clophen a 30 : a 60 1 : 1 (BioDeep_00001868168)

Main id: BioDeep_00000012089

 

Industrial Pollutants Volatile Flavor Compounds


代谢物信息卡片


3,3,4,4,5,5-Hexachlorobiphenyl

化学式: C12H4Cl6 (357.8444164)
中文名称: 3,3,4,4,5,5-六氯联苯, 八氯化萘
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=C(C=C(C(=C1Cl)Cl)Cl)C2=CC(=C(C(=C2)Cl)Cl)Cl
InChI: InChI=1S/C12H4Cl6/c13-7-1-5(2-8(14)11(7)17)6-3-9(15)12(18)10(16)4-6/h1-4H

描述信息

D004785 - Environmental Pollutants > D011078 - Polychlorinated Biphenyls

同义名列表

3 个代谢物同义名

3,3,4,4,5,5-Hexachlorobiphenyl; clophen a 30 : a 60 1 : 1; 3,4,5,3',4',5'-Hexachlorobiphenyl



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Xiaolong Duan, Jiake Li, Yuxing Li. The fate of three typical persistent organic pollutants in bioretention columns as revealed by stable carbon isotopes. Chemosphere. 2023 Sep; 334(?):138996. doi: 10.1016/j.chemosphere.2023.138996. [PMID: 37211166]
  • Meriem Koual, German Cano-Sancho, Anne-Sophie Bats, Céline Tomkiewicz, Yael Kaddouch-Amar, Nathalie Douay-Hauser, Charlotte Ngo, Hélène Bonsang, Myriam Deloménie, Fabrice Lecuru, Bruno Le Bizec, Philippe Marchand, Jeremie Botton, Robert Barouki, Jean-Philippe Antignac, Xavier Coumoul. Associations between persistent organic pollutants and risk of breast cancer metastasis. Environment international. 2019 11; 132(?):105028. doi: 10.1016/j.envint.2019.105028. [PMID: 31382183]
  • Jana Brankovič, Gregor Fazarinc, Maja Antanasova, Peter Jevnikar, Janja Jan, Ines Anders, Katarina Pavšič Vrtač, Breda Jakovac Strajn, David Antolinc, Milka Vrecl. Lactational exposure to dioxin-like polychlorinated biphenyl 169 and nondioxin-like polychlorinated biphenyl 155: Effects on rat femur growth, biomechanics and mineral composition. Ecotoxicology and environmental safety. 2019 Sep; 180(?):106-113. doi: 10.1016/j.ecoenv.2019.04.076. [PMID: 31078017]
  • Jana Brankovič, Sašo Jovanovski, Peter Jevnikar, Alexander Hofmeister, Birgit Reininger-Gutmann, Janja Jan, Maja Grošelj, Joško Osredkar, Matjaž Uršič, Gregor Fazarinc, Azra Pogačnik, Milka Vrecl. Alterations in geometry, biomechanics, and mineral composition of juvenile rat femur induced by nonplanar PCB-155 and/or planar PCB-169. Environmental toxicology. 2017 Apr; 32(4):1135-1146. doi: 10.1002/tox.22309. [PMID: 27393578]
  • Tobias Lammel, Paul Boisseaux, José M Navas. Potentiating effect of graphene nanomaterials on aromatic environmental pollutant-induced cytochrome P450 1A expression in the topminnow fish hepatoma cell line PLHC-1. Environmental toxicology. 2015 Sep; 30(10):1192-204. doi: 10.1002/tox.21991. [PMID: 24706484]
  • Wusheng Xiao, Jie Zhang, Jiren Liang, Hongyan Zhu, Zhijun Zhou, Qing Wu. Adverse effects of neonatal exposure to 3,3',4,4',5,5'-hexachlorobiphenyl on hormone levels and testicular function in male Sprague-Dawley rats. Environmental toxicology. 2011 Nov; 26(6):657-68. doi: 10.1002/tox.20677. [PMID: 21374784]
  • J S Lim, H-K Son, S-K Park, D R Jacobs, D-H Lee. Inverse associations between long-term weight change and serum concentrations of persistent organic pollutants. International journal of obesity (2005). 2011 May; 35(5):744-7. doi: 10.1038/ijo.2010.188. [PMID: 20820170]
  • Matt Cave, Savitri Appana, Mihir Patel, Keith Cameron Falkner, Craig J McClain, Guy Brock. Polychlorinated biphenyls, lead, and mercury are associated with liver disease in American adults: NHANES 2003-2004. Environmental health perspectives. 2010 Dec; 118(12):1735-42. doi: 10.1289/ehp.1002720. [PMID: 21126940]
  • J M Hedge, M J DeVito, K M Crofton. In vivo acute exposure to polychlorinated biphenyls: effects on free and total thyroxine in rats. International journal of toxicology. 2009 Sep; 28(5):382-91. doi: 10.1177/1091581809344631. [PMID: 19815845]
  • Jianying Zhang, Hangjun Zhang, Wanmin Ni. Oxidative stress and apoptosis of Carassius auratus lymphocytes induced by nonplanar (PCB153) and coplanar (PCB169) polychlorinated biphenyl congeners in vitro. Journal of environmental sciences (China). 2009; 21(9):1284-9. doi: 10.1016/s1001-0742(08)62416-x. [PMID: 19999978]
  • Richard M Green, Nikolas J Hodges, J Kevin Chipman, Michael R O'Donovan, Mark Graham. Reactive oxygen species from the uncoupling of human cytochrome P450 1B1 may contribute to the carcinogenicity of dioxin-like polychlorinated biphenyls. Mutagenesis. 2008 Nov; 23(6):457-63. doi: 10.1093/mutage/gen035. [PMID: 18583386]
