H-Aib-OH (BioDeep_00001868287)

Main id: BioDeep_00000014509

 

PANOMIX_OTCML-2023 BioNovoGene_Lab2019 Volatile Flavor Compounds natural product


代谢物信息卡片


3-Amino-2-methylpropanoic acid

化学式: C4H9NO2 (103.0633254)
中文名称: DL-3-氨基异丁酸, 3-氨基异丁酸, 3-氨基-2-甲基丙酸
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(CN)C(=O)O
InChI: InChI=1S/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)

描述信息

A beta-amino-acid that is isobutyric acid in which one of the methyl hydrogens is substituted by an amino group.
3-Amino-2-methylpropanoic acid could induce browning of white fat and hepatic β-oxidation and is inversely correlated with cardiometabolic risk factors.

同义名列表

6 个代谢物同义名

3-Amino-2-methylpropanoic acid; 3-Aminoisobutanoic acid; 3-Aminoisobutyric acid; H-Aib-OH; 3-Aminoisobutyric acid; 3-Amino-2-methylpropanoic acid



数据库引用编号

15 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

19 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Xinghua Qin, Peng Liu, Lingyan Jin, Ke Zhu, Yuanqing Yang, Zuoxu Hou, Huiliang Zhang, Qiangsun Zheng. Exerkine β-aminoisobutyric acid protects against atrial structural remodeling and atrial fibrillation in obesity via activating AMPK signaling and improving insulin sensitivity. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2024 Feb; 171(?):116137. doi: 10.1016/j.biopha.2024.116137. [PMID: 38219388]
  • Ziyue Zhang, Xingbing Li, Jingwen Guo, Bo He, Lianpan Wu, Rongpei Yang, Xingyue Li, Dandong Fang, XiaoLi Yang, Donghai Yang, Fengxian Wang, Ming Tang, Yu Han, Pedro A Jose, Hongyong Wang, Chunyu Zeng. β-aminoisobutyrics acid, a metabolite of BCAA, activates the AMPK/Nrf-2 pathway to prevent ferroptosis and ameliorates lung ischemia-reperfusion injury. Molecular medicine (Cambridge, Mass.). 2023 Dec; 29(1):164. doi: 10.1186/s10020-023-00729-z. [PMID: 38049750]
  • Dan-Dan Bai, Wei-Hua Xiao. [Regulatory effects and mechanisms of branched chain amino acids and metabolic intermediates on insulin resistance]. Sheng li xue bao : [Acta physiologica Sinica]. 2023 Apr; 75(2):291-302. doi: . [PMID: 37089103]
  • Xuejie Yi, Yang Yang, Tao Li, Menghuan Li, Tingting Yao, Guangxuan Hu, Genmeng Wan, Bo Chang. Signaling metabolite β-aminoisobutyric acid as a metabolic regulator, biomarker, and potential exercise pill. Frontiers in endocrinology. 2023; 14(?):1192458. doi: 10.3389/fendo.2023.1192458. [PMID: 37313446]
  • Devanand Shanmugasundaram, Qiru Fan, Mingru Wang, Ronghua Yi, Ou Wang. Safety Assessment of L-β-Aminoisobutyric Acid (L-BAIBA): Subchronic Toxicity Study in Sprague Dawley Rats. International journal of toxicology. 2022 Aug; 41(4):329-346. doi: 10.1177/10915818221094487. [PMID: 35549583]
  • Fatih Mehmet Gur, Ibrahim Aktas. The ameliorative effects of thymoquinone and beta-aminoisobutyric acid on streptozotocin-induced diabetic cardiomyopathy. Tissue & cell. 2021 Aug; 71(?):101582. doi: 10.1016/j.tice.2021.101582. [PMID: 34171519]
  • Jie Zheng, Hao Xiao, Yehui Duan, Bo Song, Changbing Zheng, Qiuping Guo, Fengna Li, Tiejun Li. Roles of amino acid derivatives in the regulation of obesity. Food & function. 2021 Jul; 12(14):6214-6225. doi: 10.1039/d1fo00780g. [PMID: 34105579]
  • Michael Ziemba, Molly Barkhouse, Kitipong Uaesoontrachoon, Mamta Giri, Yetrib Hathout, Utkarsh J Dang, Heather Gordish-Dressman, Kanneboyina Nagaraju, Eric P Hoffman. Biomarker-focused multi-drug combination therapy and repurposing trial in mdx mice. PloS one. 2021; 16(2):e0246507. doi: 10.1371/journal.pone.0246507. [PMID: 33617542]
  • Yuki Shimba, Keigo Katayama, Noriyuki Miyoshi, Masahiko Ikeda, Akihito Morita, Shinji Miura. β-Aminoisobutyric Acid Suppresses Atherosclerosis in Apolipoprotein E-Knockout Mice. Biological & pharmaceutical bulletin. 2020; 43(6):1016-1019. doi: 10.1248/bpb.b20-00078. [PMID: 32475911]
  • Hanna Davideit, Susanne Becker, Johannes Müller, Niels-Peter Becker, Peter Göttel, Ayşe Abay, Angela Sinn, Matthias Grossmann, Markus Mallek, Annekathrin Haberland, Hardy Weisshoff. In-Vivo Degradation of DNA-Based Therapeutic BC 007 in Humans. European journal of drug metabolism and pharmacokinetics. 2019 Aug; 44(4):567-578. doi: 10.1007/s13318-019-00541-3. [PMID: 30674038]
