diethylcarbamazine (BioDeep_00001868090)

Main id: BioDeep_00000003903

 


代谢物信息卡片


diethylcarbamazine

化学式: C10H21N3O (199.1685)
中文名称: 乙胺嗪, 二乙基咔嗪
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCN(CC)C(=O)N1CCN(CC1)C
InChI: InChI=1S/C10H21N3O/c1-4-12(5-2)10(14)13-8-6-11(3)7-9-13/h4-9H2,1-3H3

描述信息

P - Antiparasitic products, insecticides and repellents > P02 - Anthelmintics > P02C - Antinematodal agents > P02CB - Piperazine and derivatives
D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000871 - Anthelmintics
C254 - Anti-Infective Agent > C276 - Antiparasitic Agent > C250 - Antihelminthic Agent
D004791 - Enzyme Inhibitors > D016859 - Lipoxygenase Inhibitors

同义名列表

3 个代谢物同义名

diethylcarbamazine; Diethylcarbamazine; Diethylcarbamazine



数据库引用编号

11 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Kiran Agarwal, Kavita Gaur, Nazma Khasim. Filariasis presenting with bicytopenia, progressive splenomegaly and acute renal failure: An unusual case report. Tropical doctor. 2021 Oct; 51(4):588-590. doi: 10.1177/00494755211002027. [PMID: 33977778]
  • Anuruddha Abeygunasekera, Saroj Jayasinghe. Is the anti-filarial drug diethylcarbamazine useful to treat COVID-19?. Medical hypotheses. 2020 Oct; 143(?):109843. doi: 10.1016/j.mehy.2020.109843. [PMID: 32492560]
  • Nosibah Abdul-Razek, Al-Mahy M El-Mallah, Abdelaziz S A Abuelsaad, Mahmoud Abdel-Latif. Enhancement of Anti-allergic Effect of Diethylcarbamazine Citrate in Asthmatic Mouse Model: Testing of Anti-drug Antibodies and Quercetin. Iranian journal of allergy, asthma, and immunology. 2020 Aug; 19(4):373-385. doi: 10.18502/ijaai.v19i4.4112. [PMID: 33463104]
  • Andi Dian Permana, Ismaiel A Tekko, Maelíosa T C McCrudden, Qonita Kurnia Anjani, Delly Ramadon, Helen O McCarthy, Ryan F Donnelly. Solid lipid nanoparticle-based dissolving microneedles: A promising intradermal lymph targeting drug delivery system with potential for enhanced treatment of lymphatic filariasis. Journal of controlled release : official journal of the Controlled Release Society. 2019 12; 316(?):34-52. doi: 10.1016/j.jconrel.2019.10.004. [PMID: 31655132]
  • Britt J Andersen, Bruce A Rosa, Jonah Kupritz, Aboulaye Meite, Traye Serge, Marla I Hertz, Kurt Curtis, Christopher L King, Makedonka Mitreva, Peter U Fischer, Gary J Weil. Systems analysis-based assessment of post-treatment adverse events in lymphatic filariasis. PLoS neglected tropical diseases. 2019 09; 13(9):e0007697. doi: 10.1371/journal.pntd.0007697. [PMID: 31557154]
  • Andi Dian Permana, Ismaiel A Tekko, Helen O McCarthy, Ryan F Donnelly. New HPLC-MS method for rapid and simultaneous quantification of doxycycline, diethylcarbamazine and albendazole metabolites in rat plasma and organs after concomitant oral administration. Journal of pharmaceutical and biomedical analysis. 2019 Jun; 170(?):243-253. doi: 10.1016/j.jpba.2019.03.047. [PMID: 30947125]
  • Gabriel Barros Rodrigues, Elquio Eleamen Oliveira, Francisco Jaime Bezerra Mendonça Junior, Laise Aline Martins Dos Santos, Wilma Helena de Oliveira, Maria Eduarda Rocha de França, Deniele Bezerra Lós, Brennda Martins Gabínio, Christina Alves Peixoto. A new diethylcarbamazine formulation (NANO-DEC) as a therapeutic tool for hepatic fibrosis. International immunopharmacology. 2018 Nov; 64(?):280-288. doi: 10.1016/j.intimp.2018.09.010. [PMID: 30219503]
  • Yashpal S Chhonker, Constant Edi, Daryl J Murry. LC-MS/MS method for simultaneous determination of diethylcarbamazine, albendazole and albendazole metabolites in human plasma: Application to a clinical pharmacokinetic study. Journal of pharmaceutical and biomedical analysis. 2018 Mar; 151(?):84-90. doi: 10.1016/j.jpba.2017.12.037. [PMID: 29310051]
