Pyrazine-2-carboxylic acid (BioDeep_00001868228)
Main id: BioDeep_00000013127
Chemicals and Drugs
代谢物信息卡片
Pyrazine-2-carboxylic acid
化学式: C5H4N2O2 (124.02727639999999)
中文名称: 2-吡嗪羧酸
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CN=C(C=N1)C(=O)O
InChI: InChI=1S/C5H4N2O2/c8-5(9)4-3-6-1-2-7-4/h1-3H,(H,8,9)
描述信息
The parent compound of the class of pyrazinecarboxylic acids, that is pyrazine bearing a single carboxy substituent. The active metabolite of the antitubercular drug pyrazinamide.
同义名列表
1 个代谢物同义名
数据库引用编号
8 个数据库交叉引用编号
- ChEBI: CHEBI:71311
- KEGG: C19915
- PubChem: 1047
- ChEMBL: CHEMBL613
- CAS: 98-97-5
- MetaboLights: MTBLC71311
- PubChem: 135626381
- PDB-CCD: VGL
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Taísa Busaranho Franchin, Bruna Cristina Ulian Silva, Rone Aparecido DeGrandis, Michelle Fidelis Corrêa, Cecília Maria Simões de Queiroz Aranha, Joáo Paulo S Fernandes, Michel Leandro Campos, Rosângela Gonçalves Peccinini. Assessment of the Physicochemical Properties and Stability for Pharmacokinetic Prediction of Pyrazinoic Acid Derivatives.
Current drug metabolism.
2020; 21(9):714-721. doi:
10.2174/1389200221666200907145722. [PMID: 32895039] - Edgar A Florentini, Noelia Angulo, Robert H Gilman, Roberto Alcántara, Elisa Roncal, Ricardo Antiparra, Emily Toscano, Katherine Vallejos, Danni Kirwan, Mirko Zimic, Patricia Sheen. Immunological detection of pyrazine-2-carboxylic acid for the detection of pyrazinamide resistance in Mycobacterium tuberculosis.
PloS one.
2020; 15(11):e0241600. doi:
10.1371/journal.pone.0241600. [PMID: 33151985] - Pierre Mugabo, Mwila Mulubwa. Population Pharmacokinetic Modelling of Pyrazinamide and Pyrazinoic Acid in Patients with Multi-Drug Resistant Tuberculosis.
European journal of drug metabolism and pharmacokinetics.
2019 Aug; 44(4):519-530. doi:
10.1007/s13318-018-00540-w. [PMID: 30617957] - Jonathan I Kremer, Stephanie Pickard, Lara F Stadlmair, Anika Glaß-Theis, Leon Buckel, Tamara Bakuradze, Gerhard Eisenbrand, Elke Richling. Alkylpyrazines from Coffee are Extensively Metabolized to Pyrazine Carboxylic Acids in the Human Body.
Molecular nutrition & food research.
2019 07; 63(14):e1801341. doi:
10.1002/mnfr.201801341. [PMID: 31125183] - Tetsuya Taniguchi, Naoki Ashizawa, Koji Matsumoto, Takashi Iwanaga. Enhancement of pharmacological effects of uricosuric agents by concomitant treatment with pyrazinamide in rats.
Naunyn-Schmiedeberg's archives of pharmacology.
2017 Mar; 390(3):253-260. doi:
10.1007/s00210-016-1324-5. [PMID: 27933340] - M S Attia, Najlaa S Al-Radadi. Nano optical sensor binuclear Pt-2-pyrazinecarboxylic acid -bipyridine for enhancement of the efficiency of 3-nitrotyrosine biomarker for early diagnosis of liver cirrhosis with minimal hepatic encephalopathy.
Biosensors & bioelectronics.
2016 Dec; 86(?):406-412. doi:
10.1016/j.bios.2016.06.074. [PMID: 27414246] - Jean-Philippe Lanoix, Rokeya Tasneen, Paul O'Brien, Jansy Sarathy, Hassan Safi, Michael Pinn, David Alland, Véronique Dartois, Eric Nuermberger. High Systemic Exposure of Pyrazinoic Acid Has Limited Antituberculosis Activity in Murine and Rabbit Models of Tuberculosis.