  • Yuki Shimba, Hanako Togawa, Nanami Senoo, Masahiko Ikeda, Noriyuki Miyoshi, Akihito Morita, Shinji Miura. Skeletal Muscle-specific PGC-1α Overexpression Suppresses Atherosclerosis in Apolipoprotein E-Knockout Mice. Scientific reports. 2019 03; 9(1):4077. doi: 10.1038/s41598-019-40643-1. [PMID: 30858489]
  • Dmitrii A Tanianskii, Natalia Jarzebska, Andreas L Birkenfeld, John F O'Sullivan, Roman N Rodionov. Beta-Aminoisobutyric Acid as a Novel Regulator of Carbohydrate and Lipid Metabolism. Nutrients. 2019 Feb; 11(3):. doi: 10.3390/nu11030524. [PMID: 30823446]
  • Jian Shou, Pei-Jie Chen, Wei-Hua Xiao. The Effects of BCAAs on Insulin Resistance in Athletes. Journal of nutritional science and vitaminology. 2019; 65(5):383-389. doi: 10.3177/jnsv.65.383. [PMID: 31666474]
  • Monica Colitti, Federico Boschi, Tommaso Montanari. Dynamic of lipid droplets and gene expression in response to β-aminoisobutyric acid treatment on 3T3-L1 cells. European journal of histochemistry : EJH. 2018 Nov; 62(4):. doi: 10.4081/ejh.2018.2984. [PMID: 30482005]
  • Tae Woo Jung, Hyung Sub Park, Geum Hee Choi, Daehwan Kim, Taeseung Lee. β-aminoisobutyric acid attenuates LPS-induced inflammation and insulin resistance in adipocytes through AMPK-mediated pathway. Journal of biomedical science. 2018 Mar; 25(1):27. doi: 10.1186/s12929-018-0431-7. [PMID: 29592806]
  • Yuan Cheng, Haiying Song, Xiaoqing Pan, Hong Xue, Yifei Wan, Tao Wang, Zhongmin Tian, Entai Hou, Ian R Lanza, Pengyuan Liu, Yong Liu, Purushottam W Laud, Kristie Usa, Yongcheng He, Mingyu Liang. Urinary Metabolites Associated with Blood Pressure on a Low- or High-Sodium Diet. Theranostics. 2018; 8(6):1468-1480. doi: 10.7150/thno.22018. [PMID: 29556335]
  • Xanthi D Andrianou, Pantelis Charisiadis, Konstantinos C Makris. Coupling Urinary Trihalomethanes and Metabolomic Profiles of Type II Diabetes: A Case-Control Study. Journal of proteome research. 2017 08; 16(8):2743-2751. doi: 10.1021/acs.jproteome.6b01061. [PMID: 28621139]
  • Jana Konkoľová, Ján Chandoga, Juraj Kováčik, Marcel Repiský, Veronika Kramarová, Ivana Paučinová, Daniel Böhmer. Severe child form of primary hyperoxaluria type 2 - a case report revealing consequence of GRHPR deficiency on metabolism. BMC medical genetics. 2017 05; 18(1):59. doi: 10.1186/s12881-017-0421-8. [PMID: 28569194]
  • Flor E Morales, Jeffrey S Forsse, Thomas L Andre, Sarah K McKinley-Barnard, Paul S Hwang, Ian G Anthony, Grant M Tinsley, Mike Spillane, Peter W Grandjean, Alejandro Ramirez, Darryn S Willoughby. BAIBA Does Not Regulate UCP-3 Expression in Human Skeletal Muscle as a Response to Aerobic Exercise. Journal of the American College of Nutrition. 2017 Mar; 36(3):200-209. doi: 10.1080/07315724.2016.1256240. [PMID: 28318397]
  • Alessio Molfino, Maria Ida Amabile, Thomas Ammann, Alessio Farcomeni, Luana Lionetto, Maurizio Simmaco, Silvia Lai, Alessandro Laviano, Filippo Rossi Fanelli, Maria Grazia Chiappini, Maurizio Muscaritoli. The metabolite beta-aminoisobutyric acid and physical inactivity among hemodialysis patients. Nutrition (Burbank, Los Angeles County, Calif.). 2017 Feb; 34(?):101-107. doi: 10.1016/j.nut.2016.07.012. [PMID: 28063504]
  • Dmitry V Burdin, Alexey A Kolobov, Chad Brocker, Alexey A Soshnev, Nikolay Samusik, Anton V Demyanov, Silke Brilloff, Natalia Jarzebska, Jens Martens-Lobenhoffer, Maren Mieth, Renke Maas, Stefan R Bornstein, Stefanie M Bode-Böger, Frank Gonzalez, Norbert Weiss, Roman N Rodionov. Diabetes-linked transcription factor HNF4α regulates metabolism of endogenous methylarginines and β-aminoisobutyric acid by controlling expression of alanine-glyoxylate aminotransferase 2. Scientific reports. 2016 10; 6(?):35503. doi: 10.1038/srep35503. [PMID: 27752141]
  • Chang-Xiang Shi, Ming-Xia Zhao, Xiao-Dong Shu, Xiao-Qing Xiong, Jue-Jin Wang, Xing-Ya Gao, Qi Chen, Yue-Hua Li, Yu-Ming Kang, Guo-Qing Zhu. β-aminoisobutyric acid attenuates hepatic endoplasmic reticulum stress and glucose/lipid metabolic disturbance in mice with type 2 diabetes. Scientific reports. 2016 Feb; 6(?):21924. doi: 10.1038/srep21924. [PMID: 26907958]
