passara Maimongkol, Orawan Anunsittichai, Jiratchaya Sophonphan, Tanittha Chatsuwan, Thanyawee Puthanakit. Comparison of piperacillin plasma concentrations in a prospective randomised trial of extended infusion versus intermittent bolus of piperacillin/tazobactam in paediatric patients.
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases.
2021 Jul; 108(?):102-108. doi:
10.1016/j.ijid.2021.05.044. [PMID: 34029707] - Joseph M Yabes, Laveta Stewart, Faraz Shaikh, Paul M Robben, Joseph L Petfield, Anuradha Ganesan, Wesley R Campbell, David R Tribble, Dana M Blyth. Risk of Acute Kidney Injury in Combat-Injured Patients Associated With Concomitant Vancomycin and Extended-Spectrum β-Lactam Antibiotic Use.
Journal of intensive care medicine.
2021 Jul; 36(7):818-827. doi:
10.1177/0885066620930994. [PMID: 32508215] - Dušan Krnáč, Katarína Reiffová, Boris Rolinski. A new HPLC-MS/MS analytical method for quantification of tazobactam, piperacillin, and meropenem in human plasma.
Journal of separation science.
2021 Jul; 44(14):2744-2753. doi:
10.1002/jssc.202100067. [PMID: 33988308] - Irene Krämer, Jelena Rosentreter, Marius Fried, Michael Kühn. Significant interaction between high-dose methotrexate and high-dose piperacillin-tazobactam causing reversible neurotoxicity and renal failure in an osteosarcoma patient.
Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners.
2021 Jun; 27(4):1000-1004. doi:
10.1177/1078155220953878. [PMID: 32878553] - Sînziana Cristea, Elke H J Krekels, Karel Allegaert, Peter De Paepe, Annick de Jaeger, Pieter De Cock, Catherijne A J Knibbe. Estimation of Ontogeny Functions for Renal Transporters Using a Combined Population Pharmacokinetic and Physiology-Based Pharmacokinetic Approach: Application to OAT1,3.
The AAPS journal.
2021 05; 23(3):65. doi:
10.1208/s12248-021-00595-9. [PMID: 33948771] - M Kächele, F Keller. [Pharmacokinetics and pharmacodynamics in extracorporeal renal replacement therapy].
Medizinische Klinik, Intensivmedizin und Notfallmedizin.
2021 May; 116(4):295-300. doi:
10.1007/s00063-020-00654-7. [PMID: 32047978] - Sugui Lan, Zhirong Li, Aiqiu Su, Yanhong Peng, Yanke Liao, Xuemei Liu, Qiang Tan. Study on the mechanisms of the cross-resistance to TET, PIP, and GEN in Staphylococcus aureus mediated by the Rhizoma Coptidis extracts.
The Journal of antibiotics.
2021 05; 74(5):330-336. doi:
10.1038/s41429-021-00407-4. [PMID: 33500562] - Ryohei Yamamoto, Mitsuru Saito, Kyoko Abe, Takuro Saito, Ryuichiro Sagehashi, Taketoshi Nara, Kazuyuki Numakura, Shintaro Narita, Shigeru Satoh, Tomonori Habuchi. Anaphylaxis Induced by Intravenous Tacrolimus Administration During Kidney Transplant Surgery: A Case Report.
Transplantation proceedings.
2021 May; 53(4):1292-1294. doi:
10.1016/j.transproceed.2021.02.010. [PMID: 33714607] - P Fillâtre, F Lemaitre, N Nesseler, M Schmidt, S Besset, Y Launey, A Maamar, P Daufresne, E Flecher, Y Le Tulzo, J M Tadie, P Tattevin. Impact of extracorporeal membrane oxygenation (ECMO) support on piperacillin exposure in septic patients: a case-control study.
The Journal of antimicrobial chemotherapy.
2021 04; 76(5):1242-1249. doi:
10.1093/jac/dkab031. [PMID: 33569597] - Adrien Contejean, Mylène Tisseyre, Etienne Canouï, Jean-Marc Treluyer, Solen Kerneis, Laurent Chouchana. Combination of vancomycin plus piperacillin and risk of acute kidney injury: a worldwide pharmacovigilance database analysis.
The Journal of antimicrobial chemotherapy.