Antimicrobial agents and chemotherapy.
2016 07; 60(7):4197-205. doi:
10.1128/aac.03085-15. [PMID: 27139472] - Priyanka A Shah, Primal Sharma, Jaivik V Shah, Mallika Sanyal, Pranav S Shrivastav. An improved LC-MS/MS method for the simultaneous determination of pyrazinamide, pyrazinoic acid and 5-hydroxy pyrazinoic acid in human plasma for a pharmacokinetic study.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2016 Apr; 1017-1018(?):52-61. doi:
10.1016/j.jchromb.2016.02.036. [PMID: 26945134] - David Pires, Emília Valente, Marta Filipa Simões, Nuno Carmo, Bernard Testa, Luís Constantino, Elsa Anes. Esters of Pyrazinoic Acid Are Active against Pyrazinamide-Resistant Strains of Mycobacterium tuberculosis and Other Naturally Resistant Mycobacteria In Vitro and Ex Vivo within Macrophages.
Antimicrobial agents and chemotherapy.
2015 Dec; 59(12):7693-9. doi:
10.1128/aac.00936-15. [PMID: 26438493] - Takeo Nakanishi, Kouhei Ohya, Sho Shimada, Naohiko Anzai, Ikumi Tamai. Functional cooperation of URAT1 (SLC22A12) and URATv1 (SLC2A9) in renal reabsorption of urate.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2013 Mar; 28(3):603-11. doi:
10.1093/ndt/gfs574. [PMID: 23291366] - Masanobu Sato, Tomohiko Wakayama, Hideaki Mamada, Yoshiyuki Shirasaka, Takeo Nakanishi, Ikumi Tamai. Identification and functional characterization of uric acid transporter Urat1 (Slc22a12) in rats.
Biochimica et biophysica acta.
2011 Jun; 1808(6):1441-7. doi:
10.1016/j.bbamem.2010.11.002. [PMID: 21074513] - K S Rajini, Ch Sasikala, Ch V Ramana. Reductive degradation of pyrazine-2-carboxylate by a newly isolated Stenotrophomonas sp. HCU1.
Biodegradation.
2010 Sep; 21(5):801-13. doi:
10.1007/s10532-010-9345-0. [PMID: 20217461] - Masanobu Sato, Hideaki Mamada, Naohiko Anzai, Yoshiyuki Shirasaka, Takeo Nakanishi, Ikumi Tamai. Renal secretion of uric acid by organic anion transporter 2 (OAT2/SLC22A7) in human.
Biological & pharmaceutical bulletin.
2010; 33(3):498-503. doi:
10.1248/bpb.33.498. [PMID: 20190416] - Kimiyoshi Ichida. What lies behind serum urate concentration? Insights from genetic and genomic studies.
Genome medicine.
2009 Dec; 1(12):118. doi:
10.1186/gm118. [PMID: 20090896] - Marta Filipa Simões, Emília Valente, M José Rodríguez Gómez, Elsa Anes, Luís Constantino. Lipophilic pyrazinoic acid amide and ester prodrugs stability, activation and activity against M. tuberculosis.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2009 Jun; 37(3-4):257-63. doi:
10.1016/j.ejps.2009.02.012. [PMID: 19491013] - Iwao Akashi, Keisuke Kagami, Toshihiko Hirano, Kitaro Oka. Protective effects of coffee-derived compounds on lipopolysaccharide/D-galactosamine induced acute liver injury in rats.
The Journal of pharmacy and pharmacology.
2009 Apr; 61(4):473-8. doi:
10.1211/jpp/61.04.0009. [PMID: 19298694] - Keisuke Kagami, Kenji Onda, Kitaro Oka, Toshihiko Hirano. Suppression of blood lipid concentrations by volatile Maillard reaction products.
Nutrition (Burbank, Los Angeles County, Calif.).