  • Gaurav Garg, Apul Goel, Sunny Goel, Manmeet Singh. Chyluria in young child: a rare presentation. BMJ case reports. 2018 Mar; 2018(?):. doi: 10.1136/bcr-2017-223516. [PMID: 29549133]
  • Gabriel Barros Rodrigues, Elquio Eleamen Oliveira, Francisco Jaime Bezerra Mendonça Junior, Laise Aline Martins Dos Santos, Wilma Helena de Oliveira, Maria Eduarda Rocha de França, Deniele Bezerra Lós, Brennda Martins Gabínio, Fábia Cristiane Melo Leite de Lira, Christina Alves Peixoto. Characterization and evaluation of nanoencapsulated diethylcarbamazine in model of acute hepatic inflammation. International immunopharmacology. 2017 Sep; 50(?):330-337. doi: 10.1016/j.intimp.2017.07.014. [PMID: 28743082]
  • Anuruddha M Abeygunasekera, Kugadas Sutharshan, Balasingam Balagobi. New developments in chyluria after global programs to eliminate lymphatic filariasis. International journal of urology : official journal of the Japanese Urological Association. 2017 08; 24(8):582-588. doi: 10.1111/iju.13378. [PMID: 28556416]
  • Alaa El-Din El-Sayed El-Sisi, Samia Salim Sokar, Abdelhadi Mohamed Shebl, Dina Zakaria Mohamed. Antifibrotic effect of diethylcarbamazine combined with hesperidin against ethanol induced liver fibrosis in rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2017 May; 89(?):1196-1206. doi: 10.1016/j.biopha.2017.03.013. [PMID: 28320086]
  • Jesica A Herrick, Fanny Legrand, Raceline Gounoue, Godwin Nchinda, Céline Montavon, Jean Bopda, Steve Mbickmen Tchana, Bienvenu Etogo Ondigui, Konrad Nguluwe, Michael P Fay, Michelle Makiya, Simon Metenou, Thomas B Nutman, Joseph Kamgno, Amy D Klion. Posttreatment Reactions After Single-Dose Diethylcarbamazine or Ivermectin in Subjects With Loa loa Infection. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2017 04; 64(8):1017-1025. doi: 10.1093/cid/cix016. [PMID: 28329346]
  • Vikas Kushwaha, Kirti Saxena, Richa Verma, Shiv K Verma, Deepali Katoch, Neeraj Kumar, Brij Lal, P Kalpana Murthy, Bikram Singh. Antifilarial activity of diterpenoids from Taxodium distichum. Parasites & vectors. 2016 05; 9(1):312. doi: 10.1186/s13071-016-1592-4. [PMID: 27245322]
  • Saurabh Kumar, Rajbeer Singh Beri. A rare presentation of hydropneumothorax in tropical pulmonary eosinophilia: cavitation and pneumonic consolidation in a child. Tropical doctor. 2016 Apr; 46(2):105-8. doi: 10.1177/0049475515606011. [PMID: 26376823]
  • Praveen Kumar Tripathi, Ramesh Chander Mahajan, Nancy Malla, Abhishek Mewara, Shailja Misra Bhattacharya, Ranganatha Krishna Shenoy, Rakesh Sehgal. Circulating filarial antigen detection in brugian filariasis. Parasitology. 2016 Mar; 143(3):350-7. doi: 10.1017/s0031182015001675. [PMID: 26646772]
  • Johnny Vlaminck, Taniawati Supali, Peter Geldhof, Cornelis H Hokke, Peter U Fischer, Gary J Weil. Community Rates of IgG4 Antibodies to Ascaris Haemoglobin Reflect Changes in Community Egg Loads Following Mass Drug Administration. PLoS neglected tropical diseases. 2016 Mar; 10(3):e0004532. doi: 10.1371/journal.pntd.0004532. [PMID: 26991326]
  • Edward K Thomsen, Nelly Sanuku, Manasseh Baea, Samson Satofan, Elit Maki, Bart Lombore, Mark S Schmidt, Peter M Siba, Gary J Weil, James W Kazura, Lawrence L Fleckenstein, Christopher L King. Efficacy, Safety, and Pharmacokinetics of Coadministered Diethylcarbamazine, Albendazole, and Ivermectin for Treatment of Bancroftian Filariasis. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2016 Feb; 62(3):334-341. doi: 10.1093/cid/civ882. [PMID: 26486704]