2021 04; 76(5):1311-1314. doi:
10.1093/jac/dkab003. [PMID: 33617641] - Sonya C Tang Girdwood, Peter H Tang, Mark E Murphy, Andrea R Chamberlain, Laura A Benken, Rhonda L Jones, Erin M Stoneman, Jennifer M Kaplan, Alexander A Vinks. Demonstrating Feasibility of an Opportunistic Sampling Approach for Pharmacokinetic Studies of β-Lactam Antibiotics in Critically Ill Children.
Journal of clinical pharmacology.
2021 04; 61(4):565-573. doi:
10.1002/jcph.1773. [PMID: 33111331] - J Petersson, C G Giske, E Eliasson. Poor Correlation between Meropenem and Piperacillin Plasma Concentrations and Delivered Dose of Continuous Renal Replacement Therapy.
Antimicrobial agents and chemotherapy.
2021 03; 65(4):. doi:
10.1128/aac.02029-20. [PMID: 33495227] - Agathe Béranger, Sihem Benaboud, Saïk Urien, Thao Nguyen-Khoa, Inès Gana, Julie Toubiana, Yi Zheng, Fabrice Lesage, Sylvain Renolleau, Déborah Hirt, Jean-Marc Tréluyer, Mehdi Oualha. Estimation of piperacillin clearance with different glomerular filtration rate formulas in critically ill children.
British journal of clinical pharmacology.
2021 03; 87(3):1275-1281. doi:
10.1111/bcp.14505. [PMID: 32737909] - Chih-Hsun Tai, Chi-Hao Shao, Chi-Chuan Wang, Fang-Ju Lin, Jann-Tay Wang, Chien-Chih Wu. Nephrotoxicity of teicoplanin-based combination therapy: focus on piperacillin/tazobactam and other anti-pseudomonal β-lactams.
The Journal of antimicrobial chemotherapy.
2021 01; 76(2):499-506. doi:
10.1093/jac/dkaa458. [PMID: 33152760] - Ranashia L Boone, Briana Whitehead, Tyra M Avery, Jacky Lu, Jamisha D Francis, Miriam A Guevara, Rebecca E Moore, Schuyler A Chambers, Ryan S Doster, Shannon D Manning, Steven D Townsend, Leon Dent, Dana Marshall, Jennifer A Gaddy, Steven M Damo. Analysis of virulence phenotypes and antibiotic resistance in clinical strains of Acinetobacter baumannii isolated in Nashville, Tennessee.
BMC microbiology.
2021 01; 21(1):21. doi:
10.1186/s12866-020-02082-1. [PMID: 33422000] - J D Workum, C Kramers, E Kolwijck, J A Schouten, S N de Wildt, R J Brüggemann. Nephrotoxicity of concomitant piperacillin/tazobactam and teicoplanin compared with monotherapy.
The Journal of antimicrobial chemotherapy.
2021 01; 76(1):212-219. doi:
10.1093/jac/dkaa385. [PMID: 32944771] - Sami Ullah, Ronny Beer, Uwe Fuhr, Max Taubert, Markus Zeitlinger, Alexander Kratzer, Christoph Dorn, Usman Arshad, Mario Kofler, Raimund Helbok. Brain Exposure to Piperacillin in Acute Hemorrhagic Stroke Patients Assessed by Cerebral Microdialysis and Population Pharmacokinetics.
Neurocritical care.
2020 12; 33(3):740-748. doi:
10.1007/s12028-020-00947-x. [PMID: 32219679] - Jing Ren, Yao Zheng, Hui Du, Shan Wang, Linna Liu, Wanshi Duan, Zeping Zhang, Lijun Heng, Qi Yang. Antibiotic-induced black hairy tongue: two case reports and a review of the literature.
The Journal of international medical research.
2020 Oct; 48(10):300060520961279. doi:
10.1177/0300060520961279. [PMID: 33044871] - Veronika Kubíčková, Karel Urbánek. [Pharmacokinetics and therapeutic monitoring of piperacillin/tazobactam].
Klinicka mikrobiologie a infekcni lekarstvi.
2020 Sep; 26(3):86-94. doi:
NULL. [PMID: 33418596] - Caleb J P Economou, Jennifer Ordoñez, Steven C Wallis, Brent Richards, Brett McWhinney, Jeffrey Lipman, Jason A Roberts. Ticarcillin and piperacillin adsorption on to polyethersulfone haemodiafilter membranes in an ex-vivo circuit.
