Edrophonium (BioDeep_00001868420)
Main id: BioDeep_00000006390
代谢物信息卡片
Edrophonium
化学式: C10H16NO+ (166.1232)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC[N+](C)(C)C1=CC(=CC=C1)O
InChI: InChI=1S/C10H15NO/c1-4-11(2,3)9-6-5-7-10(12)8-9/h5-8H,4H2,1-3H3/p+1
描述信息
D018377 - Neurotransmitter Agents > D018678 - Cholinergic Agents > D002800 - Cholinesterase Inhibitors
C471 - Enzyme Inhibitor > C47792 - Acetylcholinesterase Inhibitor
D020011 - Protective Agents > D000931 - Antidotes
V - Various > V04 - Diagnostic agents
D004791 - Enzyme Inhibitors
同义名列表
2 个代谢物同义名
数据库引用编号
11 个数据库交叉引用编号
- ChEBI: CHEBI:251408
- KEGG: C06976
- PubChem: 3202
- DrugBank: DB01010
- ChEMBL: CHEMBL1104
- MeSH: Edrophonium
- CAS: 312-48-1
- PubChem: 9190
- PDB-CCD: EDR
- NIKKAJI: J5.502F
- KNApSAcK: 251408
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Yukio Sugiyama, Yoshiki Esa, Akihiro Watanabe, Junya Kobayashi, Shigeaki Suzuki, Daisuke Takahashi. [Immune checkpoint inhibitor-induced anti-striational antibodies in myasthenia gravis and myositis: a case report].
Rinsho shinkeigaku = Clinical neurology.
2021 Sep; 61(9):630-634. doi:
10.5692/clinicalneurol.cn-001604. [PMID: 34433744] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Ramachandra S Naik, Tatyana Belinskaya, C R Vinayaka, Ashima Saxena. Monoclonal antibodies to fetal bovine serum acetylcholinesterase distinguish between acetylcholinesterases from ruminant and non-ruminant species.
Chemico-biological interactions.
2020 Oct; 330(?):109225. doi:
10.1016/j.cbi.2020.109225. [PMID: 32795450] - Edoardo Fabini, Anna Tramarin, Manuela Bartolini. Combination of human acetylcholinesterase and serum albumin sensing surfaces as highly informative analytical tool for inhibitor screening.
Journal of pharmaceutical and biomedical analysis.
2018 Jun; 155(?):177-184. doi:
10.1016/j.jpba.2018.03.060. [PMID: 29635172] - Terrone L Rosenberry, Patricia K Martin, A Jeremy Nix, Scott A Wildman, Jonah Cheung, Scott A Snyder, Ren Xiang Tan. Hopeahainol A binds reversibly at the acetylcholinesterase (AChE) peripheral site and inhibits enzyme activity with a novel higher order concentration dependence.
Chemico-biological interactions.
2016 Nov; 259(Pt B):78-84. doi:
10.1016/j.cbi.2016.05.032. [PMID: 27297626] - Jee-Ae Kim, Young-Min Lim, Eun Hye Jang, Kwang-Kuk Kim. A patient with coexisting myasthenia gravis and lambert-eaton myasthenic syndrome.
Journal of clinical neurology (Seoul, Korea).
2012 Sep; 8(3):235-7. doi:
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Current treatment options in neurology.
2011 Dec; 13(6):590-607. doi:
10.1007/s11940-011-0146-5. [PMID: 21912840] - Zsuzsanna Pál, Judit Boczán, Benjamin Bereznai, Gábor Lovas, Mária Judit Molnár. [Therapy for anti-MuSK antibody positive myasthenia gravis].
Orvosi hetilap.
2011 Sep; 152(39):1586-9. doi:
10.1556/oh.2011.29177. [PMID: 21920845] - Mariángela Vargas, Alvaro Segura, María Herrera, Mauren Villalta, Ricardo Estrada, Maykel Cerdas, Owen Paiva, Teatulohi Matainaho, Simon D Jensen, Kenneth D Winkel, Guillermo León, José María Gutiérrez, David J Williams. Preclinical evaluation of caprylic acid-fractionated IgG antivenom for the treatment of Taipan (Oxyuranus scutellatus) envenoming in Papua New Guinea.
PLoS neglected tropical diseases.
2011 May; 5(5):e1144. doi:
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Autoimmune diseases.
2011; 2011(?):404101. doi:
10.4061/2011/404101. [PMID: 22110902] - T Stojkovic, A Béhin. [Ocular myasthenia: diagnosis and treatment].
Revue neurologique.