  • Jordi Mayneris-Perxachs, Aldo A M Lima, Richard L Guerrant, Álvaro M Leite, Alessandra F Moura, Noélia L Lima, Alberto M Soares, Alexandre Havt, Sean R Moore, Relana Pinkerton, Jonathan R Swann. Urinary N-methylnicotinamide and β-aminoisobutyric acid predict catch-up growth in undernourished Brazilian children. Scientific reports. 2016 Jan; 6(?):19780. doi: 10.1038/srep19780. [PMID: 26816084]
  • A Miccheli, G Capuani, F Marini, A Tomassini, G Praticò, S Ceccarelli, D Gnani, G Baviera, A Alisi, L Putignani, V Nobili. Urinary (1)H-NMR-based metabolic profiling of children with NAFLD undergoing VSL#3 treatment. International journal of obesity (2005). 2015 Jul; 39(7):1118-25. doi: 10.1038/ijo.2015.40. [PMID: 25809828]
  • Daniela Moyankova, Petko Mladenov, Strahil Berkov, Darin Peshev, Desislava Georgieva, Dimitar Djilianov. Metabolic profiling of the resurrection plant Haberlea rhodopensis during desiccation and recovery. Physiologia plantarum. 2014 Dec; 152(4):675-87. doi: 10.1111/ppl.12212. [PMID: 24735127]
  • Yuta Yoshino, Masao Abe, Shusuke Numata, Shinichiro Ochi, Yoko Mori, Takashi Ishimaru, Makoto Kinoshita, Hidehiro Umehara, Kiyohiro Yamazaki, Takaaki Mori, Tetsuro Ohmori, Shu-ichi Ueno. Missense variants of the alanine:glyoxylate aminotransferase 2 gene are not associated with Japanese schizophrenia patients. Progress in neuro-psychopharmacology & biological psychiatry. 2014 Aug; 53(?):137-41. doi: 10.1016/j.pnpbp.2014.04.002. [PMID: 24727203]
  • Lee D Roberts, Pontus Boström, John F O'Sullivan, Robert T Schinzel, Gregory D Lewis, Andre Dejam, Youn-Kyoung Lee, Melinda J Palma, Sondra Calhoun, Anastasia Georgiadi, Ming-Huei Chen, Vasan S Ramachandran, Martin G Larson, Claude Bouchard, Tuomo Rankinen, Amanda L Souza, Clary B Clish, Thomas J Wang, Jennifer L Estall, Alexander A Soukas, Chad A Cowan, Bruce M Spiegelman, Robert E Gerszten. β-Aminoisobutyric acid induces browning of white fat and hepatic β-oxidation and is inversely correlated with cardiometabolic risk factors. Cell metabolism. 2014 Jan; 19(1):96-108. doi: 10.1016/j.cmet.2013.12.003. [PMID: 24411942]
  • Anja Kittel, Fabian Müller, Jörg König, Maren Mieth, Heinrich Sticht, Oliver Zolk, Ana Kralj, Markus R Heinrich, Martin F Fromm, Renke Maas. Alanine-glyoxylate aminotransferase 2 (AGXT2) polymorphisms have considerable impact on methylarginine and β-aminoisobutyrate metabolism in healthy volunteers. PloS one. 2014; 9(2):e88544. doi: 10.1371/journal.pone.0088544. [PMID: 24586340]
  • Vassilios Fanos, Emanuela Locci, Antonio Noto, Tiziana Lazzarotto, Paolo Manzoni, Luigi Atzori, Marcello Lanari. Urinary metabolomics in newborns infected by human cytomegalovirus: a preliminary investigation. Early human development. 2013 Jun; 89 Suppl 1(?):S58-61. doi: 10.1016/s0378-3782(13)70017-3. [PMID: 23809353]
  • Anja Kittel, Renke Maas, Jörg König, Maren Mieth, Norbert Weiss, Natalia Jarzebska, Bernd Hohenstein, Jens Martens-Lobenhoffer, Stefanie M Bode-Böger, Roman N Rodionov. In vivo evidence that Agxt2 can regulate plasma levels of dimethylarginines in mice. Biochemical and biophysical research communications. 2013 Jan; 430(1):84-9. doi: 10.1016/j.bbrc.2012.11.008. [PMID: 23154179]
  • André B P van Kuilenburg, Doreen Dobritzsch, Judith Meijer, Michael Krumpel, Laila A Selim, Mohamed S Rashed, Birgit Assmann, Rutger Meinsma, Bernhard Lohkamp, Tetsuya Ito, Nico G G M Abeling, Kayoko Saito, Kaoru Eto, Martin Smitka, Martin Engvall, Chunhua Zhang, Wang Xu, Lida Zoetekouw, Raoul C M Hennekam. ß-ureidopropionase deficiency: phenotype, genotype and protein structural consequences in 16 patients. Biochimica et biophysica acta. 2012 Jul; 1822(7):1096-108. doi: 10.1016/j.bbadis.2012.04.001. [PMID: 22525402]
  • Leonard Pysh, Nathan Alexander, Laura Swatzyna, Robert Harbert. Four alleles of AtCESA3 form an allelic series with respect to root phenotype in Arabidopsis thaliana. Physiologia plantarum. 2012 Apr; 144(4):369-81. doi: 10.1111/j.1399-3054.2012.01575.x. [PMID: 22514801]