  • Michio X Watanabe, Hisato Iwata, Mio Okamoto, Eun-Young Kim, Kumiko Yoneda, Takuma Hashimoto, Shinsuke Tanabe. Induction of cytochrome P450 1A5 mRNA, protein and enzymatic activities by dioxin-like compounds, and congener-specific metabolism and sequestration in the liver of wild jungle crow (Corvus macrorhynchos) from Tokyo, Japan. Toxicological sciences : an official journal of the Society of Toxicology. 2005 Dec; 88(2):384-99. doi: 10.1093/toxsci/kfi326. [PMID: 16177242]
  • Masako Yamamoto, Akiko Narita, Mari Kagohata, Mitsuyuki Shirai, Fumiaki Akahori, Kazuyoshi Arishima. Effects of maternal exposure to 3,3',4,4',5-pentachlorobiphenyl (PCB126) or 3,3',4,4',5,5'-hexachlorobiphenyl (PCB169) on testicular steroidogenesis and spermatogenesis in male offspring rats. Journal of andrology. 2005 Mar; 26(2):205-14. doi: 10.1002/j.1939-4640.2005.tb01087.x. [PMID: 15713826]
  • C Y Chen, J T Hamm, J R Hass, L S Birnbaum. Disposition of polychlorinated dibenzo-p-dioxins, dibenzofurans, and non-ortho polychlorinated biphenyls in pregnant long evans rats and the transfer to offspring. Toxicology and applied pharmacology. 2001 Jun; 173(2):65-88. doi: 10.1006/taap.2001.9143. [PMID: 11384209]
  • S A Saghir, L G Hansen, K R Holmes, P R Kodavanti. Differential and non-uniform tissue and brain distribution of two distinct 14C-hexachlorobiphenyls in weanling rats. Toxicological sciences : an official journal of the Society of Toxicology. 2000 Mar; 54(1):60-70. doi: 10.1093/toxsci/54.1.60. [PMID: 10746932]
  • E V Hestermann, J J Stegeman, M E Hahn. Serum alters the uptake and relative potencies of halogenated aromatic hydrocarbons in cell culture bioassays. Toxicological sciences : an official journal of the Society of Toxicology. 2000 Feb; 53(2):316-25. doi: 10.1093/toxsci/53.2.316. [PMID: 10696780]
  • L Gribaldo, M G Sacco, S Casati, I Zucchi, M K Dosanjh, P Catalani, E Marafante. Modulation of proto-oncogene expression by polychlorinated biphenyls in 3T3-L1 cell line. Journal of toxicology and environmental health. Part A. 1998 Sep; 55(2):121-31. doi: 10.1080/009841098158557. [PMID: 9761132]
  • K A Patnode, L R Curtis. 2,2',4,4',5,5'- and 3,3',4,4',5,5'-hexachlorobiphenyl alteration of uterine progesterone and estrogen receptors coincides with embryotoxicity in mink (Mustela vision). Toxicology and applied pharmacology. 1994 Jul; 127(1):9-18. doi: 10.1006/taap.1994.1133. [PMID: 8048058]
  • G K De Krey, N C Hollingshead, N I Kerkvliet, B B Smith. Suppression of prolactin and cytotoxic T-lymphocyte activity in PCB-treated mice. International journal of immunopharmacology. 1994 Mar; 16(3):251-7. doi: 10.1016/0192-0561(94)90020-5. [PMID: 8206692]
  • D C Morse, D Groen, M Veerman, C J van Amerongen, H B Koëter, A E Smits van Prooije, T J Visser, J H Koeman, A Brouwer. Interference of polychlorinated biphenyls in hepatic and brain thyroid hormone metabolism in fetal and neonatal rats. Toxicology and applied pharmacology. 1993 Sep; 122(1):27-33. doi: 10.1006/taap.1993.1168. [PMID: 8378931]
  • H N Yeowell, D J Waxman, G A LeBlanc, P Linko, J A Goldstein. Suppression of male-specific cytochrome P450 2c and its mRNA by 3,4,5,3',4',5'-hexachlorobiphenyl in rat liver is not causally related to changes in serum testosterone. Archives of biochemistry and biophysics. 1989 Jun; 271(2):508-14. doi: 10.1016/0003-9861(89)90302-0. [PMID: 2499261]
  • H N Yeowell, D J Waxman, G A LeBlanc, P Linko, J A Goldstein. Induction of rat cytochrome P-450 3 and its mRNA by 3,4,5,3',4',5'-hexachlorobiphenyl. Molecular pharmacology. 1988 Mar; 33(3):272-8. doi: NULL. [PMID: 3127689]
  • H N Yeowell, D J Waxman, A Wadhera, J A Goldstein. Suppression of the constitutive, male-specific rat hepatic cytochrome P-450 2c and its mRNA by 3,4,5,3',4',5'-hexachlorobiphenyl and 3-methylcholanthrene. Molecular pharmacology. 1987 Sep; 32(3):340-7. doi: NULL. [PMID: 3118178]
  • L G Pedersen, T A Darden, S J Oatley, J D McKinney. A theoretical study of the binding of polychlorinated biphenyls (PCBs), dibenzodioxins, and dibenzofuran to human plasma prealbumin. Journal of medicinal chemistry. 1986 Dec; 29(12):2451-7. doi: 10.1021/jm00162a006. [PMID: 3097319]
  • R J Aulerich, S J Bursian, W J Breslin, B A Olson, R K Ringer. Toxicological manifestations of 2,4,5,2',4',5'-, 2,3,6,2',3',6'-, and 3,4,5,3',4',5'-hexachlorobiphenyl and Aroclor 1254 in mink. Journal of toxicology and environmental health. 1985; 15(1):63-79. doi: 10.1080/15287398509530636. [PMID: 3920403]