International journal of antimicrobial agents.
2020 Sep; 56(3):106058. doi:
10.1016/j.ijantimicag.2020.106058. [PMID: 32590056] - C Triffault-Fillit, E Mabrut, K Corbin, E Braun, A Becker, S Goutelle, P Chaudier, M H Fessy, C Dupieux, F Laurent, S Gunst, S Lustig, C Chidiac, T Ferry, F Valour. Tolerance and microbiological efficacy of cefepime or piperacillin/tazobactam in combination with vancomycin as empirical antimicrobial therapy of prosthetic joint infection: a propensity-matched cohort study.
The Journal of antimicrobial chemotherapy.
2020 08; 75(8):2299-2306. doi:
10.1093/jac/dkaa166. [PMID: 32407512] - Sean N Avedissian, Gwendolyn M Pais, Jiajun Liu, Nathaniel J Rhodes, Marc H Scheetz. Piperacillin-Tazobactam Added to Vancomycin Increases Risk for Acute Kidney Injury: Fact or Fiction?.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
2020 07; 71(2):426-432. doi:
10.1093/cid/ciz1189. [PMID: 31833540] - Gwendolyn M Pais, Jiajun Liu, Sean N Avedissian, Danielle Hiner, Theodoros Xanthos, Athanasios Chalkias, Ernesto d'Aloja, Emanuela Locci, Annette Gilchrist, Walter C Prozialeck, Nathaniel J Rhodes, Thomas P Lodise, Julie C Fitzgerald, Kevin J Downes, Athena F Zuppa, Marc H Scheetz. Lack of synergistic nephrotoxicity between vancomycin and piperacillin/tazobactam in a rat model and a confirmatory cellular model.
The Journal of antimicrobial chemotherapy.
2020 05; 75(5):1228-1236. doi:
10.1093/jac/dkz563. [PMID: 32011685] - Marin H Kollef, Paul Juang, Scott T Micek. Vancomycin/Piperacillin-tazobactam Nephrotoxicity in the Critically Ill.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
2020 03; 70(7):1520-1521. doi:
10.1093/cid/ciz643. [PMID: 31297504] - Tiziana Ciarambino, Orazio Valerio Giannico, Amalia Campanile, Paolo Tirelli, Ombretta Para, Giuseppe Signoriello, Mauro Giordano. Acute kidney injury and vancomycin/piperacillin/tazobactam in adult patients: a systematic review.
Internal and emergency medicine.
2020 03; 15(2):327-331. doi:
10.1007/s11739-020-02287-2. [PMID: 32040830] - Mohammad H Al-Shaer, Wael A Alghamdi, Emily Graham, Charles A Peloquin. Meropenem, Cefepime, and Piperacillin Protein Binding in Patient Samples.
Therapeutic drug monitoring.
2020 02; 42(1):129-132. doi:
10.1097/ftd.0000000000000675. [PMID: 31318843] - Wafaa Jamal, Fatima Bibi Khodakhast, Ameerah AlAzmi, Jόzsef Sόki, Ghayda AlHashem, Vincent O Rotimi. Prevalence and antimicrobial susceptibility of enterotoxigenic extra-intestinal Bacteroides fragilis among 13-year collection of isolates in Kuwait.
BMC microbiology.
2020 01; 20(1):14. doi:
10.1186/s12866-020-1703-4. [PMID: 31941446] - S A M Dhaese, P Colin, H Willems, A Heffernan, B Gadeyne, S Van Vooren, P Depuydt, E Hoste, V Stove, A G Verstraete, J Lipman, J A Roberts, J J De Waele. Saturable elimination of piperacillin in critically ill patients: implications for continuous infusion.
International journal of antimicrobial agents.
2019 Dec; 54(6):741-749. doi:
10.1016/j.ijantimicag.2019.08.024. [PMID: 31479741] - Caroline Damen, Sofie Dhaese, Alain G Verstraete, Veronique Stove, Jan J De Waele. Subtherapeutic piperacillin concentrations in neurocritical patients.
Journal of critical care.
2019 12; 54(?):48-51. doi:
10.1016/j.jcrc.2019.07.007. [PMID: 31349159] - Sophie Magréault, Stephanie Leroux, Jeremie Touati, Thomas Storme, Evelyne Jacqz-Aigrain. UPLC/MS/MS assay for the simultaneous determination of seven antibiotics in human serum-Application to pediatric studies.