  • Parvesh Wadhwani, Johannes Reichert, Jochen Bürck, Anne S Ulrich. Antimicrobial and cell-penetrating peptides induce lipid vesicle fusion by folding and aggregation. European biophysics journal : EBJ. 2012 Feb; 41(2):177-87. doi: 10.1007/s00249-011-0771-7. [PMID: 22080286]
  • Jessie Fernandez, Janet D Wright, David Hartline, Cristian F Quispe, Nandakumar Madayiputhiya, Richard A Wilson. Principles of carbon catabolite repression in the rice blast fungus: Tps1, Nmr1-3, and a MATE-family pump regulate glucose metabolism during infection. PLoS genetics. 2012; 8(5):e1002673. doi: 10.1371/journal.pgen.1002673. [PMID: 22570632]
  • Andre R Nelson, Stuart M Phillips, Trent Stellingwerff, Serge Rezzi, Stephen J Bruce, Isabelle Breton, Anita Thorimbert, Philippe A Guy, Jim Clarke, Suzanne Broadbent, David Stephen Rowlands. A protein-leucine supplement increases branched-chain amino acid and nitrogen turnover but not performance. Medicine and science in sports and exercise. 2012 Jan; 44(1):57-68. doi: 10.1249/mss.0b013e3182290371. [PMID: 21685813]
  • S U Munshi, S Taneja, N S Bhavesh, J Shastri, R Aggarwal, S Jameel. Metabonomic analysis of hepatitis E patients shows deregulated metabolic cycles and abnormalities in amino acid metabolism. Journal of viral hepatitis. 2011 Oct; 18(10):e591-602. doi: 10.1111/j.1365-2893.2011.01488.x. [PMID: 21914081]
  • George Nicholson, Mattias Rantalainen, Jia V Li, Anthony D Maher, Daniel Malmodin, Kourosh R Ahmadi, Johan H Faber, Amy Barrett, Josine L Min, N William Rayner, Henrik Toft, Maria Krestyaninova, Juris Viksna, Sudeshna Guha Neogi, Marc-Emmanuel Dumas, Ugis Sarkans, Peter Donnelly, Thomas Illig, Jerzy Adamski, Karsten Suhre, Maxine Allen, Krina T Zondervan, Tim D Spector, Jeremy K Nicholson, John C Lindon, Dorrit Baunsgaard, Elaine Holmes, Mark I McCarthy, Chris C Holmes. A genome-wide metabolic QTL analysis in Europeans implicates two loci shaped by recent positive selection. PLoS genetics. 2011 Sep; 7(9):e1002270. doi: 10.1371/journal.pgen.1002270. [PMID: 21931564]
  • James B Adams, Tapan Audhya, Sharon McDonough-Means, Robert A Rubin, David Quig, Elizabeth Geis, Eva Gehn, Melissa Loresto, Jessica Mitchell, Sharon Atwood, Suzanne Barnhouse, Wondra Lee. Nutritional and metabolic status of children with autism vs. neurotypical children, and the association with autism severity. Nutrition & metabolism. 2011 Jun; 8(1):34. doi: 10.1186/1743-7075-8-34. [PMID: 21651783]
  • Karsten Suhre, Henri Wallaschofski, Johannes Raffler, Nele Friedrich, Robin Haring, Kathrin Michael, Christina Wasner, Alexander Krebs, Florian Kronenberg, David Chang, Christa Meisinger, H-Erich Wichmann, Wolfgang Hoffmann, Henry Völzke, Uwe Völker, Alexander Teumer, Reiner Biffar, Thomas Kocher, Stephan B Felix, Thomas Illig, Heyo K Kroemer, Christian Gieger, Werner Römisch-Margl, Matthias Nauck. A genome-wide association study of metabolic traits in human urine. Nature genetics. 2011 Jun; 43(6):565-9. doi: 10.1038/ng.837. [PMID: 21572414]
  • Chrysi Koliaki, John Doupis. Incretin-based therapy: a powerful and promising weapon in the treatment of type 2 diabetes mellitus. Diabetes therapy : research, treatment and education of diabetes and related disorders. 2011 May; 2(2):101-21. doi: 10.1007/s13300-011-0002-3. [PMID: 22127804]
  • Karima Begriche, Julie Massart, Bernard Fromenty. Effects of β-aminoisobutyric acid on leptin production and lipid homeostasis: mechanisms and possible relevance for the prevention of obesity. Fundamental & clinical pharmacology. 2010 Jun; 24(3):269-82. doi: 10.1111/j.1472-8206.2009.00765.x. [PMID: 19735301]
  • Karima Begriche, Julie Massart, Adjé Abbey-Toby, Anissa Igoudjil, Philippe Lettéron, Bernard Fromenty. Beta-aminoisobutyric acid prevents diet-induced obesity in mice with partial leptin deficiency. Obesity (Silver Spring, Md.). 2008 Sep; 16(9):2053-67. doi: 10.1038/oby.2008.337. [PMID: 19186330]