2008 Nov; 24(11-12):1159-66. doi:
10.1016/j.nut.2008.05.010. [PMID: 18586457] - Naohiko Anzai, Kimiyoshi Ichida, Promsuk Jutabha, Toru Kimura, Ellappan Babu, Chun Ji Jin, Sunena Srivastava, Kenichiro Kitamura, Ichiro Hisatome, Hitoshi Endou, Hiroyuki Sakurai. Plasma urate level is directly regulated by a voltage-driven urate efflux transporter URATv1 (SLC2A9) in humans.
The Journal of biological chemistry.
2008 Oct; 283(40):26834-8. doi:
10.1074/jbc.c800156200. [PMID: 18701466] - Sude Eminzade, Fikriye Uraz, Fikret V Izzettin. Silymarin protects liver against toxic effects of anti-tuberculosis drugs in experimental animals.
Nutrition & metabolism.
2008 Jul; 5(?):18. doi:
10.1186/1743-7075-5-18. [PMID: 18601745] - Hua Zhang, Jiao-Yu Deng, Li-Jun Bi, Ya-Feng Zhou, Zhi-Ping Zhang, Cheng-Gang Zhang, Ying Zhang, Xian-En Zhang. Characterization of Mycobacterium tuberculosis nicotinamidase/pyrazinamidase.
The FEBS journal.
2008 Feb; 275(4):753-62. doi:
10.1111/j.1742-4658.2007.06241.x. [PMID: 18201201] - Yuu Aoki, Masahiro Yoshida, Hiroshi Kawaide, Hiroshi Abe, Masahiro Natsume. Structural determination of hypnosin, a spore germination inhibitor of phytopathogenic Streptomyces sp. causing root tumor in melon (Cucumis sp.).
Journal of agricultural and food chemistry.
2007 Dec; 55(26):10622-7. doi:
10.1021/jf072719x. [PMID: 18052243] - Yohannes Hagos, Daniel Stein, Bernhard Ugele, Gerhard Burckhardt, Andrew Bahn. Human renal organic anion transporter 4 operates as an asymmetric urate transporter.
Journal of the American Society of Nephrology : JASN.
2007 Feb; 18(2):430-9. doi:
10.1681/asn.2006040415. [PMID: 17229912] - David B Mount, Charles Y Kwon, Kambiz Zandi-Nejad. Renal urate transport.
Rheumatic diseases clinics of North America.
2006 May; 32(2):313-31, vi. doi:
10.1016/j.rdc.2006.02.006. [PMID: 16716882] - Shirou Itagaki, Soji Shimamoto, Mitsuru Sugawara, Michiya Kobayashi, Katsumi Miyazaki, Takeshi Hirano, Ken Iseki. Phenolsulfonphthalein transport by potential-sensitive urate transport system.
European journal of pharmacology.
2005 Aug; 518(2-3):83-9. doi:
10.1016/j.ejphar.2005.06.009. [PMID: 16083873] - Makoto Hosoyamada, Kimiyoshi Ichida, Atsushi Enomoto, Tatsuo Hosoya, Hitoshi Endou. Function and localization of urate transporter 1 in mouse kidney.
Journal of the American Society of Nephrology : JASN.
2004 Feb; 15(2):261-8. doi:
10.1097/01.asn.0000107560.80107.19. [PMID: 14747372] - Kimiyoshi Ichida, Makoto Hosoyamada, Hiroaki Kimura, Michio Takeda, Yasunori Utsunomiya, Tatsuo Hosoya, Hitoshi Endou. Urate transport via human PAH transporter hOAT1 and its gene structure.
Kidney international.
2003 Jan; 63(1):143-55. doi:
10.1046/j.1523-1755.2003.00710.x. [PMID: 12472777] - Edgar Leal-Pinto, B Eleazar Cohen, Michael S Lipkowitz, Ruth G Abramson. Functional analysis and molecular model of the human urate transporter/channel, hUAT.
American journal of physiology. Renal physiology.
2002 Jul; 283(1):F150-63. doi:
10.1152/ajprenal.00333.2001. [PMID: 12060597] - Aida Mehmedagic, Philippe Verite, Sabine Menager, Christine Tharasse, Christiane Chabenat, Dominique Andre, Olivier Lafont. Investigation of the effects of concomitant caffeine administration on the metabolic disposition of pyrazinamide in rats.