  • Arjang Talattof, Judy C Price, Gordon L Amidon. Gastrointestinal Motility Variation and Implications for Plasma Level Variation: Oral Drug Products. Molecular pharmaceutics. 2016 Feb; 13(2):557-67. doi: 10.1021/acs.molpharmaceut.5b00774. [PMID: 26692042]
  • Mahmoud Abdel-Latif. Diethylcarbamazine citrate ameliorates insulin resistance in high-fat diet-induced obese mice via modulation of adipose tissue inflammation. International immunopharmacology. 2015 Dec; 29(2):607-612. doi: 10.1016/j.intimp.2015.09.021. [PMID: 26432178]
  • Mahmoud Abdel-Latif, Thabet Sakran, Gamal El-Shahawi, Hoda El-Fayoumi, Al-Mahy El-Mallah. Immunomodulatory effect of diethylcarbamazine citrate plus filarial excretory-secretory product on rat hepatocarcinogenesis. International immunopharmacology. 2015 Feb; 24(2):173-181. doi: 10.1016/j.intimp.2014.12.004. [PMID: 25499729]
  • Mahmoud Abdel-Latif, Thabet Sakran, Gamal El-Shahawi, Hoda El-Fayoumi, Al-Mahy El-Mallah. Effect of diethylcarbamazine citrate and Setaria equina excretory-secretory material on rat hepatocellular carcinoma. Archivum immunologiae et therapiae experimentalis. 2014 Dec; 62(6):511-20. doi: 10.1007/s00005-014-0292-z. [PMID: 24879096]
  • Karthik Siram, Vijaya Raghavan Chellan, Tamilselvan Natarajan, Balakumar Krishnamoorthy, Habibur Rahman Mohamed Ebrahim, Vamshikrishna Karanam, Siva Selva Kumar Muthuswamy, Hari Prasad Ranganathan. Solid lipid nanoparticles of diethylcarbamazine citrate for enhanced delivery to the lymphatics: in vitro and in vivo evaluation. Expert opinion on drug delivery. 2014 Sep; 11(9):1351-65. doi: 10.1517/17425247.2014.915310. [PMID: 24847779]
  • Mark S Schmidt, Christopher L King, Edward K Thomsen, Peter M Siba, Nelly Sanuku, Lawrence Fleckenstein. Liquid chromatography-mass spectrometry analysis of diethylcarbamazine in human plasma for clinical pharmacokinetic studies. Journal of pharmaceutical and biomedical analysis. 2014 Sep; 98(?):307-10. doi: 10.1016/j.jpba.2014.05.016. [PMID: 24975211]
  • Hideharu Hagiya, Tomohiro Terasaka, Kosuke Kimura, Asuka Satou, Kikuko Asano, Koichi Waseda, Yoshihisa Hanayama, Takahide Takahashi, Michinori Aoe, Koji Iio, Toshiyuki Watanabe, Eisei Kondo, Fumio Otsuka. Filarial chyluria as a rare cause of urinary retention. Internal medicine (Tokyo, Japan). 2014; 53(17):2001-5. doi: 10.2169/internalmedicine.53.2572. [PMID: 25175138]
  • Vishal Golay, Puneet Arora, Anila Abraham, Rajendra Pandey. Quiz page November 2013: an unusual cause of nephrotic syndrome: minimal change disease (MCD). American journal of kidney diseases : the official journal of the National Kidney Foundation. 2013 Nov; 62(5):xxvii-xxix. doi: 10.1053/j.ajkd.2013.06.027. [PMID: 24157278]
  • Jai B Mullerpattan, Zarir F Udwadia, Farokh E Udwadia. Tropical pulmonary eosinophilia--a review. The Indian journal of medical research. 2013 Sep; 138(3):295-302. doi: . [PMID: 24135173]
  • T Sankari, S L Hoti, L K Das, V Govindaraj, P K Das. Effect of Diethylcarbamazine (DEC) on prostaglandin levels in Wuchereria bancrofti infected microfilaraemics. Parasitology research. 2013 Jun; 112(6):2353-9. doi: 10.1007/s00436-013-3399-y. [PMID: 23525692]
  • Gary O Rankin, Suk K Hong, Dianne K Anestis, John G Ball, Monica A Valentovic, Vincent A Graffeo. Role of leukotrienes in N-(3,5-dichlorophenyl)succinimide (NDPS) and NDPS metabolite nephrotoxicity in male Fischer 344 rats. Toxicology. 2012 Oct; 300(1-2):92-9. doi: 10.1016/j.tox.2012.06.003. [PMID: 22706168]