  • Anissa Igoudjil, Julie Massart, Karima Begriche, Véronique Descatoire, Marie-Anne Robin, Bernard Fromenty. High concentrations of stavudine impair fatty acid oxidation without depleting mitochondrial DNA in cultured rat hepatocytes. Toxicology in vitro : an international journal published in association with BIBRA. 2008 Jun; 22(4):887-98. doi: 10.1016/j.tiv.2008.01.011. [PMID: 18299183]
  • A B P van Kuilenburg, A E M Stroomer, A M Bosch, M Duran. Beta-alanine and beta-aminoisobutyric acid levels in two siblings with dihydropyrimidinase deficiency. Nucleosides, nucleotides & nucleic acids. 2008 Jun; 27(6):825-9. doi: 10.1080/15257770802146445. [PMID: 18600547]
  • Yu-Haey Kuo, Barbara Defoort, Haileyesus Getahun, Redda Tekle Haimanot, Fernand Lambein. Comparison of urinary amino acids and trace elements (copper, zinc and manganese) of recent neurolathyrism patients and healthy controls from Ethiopia. Clinical biochemistry. 2007 Mar; 40(5-6):397-402. doi: 10.1016/j.clinbiochem.2006.11.020. [PMID: 17291478]
  • Anissa Igoudjil, Adjé Abbey-Toby, Karima Begriche, Alain Grodet, Karine Chataigner, Gilles Peytavin, Mustapha Maachi, Marion Colin, Marie-Anne Robin, Philippe Lettéron, Gérard Feldmann, Dominique Pessayre, Bernard Fromenty. High doses of stavudine induce fat wasting and mild liver damage without impairing mitochondrial respiration in mice. Antiviral therapy. 2007; 12(3):389-400. doi: . [PMID: 17591029]
  • L Qin, J He, S K Lee, I C Dodd. An assessment of the role of ethylene in mediating lettuce (Lactuca sativa) root growth at high temperatures. Journal of experimental botany. 2007; 58(11):3017-24. doi: 10.1093/jxb/erm156. [PMID: 17728295]
  • Timo Stark, Sabine Bareuther, Thomas Hofmann. Molecular definition of the taste of roasted cocoa nibs (Theobroma cacao) by means of quantitative studies and sensory experiments. Journal of agricultural and food chemistry. 2006 Jul; 54(15):5530-9. doi: 10.1021/jf0608726. [PMID: 16848542]
  • Chih-Kuang Chuang, Shuan-Pei Lin, Han-Hsiang Chen, Yi-Chou Chen, Tuan-Jen Wang, Wen-Hsiang Shieh, Chih-Jen Wu. Plasma free amino acids and their metabolites in Taiwanese patients on hemodialysis and continuous ambulatory peritoneal dialysis. Clinica chimica acta; international journal of clinical chemistry. 2006 Feb; 364(1-2):209-16. doi: 10.1016/j.cccn.2005.07.001. [PMID: 16087168]
  • A B P van Kuilenburg, A E M Stroomer, N G G M Abeling, A H van Gennip. A pivotal role for beta-aminoisobutyric acid and oxidative stress in dihydropyrimidine dehydrogenase deficiency?. Nucleosides, nucleotides & nucleic acids. 2006; 25(9-11):1103-6. doi: 10.1080/15257770600894097. [PMID: 17065072]
  • Sumin Gu, Carla J Villegas, Jean X Jiang. Differential regulation of amino acid transporter SNAT3 by insulin in hepatocytes. The Journal of biological chemistry. 2005 Jul; 280(28):26055-62. doi: 10.1074/jbc.m504401200. [PMID: 15899884]
  • Yousef M Abdulrazzaq, Ahmed Ibrahim, Abdulla I Al-Khayat, Kenneth Dawson. Beta-thalassemia major and its effect on amino acid metabolism and growth in patients in the United Arab Emirates. Clinica chimica acta; international journal of clinical chemistry. 2005 Feb; 352(1-2):183-90. doi: 10.1016/j.cccn.2004.09.017. [PMID: 15653113]
  • C Schmidt, U Hofmann, D Kohlmüller, T Mürdter, U M Zanger, M Schwab, G F Hoffmann. Comprehensive analysis of pyrimidine metabolism in 450 children with unspecific neurological symptoms using high-pressure liquid chromatography-electrospray ionization tandem mass spectrometry. Journal of inherited metabolic disease. 2005; 28(6):1109-22. doi: 10.1007/s10545-005-0133-7. [PMID: 16435204]
  • André B P van Kuilenburg, Rutger Meinsma, Eva Beke, Birgit Assmann, Antonia Ribes, Isabel Lorente, Rebekka Busch, Ertan Mayatepek, Nico G G M Abeling, Arno van Cruchten, Alida E M Stroomer, Henk van Lenthe, Lida Zoetekouw, Willem Kulik, Georg F Hoffmann, Thomas Voit, Ron A Wevers, Frank Rutsch, Albert H van Gennip. beta-Ureidopropionase deficiency: an inborn error of pyrimidine degradation associated with neurological abnormalities. Human molecular genetics. 2004 Nov; 13(22):2793-801. doi: 10.1093/hmg/ddh303. [PMID: 15385443]