Journal of pharmaceutical and biomedical analysis.
2019 Sep; 174(?):256-262. doi:
10.1016/j.jpba.2019.03.004. [PMID: 31181488] - Michael Paal, Marcus Heilmann, Simone Koch, Thomas Bertsch, Jörg Steinmann, Rainer Höhl, Uwe Liebchen, Carina Schuster, Frederick M Kleine, Michael Vogeser. Comparative LC-MS/MS and HPLC-UV Analyses of Meropenem and Piperacillin in Critically Ill Patients.
Clinical laboratory.
2019 Sep; 65(9):. doi:
10.7754/clin.lab.2019.190210. [PMID: 31532096] - Janni S Mortensen, Berit P Jensen, Mei Zhang, Matthew Doogue. Preanalytical Stability of Piperacillin, Tazobactam, Meropenem, and Ceftazidime in Plasma and Whole Blood Using Liquid Chromatography-Tandem Mass Spectrometry.
Therapeutic drug monitoring.
2019 08; 41(4):538-543. doi:
10.1097/ftd.0000000000000650. [PMID: 31306394] - Henry T Quach, Adam J Esbenshade, Zhiguo Zhao, Ritu Banerjee. Incidence of acute kidney injury among pediatric hematology/oncology patients receiving vancomycin in combination with piperacillin/tazobactam or cefepime.
Pediatric blood & cancer.
2019 07; 66(7):e27750. doi:
10.1002/pbc.27750. [PMID: 30989780] - H Periasamy, S Iswarya, N Pavithra, S Senthilnathan, A Gnanamani. In vitro antibacterial activity of plumbagin isolated from Plumbago zeylanica L. against methicillin-resistant Staphylococcus aureus.
Letters in applied microbiology.
2019 Jul; 69(1):41-49. doi:
10.1111/lam.13160. [PMID: 31044446] - Sofie Colman, Veronique Stove, Jan J De Waele, Alain G Verstraete. Measuring Unbound Versus Total Piperacillin Concentrations in Plasma of Critically Ill Patients: Methodological Issues and Relevance.
Therapeutic drug monitoring.
2019 06; 41(3):325-330. doi:
10.1097/ftd.0000000000000602. [PMID: 30633089] - F Keller. [Pharmacotherapy and kidney dysfunction].
Medizinische Klinik, Intensivmedizin und Notfallmedizin.
2019 Jun; 114(5):444-451. doi:
10.1007/s00063-018-0455-5. [PMID: 29980815] - Davide Ferrari, Marco Ripa, Simone Premaschi, Giuseppe Banfi, Antonella Castagna, Massimo Locatelli. LC-MS/MS method for simultaneous determination of linezolid, meropenem, piperacillin and teicoplanin in human plasma samples.
Journal of pharmaceutical and biomedical analysis.
2019 May; 169(?):11-18. doi:
10.1016/j.jpba.2019.02.037. [PMID: 30826487] - Adam M Blevins, Jennifer N Lashinsky, Craig McCammon, Marin Kollef, Scott Micek, Paul Juang. Incidence of Acute Kidney Injury in Critically Ill Patients Receiving Vancomycin with Concomitant Piperacillin-Tazobactam, Cefepime, or Meropenem.
Antimicrobial agents and chemotherapy.
2019 05; 63(5):. doi:
10.1128/aac.02658-18. [PMID: 30782987] - Friederike Bachmann, Thomas Adam, Frank Friedersdorff, Lutz Liefeldt, Torsten Slowinski, Klemens Budde, Johannes Waiser. Perioperative antibiotic prophylaxis in renal transplantation: a single-center comparison between two regimens and a brief survey among the Eurotransplant renal transplantation centers.
World journal of urology.
2019 May; 37(5):957-967. doi:
10.1007/s00345-018-2440-2. [PMID: 30109484] - Ana Motos, Joseph L Kuti, Gianluigi Li Bassi, Antoni Torres, David P Nicolau. Is One Sample Enough? β-Lactam Target Attainment and Penetration into Epithelial Lining Fluid Based on Multiple Bronchoalveolar Lavage Sampling Time Points in a Swine Pneumonia Model.
Antimicrobial agents and chemotherapy.