Biopharmaceutics & drug disposition.
2002 Jul; 23(5):191-5. doi:
10.1002/bdd.305. [PMID: 12116050] - Tsutomu Fukuwatari, Etsuro Sugimoto, Katsumi Shibata. Growth-promoting activity of pyrazinoic acid, a putative active compound of antituberculosis drug pyrazinamide, in niacin-deficient rats through the inhibition of ACMSD activity.
Bioscience, biotechnology, and biochemistry.
2002 Jul; 66(7):1435-41. doi:
10.1271/bbb.66.1435. [PMID: 12224625] - Ying Zhang, Sallie Permar, Zhonghe Sun. Conditions that may affect the results of susceptibility testing of Mycobacterium tuberculosis to pyrazinamide.
Journal of medical microbiology.
2002 Jan; 51(1):42-49. doi:
10.1099/0022-1317-51-1-42. [PMID: 11800471] - P Draper. Lipid biochemistry takes a stand against tuberculosis.
Nature medicine.
2000 Sep; 6(9):977-8. doi:
10.1038/79670. [PMID: 10973314] - H Yamada, H Kotaki, H Furitsu, Y Sawada, T Iga. Mechanism of the uricosuric action of E3040, a drug used to treat inflammatory bowel disease II: study using DBA/2N mice.
Biopharmaceutics & drug disposition.
1999 Jul; 20(5):271-6. doi:
10.1002/(sici)1099-081x(199907)20:5<271::aid-bdd185>3.0.co;2-i. [PMID: 10594872] - E Leal-Pinto, B E Cohen, R G Abramson. Functional analysis and molecular modeling of a cloned urate transporter/channel.
The Journal of membrane biology.
1999 May; 169(1):13-27. doi:
10.1007/pl00005897. [PMID: 10227848] - E S Vesell, K H Beyer. Studies on pyrazinoylguanidine. 7. Effects of single oral doses in normal human subjects.
Pharmacology.
1999 Mar; 58(3):140-6. doi:
10.1159/000028276. [PMID: 9925970] - A Mehmedagic, P Vérité, S Ménager, C Tharasse, C Chabenat, D André, O Lafont. Determination of pyrazinamide and its main metabolites in rat urine by high-performance liquid chromatography.
Journal of chromatography. B, Biomedical sciences and applications.
1997 Aug; 695(2):365-72. doi:
10.1016/s0378-4347(97)00175-8. [PMID: 9300873] - F Roch-Ramel, B Guisan, J Diezi. Effects of uricosuric and antiuricosuric agents on urate transport in human brush-border membrane vesicles.
The Journal of pharmacology and experimental therapeutics.
1997 Feb; 280(2):839-45. doi:
. [PMID: 9023298] - K E Bergmann, M H Cynamon, J T Welch. Quantitative structure-activity relationships for the in vitro antimycobacterial activity of pyrazinoic acid esters.
Journal of medicinal chemistry.
1996 Aug; 39(17):3394-400. doi:
10.1021/jm950538t. [PMID: 8765523] - Y I A-Rahim, K H Beyer, E S Vesell. Studies on pyrazinoylguanidine. 2. Comparative drug and dose effects on glucose and lipid metabolism in streptozotocin-induced diabetic rats.
Pharmacology.
1996 Mar; 52(3):145-52. doi:
10.1159/000139378. [PMID: 8849483] - F Roch-Ramel, B Guisan, L Schild. Indirect coupling of urate and p-aminohippurate transport to sodium in human brush-border membrane vesicles.
The American journal of physiology.
1996 Jan; 270(1 Pt 2):F61-8. doi:
10.1152/ajprenal.1996.270.1.f61. [PMID: 8769823] - E Leal-Pinto, R D London, B A Knorr, R G Abramson. Reconstitution of hepatic uricase in planar lipid bilayer reveals a functional organic anion channel.
The Journal of membrane biology.