  • Caroline Maisonneuve, Anissa Igoudjil, Karima Begriche, Philippe Lettéron, Marie-Christine Guimont, Jean Bastin, Jean-Pierre Laigneau, Dominique Pessayre, Bernard Fromenty. Effects of zidovudine, stavudine and beta-aminoisobutyric acid on lipid homeostasis in mice: possible role in human fat wasting. Antiviral therapy. 2004 Oct; 9(5):801-10. doi: 10.1177/135965350400900513. [PMID: 15535418]
  • André B P Van Kuilenburg, Alida E M Stroomer, Henk Van Lenthe, Nico G G M Abeling, Albert H Van Gennip. New insights in dihydropyrimidine dehydrogenase deficiency: a pivotal role for beta-aminoisobutyric acid?. The Biochemical journal. 2004 Apr; 379(Pt 1):119-24. doi: 10.1042/bj20031463. [PMID: 14705962]
  • Ts Enkhjargal, Ch Tserennadmid. Urinary excretion of beta-aminoisobutyric acid in hematological diseases. Rinsho byori. The Japanese journal of clinical pathology. 2004 Jan; 52(1):17-21. doi: NULL. [PMID: 14968554]
  • Reine Note, Caroline Maisonneuve, Philippe Lettéron, Gilles Peytavin, Fatima Djouadi, Anissa Igoudjil, Marie-Christine Guimont, Michel Biour, Dominique Pessayre, Bernard Fromenty. Mitochondrial and metabolic effects of nucleoside reverse transcriptase inhibitors (NRTIs) in mice receiving one of five single- and three dual-NRTI treatments. Antimicrobial agents and chemotherapy. 2003 Nov; 47(11):3384-92. doi: 10.1128/aac.47.11.3384-3392.2003. [PMID: 14576092]
  • Ute Hofmann, Matthias Schwab, Sonja Seefried, Claudia Marx, Ulrich M Zanger, Michel Eichelbaum, Thomas E Mürdter. Sensitive method for the quantification of urinary pyrimidine metabolites in healthy adults by gas chromatography-tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2003 Jul; 791(1-2):371-80. doi: 10.1016/s1570-0232(03)00251-4. [PMID: 12798197]
  • S Ito, T Ohyama, Y Kontani, K Matslida, S F Sakata, N Tamaki. Influence of dietary protein levels on beta-alanine aminotransferase expression and activity in rats. Journal of nutritional science and vitaminology. 2001 Aug; 47(4):275-82. doi: 10.3177/jnsv.47.275. [PMID: 11767207]
  • T A Patterson, Z K Binienda, G D Newport, G W Lipe, M P Gillam, W Slikker, J A Sandberg. Transplacental pharmacokinetics and fetal distribution of 2', 3'-didehydro-3'-deoxythymidine (d4T) and its metabolites in late-term rhesus macaques. Teratology. 2000 Aug; 62(2):93-9. doi: 10.1002/1096-9926(200008)62:2<93::aid-tera5>3.0.co;2-m. [PMID: 10931506]
  • F Podebrad, M Heil, T Beck, A Mosandl, A C Sewell, H Böhles. Stereodifferentiation of 3-hydroxyisobutyric- and 3-aminoisobutyric acid in human urine by enantioselective multidimensional capillary gas chromatography-mass spectrometry. Clinica chimica acta; international journal of clinical chemistry. 2000 Feb; 292(1-2):93-105. doi: 10.1016/s0009-8981(99)00210-7. [PMID: 10686279]
  • P M Zeis, M Tzaki, L Nakopoulou, P Nicolaidou, E Kavazarakis, A Messaritaki, M Moustaki, M P Zeis, D Gourgiotis. DNA degradation in the kidney of folic acid-treated guinea pigs. Cytobios. 2000; 102(400):107-13. doi: NULL. [PMID: 10885507]
  • E Lahat, B Ben-Zeev, J Zlotnik, B A Sela. Aminoaciduria resulting from vigabatrin administration in children with epilepsy. Pediatric neurology. 1999 Jul; 21(1):460-3. doi: 10.1016/s0887-8994(99)00022-3. [PMID: 10428431]
  • Y Kurozumi, T Abe, W B Yao, T Ubuka. Experimental beta-alaninuria induced by (aminooxy)acetate. Acta medica Okayama. 1999 Feb; 53(1):13-8. doi: 10.18926/amo/31647. [PMID: 10096733]
  • T Abe, Y Kurozumi, W B Yao, T Ubuka. High-performance liquid chromatographic determination of beta-alanine, beta-aminoisobutyric acid and gamma-aminobutyric acid in tissue extracts and urine of normal and (aminooxy)acetate-treated rats. Journal of chromatography. B, Biomedical sciences and applications. 1998 Aug; 712(1-2):43-9. doi: 10.1016/s0378-4347(98)00154-6. [PMID: 9698227]