2010 Dec; 166(12):987-97. doi:
10.1016/j.neurol.2010.08.004. [PMID: 21075410] - Beyazit Zencirci. Sertraline-induced pseudocholinesterase enzyme deficiency.
International journal of general medicine.
2010 Nov; 3(?):375-8. doi:
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Drug design, development and therapy.
2009 Sep; 3(?):119-29. doi:
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Rinsho shinkeigaku = Clinical neurology.
2009 Jul; 49(7):424-7. doi:
10.5692/clinicalneurol.49.424. [PMID: 19715171] - Shin Joong Oh. Muscle-specific receptor tyrosine kinase antibody positive myasthenia gravis current status.
Journal of clinical neurology (Seoul, Korea).
2009 Jun; 5(2):53-64. doi:
10.3988/jcn.2009.5.2.53. [PMID: 19587811] - Yehonatan Sharabi, Richard Imrich, Courtney Holmes, Sandra Pechnik, David S Goldstein. Generalized and neurotransmitter-selective noradrenergic denervation in Parkinson's disease with orthostatic hypotension.
Movement disorders : official journal of the Movement Disorder Society.
2008 Sep; 23(12):1725-32. doi:
10.1002/mds.22226. [PMID: 18661549] - Takashi Kurokawa, Takehiko Nishiyama, Ryoo Yamamoto, Hitaru Kishida, Yasuhito Hakii, Yoshiyuki Kuroiwa. [Anti-MuSK antibody positive myasthenia gravis with HIV infection successfully treated with cyclosporin: a case report].
Rinsho shinkeigaku = Clinical neurology.
2008 Sep; 48(9):666-9. doi:
10.5692/clinicalneurol.48.666. [PMID: 19048951] - Hidenori Kawasaki, Kensei Yahata, Chinatsu Okamoto, Hirotaka Imamaki, Koichi Seta, Akira Sugawara. [Myasthenia-like syndrome induced by cibenzoline overdose in a patient with chronic kidney disease].
Nihon Jinzo Gakkai shi.
2008; 50(7):942-7. doi:
NULL. [PMID: 19069153] - Vern C Juel, Janice M Massey. Myasthenia gravis.
Orphanet journal of rare diseases.
2007 Nov; 2(?):44. doi:
10.1186/1750-1172-2-44. [PMID: 17986328] - Yutaka Nakahama, Masakazu Kawajiri, Masayuki Ochi, Katsuhiko Kohara, Kiyoe Ohta, Tetsurou Miki. [Titer of anti-muscle-specific receptor tyrosine kinase (MuSK) antibody correlated with symptomatic improvement in response to corticosteroid therapy in a patient with anti-MuSK antibody-positive myasthenia gravis: a case report].
Rinsho shinkeigaku = Clinical neurology.
2007 Jun; 47(6):356-8. doi:
. [PMID: 17633110] - Hans D de Boer, Jan van Egmond, Jacques J Driessen, Leo H D Booij. Update on the management of neuromuscular block: focus on sugammadex.
Neuropsychiatric disease and treatment.
2007; 3(5):539-44. doi:
NULL. [PMID: 19300584] - Maki Sunayama, Katsuichi Miyamoto, Mitsuaki Shioyama, Takao Sato, Susumu Kusunoki. [A case of myasthenia gravis appearing after thymomectomy: with histopathological investigation].
No to shinkei = Brain and nerve.
2006 Jul; 58(7):615-9. doi:
NULL. [PMID: 16910471] - Barbara Emeryk-Szajewska, Halina Strugalska-Cynowska, Beata Zakrzewska-Pniewska, Beata Szyluk, Anna Kostera-Pruszczyk. [A case of the Lambert-Eaton syndrome of non-neoplastic origin. Ten-year follow-up].
Neurologia i neurochirurgia polska.
2006 May; 40(3):243-7. doi:
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Journal of veterinary internal medicine.
2005 Nov; 19(6):920-3. doi:
10.1892/0891-6640(2005)19[920:cmgism]2.0.co;2. [PMID: 16355692] - Robert N Schwendimann, Eric Burton, Alireza Minagar. Management of myasthenia gravis.
American journal of therapeutics.
2005 May; 12(3):262-8. doi:
NULL. [PMID: 15891271] - Adnan I Qureshi, Mohammad A Choundry, Yousef Mohammad, Hoe C Chua, Abutaher M Yahia, John A Ulatowski, David A Krendel, Robert T Leshner. Respiratory failure as a first presentation of myasthenia gravis.
Medical science monitor : international medical journal of experimental and clinical research.