1995 Jul; 146(2):123-32. doi:
10.1007/bf00238003. [PMID: 7473683] - B A Knorr, J C Beck, R G Abramson. Classical and channel-like urate transporters in rabbit renal brush border membranes.
Kidney international.
1994 Mar; 45(3):727-36. doi:
10.1038/ki.1994.97. [PMID: 7515128] - Y K Kim, D K Jung, J S Jung, S H Lee. Urate excretion by the cat kidney.
Comparative biochemistry and physiology. Comparative physiology.
1992 Aug; 102(4):735-9. doi:
10.1016/0300-9629(92)90733-7. [PMID: 1355039] - G T Passananti, E S Vesell, E V Jeszenka, R T Gelarden, K H Beyer. Pharmacokinetics of pyrazinoyl-guanidine, 3-aminopyrazinoyl-guanidine and their corresponding pyrazinoic acid metabolites in humans and dogs.
Pharmacology.
1992; 45(3):129-41. doi:
10.1159/000138991. [PMID: 1438523] - T Shinosaki, Y Yonetani. Hyperuricemia induced by the uricosuric drug probenecid in rats.
Japanese journal of pharmacology.
1991 Apr; 55(4):461-8. doi:
10.1254/jjp.55.461. [PMID: 1886291] - D Werner, B Guisan, F Roch-Ramel. Urate transport in the proximal tubule of human kidney.
Advances in experimental medicine and biology.
1991; 309A(?):177-80. doi:
10.1007/978-1-4899-2638-8_40. [PMID: 1789202] - M L MacDougall, T B Wiegmann. Urate excretion by the isolated perfused rat kidney and modification by drugs.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.).
1989 Dec; 192(3):276-80. doi:
10.3181/00379727-192-42997. [PMID: 2602393] - C Lacroix, T P Hoang, J Nouveau, C Guyonnaud, G Laine, H Duwoos, O Lafont. Pharmacokinetics of pyrazinamide and its metabolites in healthy subjects.
European journal of clinical pharmacology.
1989; 36(4):395-400. doi:
10.1007/bf00558302. [PMID: 2737233] - T Shinosaki, Y Yonetani. Stop-flow studies on tubular transport of uric acid in rats.
Advances in experimental medicine and biology.
1989; 253A(?):293-300. doi:
10.1007/978-1-4684-5673-8_49. [PMID: 2624206] - P Vayre, E Chambraud, G Fredj, A Thuillier. [Pharmacokinetic study of pyrazinamide and pyrazinoic acid in subjects with normal renal function and patients with renal failure].
Therapie.
1989 Jan; 44(1):1-4. doi:
NULL. [PMID: 2734715] - G Stamatakis, C Montes, J H Trouvin, R Farinotti, H Fessi, S Kenouch, J P Méry. Pyrazinamide and pyrazinoic acid pharmacokinetics in patients with chronic renal failure.
Clinical nephrology.
1988 Oct; 30(4):230-4. doi:
NULL. [PMID: 3214968] - C Lacroix, P Poncet, G Laine, C Guyonnaud, M Ray, S Menager, O Lafont. [Microdetermination of pyrazinamide and its metabolites (pyrazinoic acid, 5-hydroxypyrazinoic acid, 5-hydroxypyrazinamide and pyrazinuric acid) in plasma and urine with liquid chromatography].
Journal of chromatography.
1987 Nov; 422(?):217-25. doi:
NULL. [PMID: 3437007] - T Yamamoto, Y Moriwaki, S Takahashi, T Hada, K Higashino. 5-Hydroxypyrazinamide, a human metabolite of pyrazinamide.
Biochemical pharmacology.
1987 Jul; 36(14):2415-6. doi:
10.1016/0006-2952(87)90611-3. [PMID: 3606648] - L W Whitehouse, B A Lodge, A W By, B H Thomas. Metabolic disposition of pyrazinamide in the rat: identification of a novel in vivo metabolite common to both rat and human.
Biopharmaceutics & drug disposition.
1987 Jul; 8(4):307-18. doi:
10.1002/bdd.2510080402. [PMID: 3620591] - T Yamamoto, Y Moriwaki, S Takahashi, T Hada, K Higashino. Study of the metabolism of pyrazinamide using a high-performance liquid chromatographic analysis of urine samples.