  • D P Stevenson, S R Milligan, W P Collins. Effects of platelet-derived endothelial cell growth factor/thymidine phosphorylase, substrate, and products in a three-dimensional model of angiogenesis. The American journal of pathology. 1998 Jun; 152(6):1641-6. doi: . [PMID: 9626068]
  • Y Ohro, Y Wada. [beta-Aminoisobutyricaciduria]. Ryoikibetsu shokogun shirizu. 1998; ?(18 Pt 1):241-3. doi: NULL. [PMID: 9590036]
  • V A Spitsyn, D V Stakishaĭtis, R A Preĭksha. [Genetic dimorphism in beta-aminoisobutyric acid excretion in patients with atherosclerosis of the coronary artery and in groups at risk for atherosclerosis in the Lithuanian population]. Genetika. 1993 Nov; 29(11):1861-70. doi: NULL. [PMID: 8307373]
  • V A Spitsyn, I S Afanas'eva, N V Alekseeva. [Ecogenetic aspects of the study of phenotypes and levels of beta-aminoisobutyric acid excretion]. Genetika. 1993 Nov; 29(11):1871-7. doi: NULL. [PMID: 8307374]
  • E M Cretton, Z Zhou, L B Kidd, H M McClure, S Kaul, M J Hitchcock, J P Sommadossi. In vitro and in vivo disposition and metabolism of 3'-deoxy-2',3'-didehydrothymidine. Antimicrobial agents and chemotherapy. 1993 Sep; 37(9):1816-25. doi: 10.1128/aac.37.9.1816. [PMID: 8239589]
  • O Konjiki, Y Yoneda, Y Sato, Y Oosawa, T Imamura, M Takasaki. [A case of megaloblastic anemia with abnormally high urine level of beta-aminoisobutyric acid]. Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics. 1993 Jan; 30(1):65-9. doi: 10.3143/geriatrics.30.65. [PMID: 8474230]
  • K Tomokuni, M Ichiba, Y Hirai. Urinary N-acetyl-beta-D-glucosaminidase and beta-aminoisobutyric acid in workers occupationally exposed to metals such as chromium, nickel, and iron. International archives of occupational and environmental health. 1993; 65(1):19-21. doi: 10.1007/bf00586053. [PMID: 8354570]
  • E Kvist, K E Sjølin, J Iversen, K Nyholm. Urinary excretion patterns of pseudouridine and beta-aminoisobutyric acid in patients with tumours of the urinary bladder. Scandinavian journal of urology and nephrology. 1993; 27(1):45-53. doi: 10.3109/00365599309180413. [PMID: 8493467]
  • K Tomokuni, M Ichiba, K Mori. Relation between urinary beta-aminoisobutyric acid excretion and concentration of lead in the blood of workers occupationally exposed to lead. British journal of industrial medicine. 1992 May; 49(5):365-8. doi: 10.1136/oem.49.5.365. [PMID: 1599874]
  • D Ketting, S K Wadman, L J Spaapen, S B Van der Meer, M Duran. Gas chromatography method for the separation of amino acids enantiomers in plasma and urine. Application in a case of short bowel syndrome. Clinica chimica acta; international journal of clinical chemistry. 1991 Dec; 204(1-3):79-86. doi: 10.1016/0009-8981(91)90219-3. [PMID: 1819475]
  • K Tomokuni, M Ichiba, Y Hirai. Elevated urinary excretion of beta-aminoisobutyric acid and delta-aminolevulinic acid (ALA) and the inhibition of ALA-synthase and ALA-dehydratase activities in both liver and kidney in mice exposed to lead. Toxicology letters. 1991 Dec; 59(1-3):169-73. doi: 10.1016/0378-4274(91)90069-i. [PMID: 1755023]
  • O Ladrón de Guevara, C Cortinas de Nava, P Padilla, J Espinosa, M Cebrian, L García. Rapid determination of beta-aminoisobutyric acid by reversed-phase high-performance liquid chromatography. Journal of chromatography. 1990 Jun; 528(1):35-41. doi: 10.1016/s0378-4347(00)82360-9. [PMID: 2117018]
  • E Kvist, K E Sjølin, J Iversen. Excretion patterns of pseudouridine and beta-aminoisobutyric acid in patients with tumours of the upper urinary tract. Scandinavian journal of urology and nephrology. 1990; 24(4):287-92. doi: NULL. [PMID: 2274753]
  • E Kvist, K E Sjølin. Pseudouridine and beta-aminoisobutyric acid excretion in urine: diagnostic and prognostic value. Scandinavian journal of urology and nephrology. 1990; 24(4):283-5. doi: NULL. [PMID: 2274752]
  • K E Sjølin. Increased urinary excretion of beta-aminoisobutyric acid in a Danish family. Danish medical bulletin. 1988 Aug; 35(4):397-9. doi: NULL. [PMID: 3168560]
  • W R Farkas, A Fischbein, S Solomon, F Buschman, E Borek, O K Sharma. Elevated urinary excretion of beta-aminoisobutyric acid and exposure to inorganic lead. Archives of environmental health. 1987 Mar; 42(2):96-9. doi: 10.1080/00039896.1987.9935803. [PMID: 3579372]