2004 Dec; 10(12):CR684-9. doi:
. [PMID: 15567987] - R Webster, M Brydson, R Croxen, J Newsom-Davis, A Vincent, D Beeson. Mutation in the AChR ion channel gate underlies a fast channel congenital myasthenic syndrome.
Neurology.
2004 Apr; 62(7):1090-6. doi:
10.1212/01.wnl.0000118205.99701.41. [PMID: 15079006] - Ashima Saxena, Regina S Hur, Chunyuan Luo, Bhupendra P Doctor. Natural monomeric form of fetal bovine serum acetylcholinesterase lacks the C-terminal tetramerization domain.
Biochemistry.
2003 Dec; 42(51):15292-9. doi:
10.1021/bi030150x. [PMID: 14690439] - Amelia Evoli, Pietro A Tonali, Luca Padua, Mauro Lo Monaco, Flavia Scuderi, Anna P Batocchi, Mariapaola Marino, Emanuela Bartoccioni. Clinical correlates with anti-MuSK antibodies in generalized seronegative myasthenia gravis.
Brain : a journal of neurology.
2003 Oct; 126(Pt 10):2304-11. doi:
10.1093/brain/awg223. [PMID: 12821509] - Glynis Johnson, Samuel W Moore. Idiotypic mimicry of a catalytic antibody active site.
Molecular immunology.
2002 Oct; 39(5-6):273-88. doi:
10.1016/s0161-5890(02)00113-x. [PMID: 12220886] - J Finsterer, I Oberman, A Reitner. Respiratory chain complex-I defect mimicking myasthenia.
Metabolic brain disease.
2002 Mar; 17(1):41-6. doi:
10.1023/a:1014052330663. [PMID: 11893008] - Małgorzata Bilińska. [Seronegative myasthenia gravis].
Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego.
2002 Jan; 12(67):49-53. doi:
NULL. [PMID: 11957803] - N Kanzato, I Nakasone, O Sunagawa, Y Komine, K Fukiyama. [Giant-cell myocarditis without a symptom of heart failure seen in a patient with myasthenia gravis and concurrent Hashimoto's disease].
Rinsho shinkeigaku = Clinical neurology.
2001 Nov; 41(11):813-7. doi:
. [PMID: 12080616] - O Cohen, C Kronman, T Chitlaru, A Ordentlich, B Velan, A Shafferman. Effect of chemical modification of recombinant human acetylcholinesterase by polyethylene glycol on its circulatory longevity.
The Biochemical journal.
2001 Aug; 357(Pt 3):795-802. doi:
10.1042/0264-6021:3570795. [PMID: 11463350] - K Uehara, M Kobayashi, A Hirasaki, Y Asao, O Kobayashi. [Myasthenia gravis is improved temporarily at postburn period].
Masui. The Japanese journal of anesthesiology.
2001 May; 50(5):521-4. doi:
NULL. [PMID: 11424470] - H Sakuma, S Shimazaki, H Saito, M Ohuchi. [A patient with facioscapulohumeral muscular dystrophy accompanied by myasthenia gravis].
Rinsho shinkeigaku = Clinical neurology.
2001 Apr; 41(4-5):179-83. doi:
NULL. [PMID: 11676158] - J Szenohradszky, D Fogarty, H Kirkegaard-Nielsen, R Brown, M L Sharma, D M Fisher. Effect of edrophonium and neostigmine on the pharmacokinetics and neuromuscular effects of mivacurium.
Anesthesiology.
2000 Mar; 92(3):708-14. doi:
10.1097/00000542-200003000-00015. [PMID: 10719950] - C Luo, A Saxena, M Smith, G Garcia, Z Radić, P Taylor, B P Doctor. Phosphoryl oxime inhibition of acetylcholinesterase during oxime reactivation is prevented by edrophonium.
Biochemistry.
1999 Aug; 38(31):9937-47. doi:
10.1021/bi9905720. [PMID: 10433700] - M S García-Ayllón, J L Gómez, C J Vidal. Amphiphilic properties of acetylcholinesterase monomers in mouse plasma.
Neuroscience letters.
1999 Apr; 265(3):211-4. doi:
10.1016/s0304-3940(99)00252-9. [PMID: 10327168] - C Luo, Y Ashani, B P Doctor. Acceleration of oxime-induced reactivation of organophosphate-inhibited fetal bovine serum acetylcholinesterase by monoquaternary and bisquaternary ligands.
Molecular pharmacology.