Analytical biochemistry.
1987 Feb; 160(2):346-9. doi:
10.1016/0003-2697(87)90058-3. [PMID: 3578761] - C Lacroix, B Langlois, S Ménager, O Lafont. [Simultaneous microdetermination of pyrazinamide and pyrazinoic acid by liquid chromatography].
Annales de biologie clinique.
1987; 45(3):297-9. doi:
NULL. [PMID: 3662137] - K Besseghir, F Roch-Ramel. Pyrazinoate transport in the isolated perfused rabbit proximal tubule.
Pflugers Archiv : European journal of physiology.
1986 Dec; 407(6):643-8. doi:
10.1007/bf00582646. [PMID: 3797219] - J Bidiville, F Roch-Ramel. Competition of organic anions for furosemide and p-aminohippurate secretion in the rabbit.
The Journal of pharmacology and experimental therapeutics.
1986 May; 237(2):636-43. doi:
NULL. [PMID: 3701646] - M Shimoda, E Aihara, M Koyanagi, E Kokue, T Hayama. Possible active tubular secretion of sulfamonomethoxine and its metabolites in pigs.
Journal of pharmacobio-dynamics.
1986 Mar; 9(3):229-33. doi:
10.1248/bpb1978.9.229. [PMID: 3723317] - A M Kahn, E J Weinman. Urate transport in the proximal tubule: in vivo and vesicle studies.
The American journal of physiology.
1985 Dec; 249(6 Pt 2):F789-98. doi:
10.1152/ajprenal.1985.249.6.f789. [PMID: 3000189] - G Acocella, N A Carlone, A M Cuffini, G Cavallo. The penetration of rifampicin, pyrazinamide, and pyrazinoic acid into mouse macrophages.
The American review of respiratory disease.
1985 Dec; 132(6):1268-73. doi:
10.1164/arrd.1985.132.6.1268. [PMID: 4073666] - M Manganel, F Roch-Ramel, H Murer. Sodium-pyrazinoate cotransport in rabbit renal brush border membrane vesicles.
The American journal of physiology.
1985 Sep; 249(3 Pt 2):F400-8. doi:
10.1152/ajprenal.1985.249.3.f400. [PMID: 4037092] - S E Guggino, P S Aronson. Paradoxical effects of pyrazinoate and nicotinate on urate transport in dog renal microvillus membranes.
The Journal of clinical investigation.
1985 Aug; 76(2):543-7. doi:
10.1172/jci112004. [PMID: 4031062] - R G Abramson, M S Lipkowitz. Carrier-mediated concentrative urate transport in rat renal membrane vesicles.
The American journal of physiology.
1985 Apr; 248(4 Pt 2):F574-84. doi:
10.1152/ajprenal.1985.248.4.f574. [PMID: 3985164] - W H Dantzler, O H Brokl. Lack of effect of low [Ca2+], La3+, and pyrazinoate on urate transport by isolated, perfused snake renal tubules.
Pflugers Archiv : European journal of physiology.
1984 Jul; 401(3):262-5. doi:
10.1007/bf00582593. [PMID: 6473078] - K Iwaki, Y Yonetani. Decreased renal excretion of uric acid following diuretic administration in rats.
Japanese journal of pharmacology.
1984 Apr; 34(4):389-96. doi:
10.1254/jjp.34.389. [PMID: 6374219] - M Perez-Gonzalez, I M Weiner. Effects of p-aminohippurate and pyrazinoate on urate excretion in Cebus monkeys.
The Journal of pharmacology and experimental therapeutics.
1984 Jan; 228(1):252-5. doi:
NULL. [PMID: 6694107] - A M Kahn, S Branham, E J Weinman. Mechanism of urate and p-aminohippurate transport in rat renal microvillus membrane vesicles.
The American journal of physiology.
1983 Aug; 245(2):F151-8. doi:
10.1152/ajprenal.1983.245.2.f151. [PMID: 6309010] - G R Sarma, G S Acharyulu, M Kannapiran, P V Murthy, P Gurumurthy, S P Tripathy. Role of rifampicin in arthralgia induced by pyrazinamide.