  • N G Abeling, A H van Gennip, H Overmars, P A Voûte. Biochemical monitoring of children with neuroblastoma. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology. 1986 Sep; 7(1):27-35. doi: 10.1016/s0167-8140(86)80122-0. [PMID: 3095895]
  • F L Buschman, G Apell, O K Sharma. High-performance liquid chromatographic determination of beta-aminoisobutyric acid in the picomole range. Journal of chromatography. 1986 Jan; 374(1):129-36. doi: 10.1016/s0378-4347(00)83261-2. [PMID: 3949920]
  • R J Pollitt, A Green, R Smith. Excessive excretion of beta-alanine and of 3-hydroxypropionic, R- and S-3-aminoisobutyric, R- and S-3-hydroxyisobutyric and S-2-(hydroxymethyl)butyric acids probably due to a defect in the metabolism of the corresponding malonic semialdehydes. Journal of inherited metabolic disease. 1985; 8(2):75-9. doi: 10.1007/bf01801669. [PMID: 3939535]
  • N J Brandt, E Christensen. Omega-aminoaciduria induced by gamma-vinyl GABA. Lancet (London, England). 1984 Feb; 1(8374):450-1. doi: 10.1016/s0140-6736(84)91777-x. [PMID: 6142173]
  • H R Nielsen, S A Killmann. Urinary excretion of beta-aminoisobutyrate and pseudouridine in acute and chronic myeloid leukemia. Journal of the National Cancer Institute. 1983 Nov; 71(5):887-91. doi: NULL. [PMID: 6580488]
  • S P Simpson, N E Morton. Complex segregation analysis of the locus for beta-aminoisobutyric acid excretion (BAIB). Human genetics. 1981; 59(1):64-7. doi: 10.1007/bf00278856. [PMID: 10819024]
  • W SCHIETECATTE, G MAES, M H FAES, R BERNARDELLI. [SIMPLE METHOD FOR QUANTITATIVE DETERMINATION OF BETA-AMINOISOBUTYRIC ACID IN HUMAN URINE BY PAPER CHROMATOGRAPHY]. Clinica chimica acta; international journal of clinical chemistry. 1965 Mar; 11(?):259-62. doi: 10.1016/0009-8981(65)90071-9. [PMID: 14339024]
  • R TRUHAUT, E DELACOUX, C PAOLETTI. URINARY BETA-AMINO ISOBUTYRIC ACID IN THE MOUSE: ELIMINATION AFTER INTRAVENOUS ADMINISTRATION OF DEOXYRIBONUCLEIC ACID. Nature. 1965 Feb; 205(?):806-7. doi: 10.1038/205806a0. [PMID: 14292315]
  • H O GOODMAN, J S KING, J J THOMAS. URINARY EXCRETION OF BETA-AMINO-ISOBUTYRIC ACID AND TAURINE MONGOLISM. Nature. 1964 Nov; 204(?):650-2. doi: 10.1038/204650a0. [PMID: 14236278]
  • H SMITH, T H BATES, C I SMITH. EXCRETION OF BETA-AMINO-ISOBUTYRIC ACID AS AN INDEX OF RADIATION EXPOSURE. International journal of radiation biology and related studies in physics, chemistry, and medicine. 1964; 8(?):263-9. doi: 10.1080/09553006414550271. [PMID: 14234752]
  • H SMITH, B DYMOND. THE DETERMINATION OF BETA-AMINO-ISOBUTYRIC ACID IN URINE. Clinica chimica acta; international journal of clinical chemistry. 1963 Jul; 8(?):614-20. doi: 10.1016/0009-8981(63)90113-x. [PMID: 14063978]
  • D BAWDEN. The estimation of beta amino-isobutyric acid in human urine. Journal of clinical pathology. 1963 May; 16(?):284-7. doi: 10.1136/jcp.16.3.284. [PMID: 13967049]
  • S T TAKATS, R M SMELLIE. Thymidine degradation products in plant tissues labeled with tritiated thymidine. The Journal of cell biology. 1963 Apr; 17(?):59-66. doi: 10.1083/jcb.17.1.59. [PMID: 13984611]
  • V JIRGL, J SOCHMAN. A method for the quantitative determination of beta-aminoisobutyric acid in the human urine by paper electrophoresis. Clinica chimica acta; international journal of clinical chemistry. 1962 May; 7(?):388-91. doi: 10.1016/0009-8981(62)90038-4. [PMID: 14451869]
  • B L HILLCOAT. Altered urinary excretion of beta-amino-isobutyric acid after splenectomy. Lancet (London, England). 1962 Jan; 1(7220):74-5. doi: 10.1016/s0140-6736(62)91721-x. [PMID: 13907401]
  • B S BLUMBERG, S M GARTLER. The urinary excretion of beta-amino-isobutyric acid in Pacific populations. Human biology. 1961 Dec; 33(?):355-62. doi: NULL. [PMID: 13870230]
  • S A KILLMANN, J R RUBINI, E P CRONKITE, V P BOND. Urinary excretion of beta-aminoisobutyric acid (BAIBA) in leukemia and polycythemia vera. Acta haematologica. 1961 Feb; 25(?):81-97. doi: 10.1159/000206521. [PMID: 13755966]