2019 02; 63(2):. doi:
10.1128/aac.01922-18. [PMID: 30509937] - Agathe Béranger, Sihem Benaboud, Saïk Urien, Florence Moulin, Emmanuelle Bille, Fabrice Lesage, Yi Zheng, Mathieu Genuini, Inès Gana, Sylvain Renolleau, Déborah Hirt, Jean-Marc Tréluyer, Mehdi Oualha. Piperacillin Population Pharmacokinetics and Dosing Regimen Optimization in Critically Ill Children with Normal and Augmented Renal Clearance.
Clinical pharmacokinetics.
2019 02; 58(2):223-233. doi:
10.1007/s40262-018-0682-1. [PMID: 29862466] - Masaya Murakami, Hiroshi Kiyota, Kanako Kasai, Shigehiro Bando, Shinichiro Kira, Haruhisa Koide, Hiroki Yamada, Takahiro Kimura, Shin Egawa. Antimicrobial prophylaxis for transurethral resection of bladder tumor: A retrospective comparison of preoperative single-dose administration of piperacillin and tazobactam/piperacillin.
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy.
2018 Dec; 24(12):954-957. doi:
10.1016/j.jiac.2018.08.008. [PMID: 30193786] - Gloria Wong, Scott Briscoe, Brett McWhinney, Mumtaz Ally, Jacobus Ungerer, Jeffrey Lipman, Jason A Roberts. Therapeutic drug monitoring of β-lactam antibiotics in the critically ill: direct measurement of unbound drug concentrations to achieve appropriate drug exposures.
The Journal of antimicrobial chemotherapy.
2018 11; 73(11):3087-3094. doi:
10.1093/jac/dky314. [PMID: 30137377] - Joseph Carreno, Tori Smiraglia, Christopher Hunter, Ellis Tobin, Ben Lomaestro. Comparative incidence and excess risk of acute kidney injury in hospitalised patients receiving vancomycin and piperacillin/tazobactam in combination or as monotherapy.
International journal of antimicrobial agents.
2018 Nov; 52(5):643-650. doi:
10.1016/j.ijantimicag.2018.08.001. [PMID: 30103003] - Salmaan Kanji, Jason A Roberts, Jiao Xie, Abdulaziz Alobaid, Sheryl Zelenitsky, Swapnil Hiremath, Guijun Zhang, Irene Watpool, Rebecca Porteous, Rakesh Patel. Piperacillin Population Pharmacokinetics in Critically Ill Adults During Sustained Low-Efficiency Dialysis.
The Annals of pharmacotherapy.
2018 10; 52(10):965-973. doi:
10.1177/1060028018773771. [PMID: 29730948] - Milan Kaska, Eduard Havel, Iva Selke-Krulichova, Petr Safranek, Jan Bezouska, Jirina Martinkova. Covariate determinants of effective dosing regimens for time-dependent beta-lactam antibiotics for critically ill patients.
Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia.
2018 Sep; 162(3):219-226. doi:
10.5507/bp.2018.011. [PMID: 29582860] - Ronilda D'Cunha, Thanh Bach, Beth Ann Young, Peizhi Li, Demet Nalbant, Jun Zhang, Patricia Winokur, Guohua An. Quantification of Cefepime, Meropenem, Piperacillin, and Tazobactam in Human Plasma Using a Sensitive and Robust Liquid Chromatography-Tandem Mass Spectrometry Method, Part 2: Stability Evaluation.
Antimicrobial agents and chemotherapy.
2018 09; 62(9):. doi:
10.1128/aac.00861-18. [PMID: 29941653] - Ronilda D'Cunha, Thanh Bach, Beth Ann Young, Peizhi Li, Demet Nalbant, Jun Zhang, Patricia Winokur, Guohua An. Quantification of Cefepime, Meropenem, Piperacillin, and Tazobactam in Human Plasma Using a Sensitive and Robust Liquid Chromatography-Tandem Mass Spectrometry Method, Part 1: Assay Development and Validation.
Antimicrobial agents and chemotherapy.
2018 09; 62(9):. doi:
10.1128/aac.00859-18. [PMID: 29941654] - Peter E Wu, Derek Leong. Acute Kidney Injury Due to Concomitant Vancomycin and Piperacillin-Tazobactam.
JAMA internal medicine.