1998 Apr; 53(4):718-26. doi:
10.1124/mol.53.4.718. [PMID: 9547363] - A Bartunek, H Gilly, G Huemer, S Yildiz, W Schramm, F X Lackner, F F Foldes. [Neostigmine and edrophonium. Antagonism of profound and shallow mivacurium blockade].
Der Anaesthesist.
1997 Feb; 46(2):96-100. doi:
10.1007/s001010050377. [PMID: 9133184] - M J Symington, R K Mirakhur, N Kumar. Neostigmine but not edrophonium prolongs the action of mivacurium.
Canadian journal of anaesthesia = Journal canadien d'anesthesie.
1996 Dec; 43(12):1220-3. doi:
10.1007/bf03013428. [PMID: 8955970] - Y J Kao, N D Le. The reversal of profound mivacurium-induced neuromuscular blockade.
Canadian journal of anaesthesia = Journal canadien d'anesthesie.
1996 Nov; 43(11):1128-33. doi:
10.1007/bf03011839. [PMID: 8922768] - N W Fleming, S Macres, J F Antognini, J Vengco. Neuromuscular blocking action of suxamethonium after antagonism of vecuronium by edrophonium, pyridostigmine or neostigmine.
British journal of anaesthesia.
1996 Oct; 77(4):492-5. doi:
10.1093/bja/77.4.492. [PMID: 8942334] - M Naguib, A H Samarkandi, H S Bakhamees, A Turkistani, S W Alharby. Edrophonium and human plasma cholinesterase combination for antagonism of mivacurium-induced neuromuscular block.
British journal of anaesthesia.
1996 Sep; 77(3):424-6. doi:
10.1093/bja/77.3.424. [PMID: 8949825] - K Yamamoto, Y Sawada, T Iga. Pharmacodynamic analysis of contractile potentiation by cholinesterase inhibitors in rats.
Journal of pharmacokinetics and biopharmaceutics.
1996 Aug; 24(4):327-48. doi:
10.1007/bf02353516. [PMID: 9044164] - W B Wastila, R B Maehr, G L Turner, D A Hill, J J Savarese. Comparative pharmacology of cisatracurium (51W89), atracurium, and five isomers in cats.
Anesthesiology.
1996 Jul; 85(1):169-77. doi:
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Neuromuscular disorders : NMD.
1996 May; 6(3):155-61. doi:
10.1016/0960-8966(96)00009-0. [PMID: 8784802] - M Naguib, M Selim, H S Bakhamees, A H Samarkandi, A Turkistani. Enzymatic versus pharmacologic antagonism of profound mivacurium- induced neuromuscular blockade.
Anesthesiology.
1996 May; 84(5):1051-9. doi:
10.1097/00000542-199605000-00006. [PMID: 8623998] - P Pessotto, R Liberati, O Petrella, W C Hülsmann. Quaternary nitrogen compounds affect carnitine distribution in rats. Particular emphasis on edrophonium.
Biochimica et biophysica acta.
1996 Jan; 1299(2):245-51. doi:
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Canadian journal of anaesthesia = Journal canadien d'anesthesie.
1995 Nov; 42(11):996-1002. doi:
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Anesthesia and analgesia.
1995 Nov; 81(5):1005-9. doi:
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Biological & pharmaceutical bulletin.
1995 Sep; 18(9):1292-5. doi:
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Acta anaesthesiologica Scandinavica.
1995 Aug; 39(6):744-7. doi:
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The Journal of neuroscience nursing : journal of the American Association of Neuroscience Nurses.
1995 Aug; 27(4):207-15; quiz 216. doi:
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Anesthesiology.
1995 Apr; 82(4):912-8. doi:
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Renal failure.
1995 Jan; 17(1):65-71. doi:
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Acta anaesthesiologica Scandinavica. Supplementum.
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Anesthesia and analgesia.
1994 Mar; 78(3):520-6. doi:
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Revue neurologique.
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The Biochemical journal.
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Anaesthesia.
1993 Jun; 48(6):511-3. doi:
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Acta anaesthesiologica Scandinavica.
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Clinical autonomic research : official journal of the Clinical Autonomic Research Society.
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Rinsho shinkeigaku = Clinical neurology.
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Anesthesia and analgesia.
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Arquivos de neuro-psiquiatria.
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Nihon rinsho. Japanese journal of clinical medicine.
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British journal of anaesthesia.
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Biochimica et biophysica acta.
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Metabolism: clinical and experimental.
1989 Nov; 38(11):1082-8. doi:
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Lancet (London, England).
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Journal of veterinary internal medicine.
1988 Apr; 2(2):75-9. doi:
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Diabetes research (Edinburgh, Scotland).
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