  • Carlos E Medina-De la Garza, Graciela Guerrero-Ramírez, Marisela García-Hernández, M Angeles Castro-Corona, Ernesto Torres-López, Norbert W Brattig, Mario C Salinas-Carmona. Immunomodulatory activity of diethylcarbamazine on humoral, cellular cytokine response and respiratory burst in BALB/c mice. Immunopharmacology and immunotoxicology. 2012 Jun; 34(3):477-83. doi: 10.3109/08923973.2011.630008. [PMID: 22564175]
  • Koneni V Sashidhara, Suriya P Singh, Sweta Misra, Jyoti Gupta, Shailja Misra-Bhattacharya. Galactolipids from Bauhinia racemosa as a new class of antifilarial agents against human lymphatic filarial parasite, Brugia malayi. European journal of medicinal chemistry. 2012 Apr; 50(?):230-5. doi: 10.1016/j.ejmech.2012.01.057. [PMID: 22348826]
  • Li-Guang Tian, Jia-Xu Chen, Tian-Ping Wang, Guo-Jin Cheng, Peter Steinmann, Feng-Feng Wang, Yu-Chun Cai, Xiao-Mei Yin, Jian Guo, Li Zhou, Xiao-Nong Zhou. Co-infection of HIV and intestinal parasites in rural area of China. Parasites & vectors. 2012 Feb; 5(?):36. doi: 10.1186/1756-3305-5-36. [PMID: 22330320]
  • Benjamin Knier, Beatrix Büschges-Seraphin, Karl F Hilgers, Kerstin U Amann, Michael Uder, Kai-Uwe Eckardt, Johannes Jacobi. From red to white urine: a patient's nightmare with a rather benign outcome. BMC nephrology. 2012 Feb; 13(?):7. doi: 10.1186/1471-2369-13-7. [PMID: 22296661]
  • Katherine Gass, Madsen V E Beau de Rochars, Daniel Boakye, Mark Bradley, Peter U Fischer, John Gyapong, Makoto Itoh, Nese Ituaso-Conway, Hayley Joseph, Dominique Kyelem, Sandra J Laney, Anne-Marie Legrand, Tilaka S Liyanage, Wayne Melrose, Khalfan Mohammed, Nils Pilotte, Eric A Ottesen, Catherine Plichart, Kapa Ramaiah, Ramakrishna U Rao, Jeffrey Talbot, Gary J Weil, Steven A Williams, Kimberly Y Won, Patrick Lammie. A multicenter evaluation of diagnostic tools to define endpoints for programs to eliminate bancroftian filariasis. PLoS neglected tropical diseases. 2012 Jan; 6(1):e1479. doi: 10.1371/journal.pntd.0001479. [PMID: 22272369]
  • Rajamanickam Anuradha, Jovvian P George, Nathella Pavankumar, Vasanthapuram Kumaraswami, Thomas B Nutman, Subash Babu. Altered circulating levels of matrix metalloproteinases and inhibitors associated with elevated type 2 cytokines in lymphatic filarial disease. PLoS neglected tropical diseases. 2012; 6(6):e1681. doi: 10.1371/journal.pntd.0001681. [PMID: 22679524]
  • R Anuradha, P Jovvian George, N Pavan Kumar, Michael P Fay, V Kumaraswami, Thomas B Nutman, Subash Babu. Circulating microbial products and acute phase proteins as markers of pathogenesis in lymphatic filarial disease. PLoS pathogens. 2012; 8(6):e1002749. doi: 10.1371/journal.ppat.1002749. [PMID: 22685406]
  • Makoto Itoh, Mirani V Weerasooriya, Thishan C Yahathugoda, Hidekazu Takagi, Wilfred A Samarawickrema, Fumiaki Nagaoka, Eisaku Kimura. Effects of 5 rounds of mass drug administration with diethylcarbamazine and albendazole on filaria-specific IgG4 titers in urine: 6-year follow-up study in Sri Lanka. Parasitology international. 2011 Dec; 60(4):393-7. doi: 10.1016/j.parint.2011.06.019. [PMID: 21723413]
  • Ritu Verma, Mukul Vij. Microfilariae of Wuchereria bancrofti in urine: an uncommon finding. Diagnostic cytopathology. 2011 Nov; 39(11):847-8. doi: 10.1002/dc.21562. [PMID: 21994197]
  • Sammy M Njenga, Charles S Mwandawiro, Erastus Muniu, Mariam T Mwanje, Fatma M Haji, Moses J Bockarie. Adult population as potential reservoir of NTD infections in rural villages of Kwale district, Coastal Kenya: implications for preventive chemotherapy interventions policy. Parasites & vectors. 2011 Sep; 4(?):175. doi: 10.1186/1756-3305-4-175. [PMID: 21917166]
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