2018 08; 178(8):1137. doi:
10.1001/jamainternmed.2018.2930. [PMID: 30083734] - Colin Bergstrom, Srikanth Nagalla, Arjun Gupta. Acute Kidney Injury Due to Concomitant Vancomycin and Piperacillin-Tazobactam-Reply.
JAMA internal medicine.
2018 08; 178(8):1137-1138. doi:
10.1001/jamainternmed.2018.2921. [PMID: 30083742] - Ryoji Kobayashi, Daiki Hori, Hirozumi Sano, Daisuke Suzuki, Kenji Kishimoto, Kunihiko Kobayashi. Meropenem versus piperacillin/tazobactam with or without immunoglobulin as second-line therapy for febrile neutropenia in pediatric patients.
Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi.
2018 Aug; 51(4):473-477. doi:
10.1016/j.jmii.2017.06.005. [PMID: 28690028] - Cafer Balcı, Ömrüm Uzun, Mustafa Arıcı, Sibel Aşçıoğlu Hayran, Deniz Yüce, Serhat Ünal. Nephrotoxicity of piperacillin/tazobactam combined with vancomycin: should it be a concern?.
International journal of antimicrobial agents.
2018 Aug; 52(2):180-184. doi:
10.1016/j.ijantimicag.2018.03.024. [PMID: 29649586] - Cédric Carrié, Sébastien Rubin, Pierre Sioniac, Dominique Breilh, Matthieu Biais. The kinetic glomerular filtration rate is not interchangeable with measured creatinine clearance for prediction of piperacillin underexposure in critically ill patients with augmented renal clearance.
Critical care (London, England).
2018 07; 22(1):177. doi:
10.1186/s13054-018-2117-7. [PMID: 30037335] - Sylvia M Verhoven, Joseph J Groszek, William H Fissell, Adam Seegmiller, Jennifer Colby, Pratish Patel, Alain Verstraete, Matthew Shotwell. Therapeutic drug monitoring of piperacillin and tazobactam by RP-HPLC of residual blood specimens.
Clinica chimica acta; international journal of clinical chemistry.
2018 Jul; 482(?):60-64. doi:
10.1016/j.cca.2018.03.021. [PMID: 29596815] - Meritxell Royuela, Juliana Jaramillo, María Teresa Martín, Oscar Len. Skin infection in a renal transplant recipient.
Medicina clinica.
2018 06; 150(11):454. doi:
10.1016/j.medcli.2017.07.028. [PMID: 29054576] - John Paul Iguidbashian, Jai D Parekh, Shweta Kukrety, Venkata Giri Andukuri. Campylobacter jejuni and Pseudomonas coinfection in the setting of ulcerative colitis.
BMJ case reports.
2018 Jun; 2018(?):. doi:
10.1136/bcr-2018-224941. [PMID: 29880626] - Mahipal G Sinnollareddy, Michael S Roberts, Jeffrey Lipman, Sandra L Peake, Jason A Roberts. Pharmacokinetics of piperacillin in critically ill patients with acute kidney injury receiving sustained low-efficiency diafiltration.
The Journal of antimicrobial chemotherapy.
2018 06; 73(6):1647-1650. doi:
10.1093/jac/dky057. [PMID: 29506150] - Zachary I Willis, Ravi Jhaveri. The Cost of Vancomycin and Piperacillin/Tazobactam Treatment.
JAMA pediatrics.
2018 05; 172(5):494. doi:
10.1001/jamapediatrics.2018.0052. [PMID: 29507940] - Hiroki Miyabayashi, Satoru Kumaki, Atsushi Sato, Ryoichi Onuma, Rie Noguchi, Taiki Sato, Takaya Metoki, Yohei Watanabe, Yusaku Tazawa, Masue Imaizumi, Setsuko Kitaoka. Onset of Hemophagocytic Lymphohistiocytosis during Piperacillin-Tazobactam Therapy in Three Children with Acute Focal Bacterial Nephritis.
The Tohoku journal of experimental medicine.
2018 05; 245(1):55-59. doi:
10.1620/tjem.245.55. [PMID: 29798969] - Kevin J Downes, Benjamin L Laskin, Brian T Fisher. The Cost of Vancomycin and Piperacillin/Tazobactam Treatment-Reply.
JAMA pediatrics.