Tubercle.
1983 Jun; 64(2):93-100. doi:
10.1016/0041-3879(83)90033-8. [PMID: 6612796] - B Ferrier, M Martin, F Roch-Ramel. Effects of p-aminohippurate and pyrazinoate on the renal excretion of salicylate in the rat: a micropuncture study.
The Journal of pharmacology and experimental therapeutics.
1983 Feb; 224(2):451-8. doi:
NULL. [PMID: 6822966] - M Perez-Gonzalez, I M Weiner. Effects of pyrazinoate and p-aminohippurate on renal urate excretion by the dog and guinea pig.
The Journal of pharmacology and experimental therapeutics.
1983 Feb; 224(2):364-8. doi:
NULL. [PMID: 6822960] - B Moulin, P Vinay, N Duong, A Gougoux, G Lemieux. Net urate reabsorption in the Dalmatian coach hound with a note on automated measurement of urate in species with low plasma urate.
Canadian journal of physiology and pharmacology.
1982 Dec; 60(12):1499-504. doi:
10.1139/y82-221. [PMID: 7165848] - K J Ullrich, G Rumrich, S Klöss, H Fasold. Reabsorption of monocarboxylic acids in the proximal tubule of the rat kidney. III. Specificity for aromatic compounds.
Pflugers Archiv : European journal of physiology.
1982 Nov; 395(3):227-31. doi:
10.1007/bf00584814. [PMID: 7155796] - B Ratti, A Toselli, E Beretta, A Bernareggi. HPLC assay of pyrazinoic acid in human plasma in the presence of pyrazinamide and other antituberculosis drugs using an automatic sampler.
Il Farmaco; edizione pratica.
1982 Jul; 37(7):226-34. doi:
NULL. [PMID: 7128773] - C Schäli, F Roch-Ramel. Uptake of [3H]PAH and [14C]urate into isolated proximal tubular segments of the pig kidney.
The American journal of physiology.
1981 Dec; 241(6):F591-6. doi:
10.1152/ajprenal.1981.241.6.f591. [PMID: 7325230] - P Gurumurthy, N G Nair, G R Sarma. Methods for the estimation of pyrazinamide and pyrazinoic acid in body fluids.
The Indian journal of medical research.
1980 Jan; 71(?):129-34. doi:
NULL. [PMID: 7380485] - G M Fanelli, I M Weiner. Urate excretion: drug interactions.
The Journal of pharmacology and experimental therapeutics.
1979 Aug; 210(2):186-95. doi:
NULL. [PMID: 110920] - S J Frankfurt, E J Weinman. Pyrazinoic acid and urate transport in the rat.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.).
1978 Oct; 159(1):16-20. doi:
10.3181/00379727-159-40274. [PMID: 714929] - J Roboz, R Suzuki, T F Yü. Mass fragmentographic determination of pyrazinamide and its metabolites in serum and urine.
Journal of chromatography.
1978 Jan; 147(?):337-47. doi:
10.1016/s0021-9673(00)85145-6. [PMID: 621253] - G M Fanelli, D L Bohn, A G Zacchei. Renal excretion of a slauretic-uricosuric agent (MK-196) and interaction with a urate-retaining drug, pyrazinoate, in the chimpanzee.
The Journal of pharmacology and experimental therapeutics.
1977 Feb; 200(2):413-9. doi:
NULL. [PMID: 14251] - G A Ellard, R M Haslam. Observations on the reduction of the renal elimination of urate in man caused by the administration of pyrazinamide.
Tubercle.
1976 Jun; 57(2):97-103. doi:
10.1016/0041-3879(76)90046-5. [PMID: 960228] - T F YU, L BERGER, D J STONE, J WOLF, A B GUTMAN. Effect of pyrazinamide and pyrazinoic acid on urate clearance and other discrete renal functions.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.).
1957 Oct; 96(1):264-7. doi:
10.3181/00379727-96-23450. [PMID: 13485075]