2018 05; 172(5):494-495. doi:
10.1001/jamapediatrics.2018.0038. [PMID: 29507935] - T W Felton, K Ogungbenro, E Boselli, W W Hope, K A Rodvold. Comparison of piperacillin exposure in the lungs of critically ill patients and healthy volunteers.
The Journal of antimicrobial chemotherapy.
2018 05; 73(5):1340-1347. doi:
10.1093/jac/dkx541. [PMID: 29385448] - M Paal, M Zoller, C Schuster, M Vogeser, G Schütze. Simultaneous quantification of cefepime, meropenem, ciprofloxacin, moxifloxacin, linezolid and piperacillin in human serum using an isotope-dilution HPLC-MS/MS method.
Journal of pharmaceutical and biomedical analysis.
2018 Apr; 152(?):102-110. doi:
10.1016/j.jpba.2018.01.031. [PMID: 29414000] - Sofie A M Dhaese, Jason A Roberts, Mieke Carlier, Alain G Verstraete, Veronique Stove, Jan J De Waele. Population pharmacokinetics of continuous infusion of piperacillin in critically ill patients.
International journal of antimicrobial agents.
2018 Apr; 51(4):594-600. doi:
10.1016/j.ijantimicag.2017.12.015. [PMID: 29277531] - Natalia D Popowicz, Sean J O'Halloran, Deirdre Fitzgerald, Y C Gary Lee, David A Joyce. A rapid, LC-MS/MS assay for quantification of piperacillin and tazobactam in human plasma and pleural fluid; application to a clinical pharmacokinetic study.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2018 Apr; 1081-1082(?):58-66. doi:
10.1016/j.jchromb.2018.02.027. [PMID: 29505960] - Malini Hatti, Nikolitsa Solomonidi, Inga Odenholt, Johan Tham, Fredrik Resman. Considerable variation of trough β-lactam concentrations in older adults hospitalized with infection-a prospective observational study.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology.
2018 Mar; 37(3):485-493. doi:
10.1007/s10096-018-3194-x. [PMID: 29380225] - Keith S Kaye, Tanaya Bhowmick, Symeon Metallidis, Susan C Bleasdale, Olexiy S Sagan, Viktor Stus, Jose Vazquez, Valerii Zaitsev, Mohamed Bidair, Erik Chorvat, Petru Octavian Dragoescu, Elena Fedosiuk, Juan P Horcajada, Claudia Murta, Yaroslav Sarychev, Ventsislav Stoev, Elizabeth Morgan, Karen Fusaro, David Griffith, Olga Lomovskaya, Elizabeth L Alexander, Jeffery Loutit, Michael N Dudley, Evangelos J Giamarellos-Bourboulis. Effect of Meropenem-Vaborbactam vs Piperacillin-Tazobactam on Clinical Cure or Improvement and Microbial Eradication in Complicated Urinary Tract Infection: The TANGO I Randomized Clinical Trial.
JAMA.
2018 02; 319(8):788-799. doi:
10.1001/jama.2018.0438. [PMID: 29486041] - Shijie Wen, Changyuan Wang, Yingjie Duan, Xiaokui Huo, Qiang Meng, Zhihao Liu, Shilei Yang, Yanna Zhu, Huijun Sun, Xiaodong Ma, Siyun Yang, Kexin Liu. OAT1 and OAT3 also mediate the drug-drug interaction between piperacillin and tazobactam.
International journal of pharmaceutics.
2018 Feb; 537(1-2):172-182. doi:
10.1016/j.ijpharm.2017.12.037. [PMID: 29277663] - Manal Abouelkheir, Sarah Alsubaie. Pediatric acute kidney injury induced by concomitant vancomycin and piperacillin-tazobactam.
Pediatrics international : official journal of the Japan Pediatric Society.
2018 Feb; 60(2):136-141. doi:
10.1111/ped.13463. [PMID: 29181890] - Saiyuri Naicker, Yarmarly C Guerra Valero, Jenny L Ordenez Meija, Jeffrey Lipman, Jason A Roberts, Steven C Wallis, Suzanne L Parker. A UHPLC-MS/MS method for the simultaneous determination of piperacillin and tazobactam in plasma (total and unbound), urine and renal replacement therapy effluent.
Journal of pharmaceutical and biomedical analysis.
2018 Jan; 148(?):324-333. doi:
10.1016/j.jpba.2017.10.023. [PMID: 29080413]